• Molecules and Cells
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• v.45 no.12
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• pp.923-934
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• 2022

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in applications such as regenerative medicine, cardiac disease modeling, and in vitro drug evaluation. However, hPSC-CMs are immature, which limits their applications. During development, the maturation of CMs is accompanied by a decline in their proliferative capacity. This phenomenon suggests that regulating the cell cycle may facilitate the maturation of hPSC-CMs. Aurora kinases are essential kinases that regulate the cell cycle, the role of which is not well studied in hPSC-CM maturation. Here, we demonstrate that CYC116, an inhibitor of Aurora kinases, significantly promotes the maturation of CMs derived from both human embryonic stem cells (H1 and H9) and iPSCs (induced PSCs) (UC013), resulting in increased expression of genes related to cardiomyocyte function, better organization of the sarcomere, increased sarcomere length, increased number of mitochondria, and enhanced physiological function of the cells. In addition, a number of other Aurora kinase inhibitors have also been found to promote the maturation of hPSC-CMs. Our data suggest that blocking aurora kinase activity and regulating cell cycle progression may promote the maturation of hPSC-CMs.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.14 no.1
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• pp.79-90
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• 2016

The second-stage near surface disposal facility for low and very low level radioactive waste's permanent disposal is to be built. During the institutional control period, the inadvertent intrusion of the general public is limited. But after the institutional control period, the access to the general public is not restricted. Therefore human who has purpose of residence and resource exploration can intrude the disposal facility. In this case, radioactive effects to the intruder should be limited within regulatory dose limits. This study conducted the safety assessment of human intrusion on the second-stage surface disposal facility through drilling and post drilling scenario. Results of drilling and post drilling scenario were satisfied with regulatory dose limits. The result showed that post-drilling scenario was more significant than drilling scenario. According to the human intrusion time and behavior after the closure of the facility, dominant radionuclide contributing to the intruder was different. Sensitivity analyses on the parameters about the human behavior were also satisfied with regulatory dose limits. Especially, manual redistribution factor was the most sensitive parameter on exposure dose. A loading plan of spent filter waste and dry active waste was more effective than a loading plan of spent filter waste and other wastes for the radiological point of view. These results can be expected to provide both robustness and defense in depth for the development of safety case further.

• International Journal of Automotive Technology
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• v.1 no.1
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• pp.17-25
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• 2000

The electromechanical valve train (EMV) technology allows for a reduction in fuel consumption while operating under a stoichiometric air-fuel-ratio and preserves the ability to use conventional exhaust gas aftertreatment technology with a 3-way-catalyst. Compared with an engine with a camshaft-driven valve train, the variable valve timing concept makes possible an additional optimization of cold start, warm-up and transient operation. In contrast with the conventionally throttled engine, optimized control of load and in-cylinder gas movement can be used for each individual cylinder and engine cycle. A load control strategy using a "Late Intake Valve Open" (LIO) provides a reduction in start-up HC emissions of approximately 60%. Due to reduced wall-wetting, the LIO control strategy improves the transition from start to idle. "Late Exhaust Valve Open" (LEO) timing during the exhaust stroke leads to exhaust gas afterburning and, thereby, results in high exhaust gas temperatures and low HC emissions. Vehicle investigations have demonstrated an improved accuracy of the air-fuel-ratio during transient operation. Results in the New European Driving Cycle have confirmed a reduction in fuel consumption of more than 15％ while meeting EURO IV emission limits.

• Journal of Korean Society for Quality Management
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• v.28 no.3
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• pp.18-30
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• 2000

Recent studies have shown that the $\bar{X}$ chart with variable sampling intervals(VSI) and the $\bar{X}$ chart with variable sample size(VSS) are much quicker than Shewhart $\bar{X}$ chart in detecting shiks in the process. Shewhart $\bar{X}$ chart has been beneficial to detect large shifts but it is hard to apply Shewhart $\bar{X}$ chart in detecting moderate shifts in the process mean. In this article the $\bar{X}$ chart using variable sample size(VSS) and variable sampling Intervals(VSI) has been proposed to supplement the weak point mentioned above. So the purpose of this paper is to consider finding the design parameters which minimize expected loss costs for unit process time and measure the performance of VSSI(variable sample size and sampling interval) $\bar{X}$ chart. It is important that assignable causes be detected to maintain the process controlled. This paper has been studied under the assumption that one cycle is from starting of the process to eliminating the assignable causes in the process. The other purpose of this article is to represent the expected loss costs in one cycle with three process parameters(sample size, sampling interval and control limits) function and find the three parameters.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.67 no.2
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• pp.179-185
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• 2018

A considerable cost gap between three major power generation technologies, namely nuclear, coal, and combined cycle gas turbine (CCGT), has been a well-established fact in the Korean electricity market. Alternatively, this paper analyzes the levelized costs of electricity (LCOE) of the three technologies reflecting overall social costs of electricity generation including accident risk, $CO_2$ emission, and air pollution damage. The paper unveils to what extent current discriminative subsidies on fuels regarding the social costs, mostly through tax exemptions, affect economic competitiveness of the technologies. In particular, it finds relative positions of coal and CCGT could be altered depending on appreciation level of the social costs. It has limits in analyzing fixed costs of the technologies, however, due to limited data availability of nuclear power, and suggests further studies on the issue.

