• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1333-1338
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• 2013

Chitosan-based nanoparticles (CSNP) were prepared through ionic cross-linking and gelation of chitosan (CS) by tripolyphosphate (TPP). CS properties such as molecular weight, and preparation conditions were screened and the resulting nanoparticles were examined by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The obtained particles were consistently spherical with an overall diameter of approximately $107{\pm}20$ nm. They were successfully used as a carrier for Zidovudine, an anti-human immunodeficiency virus (HIV) which, to our knowledge, is novel. The encapsulation ability, loading capacity, and controlled release behavior for these CSNP was evaluated. Results indicated that their intrinsic properties were strongly affected by properties inherent to CS such as molecular weight, and by the preparation condition, such as cross-linking density, which depends on the concentration of the cross-linker. In vitro release tests for the entrapped zidovudine showed that the CNNP provided a continuous release that can last upwards 20 h.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.3
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• pp.325-331
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• 2013

In this study, a complex eigenvalue analysis is implemented to verify the unstable mode of a brake system using ABAQUS software. The component participation factors and component modal participation factors are used to analyze the total contributions from each component and each component mode to a particular unstable system mode. This study shows that the 1.4-kHz unstable system mode comes from mode coupling between the 2nd nodal diametric mode and 3rd lateral axial mode (LAM) in the baseline model. A sensitivity analysis with a linking index is performed to prevent the mode coupling of the component modes. This linking index analysis shows the optimum mass loading position to move away the natural frequency of the 3rd LAM, which contributes to the unstable mode. Finally, a complex eigenvalue analysis is implemented with mass loading in the tie bar position, and no unstable system mode is generated in the low-frequency range (below 2 kHz).

• Korean Journal of Chemical Engineering
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• v.35 no.12
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• pp.2403-2412
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• 2018

The present study was aimed at evaluating the effect of variable sodium carbonate ($Na_2CO_3$) loading during wet air oxidation (WAO) pretreatment of rice straw in reducing biomass recalcitrance. The research study was intended to increase the cellulose recovery, hemicellulose solubilization, lignin removal in the solid fraction and limiting the generation of inhibitors in the liquid fraction while reducing the chemical input. The operating condition of $169^{\circ}C$, 4 bar, 18 min and 6.5 g/L $Na_2CO_3$ loading resulted in maximum cellulose recovery of 82.07% and hemicellulose solubilization and lignin removal of 85.43% and 65.42%, respectively, with a total phenolic content of 0.36 g/L in the liquid fraction. The crystallinity index increased from 47.69 to 51.25 along with enzymatic digestibility with an increase in $Na_2CO_3$ loading from 0 to 6.5 g/L as a result of removal of barriers for saccharification via effective cleavage of ether and ester bonds cross-linking the carbohydrates and lignin as indicated by FT-IR spectroscopy. A further increase in the $Na_2CO_3$ loading to 9.5 g/L did not significantly increase the sugar release. Thus, it was concluded that 6.5 g/L $Na_2CO_3$ during WAO is sufficient to increase the delignification and deacetylation, leading to significant changes in apparent cellulose crystallinity inter alia improvement in cellulose accessibility and digestibility of rice straw.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.3
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• pp.367-372
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• 2018

The objective of this paper is to optimize the cross-section of aluminum decking units used in the bass boats under operating conditions, and to verify the optimized model from the results via by ANSYS software. Aluminum decking unit is needed to endure specific loading while leisure activity and sailing. For a stiffer and more cost-neutral aluminum decking unit, optimization is often considered in the naval and marine industries. This optimization of the aluminum decking unit is performed using the ANSYS program, which is based on the topology optimization method. The generation of finite element models and stress evaluations are conducted using the ANSYS Multiphysics module, which is based on the Finite Element Method (FEM). Through such a series of studies, it was possible to determine the most suitable case for satisfying the structural strength found among the phase-optimized aluminum deck units in bass boats. From these optimization results, CASE 1 shows the best solution in comparison with the other cases for this optimization. By linking the topology optimization with the structural strength analysis, the optimal solution can be found in a relatively short amount of time, and these procedures are expected to be applicable to many fields of engineering.

• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.98-103
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• 2009

Superparamagnetic iron oxide nanoparticles (SPIOs)-embedded chitosan microspheres were developed for magnetic resonance (MR)-traceable embolotherapy. SPIOs-loaded chitosan microspheres were prepared by emulsion and cross-linking technique and 100-200 ${\mu}m$ sized spherical microsparticles were obtained. Loading efficacy and loading amount of SPIOs in microspheres were about 40% and 0.26-0.32%, respectively, when measured by inductively coupled plasma atomic emission spectroscopy. Within 30 days, about 60% of the incorporated SPIOs were released from low cross-linked microspheres, whereas only about 40% of SPIOs was released from highly cross-linked microspheres. Highly cross-linked microspheres were more efficient for lower degree of swelling leading to secure entrapment of SPIOs in matrix. Prepared novel embolic microspheres are expected to be practically applicable for traceable embolotherapy with high resolution and sensitivity through magnetic resonance imaging (MRI).

