• Journal of Korean Society on Water Environment
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• v.31 no.2
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• pp.181-195
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• 2015

Algal blooms in lakes are one of major environmental issues in Korea. A three-dimensional, hydrodynamic and water quality model was developed and tested in Lake Euiam to assess the performance and limitations of numerical modeling with multiple algal groups using field data commonly collected for algal management. In this study, EFDC was adopted as the basic model framework. Simulated vertical profiles of water temperature, dissolved oxygen and nutrients monitored at five water quality monitoring stations from March to October 2013, which are closely related to algal dynamics simulation, showed good agreement with those of observed data. The overall spatio-temporal variations of three algal groups were reasonably simulated against the chlorophyll-a levels of those estimated from the limited monitoring data (chlorophyll-a level and cell numbers of algal species) with the RMSEs ranging from 2.6 to $17.5mg/m^3$. Also, note that $PO_4-P$ level in the water column was a key limiting factor controlling the growth of three algal groups during most of simulation period. However, the algal modeling results were not fully attainable to the levels of observation during short periods of time showing abrupt increase in algae throughout the lake. In particular, the green algae/cyanobacteria and diatom simulations were underestimated in late June to early July and early October, respectively. The results shows that better understanding of internal algal processes, neglected in most algal modeling studies, is necessary to predict the sudden algal blooms more accurately because the concentrations of external $PO_4-P$ and specific algal groups originated from the tributaries (mainly, dam water releases) during the periods were too low to fully capture the sharp rise of internal algal levels. In this respect, this study suggests that future modeling efforts should be focused on the quantification of internal cycling processes including vertical movement of algal species with respect to changes in environmental conditions to enhance the modeling performance on complex algal dynamics.

• Molecules and Cells
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• v.38 no.4
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• pp.373-379
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• 2015

Pyruvate kinase M2 isoform (PKM2), a rate-limiting enzyme in the final step of glycolysis, is known to be associated with the metabolic rewiring of cancer cells, and considered an important cancer therapeutic target. Herein, we report a novel PKM2 activator, PA-12, which was identified via the molecular docking-based virtual screening. We demonstrate that PA-12 stimulates the pyruvate kinase activity of recombinant PKM2 in vitro, with a half-maximal activity concentration of $4.92{\mu}M$, and effectively suppresses both anchorage-dependent and -independent growth of lung cancer cells in non-essential amino acid-depleted medium. In addition, PA-12 blocked the nuclear translocalization of PKM2 in lung cancer cells, resulting in the inhibition of hypoxia response element (HRE)-mediated reporter activity as well as hypoxia-inducible factor 1 (HIF-1) target gene expression, eventually leading to the suppression of cell viability under hypoxia. We also verified that the effects of PA-12 were dependent on PKM2 expression in cancer cells, demonstrating the specificity of PA-12 for PKM2 protein. Taken together, our data suggest that PA-12 is a novel and potent PKM2 activator that has therapeutic implications for lung cancer.

• Korean Journal of Microbiology
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• v.39 no.3
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• pp.175-180
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• 2003

Microbial Fe(III) reduction is an important factor for biogeochemical cycle in anaerobic environments, especially sediment of freshwater such as lakes, ponds and rivers. In addition, the Fe(III) reduction serves as a model for potential mechanisms for the oxidation of organic compounds and the reduction of toxic heavy metals, such as chrome or uranium. Shewanella putrefaciens DK-1 was a gram-negative, facultative anaerobic Fe(III) reducer and used ferric ion as a terminal electron acceptor for the oxidation of organic compounds to $CO_{2}$ or other oxidized metabolites. The ability of reducing activity and utilization of various electron acceptors and donors for S. putrefaciens DK-1 were investigated. S. putrefaciens DK-1 was capable of using a wide variety of electron acceptor, including $NO_{3}^{-}$, Fe(III), AQDS, and Mn(IV). However, its ability to utilize electron donors was limited. Lactate and formate were used as electron donors but acetate and toluene were not used. Fe(III) reduction of S. putrefaciens DK-l was inhibited by the presence of either $NO_{3}^{-}$ or $NO_{2}^{-}$. Further S. putrefaciens DK-1 used humic acid as an electron acceptor and humic acid was re-oxidized by nitrate. Environmental samples showing the Fe(III)-reducing activity were used to investigate effects of the limiting factors such as carbon, nitrogen and phosphorus on the Fe(III) reducing bacteria. The highest Fe (III) reducing activity was measured, when lactate as a carbon source and S. putrefaciens DK-1 as an Fe(III) reducer added in untreated sediment samples of Cheon-ho and Dae-ho reservoirs.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.34 no.3
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• pp.199-206
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• 2001

