• Journal of Environmental Health Sciences
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• v.30 no.5 s.81
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• pp.469-480
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• 2004

The radon concentrations were measured to survey distribution of radon concentrations in Seoul subway stations. The radon concentrations in air and water were measured at seventeen subway stations(Mapo, Chungjongno, Sodaemun, Kwanghwamun, Chongno3ga, Ulchiro4ga, Tangdaemun, Sangildong on Line 5;Nowon, Chunggye, Hagye, Kongnung, Taenung, Mokkol, Chunghwa, Sangbong, Myomok on Line 7) using the $RAdtrak^{TM}$ radon gas detector, Pylon AB-5 continuous passive radon detector and liquid scintillation counting method from January to May 1999. The major results obtained from this study were as follows: The long-term mean concentrations of radon were $61.8\;Bq/m^3$ in office, $78.9\;Bq/m^3$ in platform, $38.2\;Bq/m^3$ in concourse and $20.1\;Bq/m^3$ in outdoor, respectively. These levels were less than the action level ($148\;Bq/m^3$) of the U.S. EPA. The highest level of short-term mean concentrations was $116.55\;Bq/m^3$ at Chongno3ga station on the 5th line subway stations, while the lowest mean concentration was $19.55\;Bq/m^3$ at Mokkol station on the 7th line subway stations. The highest concentration of radon in the road water and storing underground water in the subway stations was $234.7\;KBq/m^3\;and\;155.5\;KBq/m^3$ in Sodaemun subway station, respectively. The results suggest that radon concentration in subway stations seems to be affected by ventilation and radon concentratin in underground water in the subway stations.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.53 no.1
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• pp.22-30
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• 2004

As an information-oriented society comes, many people use PC and depend on database that network server has. However, the online data can be missed when a blackout happens and also a power failure effects on standard of judgment on Power Quality. Thus, it is reason of a trend using interruption-free live-line work when a trouble happens to power system. However, the 83％ among the number of people who receive an electric shock experience when a laborer is doing interruption-free live-line works. In interruption-free method, the education and the training problem has been issued. However, we have a few instructors for that training. Furthermore, the trainees have short training period, just 4 weeks. In this paper, to develope the method that has no restriction of a time and place and reduce the wasteful materials, immersion type virtual reality(or environment) technology is used. The users of a 3D immersion type VR training system can interact with the system by doing same action in the real safe environment. Thus, it can be valuable to apply this training system to a dangerous work like as "Interruption-free live-line work exchanging COS(Cut-Out-Switch)". In this program, the user works with a instruction on the window and speaker and can't work other tasks until each part of the task completed. The workers using this system can use their hands and viewpoint movement as he is in a real environment but the trainee can't use all parts and senses of a real body with the current VR technology. Despite of this weak point, when we consider the trends of improvement in electrical devices and communication technology, we can say that 3D graphic VR application has a high potentiality.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.17 no.2
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• pp.159-167
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• 1992

This paper describes a feature extraction process by using a multi-layer neural network and is applied to the Korean stroke pattern for on line hand written character recognition, In the first layer the features are detected during the writing process and in the second layer the stroke specific features are extracted. A modified Masking field algorithm for direction co9nstancy has been used in this neural network and the resulting action potential of stroke specific features represents statistical distribution of the features in the on-line input stroke pattern and these results can be used in the recognition of on-line hand written Korean characters successfully.

• Korean Journal of Applied Biomechanics
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• v.16 no.4
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• pp.39-47
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• 2006

This study long jump action to each situation on a chessboard and section of sight disabled person and normal person through third dimension reflex analysis mechanical special quality because do comparative analysis sight disabled person's exercise ability and technology structure of action that run understand. As can do better without danger of injury map and training of exercise item that action that run is included, do offer of pabulum by purpose. Through this study, conclusion is as following. 1. Sight disabled persons' long jump average recording (121.84cm) showing normal persons' average recording (259.27cm) and much differences, show that motion of body is not big to Touch-down from Ready action. 2. Each phase body center composition(r) average speed displayed result that it is more meaning more than Each phase time required. 3. Began in line carriage without body back stretching in 1 situation on Event one are sight disabled persons. Was expose that do not bend enough knee and ankle than normal person in Event two. Was expose that body is not drooped for surface of land in Event three, and knee and ankle were expose that do not unfold easily than normal person. Was expose that do not bend enough on Touch-down knee by relation that can not grasp position of the floor in Event four. 4. When taking off, the average of horizontal speed of body center are 1.80m/sec for blind people and 3.53m/sec for the normal. In this connection, the study shows that the difference of horizontal speed between the blind and the normal is bigger than difference of vertical speed, which are 1.56m/sec for the blind and 1.98m/sec for the normal. Also, composite speed also shows us big difference between 2.41m/sec of the blind and 4.07m/sec of the normal. The speed body center of take-off was expose that average adjuster are big width of deceleration than average - beginning disabled person's average by 2.23m/sec - 1.71m/sec in the vertical speed. 5. If examine change of high and low for z Sign of right hand, change of high and low showed as is small than normal person is sight obstacle, and all hand movements are small and was expose that do not use enough reaction of body as well as in ready action.

