• 대한장애인치과학회지
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• 제13권1호
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• pp.14-18
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• 2017

본 증례에서는 본과에서 발견한 임상적인 특징을 통해 X 염색체 우성 저인산혈증성 구루병으로 진단받아 13년간 의과적 및 치과적인 처치를 받고 있는 환아에 대해 보고하였다. 의과적으로 환아는 저신장 및 휜 다리 등의 전형적인 구루병 증상을 나타내었고, 치과적으로도 넓은 치수강, 상아법랑경계까지 연장된 치수각 및 자발적 치아농양 등의 전형적인 증상을 나타내었다. 본 환아는 정기적인 검진을 통해 유구치와 영구 소구치 및 대구치 모두 치면열구전색 및 수복치료 등을 적극적으로 시행해왔다. 그러나 예방적인 처치에도 불구하고 유치열에서는 총 8개의 치아에서 치아 우식에 이환 없이 자발적 치아농양이 발생하여 치수절제술을 시행하였으며, 조기 상실 등의 합병증 없이 영구치교환 시점까지 유지할 수 있었다. 영구치열에서는 그 빈도가 낮아졌으나 하악 우측 제1, 2대구치에서 발생한 자발적 치아농양으로 치료를 완료하였다. 앞으로 치아교모 등의 원인으로 영구치에서 발생할 수 있는 치아농양을 예방하기 위해 예방적인 전장관수복치료가 필요하리라 생각된다.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.49-56
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• 2022

Mitophagy, the selective degradation of damaged or surplus mitochondria using core autophagy machinery, plays an essential role in maintaining cellular mitochondrial function. Impaired mitophagy is closely linked to various human diseases, including neurodegenerative diseases, cardiovascular diseases, cancers and kidney disease. Defective mitophagy induces the accumulation of damaged mitochondria and thereby results in a decline in cellular survival and tissue function. Accordingly, enhancement of mitophagy has been proposed as a novel strategy for the treatment of human diseases closely linked to mitochondrial dysfunction. Recent studies showing that the stimulation of mitophagy has a therapeutic effect on several disease models highlight the possibility of disease treatment using mitophagy. The development of mitophagy inducers with toxicity and the identification of molecular mechanisms will enable the clinical application of mitophagy-based treatments.

• 수도
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• 제22권2호통권72호
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• pp.104-122
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• 1995

• 한국임상약학회지
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• 제23권2호
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• pp.89-96
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• 2013

This article aimed to introduce 'risk sharing' schemes for pharmaceuticals between drug manufacturers and healthcare payer. Published literature review was undertaken to summarize risk sharing concepts and collect information on existing scheme examples in other countries focusing on new anticancer drugs. Risk sharing schemes could be categorized into health outcomes-based and non-outcomes (financial) based ones. Outcome-based schemes could be broken down into performance-linked reimbursement and conditional coverage. Performance-linked reimbursement can be further broken into outcomes guarantee and pattern or process of care and conditional coverage included coverage with evidence development and conditional treatment continuation schemes. Non-outcome based schemes included market share and price volume at population level, and utilization caps and manufacturer funded treatment initiation at patient level. We reviewed the fifteen examples for anticancer drugs that risk sharing agreements in response to the inherent uncertainties and increased costs of eleven anticancer drugs. Of them, eight cases were coverage with evidence development schemes. The anticancer drugs except bevacizumab and cetuximab were all listed on the national health insurance formulary in Korea, with reimbursement criteria defined on the basis of approved indications and administrations. Risk sharing approach may be a useful tool to ensure values for drug expenditure, but there are a number of concerns such as high administration costs, lack of transparency and conflicts of interest, especially for performance-based health outcomes reimbursement schemes.

• 마이크로전자및패키징학회지
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• 제16권2호
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• pp.21-25
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• 2009

The organic-inorganic thin film transistors (OITFTs) with ZnO channel layer and the cross-linked PVP (Poly-4-vinylphenol) gate insulator were fabricated on the patterned ITO gate/glass substrate. ZnO channel layer was deposited by using atomic layer deposition (ALD). In order to improve the electrical properties, $O_2$ plasma treatment onto PVP film was introduced and investigated the effect of the plasma treatments on the electrical properties of the OITFTs. The field effect mobility and sub-threshold slope (SS) values of the OITFT decreased slightly from 0.24 to 0.16 $cm^2/V{\cdot}s$ and from 9.7 to 9.2 V/dec, respectively with increasing RF power from 30 to 50 Watt. The $I_{on/off}$ ratio was about $10^3$ for all samples with $O_2$ plasma treatment.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.118-118
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• 2003

The use of PPARν (peroxisome proliferator activated receptor ν) activators in the treatment of type 2 diabetes is well established due to their ability to lower blood glucose and insulin levels and omprove insulin sensitivity. Thiazolidinedione analog is one of the potential antidiabetic drug that binds and activates PPARν selectively. In an effort to develop novel and effective antidiabetic thiazolidindione analogs, synthesis of tetrahydroquinoline and para-substituted benzene-linked thiazolidinedione analogs were carried out via coupling reaction of the hydrophobic segments with hydroxybenzylthiazolidinedione.

