• Bulletin of the Korean Chemical Society
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• v.35 no.1
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• pp.93-97
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• 2014

A kinetic study is reported on nucleophilic substitution reactions of 4-nitrophenyl X-substituted-2-methylbenzoates (5a-e) with a series of cyclic secondary amines in MeCN at $25.0{\pm}0.1^{\circ}C$. The Hammett plots for the aminolysis of 5a-e are nonlinear, e.g., substrates possessing an electron-donating group (EDG) in the benzoyl moiety deviate negatively from the linear line composed of substrates bearing no EDG. In contrast, the Yukawa-Tsuno plots for the same reactions exhibit excellent linear correlations with ${\rho}_X$ = 0.30-0.59 and r = 0.90-1.15, indicating that the nonlinear Hammett plots are caused by stabilization of the substrates possessing an EDG through resonance interactions but are not due to a change in the rate-determining step (RDS). The Br${\phi}$nsted-type plots are linear with ${\beta}_{nuc}$ = 0.66-0.82. Thus, the aminolysis of 5a-e has been suggested to proceed through a stepwise mechanism in which departure of the leaving group occurs at the RDS. The ${\rho}_X$ and ${\beta}_{nuc}$ values for the aminolysis of 5a-e increase as the reactivity of the substrates and amines increases, indicating that the reactivity-selectivity principle is not applicable to the current reactions.

• Parasites, Hosts and Diseases
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• v.55 no.5
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• pp.541-548
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• 2017

A survey was performed to know the infection status of echinostome metacercariae in Cipangopaludina chinensis malleata snails from Korea. Total 75 snails collected in 5 localities, i.e., Imsil-gun, Jeollabuk-do, Hwasun-gun and Shinan-gun (Aphae and Jido), Jeollanam-do, and Jinju-si, Gyeongsangnam-do, were examined for metacercariae by the artificial digestion method. Infection rates of metacercariae were 80.0%, 66.7%, 100%, 60.0%, and 73.3%, and their densities were 39, 32, 183, 19, and 30 per snail infected, respectively. The metacercariae were round, $105-118{\times}105-118{\mu}m$ in size, with a thin cyst wall, collar spines on the head collar, and excretory granules in 2 canals of excretory tube. Adult flukes were elongated, ventrally curved, and $5,167{\times}939{\mu}m$ in average size. Head collar distinct, bearing 45 collar spines with 5 end groups on each side. Oral sucker subterminal, pharynx well developed, and esophagus somewhat short. Cirrus sac well developed, with a saccular seminal vesicle, and ventral sucker very large. Ovary elliptical and on the median line of the body. Testes tandem and slightly lobed. Eggs operculated, elliptical, and $90-103{\times}55-60{\mu}m$ in size. By scanning electron microscopy, the head collar was prominent with 45 collar spines resembling horns of younger stags. Scale-like tegumental spines were densely distributed on the body surface between the head collar and ventral sucker. Conclusively, it has been first confirmed that the life cycle of E. macrorchis is indigenously maintained in Korea, and C. chinensis malleata snails are popularly infected with the metacercariae of this echinostome.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.987-991
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• 2013

Aim: To study anti-tumor effects of exosomes from class II transactivator (CIITA) gene transfected CT26 cells. Methods: In this study, we established an MHC class II molecule-expressing murine colon cancer cell line (CT26-CIITA) by transduction of the CIITA gene. Immune effects in vitro and tumor protective results in vivo were tested and monitored. Results: Exosomes from CT26-CIITA cells were found to contain a high level of MHC class II protein. When loaded on dendritic cells (DCs), exosomes from CT26-CIITA cells significantly increased expression of MHC class II molecules, CD86 and CD80, as compared to exosomes from CT26 cells. In vitro assays using co-culture of immunized splenocytes and exosome-loaded DCs demonstrated that CIITA-Exo enhanced splenocyte proliferation and IFN-${\gamma}$ production of CD4+T cells, while inhibiting IL-10 secretion. In addition, compared to exosomes from CT26 cells, CT26-CIITA-derived exosomes induced higher TNF-${\alpha}$ and IL-12 mRNA levels. A mouse tumour preventive model showed that CT26-CIITA derived exosomes significantly inhibited tumour growth in a dose-dependent manner and significantly prolonged the survival time of tumour-bearing mice. Conclusion: Our findings indicate that CT26-CIITA-released exosomes are more efficient to induce anti-tumour immune responses, suggesting a potential role of MHC class II-containing tumour exosomes as cancer vaccine candidates.

• The Transactions of the Korean Institute of Power Electronics
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• v.14 no.2
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• pp.168-175
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• 2009

This paper proposes an enhanced algorithm for sensorless control of 45,000rpm/22kw type Permanent Magnetic Synchronous Motor (PMSM) with air-foil bearing. The proposed algorithm is based on iterative adaptive flux observer for sensorless control of the motor in wide speed range by on-line estimating angle and velocity of rotor. Simulation error between actual and estimated angle of rotor is analyzed to enhance characteristics of frequency response of conventional adaptive flux observer, which results in stable response in wide range of speed. Using the iteration number for stable phase-delay characteristics, the observer enhances the dynamic characteristics of the observer within current control period. The experiment results show the reliable performance of the proposed algorithm through starting to high speed operating range.

