• YAKHAK HOEJI
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• v.45 no.6
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• pp.623-633
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• 2001

Various bupivacaine-loaded microspheres were prepared using poly(d,1-lactide) (PLA) and poly(d,1-lactic-co-glycolide) (PLGA) by a solvent evaporation method for the sustained release of drug. The effects of process conditions such as drug loading, polymer type and solvent type on the characteristics of microspheres were investigated. The prepared microspheres were characterized for their drug loading, size distribution, surface morphology and release kinetics. Drug loading efficiency and yield of PLGA micro- spheres were higher than those of PLA microspheres. The prepared microspheres had an average particle size below 5${\mu}{\textrm}{m}$. The particle size range of microspheres was 1.65~2.24${\mu}{\textrm}{m}$. As a result of SEM, the particle size of PLA microspheres was smaller than that of PLGA microspheres. In morphology studies, microspheres showed a spherical shape and smooth surface in all process conditions. In thermal analysis, bupivacaine-loaded microspheres showed no peaks originating from bupivacaine. This suggested that bupivacaine base was molecular-dispersed in the polymer matrix of microspheres. The release pattern of the drug from microspheres was evaluated for 96 hours. The initial burst release of bupivacaine base decreased with increasing the molecular weight of PLGA, and the drug from microspheres released slowly. In conclusion, bupivacaine-loaded microspheres were successfully prepared from poly(d,1-lactide) and poly (d,1- lactic-co-glycolide) polymers with different molecular weights allowing control of the release rate.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3D
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• pp.435-444
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• 2006

This paper investigates the effect of 3-dimensional FE models to evaluation results of jointed concrete pavements which is back-calculated by AREA method. Sensitivity of 3-dimensional FE models developed to simulate the behavior of real jointed concrete pavement are analyzed after compared with 2-dimensional FE models using ILLISLAB. In comparison with 2-dimensional models, influence of concrete contraction under loading plate and base layer on surface deflections is more than that of loading configuration. Deflections at 3-dimensional model between linear and nonlinear temperature distribution under same temperature difference are similar, but noticeable differences are investigated in low elastic modulus of foundations. Dynamic deflections under loading plate are larger than static deflections in high elastic modulus of foundation, but smaller in low elastic modulus. Lower dynamic modulus of subgrade reactions are backcalculated by dynamic deflections than by static deflections. But reverse trend is investigated in the backcalculated elastic modulus of concrete which describes trends of the field backcalculation values calculated from AREA method.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1999.04a
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• pp.313-321
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• 1999

To design steel box girder bridge, designers have taken the classical load distribution coefficient methods. Due to the rapidly developing computer technique, steel box girder bridge is simply modeled as grillage method for analyzing the girder, or as fully finite element method for more accurate and detailed analysis. Recently, cruciform space frame method is developed for modeling and analyzing it more simply and easily compared with finite element method. So, this study for the examination of upper methods' characteristics loaded unit moment load and analyzed the distortional deflection with shell element method and cruciform space frame method, and for three span three girder steel box bridge, loading DB-24 loads, analyzed it by upper methods and compared the results.

• International Journal of Railway
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• v.3 no.1
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• pp.14-18
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• 2010

This paper describes design and characteristic analysis of long primary type linear synchronous motor (LSM) for high speed train system. LSM is designed using loading distribution method and magnetic equivalent circuit. For characteristic analysis of LSM, analytical and numerical methods are applied. Analytical method for solving the magnetic field distribution of the analytic model is based on the Maxwell’s equations. Using the characteristic equation and magnetic equivalent circuit, we analyze the effect of variation of parameters, and then we validate the result by comparing with numerical method by finite element method (FEM). We compare the analytical method with numerical method for analyzing the effect by variable parameters. This result will be useful of design and forecast of performance without FEM.

• Journal of Technologic Dentistry
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• v.29 no.1
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• pp.93-101
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• 2007

The purpose of this study is to evaluate the effect of three different oblique mechanical loading to occlusal surfaces of posterior implant partial dentures on the stress distributions in surrounding bone, using 3-dimensional finite element method. A 3-dimensional finite element model of a posterior implant partial dentures composed of three unit implants, simplified 3 gold alloy crown and supporting bone was developed according to the design of AVANA self tapping implant for this study. Three kinds of surface distributed oblique loads(300 N) are applied to following occlusal surfaces in the three crowns; 1) All occlusal surfaces in the three crown(load of 300 N was shared to three crown), 2) Occlusal surface of centered crown (load of 300 N was applied to a centered crown), 3) Occlusal surface of proximal crown(load of 300 N was applied to a distal proximal crown). In the results, 141 MPa of maximum von Mises stress was calculated at third loading condition and 98 MPa of minimum von Mises stress was calculated at first loading condition. From the results, location and type of occlusive loading conditions are important for the safety of supporting bone.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.2
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• pp.39-45
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• 2005