• Research in Community and Public Health Nursing
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• v.10 no.2
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• pp.291-306
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• 1999

Health promotion has come to the fore through new concept approach in consequence of the increase of chronic diseases. increase of medical cost and social trend of putting more emphasis on the individual responsibility for health. Studies of health promotion can be classified into two types: one is micro intervention method which is mainly focused on modifying individual life style and the other. macro intervention method in which they put another emphasis on the environment the individual is surrounded. in addition to modifying individual life style. This study belongs to the later. This study aims to develop nursing activities and program it for the purpose of community health promotion. The process of the study can be briefed as follows: to draw out nursing contents to intervene for community health promotion: to promote community health to develop nursing action indicators; to develop nursing action indicators for the development of main nursing activities. And those developed nursing activities are programmed systematically. The community health promotion program is composed of a hierarchical structure with nursing process that the nurses are supposed to apply to perform professional nursing. the level of nursing perform. the main items of nursing process. health promotion nursing indicators. health promotion nursing activities. The conclusion of this study according to objectives are as follows. First. community health promotion contents at individual and community level are remained revised and complemented and those at organizational level are developed. The developed main contents of community health promotion nursing are as follows. 1) Revised individual level nursing contents: 35 items. 2) Developed organizational level nursing contents: 24 items. 3) Revised community level nursing contents: 36 items. Second. for the development of the health promotion nursing action indicators. principles were set up and applied as follows. 1. Developed indicators should be provided with such qualities as comprehensiveness. diversity. developability, availability. practicability. 2. Developed indicators should be provided with functional abilities to measure the conditions and changes in any phenomena or state. inspect the development of the states. control the implementing program. evaluate the result of program and grasp what nurses should do. 3. Developed indicators should be provided with relevance and sequence. 4. Developed indicators should be undergo inspections from the expert. The developed community health promotion action indicators developed in this study. observing above mentioned principles. are total 330 indicators of 95 items. Third. when the main nursing activities were developed for each nursing action indicator. five priciples were set up in accordance with each nursing action indicators to decide main nursing activities. Main nursing activities developed observing those principles. are total 1273. Forth. for the programming of the developed nursing activities. three principles were set up. 1. The nursing activities are systematized in line with (nursing process) (nursing client) (key items of nursing process) (nursing action indicators for health promotion) (nursing activities). 2. The program is constructed in downward and hierarchical order. 3. The program is constructed not in relation to same level activities but in relation to high and low level activities. The process step of programming of developed main health promotion nursing activities are; Step 1. The Developed nursing action indicators are classified into nursing process. Step 2. The main nursing activities are allocated per each nursing action indicators. Step 3. The statement of main nursing activities are inspected. Step 4. The items of main nursing activities allocated by a certain nursing action indicators are sequenced. taking into consideration the elaborateness of activity. the sequency of activity. familiarity of activity. the difficulty of activity. the interest of activity. the frequency of activity. Step 5. The whole developed program should undergo comprehensive and critical inspections.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3581-3586
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• 2014

Aim: To investigate the effects of tetramethypyrazine (TMP) on proliferation and apoptosis of the human gastric carcinoma cell line 7901 and its possible mechanism of action. Methods: The viability of TMP-treated 7901 cells was measured with a 3-(4, 5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) and cell apoptosis was analyzed by flow cytometry. The distribution of cells in different phases of cell cycle after exposure of TMPs was analyzed with flow cytometry. To investigate the molecular mechanisms of TMP-mediated apoptosis, the expression of NF-${\kappa}Bp65$, cyclinD1 and p16 in SGC-7901 cells was analyzed by reverse transcription-polymerase chain reaction (RT-PCR) and western blotting. Results: TMP inhibited the proliferation of human gastric carcinoma cell line 7901 in dose and time dependent manners. Cell growth was suppressed by TMP at different concentrations (0.25, 0.5, 1.0, 2.0 mg/ml), the inhibition rate is 0.46%, 4.36%, 14.8%, 76.1% (48h) and 15.5%, 18.5%, 41.2%, 89.8% (72h) respectively. When the concentration of TMPs was 2.0mg/ml, G1-phase arrest in the SGC-7901 cells was significant based on the data for cell cycle distribution. RT-PCR demonstrated that NF-${\kappa}Bp65$ and cyclin D1 mRNA expression was significantly down-regulated in 7901 cells treated with 2.0 mg/ml TMP for 72h (p<0.05), while the p16 mRNA level was up-regulated (p<0.05). The protein expression of NF-${\kappa}Bp65$ and cyclin D1 decreased gradually with the increase in TMP concentration, compared with control cells (p<0.05), while expression of protein p16 was up-regulated (p<0.01). Conclusion: TMP exhibits significant anti-proliferative and pro-apoptotic effects on the human gastric carcinoma cell line SGC-7901. NF-${\kappa}Bp65$, cyclinD1 and p16 may also play important roles in the regulation mechanisms.

