• Coupled systems mechanics
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• v.1 no.1
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• pp.79-98
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• 2012

In the present paper, the three-dimensional model of a typical rectangular concrete tank is excited using an artificial and a natural three components earthquake ground motion and the staggered displacement method is utilized for solving the coupled problem of the tank-contained liquid system in time domain. In the proposed method, surface sloshing of the liquid is taken into account in addition to the impulsive term and the appropriate damping values are applied on both of them. The resulted responses are compared with those obtained from the ABAQUS finite element software. It is found that the convective term affects responses extensively and must be considered in seismic design/safety assessment of storage tanks. In addition, the utilized method for solving the coupled problem is stable during the conducted general dynamic analyses and is able to capture the expected phenomena.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.11a
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• pp.196-200
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• 2006

This paper describes the current development status of the major subsystems, turbopump and gas generator, for a turbopump-fed liquid oxygen-kerosene rocket engine system. As a secondary stage of the liquid rocket engine development test, turbopump-gas generator powerpack tests are planned. The schematics of the test hardware and the test facility for the TP+GG coupled test are presented. The results of a preliminary analysis for operating regimes of the TP+GG coupled test are also presented.

• Journal of Korean Society on Water Environment
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• v.20 no.2
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• pp.183-189
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• 2004

The performance of a membrane-coupled anaerobic fermenter system for the recovery of volatile fatty acids (VFAs) from liquid organic sludge was experimentally investigated. Permeation flux was stably kept around $0.2(m^3/m^2/day)$ during operational period. The membrane-coupled fermenter showed 2.2 times higher VFAs concentration and higher VFAs forming rate than those of fermenter without membrane. The fermenter with membrane proved to be an effective system for the recovery of soluble organic materials from liquid sludge.

• International Journal of Naval Architecture and Ocean Engineering
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• v.8 no.2
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• pp.153-168
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• 2016

Sloshing phenomenon is a complicated free surface flow problem that increases the dynamic pressure on the sidewalls and the bottom of the storage tanks. When the storage tanks are partially filled, it is essential to be able to evaluate the fluid dynamic loads on the tank's perimeter. In this paper, a numerical code was developed to determine the pressure distribution on the rectangular and trapezoidal storage tanks' perimeters due to liquid sloshing phenomenon. Assuming the fluid to be inviscid, the Laplace equation and the nonlinear free surface boundary conditions were solved using coupled boundary element - finite element method. The code performance for sloshing modeling was validated using Nakayama and Washizu's results. Finally, this code was used for partially filled rectangular and trapezoidal storage tanks and free surface displacement, pressure distribution and horizontal and vertical forces exerted on the tanks' perimeters due to liquid sloshing phenomenon were estimated and discussed.

• Journal of Ginseng Research
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• v.43 no.4
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• pp.539-549
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• 2019

Background: 20(S)-Protopanaxadiol (PPD), the aglycone part of 20(S)-protopanaxadiol ginsenosides, possesses antidepressant activity among many other pharmacological activities. It is currently undergoing clinical trial in China as an antidepressant. Methods: In this study, an ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass tandem mass spectrometry method was established to identify the metabolites of PPD in human plasma and urine following oral administration in phase IIa clinical trial. Results: A total of 40 metabolites in human plasma and urine were identified using this method. Four metabolites identified were isolated from rat feces, and two of them were analyzed by NMR to elucidate the exact structures. The structures of isolated compounds were confirmed as (20S,24S)-epoxydammarane-12,23,25-triol-3-one and (20S,24S)-epoxydammarane-3,12,23,25-tetrol. Both compounds were found as metabolites in human for the first time. Upon comparing our findings with the findings of the in vitro study of PPD metabolism in human liver microsomes and human hepatocytes, metabolites with m/z 475.3783 and phase II metabolites were not found in our study whereas metabolites with m/z 505.3530, 523.3641, and 525.3788 were exclusively detected in our experiments. Conclusion: The metabolites identified using ultra-performance liquid chromatography coupled with triple quadrupole time-of-flight mass spectrometry in our study were mostly hydroxylated metabolites. This indicated that PPD was metabolized in human body mainly through phase I hepatic metabolism. The main metabolites are in 20,24-oxide form with multiple hydroxylation sites. Finally, the metabolic pathways of PPD in vivo (human) were proposed based on structural analysis.

