• STI Policy Review
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• 제3권1호
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• pp.96-116
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• 2012

The establishment of Institut Pasteur Korea (IP-K) has been an intercultural experiment, which transplanted a French research organization with many foreign researchers into Korea to grow a new institution as a long-term collaboration. The Mission of the newly founded institute has been to develop more effective ways of generating value with basic life science research in the face of a world-wide Pharma crisis. The challenges have been i.) to invent new technologies and approaches in drug discovery, ii.) to convince the Korean stakeholders of their inherent value, iii.) to induce Pharma industry to adopt the new technologies and iv.) to create a context in the Korean R&D landscape where the new institute could contribute tangible benefits. If Institut Pasteur Korea has succeeded in all counts, then due to a somewhat skewed and unlikely set of cultural complementarities between Korea and France. The abstract and conceptual French approach was matched by Korean pragmatism, linearity and relentless improvement towards the defined development goal. IP-K has become an example for innovation made in Korea, which is now re-imported into Europe. As the project could arguably not have succeeded in either partner county alone, it highlights the benefits of longterm, in depth international collaborations.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2002년도 추계학술대회 논문집
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• pp.191-196
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• 2002

The paper presents a numerical and experimental investigation on dynamic behaviors of a towed low tension cable. In the numerical study, an implicit finite difference algorithm is employed for three-dimensional cable equations. Fluid and geometric non-linearity and bending stiffness are considered and solved by Newton-Raphson iteration. Block tri-diagonal matrix method is applied for the fast calculation of the huge size of matrices. In order to verify the numerical results and to see real physical phenomena, an experiment is carried out for a 6m cable in a deep and long towing tank. The cable is towed in two different ways; one is towed at a constant speed and the other is towed at a constant speed with top end horizontal oscillations. Cable tension and shear forces are measured at the top end. Numerical and experimental results are compared with good agreements in most cases but with some differences in a few cases. The differences are due to drag coefficients caused by vortex shedding. In the numerical modeling, non-uniform element length needs to be employed to cope with the sharp variation of tension and shear forces at near top end.

• Animal Bioscience
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• 제34권12호
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• pp.1912-1920
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• 2021

Objective: This study investigated the effects of 5-aminolevulinic acid (5-ALA) on the motility parameters, mitochondrial membrane depolarization, and ATP levels in chicken sperm. Methods: The pooled semen from Barred Plymouth Rock males was used. In the first experiment, the semen was diluted 4-times with phosphate-buffered saline (PBS (-)) containing various concentrations (0, 0.01, 0.05, and 0.1 mM) of 5-ALA, and then the sperm motility parameters after incubation were evaluated by computer-assisted sperm analysis (CASA). In the second experiment, the semen was diluted 4-times with PBS (-) containing 0.05 mM 5-ALA, and then sperm mitochondrial membrane depolarization and ATP levels after 1.5 h of incubation were analyzed with the MitoPT^® JC-1 Assay and ATP Assay kits, respectively. In the third experiment, the semen was removed from the seminal plasma and resuspended with the mediums of PBS (-), PBS (-) supplemented with CaCl₂ and MgCl₂ (PBS (+)) + 5-ALA, PBS (+) + caffeine, and PBS (+) + caffeine + 5-ALA. Then, the sperm motility parameters after incubation were evaluated by CASA. In the last experiment, the semen was treated with the mediums of PBS (-), PBS (-) + 5-ALA, 5.7% glucose, 5.7% glucose + 5-ALA after removing the seminal plasma, and then the sperm motility parameters were evaluated by CASA. Results: The addition of 0.05 mM 5-ALA significantly increased the chicken sperm motility, progressive motility, linearity, average path velocity, curvilinear velocity, straight-line velocity, and the wobble. The sperm mitochondrial membrane depolarization was also increased by the 5-ALA treatment. The 5-ALA treatment decreased the sperm ATP levels. Both the caffeine treatment and glucose treatment decreased the sperm motility during incubation period. Conclusion: 5-ALA might increase sperm mitochondrial membrane depolarization to utilize the ATP for enhancing sperm movement.

