• Advances in pediatric surgery
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• 제15권1호
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• pp.52-57
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• 2009

Situs inversus abdominis is a rare congenital condition commonly associated with serious cardiac and splenic malformations. The importance of recognizing the presence of situs inversus abdominis preoperatively is emphasized by the fact that the surgical incision is placed on the incorrect side of the abdomen. A 6 day-old girl was referred to our hospital because of bile stained vomiting. A plain radiography of abdomen and chest showed the heart to be normal position and a reversed "double-bubble" picture with no other gas shadow in the rest of the abdomen. Abdominal computed tomography scan revealed situs inversus with the stomach and polysplenia on the right side and the liver on the left side. A laparotomy confirmed the diagnosis of situs inversus with duodenal atresia. The obstruction was bypassed by constructing a side-to-side duodenoduodenostomy. The postoperative course was uneventful.

• Journal of Chest Surgery
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• 제40권11호
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• pp.802-804
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• 2007

선천성 횡격막 탈장이 동반된 흉강내 이소성 간은 드물지 않게 보고되고 있으나 횡격막 탈장이 동반되지 않은 흉강내 이소성 간은 매우 희귀한 선천성 질환이다. 횡격막 탈장이 동반되지 않은 흉강내 이소성 간을 체험하였기에 증례를 보고한다. 환자는 37세 여자로, 우연히 발견된 폐종양의 치료를 위해 내원하였다. 흉부 컴퓨터단층촬영 스캔상 우측 폐하엽에 횡격막에 인접해 있는 폐종양이 확인되었으며, 기관지 유암종을 의심하고 수술을 시행하였다. 수술 소견상, 우측 횡격막 중심부에 지름 3.5cm와 2.0 cm정도의 2개의 둥근 종양이 위치하고 있었으며, 종양의 절제를 시행하였다. 병리학적으로 흉강내 이소성 간으로 확진되었고, 환자는 수술 후 특별한 문제없이 퇴원하였다.

• Journal of Gastric Cancer
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• 제5권2호
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• pp.127-132
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• 2005

위암의 한 아형인 간양 선암은 조직학적으로 간세포암종과 형태학적으로 유사하며 알파태아단백 생산을 특징으로 한다. 간양 선암의 또 하나의 특징은 간과 림프절로의 조기 전이를 함으로써 불량한 예후를 갖는다는 것이다. 저자들은 간전이를 동반한 위의 간양 선암 1예를 보고하고자 한다. 소화불량을 주소로 내원한 52세 남자 환자는 위내시경 검사상 Borrmann 제2형 병변이 위암이 의심되었다. 환자의 혈청 알파태아단백은 123 ng/ml로 증가되어 있었다. 근치적 위아전절제술과 간우엽절제술을 시행하였고 조직학적 소견상 위의 병변은 점막하층에 국한된 간양 선암이었으며 간의 병변은 위로부터 전이된 선암이었다. 결국 환자는 위암 4기(T1N1M1)로분류되었다. 위의 간양 선암은 조기병변에서도 불량한 예후군으로 분류될 수 있다.

• 한국환경보건학회지
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• 제28권1호
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• pp.21-29
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• 2002

To identify and evaluate the dichlorobenzidine(DCB)-DNA adducts in liver cell and bladder epithelial cells by $^{32}$ P-postlabeling and GC/MS-SIM, we orally exposed the dichlorobenzidine(20mg/kh body wt./day) to male Sprague-Dawley rats(l85$\pm$10g) for 14 days. Two kinds of DCB-DNA adduct(A1 and A2) were found at the same site of thin layer chromatogram of $^{32}$ P-postlabeling method in liver cells and bladder epithelial cells. In liver cells, relative adduct labeling(RAL) $\times$ 10$^{12}$ of DCB-DNA adduct A1 were 34.1$\pm$3.71 and 69.9$\pm$5.02, that of adduct A2 were 74.1$\pm$10.1 and 105.1$\pm$10.1 on 10 and 14 days after treatment, respectively. And in bladder epithelia cells, RAL $\times$ 10$^{12}$ of DCB-DNA adduct A1 were 5.92$\pm$1.60 and 15.9$\pm$1.31, that of adduct A2 were 9.81$\pm$2.81 and 22.8$\pm$1.79 on 10 and 14 days after treatment, respectively. DCB metabolites formed DNA adducts were monoacetyl-dichlorobenzidine(acDCB) and diacetyl-dichlorobenzidine(di-acDCB), which was identify by gas chromatography/mass spectrometry-scan ionization mode(GC/MS-SIM), after hydrolysis of DCB-DNA adducts isolated from live cells and bladder epithelial cells. The base peak of acDCB were 252 and 294 m/z, and that of di-acDCB were 252, 294 and 336 m/z. In conclusion, the exposed DCB formed two kinds of DCB-DNA adduct, the proximate materials of that were acDCB and di-acDCB in liver and bladder epithelial cells. And the above GC/MS-SIM method was found the DCB-DNA adducts could be monitoring by gas chromatography.