• Mycobiology
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• v.48 no.3
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• pp.219-227
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• 2020

Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, an androgen-independent prostate cancer cell line. Results demonstrated that both hexane (GF-EH) and butanol (GF-EB) fraction of G. formosanum ethanol extract inhibited DU145 cell viability in a dose-dependent manner. GF-EH induced cell-cycle arrest in G1 phase of DU145 cells via downregulation of cyclin E2 protein expression. In addition, GF-EB triggered extrinsic apoptosis of DU145 cells by activating caspase 3 gene expression resulting in programed cell death. Above all, both GF-EH and GF-EB show lower toxicity to normal human fibroblast cell line compared to DU145 cell, implying that they possess specific drug action on cancer cells. This study provides a molecular basis of G. formosanum extract as a potential ingredient for treatment of androgen-independent prostate cancer.

• Journal of Acupuncture Research
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• v.23 no.4
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• pp.135-148
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• 2006

Objectives : Juglandis Semen herbal acupuncture solution(JSS) has a broad array of clinical applications in oriental medicine, including treatment of chronic musculoskeletal diseases such as arthritis. This study was performed to investigate the global gene expression profiles using microarray assay in RAW 264.7 cell line treated with JSS and to advance our understanding of the pharmacologic effect of Jss. Methods : Change of the gene expression profile in RAW cell line following treatment with JSS alone, with lipopolysaccharide(LPS) alone, or with LPS plus JSS was investigated with a cut-off level of 2 fold change in the expression. Results : Of the 8170 genes profiled in this study, 95 were upragulated and 42 downregulated following JSS treatment, 51 were upragulated and 21 downregulated following LPS treatment, and 88 were upregulated and 69 downregulated following costimulation of JSS and LPS. Conclusion : JSS treatment induced upregulation of some genes including IL-10 with its possible implication in an antiinflammatory action of JSS. However, further research on expression profile changes induced by JSS treatment is expected.

• Journal of Korean Academy of Nursing Administration
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• v.14 no.1
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• pp.13-25
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• 2008

Purpose: The study aimed at providing better understanding of the way of carrying out nursing practice tailored to meet patient's individuality, and types of customized care in home care settings. Method: This study was conducted with qualitative design, using a grounded theory method. The directors of the home care department at three general hospitals nominated 12 staff nurses who had the experience of customized care. The data were collected using interview and field observation, and analyzed line-by-line with steps of coding. Result: The core category of customized care was 'caring in a precise manner suited to patient's individuality'. The central phenomenon was 'desire to do more for patient'. The action and interactions were: (a) knowing a patient all the more, (b) making a special relationship to a patient, (c) designing care alternatives reflecting individuality, and (d) performing the care alternatives reflecting individuality. Three types of customized care were the following: (a) completion of customized care, (b) an attempt to customized care, and (c) abandonment of working for customized care. Conclusions: The knowledge of customized care would be based on development of nursing practice program focusing on patient' individuality, and instrument development necessary for further research on care customization.

• Advances in Traditional Medicine
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• v.5 no.1
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• pp.69-74
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• 2005

'SecSec' has been used for the purpose of prevention and treatment of throat diseases such as sore throat, cough, bronchial asthma and allergic asthma in Korea. However, its effect in experimental models remains unknown. To investigate the biological effect of SecSec, we examined cytotoxicity and secretion of inflammatory cytokines on human leukemic mast cell line, HMC-1, stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. SecSec by itself had no cytotoxicity on HMC-1. When SecSec (1 mg/ml) was added, the secretion of tumor necrosis factor-alpha $(TNF-{\alpha})$, interleukin (IL)-6, and granulocyte macrophage-colony stimulating factor (GM-CSF) was significantly inhibited about 47.20%, 25.55%, and 46.43%, respectively on PMA plus A23187-stimulated HMC-1 cells. But SecSec did not inhibit IL-8 secretion. These findings may help understanding the mechanism of action of this medicine leading to control activated mast cells on allergic inflammatory condition like asthma.