• Korean Journal of Acupuncture
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• v.25 no.2
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• pp.43-55
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• 2008

Objectives : The acupuncture has been in the classic arsenal of Oriental medicine over inflammatory diseases. Its physiological mechanism is not fully understood but being known better everyday. We reviewed several papers to describe current concepts over anti-inflammatory mechanism of acupuncture. Methods : Some computerized literature searches were done using the key words of 'acupuncture' AND 'Anti-inflammatory' in Medline via Pubmed between March 2007 and December 2007. Only rationally-designed studies were picked among practically associated materials. A well-known hypothesis on acupunctural physiology was adapted for integration. Result : 18 studies were selected. 17 studies were laboratory experiment and 1 was a clinical study. Data was classified into some comprehensive categories. Author's opinion was added at the end of each category. Study results supported the hypotheses on acupunctural physiology; Acupuncture has some influences on autonomic nerve system(ANS). And it stimulates several receptors from target cells like macrophage, and finally inhbits cytokines like TNF-${\alpha}$, IL-1${\beta}$ andIL-10 which are inflammation-mediated. Acupuncture increases the opioid releasing therefore relieves inflammation. And acupuncture inhibits cyclooxgenase(COX) but its mechanism is controversial until now. Conclusion : Current concepts over anti-inflammatory mechanism of acupuncture are as follows. Acupucture suppresses inflammation by stimulation of ANS, increasing of opioid releasing and inhibition of COX. But more studies are needed to fully describe the anti-inflammatory effect of acupuncture.

• Biomolecules & Therapeutics
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• v.28 no.6
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• pp.491-502
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• 2020

Sex/gender disparity has been shown in the incidence and prognosis of many types of diseases, probably due to differences in genes, physiological conditions such as hormones, and lifestyle between the sexes. The mortality and survival rates of many cancers, especially liver cancer, differ between men and women. Due to the pronounced sex/gender disparity, considering sex/gender may be necessary for the diagnosis and treatment of liver cancer. By analyzing research articles through a PubMed literature search, the present review identified 12 genes which showed practical relevance to cancer and sex disparities. Among the 12 sex-specific genes, 7 genes (BAP1, CTNNB1, FOXA1, GSTO1, GSTP1, IL6, and SRPK1) showed sex-biased function in liver cancer. Here we summarized previous findings of cancer molecular signature including our own analysis, and showed that sex-biased molecular signature CTNNB1^High, IL6^High, RHOA^High and GLIPR1^Low may serve as a female-specific index for prediction and evaluation of OS in liver cancer patients. This review suggests a potential implication of sex-biased molecular signature in liver cancer, providing a useful information on diagnosis and prediction of disease progression based on gender.

• The Journal of Korean Medicine
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• v.41 no.2
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• pp.9-22
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• 2020

Objectives: The purpose of this study is to consider the concept of Meridian Points(經穴) and to establish the directions in further research. Methods: First, based on the latest results from the researches of Meridian and Collateral(經絡), it was to infer the original concept of Meridian Points(經穴). Second, the meaning of Meridian Points(經穴) has been investigated and its directions in further research was studied founded upon Symbolic Mathematical Study(象數學). Results ＆ Conclusions : Firstly, Meridian Points(經穴) are considered to be the source of information that contains 365 numbers of human physiological information which includes physiological information of Viscera and Bowels(藏府) and Meridian and Collateral(經絡). Secondly, advanced researches are required further to clarify the meaning of Meridian Points(經穴) as Symbolic Mathematical Study(象數學) has established the systems of Meridian Points(經穴). In addition, the efficacy of each Meridian Points(經穴) needs to be revised through literature studies. Clinical studies are essential to practically verify the results from the former theoretical research. Thirdly, the contention to oppose the presence of Meridian and Collateral(經絡) and Meridian Points(經穴) was acknowledged to be incorrect. Lastly, for broadening the theoretical systems of Korean Medicine(韓醫學) with integration of Western scientific knowledge, a paradigm shift is necessary to revise the concepts of Viscera and Bowls(藏府), Meridian and Collateral (經絡) and Meridian Points(經穴) in Korean Medicine(韓醫學). In order to accomplish the shift, the ambiguity in theories of Korean Medicine(韓醫學) should be clarified through the study of Symbolic Mathematical Study(象數學).