• Journal of Pharmaceutical Investigation
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• v.34 no.4
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• pp.275-281
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• 2004

We have studied the effect of polarity, current density, current duration, crosslinking density, swelling ratio, and permeation enhancers on the transdermal flux of ketoprofen from acrylamide hydrogel. Hydrogel was prepared by free radical crosslinking polymerization of acrylamide. Drug loading was made just before transport experiment by soaking the hydrogel in solution containing drug. In vitro flux study using hairless mouse skin was performed at $36.5^{\circ}C$ using side-by-side diffusion cell, and the drug was analysed using HPLC/UV system. The result showed that, compared to passive flux, the total amount of drug transported increased about 18 folds by the application of $0.4\;mA/cm^2$ cathodal current. Anodal delivery with same current density also increased the total amount of drug transported about 13 folds. It seemed that the increase in flux was due to the electrorepulsion and the increase in passive permeability of the skin by the current application. Flux increased as current density, the duration of current application and loading amount (swelling duration) increased. As the cross linking density of the hydrogel increased, flux clearly decreased. The effect of hydrophilic enhancers (urea, N-methyl pyrrolidone, Tween 20) and some hydrophobic enhancers (propylene glycol monolaurate and isopropyl myristate) was minimal. However, about 3 folds increase in flux was observed when 5% oleic acid was used. Overall, these results provide some useful information on the design of an optimized iontophoretic delivery system of ketoprofen.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.9
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• pp.1318-1323
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• 2013

Thermal insulation material was prepared by cross-linking chemical reaction of silica aerogel and epoxy resin, which has a high porous and vacant properties. The structural, mechanical, and thermal properties were analyzed in order to verify its application for industrial and electrical applications. The thermal conductivities were changed from 115 mW/mK to 75 mW/mK by reducing the contents of nano-porous silica areogel powders. The compressive loading is also decreased by increasing the contents of silica aerogels by 20 wt% in aerogel/epoxy composites. It is concluded that the formulated composite materials can be applied to building materials, electronics parts, and heavy industries.

• Computers and Concrete
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• v.20 no.1
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• pp.85-97
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• 2017

With a special attention to the different stages of a typical loading path travelled in a fluid confined concrete test, this paper introduces a physically consistent model for the stress-strain curve of actively confined normal-strength concrete in the axial direction. The model comprises of the five elements of: (1) a criterion for the peak or failure strength, (2) an equation for the peak strain, (3) a backbone hydrostatic curve, (4) a transient hardening curve linking the point of departure from the hydrostatic curve to the failure point, and finally (5) a set of formulas for the post-peak region. Alongside, relevant details and shortcomings of existing models will be discussed in each part. Finally, the accuracy and efficiency of the proposed model have been verified in a set of simulations which compare well with the experimental results from the literature.

• Annual Conference of KIPS
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• 2003.05c
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• pp.1785-1788
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• 2003

자바의 동적 클래스 로딩은 실행 시간에 소프트웨어 컴포넌트를 동적으로 로딩하기 위한 강력한 메커니즘이다. 다른 시스템에서도 동적 료딩과 링킹을 제공하지만 지연 로딩, 타입 안전 링크, 사용자 정의 클래스 로딩 정책, 그리고 나중 이름공간 둥은 자바가 가진 중요한 특징이다. 자바에서 클래스 로딩의 핵심은 타입 안전에 대한 확신이다. 하지만 자바 가상머신에서 타입 안전에 대한 메커니즘은 매우 복잡하고 또 정확성에 대한 접근이 명확하지 않아서 지금까지 많은 버그가 발생되었고 따라서 타입 안전에 문제가 되어왔다. 본 논문은 간단한 자바 소스 코드를 이용하여 동적인 클래스 로더의 동작을 분석하여 도식화하고, 연산적 의미론으로 추상화하여 이전에 제시되었던 타입 안전에 대한 문제를 분석한다.

• Advances in aircraft and spacecraft science
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• v.1 no.2
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• pp.177-196
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• 2014

A theoretical exploration for determining the characteristic length of the cohesive zone for a double cantilever beam (DCB) specimen under mode I loading was conducted. Two traction-separation laws were studied: (i) a law with only a linear elastic stage from zero to full traction strength; and (ii) a bilinear traction law illustrating a progressive softening stage. Two analytical solutions were derived for the first law, which fit well into two existing solution groups. A transcendental equation was derived for the bilinear traction law, and a graphical method was presented to identify the resultant cohesive zone length. The study using the bilinear traction law enabled the theoretical investigation of the individual effects of cohesive law parameters (i.e., strength, stiffness, and fracture energy) on the cohesive zone length. Correlations between the theoretical and finite element (FE) results were assessed. Effects of traction law parameters on the cohesive zone length were discussed.