• 한국환경보건학회지
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• 제21권2호
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• pp.27-35
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• 1995

In order to investigate acute toxicity and bioconcentration of heavy metals for a freshwater fish, the fish used in this experiment was goldfish, Carassius auratus. Each ten goldfish was accommonidated in a water and was treated with different concentration of Pb and Cu compound. The 24 $hr-LC_{50}$ was obtained by plotting on the log-normal distribution graph. Furthermore, the combined effect of Pb and Cu was also investigated the fish was treated with Pb or Cu compound only, and Pb and Cu compound together, respectively. These results were summarized as follows: 1. The 24 $hr-LC_{50}'s$ of Pb and Cu were 7.48 mg/l and 0.666 mg/l, respectively. 2. When single or/and combined treatment with Pb(7.0 mg/l) or/and Cu(0.6 mg/l) to Carassius auratus for 24 hours were performed, there was significant difference between the single or/and the combined treatment in their bioaccumulated Cu concentrations. Cu concentrations in goldfish were higher in the combined treatment than in the single treatment. 3. When Carassius auratus was exposed to 0.748 mg/l (1/10 of 24 $hr-LC_{50}$) and 1.496 mg/l of Pb (1/5 of 24 $hr-LC_{50}$) for 7 days, the bioconcentration factors (BCF) were 79.14 and 100.11 for Pb, respectively. The BCF of Pb was obtained as a linearity according to the concentration and exposure time as follows log BCF=1.014 log $P\cdot T$+1.011 ($r^2$=0.9041) where, P: pollutant concentration(mg/l) T: exposure time(day) 4. When Carassius auratus was pxposed to 0.0666 mg/l (1/10 of 24 $hr-LC_{50}$) and 0.1332 mg/l of Cu (1/5 of 24 $hr-LC_{50}$) for 7 days, the bioconcentration factors (BCF) were 55.42 and 63.24 for Cu respectively. The BCF of Cu was obtained as a linearity according to the concentration and exposure time as follows log BCF=0.571 log $P\cdot T$+1.823 ($r^2$=0.8974) where, P: polutant concentration(mg/l) T: exposure time(day)

• 비파괴검사학회지
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• 제29권4호
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• pp.299-307
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• 2009

광섬유 센서 기술은 기존의 상용 센서의 어려움을 극복할 수 있어 전자기학 잡음과 전기 쇼크의 영향이 강한 폭발환경에서도 충분히 사용이 가능하다. 최근 이러한 장점들로 인해 여러 종류의 광섬유 센서들이 활발히 연구 개발되고 있다. 또한 비파괴검사/평가 분야로써 구조 건전성 감시를 위한 광섬유 센서의 다양한 적용 연구 분야가 존재한다. 그러나 로드셀과 같은 종류의 센서들은 상대적으로 상용화가 미흡한 실정이다. 본 논문에서는 광섬유 브래그 격자 센서를 사용한 광섬유 로드셀을 보여준다. 본 로드셀의 형상은 링크타입이고, 세 개의 광섬유 브래그 격자 센서를 사용하여 세 지점의 변형률을 각기 측정한다 특히 이들 변형률은 온도와 같은 동상 잡음을 제거하기 위해 차동법을 사용하여 신호처리 된다. 더 나아가 본 로드셀의 감도, 선형성 그리고 해상도를 인장실험을 통해 성공적으로 검증하였다.

• 분석과학
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• 제26권2호
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• pp.120-124
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• 2013

본 연구에서는 대기오염 및 화산활동에 의한 분출가스의 원거리 가스검출에 제한적으로 사용된 개방형 푸리에 변환 분광 분석기(open path FT-IR spectrometer)를 사용하여 적외선광원을 사용하지 않는 passive mode로 $CO_2$, CO, $SO_2$에 대한 정량 분석을 시도하였다. 표준가스를 이용하여 제작된 적외선흡수 스펙트럼으로 $CO_2$, CO, $SO_2$ 다중 회귀 곡선(MLR)을 사용한 농도 별 검량선 작업 결과, $CO_2$, CO는 결정 계수가 0.90 이상으로 선형성이 좋았으나, $SO_2$는 0.88로 비교적 낮은 선형성을 확인할 수 있었다. 실제 화재 실험을 통하여 3가지 가스에 대해서 측정한 결과 $CO_2$는 높은 농도를 확인하였으나, CO, $SO_2$는 확인되지 않았다. 이 결과를 통해서 적외선 광원 없이 개방형 푸리에 변환 분광 분석기를 활용하여 화재시 배출되는 가스의 원거리측정이 가능함을 확인하였다.

• 한국멀티미디어학회논문지
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• 제13권8호
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• pp.1115-1127
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• 2010