• Journal of the Earthquake Engineering Society of Korea
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• v.1 no.4
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• pp.45-58
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• 1997

This paper describes a series of shaking table and pseudodynamic tests for evaluation of seismic performance of base-isolated structures subjected to various seismic earthquake inputs. The main objectives of this study are : (1) evaluation of the effectiveness of base-isolation systems for low-rise structures against severe seismic loads through shaking table tests, (2) verification of the substructuring pseudodynamic test method for the base-isolated structures in comparison with the shaking table test results. In the shaking table test, a quarter scaled three-story structure base-isolated by laminated rubber bearings is tested. In the pseudodynamic test, only the laminated rubber bearing s are tested using the substructuring technique, while the concurrent seismic responses of the superstructure are computed using on-line numerical integration. Comparison with the shaking table test results indicates that the substructuring pseudodynamic test method is very effective for determining the dynamic responses of the base-isolated structure.

• Journal of the Korean Geotechnical Society
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• v.34 no.12
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• pp.59-69
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• 2018

In order to use the limit equilibrium theory, it is necessary to find a slip line under the ultimate failure condition. The strength reduction method using the Lagrangian finite element method defines the ultimate failure state at a time when the numerical solution cannot converge within the certain number of the iteration. When the coupled Eulerian-Lagrangian (CEL) method is used, however, such definition is inappropriate because the numerical solution of the CEL method can converge even under the ultimate failure condition. In this study, an objective condition designating the ultimate failure state in the finite element analysis adopting the CEL method was proposed. In the problem of the bearing capacity of the undrained soft ground subjected to the strip footing loading, we found that the rate of the plastic dissipated energy is highly sensitive at the load of the theoretical limit of the ultimate failure state.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2019.11a
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• pp.87-88
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• 2019

Leading Lights and Sector Lights provide a navigable channel, heading reference and a visual indication. Mariners can take easily a reference bearing or line of position. The Busan North Port needed to install a sector light to resolve blind sections because of Busan Port Redevelopment Project D-1 Block Construction Plan. And also the busan new port needed to install a sector light to give safety indication because navigation conditions will be changed due to removal of the to-island. For this reason, design development was made for installation of sector lights. In addition, the results of design development were compared with the AtoN simulation and verified. This paper is expected to be very useful for installing Sector Lights to guide the vessel to port safely in Korea.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.05a
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• pp.618-622
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• 2004

The vibration test system of SITC(Satellite Integration and Test Center) at KARI(Korea Aerospace Research Institute) has been used successfully for the environmental tests of a majority of korean space programs, such as KOMPSAT, Koreasat KITSAT, STSAT and KSR program since 1996. To meet the recent needs of large size test facility available for the vibrational tests of the huge launch vehicles and tole-communication satellites which will be developed in the near future, KARI undertook to construct the large size multi-electromagnetic shaking system with 3 $\times$ 3m head expander system. The new system will consist of three electromagnetic shakers which has 160 kN thrust force individually, and be able te sustain up to 8 tons test load and 300 kNm overturing moment. And to avoid the tremendous cost and effort to furnish the seismic block with large size and weight, it will adopt a Lin-E-Air type configuration with which the seismic block is less severe than a Solid-Truninon type. In addition, to fulfill the strong requirement of high overturning moment the additional guidance system including a central bearing system on a central support and several pad bearings around the head expander body is now considered. This paper describes the configuration and the design parameters of the multi-shaking system which is under development by KARI's engineers.

• Special Issue of the Society of Naval Architects of Korea
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• 2008.09a
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• pp.46-53
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• 2008

Recently, the synthetic material stern tube bush has been applied by ship owner's requirement because the synthetic material has a merit. That is to say, when stern tube seal is damaged and sea water comes into stern tube, it can work without problem because of water lubricating property. However, the material also has a demerit of temperature rise problem when some factors meets on synthetic material, for example, not sufficient lubrication oil supply and not proper shaft alignment and so on. As known in the world, the RAILKO bush is rampant for synthetic material by some ship owner because of the above mentioned reason. However, the bush has several accidents on large container vessel. Unfortunately or fortunately our yard has a chance to apply the RAILKO bush owing to requirement of specific ship owner. Therefore, it is much more required to approach the accurate shaft alignment analysis. In line with this reason, we had a shaft alignment calculation considering hull deformation and hull flexibility (hull stiffness). Also, in the calculation, we had considered dynamic condition which is reflected he propeller thrust forces and moments and oil film stiffness on the shaft alignment calculation. According to he shaft alignment calculation, bearing slope was applied on the tern tube bush and was measured. The RAILKO bush should be applied the running in procedure according to maker's recommendation for performing the oil film on the bush surface. Finally, the vessels were delivered successfully without any problem with AILKO bush as shown on his paper.

• Journal of the Korean Society of Radiology
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• v.85 no.3
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• pp.531-548
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• 2024

Developmental dysplasia of the hip is a condition characterized by hip joint instability due to acetabular dysplasia in infancy, necessitating precise ultrasound examination. Legg-Calvé-Perthes disease is caused by a temporary disruption in blood flow to the femoral head during childhood, progressing through avascular, fragmentation, re-ossification, and residual stages. Slipped capital femoral epiphysis is a condition where the femoral head shifts medially along the epiphyseal line during adolescence due to stress, such as weight-bearing. Differentiating between transient hip synovitis and septic arthritis may require joint fluid aspiration. Osteomyelitis can be associated with soft tissue edema and osteolysis. When multiple lesions are present, it is essential to distinguish between Langerhans cell histiocytosis and metastatic neuroblastoma. This review will introduce imaging techniques and typical findings for these conditions.