• Journal of Korean Association for Spatial Structures
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• v.6 no.3 s.21
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• pp.51-57
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• 2006

The object of this study is to examine the managerial characteristics of the Korean building projects. The study in this paperproposes to investigate the factors that affect process quality not only in the construction phase but also in all three phases (design, construction, and operation) of the whole life cycle of a building project. A questionnaire survey is conducted to investigate the differences in the perceptions of graduate students, professors, designers and practitioners with regard to process quality in building projects. Analyzing these factors helps in revising and improving the Korean existing quality control system and programs. The findings indicate that cooperation of designer's professionals, level of management leadership in promoting quality, ability to operate the facility within design limits are important factors. Theparticipation percentage of "quality" treated in any course/seminar shows only 45%. It is recommended that college programs include courses that treat the administrative aspects involved in the building project and that continuing education programs rover quality training.

• Journal of Advanced Marine Engineering and Technology
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• v.27 no.3
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• pp.412-420
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• 2003

This study describes the merits of PWM control of hydraulic system using high speed on-off valves. Generally, Electro-hydraulic valves can be classified into two classification: valves which are controlled by analog signal and which are controlled by digital. The former includes hydraulic servo valves and proportional valves which require A/D converters as interface to digital computer and too costly and sensitive to oil contamination because of complexity in structures. The latter includes high speed on-off valves which do not require A/D converters because they are normally operated in a pulse width modulation(PWM) method, and are low in price and robust to oil contamination because of their simple structures. The objectives of this study is to analyze the limit cycle which regularly appear in the position control system using 2/2way high speed on-off valves and to give a criterion for the stability of this system. The nonlinear characteristics of PWM and cylinder friction of this system are described by harmonic linearization and the effects of parameter variations to the system stability are simulated.

• Nuclear Engineering and Technology
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• v.48 no.2
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• pp.318-329
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• 2016

Reducing critical boron concentration in a commercial pressurized water reactor core offers many advantages in view of safety and economics. This paper presents a preliminary investigation of a reduced-boron pressurized water reactor core to achieve a clearly negative moderator temperature coefficient at hot zero power using the newly-proposed "Burnable absorber-Integrated Guide Thimble" (BigT) absorbers. The reference core is based on a commercial OPR1000 equilibrium configuration. The reduced-boron ORP1000 configuration was determined by simply replacing commercial gadolinia-based burnable absorbers with the optimized BigT-loaded design. The equilibrium cores in this study were directly searched via repetitive Monte Carlo depletion calculations until convergence. The results demonstrate that, with the same fuel management scheme as in the reference core, application of the BigT absorbers can effectively reduce the critical boron concentration at the beginning of cycle by about 65 ppm. More crucially, the analyses indicate promising potential of the reduced-boron OPR1000 core with the BigT absorbers, as its moderator temperature coefficient at the beginning of cycle is clearly more negative and all other vital neutronic parameters are within practical safety limits. All simulations were completed using the Monte Carlo Serpent code with the ENDF/B-VII.0 library.

• Journal of the Economic Geographical Society of Korea
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• v.20 no.2
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• pp.189-213
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• 2017

This study seeks to critically examine the significance and limits of the cluster adaptive cycle model for analysis of cluster evolution and to propose research issues for future analysis of cluster evolution based on this critical examination. Until the 1980s, research on industrial complexes including clusters was based on a 'static perspective' that focuses on the aspect of economic space at a specific point in time, but the research paradigm has recently shifted to a 'dynamic perspective' focusing on 'evolution' of 'complex adaptive systems'. As a result, the adaptive cycle model has attracted attention as an analysis tool of dynamically evolving clusters. However, the cluster adaptive cycle model has emerged by being appropriately modified and expanded according to the properties of the cluster and its evolution. The cluster adaptive cycle model is a comprehensive analysis framework that identifies the characteristics of cluster evolution in terms of resource accumulation, interdependence, and resilience and classifies cluster evolution paths into six different categories. Nevertheless, there is still a need for further discussion and supplementation in terms of theoretical and empirical research to expand and deepen the model. Therefore, research issues for future analysis of cluster evolution are to specify and elaborate the cluster evolution model, to emphasize the concept of resilience, and to verify the applicability and usefulness of the model through empirical research.

• Journal of Internet Computing and Services
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• v.9 no.4
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• pp.61-68
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• 2008

Ethernet passive optical network (EPON) is the next-generation technology mitigating the bottleneck between high-capacity local area networks (LANs) and a backbone network. The bottleneck is aggrevated depending on burstiness and long range dependence (LRD) of traffic characteristics as well as amount of outgoing traffic from the high-capacity LANs. The proposed scheme decreases average packet delay for data upstreaming by considering such traffic characteristics to dynamically allocate bandwidth to multiple optical network units (ONUs). In addition, it can appropriately support delay-sensitive traffic such as constant bit ratio (CBR) traffic by making maximum cycle time fix regardless of the number of ONUs. The comprehensive simulation results indicate that the proposed scheme acheives up to 77% and 82% lower than previous schemes in terms of average packet delay and average queue size while it limits the maximum cycle time to twice of the basic cycle time.