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.4
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• pp.848-859
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• 2005

The following conclusions are drawn, through studying of referring literature, of contents of the prescription and of clinical applications in Hyungsang Medicine. Insamyangyung-tang(인삼양영탕) was appeared first in Taepunghyemin-whajegugbang(태평혜민화제국방) which was written by Jin and others at Song Dynasty. This prescription is applied to senility and long lasting weakness, little strength of spleen and lung(비폐기허), and insufficiency of blood. The Insamyangyung-tang is composed of medical stuffs which Rhizoma Cnidii is taken out from Sipjiendaebotang and Pericarpium Citri Nobilis, Fructus Schizandrae, Radix Polygalae are added to it. This prescription is used in China up to the present. In korea, according to Donguibogam, Rhizoma Cnidii and Poria are taken out from Sipjiendaebotang and Pericarpium Citri Nobilis, Fructus Schizandrae, Radix Polygalae are added to it, and Ramulus Cinnamomi is changed to Cortex Cinnamomi, and also Radix Ledebouriellae is newly added to it. This is reorganized to fit for Korean physical conditions and to be useful for deficiency of blood, and also to be efficacious for coming and going of chillness and fever and running with sweat due to weakness of Liver. In the point of view of Hyunsang medicine, Insamyangyung-tang is applied to shapes and symptoms as follows : This prescription becomes more efficacious to women than to men. At the age of fifties when liver grows weak it effects a cure. It takes effect to the shape of going easily into the deficiency of blood, that is, to the Hyul Kwa with an oval face. It effects a cure on the man who has wrinkles on the bridge of the nose, who has marks of being choked up on the central area between two brows, or who has distinctive size of eyes and nose. It is efficacious against symptoms which are to be exhausted, to be weak, to lose flesh, to be coming and going of chillness and fever and running with sweat.

• The Journal of Korean Medicine
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• v.42 no.1
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• pp.59-74
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• 2021

Objectives: This study is to analyze Acupuncture Methods(鍼法) using Five Transport Points(五輸穴) and to consider the direction of development. Methods: This study focuses on Acupuncture Methods(鍼法) using Five Transport Points(五輸穴) that Five Phase Theory(五行學說) has been applied as a compound and it is designated Five Phase-Five Transport Points-Acupuncture Method(FPT Acupuncture Method, 五行五輸穴鍼法). Principles, Acupuncture Points(經穴), standards of diagnosis and treatment subjects of FPT Acupuncture Methods used in practices of Korean Medicine (韓醫學) were analyzed through updated literature. Next, the theoretical issues of FPT Acupuncture Methods regarding the composition of selecting exclusively on Five Transport Points(五輸穴) and targeted treatment subjects were investigated. Based upon the investigation, the future direction of development was studied. Results & Conclusions: Firstly, pattern identification and treatment of FPT Acupuncture Methods targeted mostly on Viscera and Bowels(臟腑). However, some showed the tendency to Five Phases Reductionism(五行 還元主義) which attempts to apply Five Phase Theory(五行學說) to symptoms that were not related to Viscera and Bowels(臟腑). Secondly, Five Transport Points(五輸穴) are theoretically related to 'Viscera and Bowels in Concept of Visceral Manifestation(臟象臟腑)'. Thirdly, when the cause of the symptoms exceeds the main therapeutic range of FPT Acupuncture Methods, it is effective to add Acupuncture Points(經穴) excluding Five Transport Points(五輸穴). And also, it is efficient to use Acupuncture Methods(鍼法) that is not based on principles of Five Phase Theory(五行學說). For the accomplishment, further researches on the approaches to apply basic Korean Medical principles such as Three Yin and Three Yang(三陰三陽) into Acupuncture Methods(鍼法) and Acupuncture Points(經穴) are necessary.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.1
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• pp.1-8
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• 2014

The purpose of this study is to review the literature on Danggwisayeokgaohsuyusaenggang-tang. The classic literature review was carried out using "http://www.theqi.com". The journal search was performed using MEDLINE, EMBASE, National Digital Science Links(NDSL), OASIS, Korean studies Information Service system(KISS), RISS, China National Knowledge Infrastructure(CNKI), Japan Science and Technology information Aggreator, Electronic(J-STAGE) from search engine's opening day to November 2013. Searching key words were the various combination of "Danggwisayeokgaohsuyusaenggang-tang", "Danggwisayeok", "Danggwi", "ohsuyu", "saenggang". The inclusion criteria was all kinds of journals except for review, essay, and experiment study. 40 classic literatures and 37 journals(1 chinese randomized controlled trial, 25 chinese case studies, 1 Korean case study, and 10 japanese case studies) were selected finally. The literatures and journals reported that Danggwisayeokgaohsuyusaenggang - tang was used to treat diverse types of diseases with coldness of hands and feet.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.4
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• pp.740-745
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• 2008