• 한국방사선학회논문지
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• 제5권6호
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• pp.391-400
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• 2011

폐렴은 호흡기계의 감염이고 원인균, 병인, 침범부위, 그 밖의 여러 가지 상황에 따라서 다양하게 분류된다. 비정형 병원균주 페렴으로 의심되어 내원한 46세의 남자 환자에서 이학학적 소견이나 혈액검사, 객담도말검사, 소변검사, 기생충검사, 기관지내시경검사, 침생검 등에서 특이할만한 원인균을 찾지 못했으며, 청진이상, 고열, 고혈압, 객담, 호흡곤란 등의 증상 또한 보이지 않았다. 세균성 또는 비정형 병원균의 광범위치료 항생제 복용이나 기생충제제를 복용하였으나 재발되었으며, 자연치유 및 재발이 반복되며 호전되었다. 반흔을 남기며 호전되고 새로운 부위에 결절이 재발하기를 반복하면서 서서히 없어지는 기간은 평균 20일 정도였다. 재발 이후 흉부엑스선 촬영과 흉부 고해상 전산화단층촬영을 추적 검사한 결과 흉부엑스선 촬영에서는 특이한 징후를 관찰하지 못했으나 고해상 전산화단층촬영에서는 병변이 호전되어가고 새로운 부위에 재발되는 모습을 관찰할 수가 있었다. 양측 하부 폐에 재발성 경과를 취한 비정형병원균주 폐렴이 의심되는 환자의 경우, 흉부엑스선 촬영 소견은 횡격막이나 간(Liver), 척추 등에 의해 숨기 때문에 추적검사로서 도움을 주는 데는 한계가 있으며, 흉부 고해상 전산화단층촬영 검사를 하여 비교하는 것이 바람직하다. 저자는 재발성 경과를 취한 비정형 병원균주 폐렴1예에 대한 문헌고찰과 함께 보고한다.

• 대한핵의학회지
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• 제26권2호
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• pp.318-326
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• 1992

Ga-67 citrate scan has been requested for detection or follow-up of inflammatory or neoplastic disease. Visualization of Ga-67 citrate in the kidneys at 48 and 72 hr post injection is usually interpreted as evidence of renal pathology. But precise mechanisms of abnormal Ga-67 uptake in kidneys were unknown. We undertook a study to determine the clinical value of Ga-67 citrate imaging of the kidneys in 68 patients with primary or secondary nephropathy confirmed by renal biopsy and 66 control patients without renal disease. Renal uptake in 48 to 72 hr images was graded as follows: Grade 0=back-ground activity:1=faint uptake greater than background;2=definite uptake, but less than lumbar vertebrae; 3=same uptake as lumbar vertebrae, but less than liver; 4=same or higher uptake than liver. The results were as follows. 1) 42 of 65 (62%) patients with noninfectious nephritis showed grade 2 or higher Ga-67 renal uptake but only 10 percent of control patients showed similar uptake. 2) In 14 patients with systemic lupus erythematosus, 8 of 9 (89%) patients with lupus nephritis exhibited marked renal uptake 3) 36 of 41 patients (88%) with combined nephrotic syndrome showed Grade 2 or higher renal uptake. 4) Renal Ga-67 uptake was correlated with clinical severity of nephrotic syndrome determined by serum albumin level, 24 hr urine protein excretion and serum lipid levels. 5) After complete remission of nephrotic syndrome, renal uptake in all 8 patients who were initially Grade 3 or 4, decreased to Grade 1 or 0. In conclusion, we think that the mechanism of renal Ga-67 uptake in nephrotic syndrome might be related to the pathogenesis of nephrotic syndrome. In systemic lupus erythematosus, Ga-67 citrate scan is useful in predicting renal involvement.