TFT-LCD 생산 과정에서 발생하는 결함을 정확하게 분류하여 결함 유형에 따라 폐기, 사용가능 등의 의사결정을 적절하게 내리는 것은 수율 증가 및 생산성 향상에 필수적인 요소이다. 본 논문에서는 TFT-LCD 생산 라인에서 획득한 결함 영상에 대하여 명암도 분포(intensity distribution) 및 결함 영상의 형태 특징(shape feature)을 분석하여 효과적으로 필름 결함 유형을 분류하는 기법을 제시한다. 본 연구에서는 먼저 필름 결함 영상을 결함 영역과 결함이 아닌 배경 영역으로 이진화하고, 결함 영역에서 결함의 선형성(linearity), 명암도 분포를 고려한 형태 특징 등의 여러 가지 특징을 분석하여 기준 영상(referential image) 데이터베이스를 구축하였으며, 분류하고자 하는 결함 영상과 데이터베이스에 저장된 기준 영상과의 매칭 비용 함수(matching cost function)를 정의하여 적절히 매칭시킴으로써 결함의 유형을 결정하였다. 제시한 기법의 성능을 검증하기 위하여 실제 TFT-LCD 생산 라인에서 획득한 결함 영상들을 대상으로 분류 실험을 수행하였으며, 실험 결과 생산 라인에서 이용할 수 있을 정도의 상당한 수준의 분류 정확도를 달성하였음을 보여주었다.

• 산업기술연구
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• 제28권B호
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• pp.91-99
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• 2008

Applicability of existing methods of predicting consolidation settlement was assessed by analyzing results of centrifuge tests modelling self-weight consolidation of soft marine clay. From extensive literature review about self-weight consolidation of soft marine clays located in southern coast in Korea, constitutive relationships of void ratio-effective stress-permeability and typical self-weight consolidation curves with time were obtained by centrifuge model experiments. For the condition of surcharge loading, exact solution of consolidation settlement curve was obtained by Terzaghi's consolidation theory and was compared with the results predicted by currently available methods such as Hyperbolic method, Asaoka's method, Hoshino's method and ${\sqrt{S}}$ method. All methods were found to have their own inherent error to predict final consolidation settlement. From results of analyzing the self-weight consolidation with time by using those methods, Asaoka's method predicted the best. Hyperbolic method predicted relatively well in error range of 2~24% for the case of showing the linearity in the relationship between T vs T/S in the stage of consolidation degree of 60~90 %. For the case of relation curve of T vs $T/S^2$ showing the lineality after the middle stage, error range from Hoshino method was close to those from Hyperbolic method. However, Hoshino method is not able to predict the final settlement in the case of relation curve of T vs $T/S^2$ being horizontal. For the given data about self-weight consolidation after the middle stage, relation curve of T vs T/S from ${\sqrt{S}}$ method shows the better linearity than that of T vs $T/{\sqrt{s}}$ from Hyperbolic method.

• 대한수의학회지
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• 제57권4호
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• pp.223-226
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• 2017

This study was undertaken to develop new analytical methods for assessment of anticoccidials. High-performance liquid chromatography (HPLC) was found to be a fast, reliable, and practical method. The anticoccidials used in this experiment were toltrazuril and diclazuril, and the analysis factors were specificity, linearity, accuracy, repeatability, and intermediate precision. The linearity of each anticoccidial was better than 0.99, and the accuracies were 99.5% and 99.1% with relative SD of 0.5 and 0.4, respectively. To assess whether the developed HPLC method could be effectively applied, toltrazuril and diclazuril post-market veterinary products (five products) that are currently sold were tested. The results revealed no non-compliant items and the method was applied successfully. Therefore, the newly developed HPLC method for anticoccidial assessment described in this study may be useful as a reference method in the Korean Standards of Veterinary Pharmaceuticals for the analysis of toltrazuril and diclazuril.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 추계학술대회
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• pp.1109-1112
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• 2015

소자장치가 없는 함정의 경우 탈자 시에 지구자계와 반대방향으로 수직자화를 부여하여 수중에서 수직방향의 자계가 발생하지 않도록 한다. 탈자 시에 수직자화를 부여하는 탈자방법으로는 Flash D가 있어나 수직자화의 예측이 어렵다. 본 논문에서는 Flash D와는 달리 바이어스 자계를 인가하여 수직방향으로 자화를 형성하는 것에 대해 검토하였다. 이용된 시편은 두께 0.15mm의 아연도금 강판을 이용하여 함정의 선수에서 선미까지의 형상을 고려하여 원형, 삼각, 사각형의 형태를 가진다. FEM해석을 통해 시편형상에 따른 자계신호의 차이를 구하였고 인가자계에 의한 잔류자화특성곡선을 실험을 통해 구하였다. 바이어스자계를 수평 및 수직으로 각각 인가하여 잔류자화에 의한 자계신호를 측정하였다. 시편에 인가하는 자계는 파형발생기를 이용하여 솔레노이드 코일에 전류를 흘려 발생시켰으며 수직바이어스자계는 솔레노이드 코일 아래에 사각 코일을 설치하여 발생시켰다. 신호측정은 자계센서를 이용하였다. 이 실험을 통해 수직 및 수평 바이어스 자계는 시편에 수직 및 수평자화를 각각 형성시켰으며 수직자화는 수직바이어스 자계와 선형적인 관계를 가져 함정에 형성되는 수직자화를 예측할 수 있음을 알았다.