Behavior of nutrients along the salinity gradients in the Seomjin River estuary was investigated in March July, September and November, 1999. Sampling sites were set based on the surface salinity during each cruise rather than geographic locations. The results suggest that source of nitrate and silicate was the Seomjin River discharge, while that of nitrite and phosphate was waste disposal from the Gwangynng Bay near the mouth of Seomjin River estuary. Ammonia was supplied inside the estuary at the region about $6\~8$ km far from Nancho Island. Strong removal behavior of some nutrient such as ammonia, phosphate and silicate was observed at $5\~15$ psu salinity area in November, where high concentrations of $chlorophyll\;a\;(>8{\mu}g/L$) occurred. High N : P ratios and entirely removal of phosphate at chlorophyll a peak region suggest that phosphate is the limiting factor for phytoplankton growth. Relatively high ratios of Rb to Ra (Rb: Fluorescence before acidification, Ra: Fluorescence after acidification) at $5\~15$ psu salinity region in November indicate that phytoplankton were in good physiological condition.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.11
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• pp.12-20
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• 2013

Even though extensive research results have been applied to wireless cellular systems to improve their capacity and coverage, severe performance degradation experienced in cell boundary areas still remains as a major limiting factor to prohibit further improvement of user equipment (UE) throughput. In the Long Term Evolution-Advanced (LTE-A) standard of the Third Generation Partnership Project (3GPP), Some advanced techniques have been introduced to overcome this "cell-edge problem", including coordinated multipoint transmission and reception (CoMP) and inter-cell interference coordination (ICIC). In this paper, we propose yet another strategy to improve the performance of low-tier UEs by using the concept of multiple beam direction patterns (BDPs). Such multiple BDPs can be implemented using multi-layer antenna arrays stacked vertically at base station (BS) sites to transmit signals in different main beam directions. In comparison to conventional three-sector antennas with a fixed beam pattern, the proposed methods makes signal transmission in a rotational fashion to significantly enhance the reception quality of UEs located near sector (or cell) edge areas, preventing the situation where certain UEs are marginally covered by the BS for the whole transmission time. Performance evaluation results show that the proposed scheme outperforms the conventional three-sector transmission by 171% in low 5% UEs in terms of the UE throughput.

• Proceedings of the Korean Environmental Health Society Conference
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• 2001.11a
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• pp.19-29
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• 2001