• 대한핵의학회지
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• 제15권2호
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• pp.11-17
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• 1981

Cholescintigraphic studies with $^{99m}Tc-HIDA$(dimethyl iminodiacetic acid) were performed in 22 cases of normal subjects, 21 of acute cholecystitis, 12 of chronic cholecystitis and 12 others, with the results of, 1) In normal control group, liver and intrahepatic biliary tree, CBD and gall bladder, and G-I tract appeared at 10, 20 and 30 minutes after intravenous injection of $^{99m}Tc-HIDA$ respectively, 2) In acute cholecystitis, 20 among 21 cases showed non-visualization of gall bladder with the diagnostic accuracy, sensitivity and specificity of 93.2%, 95.2% and 100% respectively. 3) In chronic cholecystitis, 5 among 12 cases showed non-visualization of gall bladder and remained 7 among 12 cases showed poor contraction of gall bladder (4), delayed visualization of gall bladder (1) and normal findings (2). 4) In the other disease group, the 12 cases which initially suspected as acute cholecystitis, revealed normal scan findings to exclude the cystic duct obstruction easily, With the above results, this scintigraphic procedure was found very rapid, accurate and easily available method for the determining of the cystic duct patency.

• 셀메드
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• 제2권1호
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• pp.10.1-10.6
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• 2012

Acupuncture works by stimulating peripheral sensory nerves and their endings causing an increase in cutaneous blood flow and microcirculation, as well as release of neurotransmitters, neuropeptides, and hormones. SP6 Patch is a nanoscale nontransdermal device that mildly stimulates Stomach 36 (zusanli) and other acupuncture points. As stimulation of these points has been indicated to have an effect on hypothalamic function, it is of great research interest to investigate the effect of SP6 Patch on the physiology of organs that are affected by hypothalamic regulation. Bioelectrical tissue impedance data indicative of cellular physiologic organ function, using an Electro Interstitial Scan (EIS) system, were acquired from hypothalamus, pancreas, liver, intestines, kidneys, thyroid and adrenal glands in 10 (1 male, 9 females) volunteers while wearing the SP6 Patch daily for 1 week. EIS testing was performed at baseline with no patch, 30 min after wearing the patch, and after wearing the patch 12 h/day for 1 week. Subjects were instructed to keep well hydrated during the study period. All subjects served as their own control. The hypothesis was: The SP6 Patch worn 12 h/day on the Stomach 36 acupuncture point for 1 week, may significantly improve cellular physiologic functional status of different organs measured by EIS. All tested organs achieved significant improvement in their functional physiologic status after wearing the SP6 Pach 12 h/day for 1 week compared to baseline with an overall average statistical power > 89%. Based upon these results the hypothesis was accepted as true.

• 대한핵의학회지
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• 제27권1호
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• pp.98-103
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• 1993

The present study was purposed to evaluate the incidence and the characteristics of metastatic "cold" lesions in $^{99m}Tc$-MDP bone scans of adult patients with solid malignancies. There were 29 cold lesions in 24 patients. The incidence of cold lesions was about 1% of total cases of bone scans for the patients with malignancy, or 2.5% of cases with bone metastases. Th primary sites of malignancies were lung (four cases), uterine cervix (three cases), kidney, nasopharynx, thyroid, urinary bladder, prostate, lymphoma (two cases each other), liver, breast and others (one case each other). But the relative incidence of cold lesion in lung cancer and breast cancer was low. The most frequent site of cold lesion was spine, and pelvis, skull and rib were followed. The incidence of cold lesion was related to the regional incidence of bone metastases. The size of the cold lesions was greater than that of the hot. There were six cases of single cold lesion without any other abnormalities and two cases of cold lesion which were initially hot. So it should be considered that bone metastases might be presented as cold lesions in bone scan.

• Journal of Yeungnam Medical Science
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• 제2권1호
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• pp.259-264
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• 1985

신경아세포종은 소아기에 발생하는 악성종양중 뇌종양 다음으로 흔히 발생하는 것으로 원발 혹은 전이된 부위에 따라 다양한 임상증상이 나타날 수 있으나 실명을 주소로 한 경우는 드물다. 본 증례는 4세된 남아의 복부에서 기원하여 사골동으로 원위전이하여 갑작스런 실명을 주소로 한 신경아세포종으로 cytoxan, vincristine, DTIC, adriamycin 및 VM-26의 병합요법으로 치료하여 실명은 그대로 있으나 복부와 사골동의 종괴는 현저히 감소하였고 환아는 건강이 양호한 상태이다.