• 한국식품과학회지
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• 제34권3호
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• pp.431-436
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• 2002

보통 옥수수 전분을 이용하여 저항전분을 제조할 때 저항 전분의 수율을 높일 수 있는 방법을 개발하기 위한 목적으로 가교결합 전분을 제조하고 annealing처리를 병행하였다. Annealing은 $40{\sim}60^{\circ}C$ 범위에서 실시하였고, 이와 비교하기 위하여 $70^{\circ}C$와 $100^{\circ}C$에서 열처리한 후 가교결합 전분을 제조하였다. RS 분석방법으로는 pancreain-gravimetric법(P/G법)을 사용하였다. 보통 옥수수전분과 고아밀로오스 옥수수전분으로 annealing하지 않고 가교결합 전분을 제조했을 때의 RS수율은 각각 14.7, 45.3%였고, annealing 한 후 가교결합 전분을 제조했을 때 28.0, 63.4%까지 증가하였다. 가교결합 전분의 팽윤력은 annealing 처리에 의해 영향받지 않았으나, 보통 옥수수전분으로 제조한 시료의 경우는 호화온도이상에서 열처리했을 때 팽윤력이 2배이상 증가하였다. 두가지 전분으로부터 제조된 가교결합 전분의 X-선 회절도와 주사전자현미경에 의한 특성 역시 annealing에 의해 영향받지 않았다.

• 대한한의학원전학회지
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• 제35권4호
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• pp.63-75
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• 2022

Objectives : The purpose of this study is to examine the significance of Korean Medical literature on representative symptoms of postpartum deep venous thrombosis (DVT), such as lower extremity edema and pulmonary embolism. Methods : Pattern differentiation, cause, symptoms and treatment related to DVT and pulmonary embolism as written in Korean Medical texts were studied comparatively. Results : In Korean Medical understanding, DVT could be linked to lower extremity edema due to blood stagnation, while pulmonary embolism could be linked to coughing, asthma and nose bleed due to stagnated blood. Conclusions : To prevent relapse and manage its after-effects, Korean Medical treatment for DVT and pulmonary embolism is much in need.

• Carbon letters
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• 제18권
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• pp.56-61
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• 2016

Cellulose fibers were stabilized by treatment with an electron-beam (E-beam). The properties of the stabilized fibers were analyzed by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis. The E-beam-stabilized cellulose fibers were carbonized in N₂ gas at 800℃ for 1 h, and their carbonization yields were measured. The structure of the cellulose fibers was determined to have changed to hemicellulose and cross-linked cellulose as a result of the E-beam stabilization. The hemicellulose decreased the initial decomposition temperature, and the cross-linked bonds increased the carbonization yield of the cellulose fibers. Increasing the absorbed E-beam dose to 1500 kGy increased the carbonization yield of the cellulose-based carbon fiber by 27.5% upon exposure compared to untreated cellulose fibers.

• Restorative Dentistry and Endodontics
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• 제42권2호
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• pp.146-151
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• 2017

X-linked hypophosphatemia (XLH) is a hereditary metabolic disease caused by the loss of phosphate through the renal tubules into the urine, and an associated decrease in serum calcium and potassium phosphate. Its dental features include spontaneous dental abscesses that occur in the absence of trauma or dental caries. The aim of this case report was to describe the dental problems of XLH patients and to evaluate limitations in their treatment. A 14 year old male and a 38 year old female with XLH were referred to the Department of Conservative Dentistry for endodontic treatment. The dental findings were periapical abscesses without obvious trauma or caries. Conservative endodontic treatment was performed in teeth with pulp necrosis and abscess. In case 1, the treated teeth showed improvements in bone healing, without clinical symptoms. However, in case 2, the implants and the treated tooth showed hypermobility, and the final restoration was therefore postponed. Early diagnosis, periodic examinations, and communication with the patient's pediatrician are important in the dental management of patients with XLH.