Although the demand on 'Ki' training because of the increased interest in health, there has not been an established theory and system in 'Ki' training from the perspective of oriental medicine. Therefore, many training associations are in operation without sound basis. The general use of the terminology 'Kigong' is the influence of China. As it was distributed to the general public through the translation and introduction of Chinese Kigong theory, the genuine Korean YangsaengKigong was not emphasized but it was included in or considered as the second-class to the Chinese Kigong. The purpose of the study was to establish and review YangsaengKigong based on our traditional ideologies. Korean Yangsaengkigong can be defined as the training method nurturing mind, energy, body based on the Sambeob training method such as Pause of thinking, Modulation of breath and Prohibition of sensibility with the goal of Yangsaengkigong, good health and long life and the maximum service for the benefit of humanity. Although this study can identify the differecnes between Korean Yangseangkigong and Chinese kigong through Korean traditional ideology, we could not develop this study to the necessity of ideological background of medical Kigong and concrete methodology of Yangsaengkigong and our traditional ideology because of scarce literature on Korea and Korean traditional ideologies. For the purspose of the study, we need cooperation between Studies of Korea, Studies of National History, and Oriental Medicine.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.5
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• pp.587-593
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• 2013

Exhaustion syndrome(虛勞) became broadly experienced symptoms in Korean population. In this work, we carried out a systematic literature review on exhaustion syndrome(ES) and chronic fatigue. We searched through the databases Koreanstudies Information Service System, Oriental Medicine Advanced Searching Integrated System, DataBase Periodical Information Academic for the articles published between 1994 and 2013, with the keywords 'exhaustion syndrome(虛勞)', 'consumption(虛損)', 'overexertion syndrome(勞倦)', 'fatigue', 'chronic fatigue' and 'degree of fatigue'. Among the first-run rough-searched 602 articles, we narrowed down the scope within the field of Oriental medicine (126 articles), and finally selected 28 articles appropriate to the intended research field; the selected articles were categorized by literature study(7 papers), clinical treatment (7), clinical diagnosis (5), treatment effects of herbal medicine (2), diagnosis in Sasang medicine and treatment effect of dry cupping therapy (2), and questionnaire-based diagnosis (5). We found that the overall research level on ES remained in the preliminary stages, and more efforts are needed in the field of terminology definition and standardization of diagnosis, and treatment efficacy validation beyond muscle fatigue. Finally, to develop reliable diagnostic devices on ES, we proposed a study design that included the development of objective ES diagnostic indicators and a clinical validation procedure.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.4
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• pp.374-382
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• 2013

In Oriental medicine, urinary incontinence is defined involuntary voiding of urine. This study was performed to investigate the treatment on urinary incontinence through the literature of oriental medicine. This study reviews the therapy method of urinary incontinence based on 63 books of oriental medicine and 20 papers about the treatment of urinary incontinence. Herbal medicine has been used as urinary incontinence treatment. One of herbal remedy is selected according to the symptoms, and then herbal products are supplemented such as warm-hot, convergence medicines. Acupuncture and moxibustion therapy has been performed with herbal medicine, electroacupuncture, pharmacopuncture, conservation therapy such as Kegel exercise, timed voiding and extracorporeal magnetic innervation for incontinence treatment. The treatment of urinary incontinence by oriental medicine includes auricular acupuncture, external medical treatment and taoist methods. There is a lack of related study about these therapy.

• The Journal of Korean Medicine
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• v.27 no.3 s.67
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• pp.212-221
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• 2006

Objectives: This study was designed to investigate acupuncture treatment of alopecia patients by researching literature and to standardize acupuncture treatment. Methods: We extracted the parts about acupuncture treatment of alopecia which are called 'Tal Bal(說髮), 'Ban Dok'(斑禿), 'Tal Mo'(脫毛), 'Bal Rak'(髮洛), 'Wonhyung Talmo'(圓形脫老) from 2 ancient and 49 modern oriental medicine literal sources. We surveyed the frequency and characteristics of the acupoints used for treatment of alopecia, and the acupoint was classified according to its meridian or demonstration. The results of this study were recorded as follows: 1. The most frequently used acupoints were GB20(風紙), GV20(百會), BL13(膈兪), SP6(三陰交), ST36(足三里), BL23(腎兪), SP10(血海), LI11(曲池), in that order. 2. The most frequently used meridians were the urinary bladder meridian (足太湯膀胱經), the Governor Vessel(督豚), the spleen meridian(足少陰脾經), and the gall bladder meridian(足少陰膽經), in that order 3. The most frequently used regions were the head, under the knee, and the back, in that order. 4. The most frequently used Jang organs and Bu organs were the spleen(脾), the stomach(胃), the liver(肝), the gall bladder(擔), the lungs(肺), and the large intestines(大腸), in that order. 5. Common methods of differentiation of alopecia are Hyulyulsaengpung(血熱生風), Gichehyutea(氣滯血瘀), Gihyulyanghea(氣血兩瘀), and Gansinbugok(肝腎不足). Conclusions : For treatment of alopecia, all the patient's symptoms, including alopecia, must taken into consideration and demonstrated.