• Journal of Ginseng Research
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• v.44 no.1
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• pp.105-114
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• 2020

Background: Exploring the pharmacokinetic (PK) changes of various active components of single herbs and their combinations is necessary to elucidate the compatibility mechanism. However, the lack of chemical standards and low concentrations of multiple active ingredients in the biological matrix restrict PK studies. Methods: A putative multiple reaction monitoring strategy based on liquid chromatography coupled with mass spectrometry (LC-MS) was developed to extend the PK scopes of quantification without resorting to the use of chemical standards. First, the compounds studied, including components with available reference standard (ARS) and components lacking reference standard (LRS), were preclassified to several groups according to their chemical structures. Herb decoctions were then subjected to ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry analysis with appropriate collision energy (CE) in MS² mode. Finally, multiple reaction monitoring transitions transformed from MS² of ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry were used for ultrahigh-performance liquid chromatography coupled with triple quadrupole mass spectrometry to obtain the mass responses of LRS components. LRS components quantification was further performed by developing an assistive group-dependent semiquantitative method. Results: The developed method was exemplified by the comparative PK process of single herbs Radix Ginseng (RG), Radix Polygala (RP), and their combinations (RG-RP). Significant changes in PK parameters were observed before and after combination. Conclusion: Results indicated that Traditional Chinese Medicine combinations can produce synergistic effects and diminish possible toxic effects, thereby reflecting the advantages of compatibility. The proposed strategy can solve the quantitative problem of LRS and extend the scopes of PK studies.

• Tribology and Lubricants
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• v.8 no.1
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• pp.30-37
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• 1992

The displacement and pressure field of liquid crystals are analyzed numerically and compared with classical Reynolds theory. A plane slider bearing is employed as a simple example considering elasticity, permeability and splay effect which are the inherent characteristics of layered liquid crystals. Due to the geometric constraint of thin wedge and the strong anchoring behavior of the liquid crystals dislocations are inevitable. A finite element method is used to solve five coupled nonlinear equations. The load characteristics based on the pressure distribution along the gap shows that the liquid crystals can carry large load compared to the conventional lubricants.

• Journal of Mechanical Science and Technology
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• v.19 no.8
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• pp.1649-1661
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• 2005

We consider. a horizontal static liquid layer on a planar solid boundary. The layer is evaporating when the plate is heated. Vapor recoil and thermo-capillary are discussed along with the effect of mass loss and vapor convection due to evaporating liquid and non-equilibrium thermodynamic effects. These coupled systems of equations are reduced to a single evolution equation for the local thickness of the liquid layer by using a long-wave asymptotics. The partial differential equation is solved numerically.

• Proceedings of the Membrane Society of Korea Conference
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• 1995.10a
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• pp.43-44
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• 1995

The diffusion behavior of liquid into polymer has been described by Fick's law, but the departure from Fickian diffusion is frequently found. In this study, 'noble' expressions for the rates of relaxation and sorption are introduced to eliminate these limitations. The ralaxation-sorption coupled mechanism model are based on the possibility of contacting liquid molecule and the active site which has the numerical concept of free volume. The concept has an analogy of reaction rate expressed by the possibility of collision with molecules and used in adsorption and reactive extraction etc. The new model simulated by Rungc-Kutta method for initial-value problem and Fickian diffusion is caompared with experimental data. The results show that the ralaxation-sorption coupled mechanism is able to account well for Fickian and non-Fickian sorption behavior including sigmoid and two-stage. In addition, this model has a chance of expansion to multi-component sorption with ease.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.8
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• pp.3774-3778
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• 2012

A dynamic simulation of a fully thermally coupled distillation is conducted for the design of a possible operation scheme, and its performance is examined with an example process of reformate fractionation process. The outcome of the dynamic simulation indicates that the column can be operated by using a $3{\times}3$ control structure. The structure consists of three controlled variables of the compositions of overhead, side products and bottom and three manipulated variables of the flow rate of reflux, liquid split ratio between a main column and a prefractionator and steam.