The aim of this research is to predict the thickness and loading noise of the round-tip shaped Hartzell propeller currently used in the general aviation aircraft. Before implementing the noise analysis, the pressure distribution on the propeller was obtained by using the free wake panel method and unsteady Bernoulli's equation. The noise signal at observer position can be obtained by using the FW-H equation. The noise prediction results for the propeller indicates that the thickness noise has s symmetric directivity pattern with respect to the tip path plane, while the noise due to loading shows higher noise directivity toward downstream than the upstream direction from the rotor plane. The loading noise is dominant rather than the thickness noise in normal operating condition.

• Computers and Concrete
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• v.4 no.5
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• pp.331-346
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• 2007

A computer program was developed to analyze the non-linear, cyclic flexural performance of reinforced concrete structural members under various types of loading paths including non-sequential variations in axial load. This performance is significantly affected by the loading history. Different monotonic material models as well as hysteresis rules for confined and unconfined concrete and steel, some developed and calibrated against test results on material samples, were implemented in a fiber-based moment-curvature and in turn force-deflection analysis. One of the assumptions on curvature distribution along the member was based on a method developed to address the variation of the plastic hinge length as a result of loading pattern. Functionality of the program was verified by reproduction of analytical results obtained by others for several cases, and accuracy of the analytical process and the implemented models were evaluated against the experimental results from large-scale reinforced concrete columns tested under the analyzed loading cases. While the program can be used to predict the response of a member under a certain loading pattern, it can also be used to examine various analytical models and methods or refine a custom material model against test data.

• Computers and Concrete
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• v.19 no.2
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• pp.143-152
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• 2017

This paper has numerically investigated the changes of loading-induced stress in concrete with the corrosion time in the sulfate-containing environment. Firstly, based on Fick's law and reaction kinetics, a diffusion-reaction equation of sulfate ion in concrete is proposed, and it is numerically solved to obtain the spatial and temporal distribution of sulfate ion concentration in concrete by the finite difference method. Secondly, by fitting the existed experimental data of concrete in sodium sulfate solutions, the chemical damage of concrete associated with sulfate ion concentration and corrosion time is quantitatively presented. Thirdly, depending on the plastic-damage mechanics, while considering the influence of sulfate attack on concrete properties, a simplified chemo-mechanical damage model, with stress-based plasticity and strain-driven damage, for concrete under axial loading and sulfate attack is determined by introducing the chemical damage degree. Finally, an axially compressed concrete prism immersed into the sodium sulfate solution is regarded as an object to investigate the time-varying stress in concrete subjected to the couplings of axial loading and sulfate attack.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.12
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• pp.3892-3898
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• 1996

In this study, the prediction of the fatigue life as well as the extimation of the characteristics of fatigue cumulative damage on GFRP under random loading were performed. The constant amplitude tests and the ramdom loading test were carried on notched GFRP specimens with a circular hole. Random waves were generated with a micro-computer and had wide band spectra. Since it is useful that the prediction of fatigue life ot the given load sequences is based on S-N curves under constant amplitude loading, the estimation of equivalent stress is done on every random waves. The equivalent stress wasat first estimated by Miner's rule and then by the proposed model which was based on Hashin-Rotem's comulative damage theory regarding nonlinear fatigue cumulative damage behavior. The fatigue lives were predicted from each equivalent stress evaluated. And each predicted fatigue llife was compared with experimental results. The number of cycles of random loads were counted by mean-cross counting method. The reuslts showed that the fatigue life predicted by proposed model was correlated well with the experimental results in comparison with Miner's model.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.05e
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• pp.104-107
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• 2003

The ageing cause in many porcelain suspension insulators which occur on transmission and distribution line with dead-end stings is mechanical stress in interface between porcelain and cement materials. It is known that the principal mechanical stress which give electrical failure is the results of the displacement is due to cement growth. We studied an analysing method to find out a deformation of brittle porcelain with a thermal expansion of cement for suspension insulator. These simulation analysis and experimental results show that cement volume growths affect severely to be mechanical failure ageing. These simulation analysis and experimental results show that axial loading affects of Porcelain insulators severely to be mechanical failure ageing.