Nutrients are key environmental factors in marine ecosystem. They limit algal growth when at low concentrations and cause algal bloom when at high contents. They also control the growth and succession of many other biota including bacteria and zooplankton, either directly or indirectly. Nutrient contents therefore affect both the structure and functions of marine ecosystem. To study the contents and distribution of nutrients in Chinese Bohai Sea, two cruise surveys were undertaken in August 2000 (summer) and January 2001 (winter), respectively. A total of 595 water samples were collected from 91 sites. After collection the samples were transported to the laboratory and five nutrients, i.e., nitrate, nitrite, ammonia, phosphate and silicate, were analyzed. The results showed that tile average concentration of total inorganic nitrogen (TIN) in Bohai Sea in winter (6.5293.717 ${\mu}$mol$.$l$\^$-1/) was significantly higher than that in summer (3.717 ${\mu}$mol$.$l$\^$-1/). The phosphorus concentration in winter (0.660 ${\mu}$mol$.$l$\^$-1/) was also significantly higher than that in summer (0.329 ${\mu}$mol$.$l$\^$-1/). Mean silicate concentration in winter (7.858 ${\mu}$mol$.$l$\^$-1/) was not significantly different from that in summer (7.200 ${\mu}$mol$.$l$\^$-1/). Nutrients also varied considerable among different areas within Bohai Sea. TIN concentration in Laizhou Bay (4.444 ${\mu}$mol$.$l$\^$-1/), for example, was significantly higher than those in Bohai Bay (2.270 ${\mu}$mol$.$l$\^$-1/) and Bohai Straight (2.431 ${\mu}$mol$.$l$\^$-1/), which probably reflects tile discharge of large amounts of nitrogen into Laizhou Bay via Yellow River. The nutrients also showed vertical distribution pattern. In summer, nutrients in bottom layer were generally higher than those in surface and medium layers. In winter, however. nutrients in different layers were not significantly different Compared with historic data, TIN contents increased continuously since early 1980s, phosphorus arid silicone contents, nevertheless, fell down to some degree. Based on atomic ratios of different nutrients, nitrogen is still the main limiting factor for algal growth in Bohai Sea.

• Journal of Korean Society of Forest Science
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• v.95 no.6
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• pp.751-758
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• 2006

To investigate soil management practices for increasing tree growth in arid regions of China, Xinjiang poplar (Populus alba var. pyramidalis) seedlings were planted in a nursery and windbreak and were treated with fertilizers (nitrogen and phosphorus) and absorbents (artificial; K-SAM and natural: Yuho (Artemisia ordosica)) at Dengkou in Inner Mongolia. Seedling height, diameter at breast height (DBH), biomass, and nitrogen (N) and phosphorus (P) concentrations were measured 1.5 years after the treatments. Soil texture was sandy loam for nursery and clay loam for windbreak, soil pH was 8.78 for nursery and 8.51 for windbreak, and total soil N concentration was 0.06% for nursey and 0.08% for windbreak. [n general, seedling height and DBH increased in the N fertilizer treatment compared to control or other treatments both in nursery and windbreak. Also seedling growth increased after the treatments of artificial and natural absorbents in windbreak. Total above- and belowground biomass increased after the N + P treatment. Foliage N and P concentrations following N and/or P treatments were same in the nursey, however, they significantly increased in the windbreak indicating N deficiency. It appeared that N was a limiting factor for early growth of Xinjiang poplar seedlings and artificial and natural absorbents (K-SAM and Yuho) would be useful to increase seedling growth in the arid region.

• Journal of Navigation and Port Research
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• v.34 no.3
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• pp.175-180
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• 2010

In the almost application parts, GNSS being used the primary navigation system on world-widely. However, some of nations attempt or deliberate to enhance current Loran system, as a backup to satellite navigation system because of the vulnerability to the disturbance signal. Loran interests in supplemental navigation system by the development and enhancement, which is called eLoran, and that consists of advancement of receiver and transmitter and of differential Loran in order to increase the accuracy of current Loran-C. A significant factor limiting the ranging accuracy of the eLoran signal is the ASF in the TOAs observed by the receiver. The ASF is mostly due to the fact that the ground-wave signal is likely to propagate over paths of varying conductivity and topography. This paper presents comparison results between the predicted ASF and the measured ASF in a southern east region of Korea. For predicting ASF, the Monteath model is used. Actual ASF is measured from the legacy Loran signal transmitted Pohang station in the GRI 9930 chain. The test results showed the repeatability of the measured ASF and the consistent characteristics between the predicted and the measured ASF values.

• Journal of Environmental Health Sciences
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• v.34 no.3
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• pp.255-260
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• 2008

This study was conducted to analyse the effects of the UFCA for treating polluted water in a reservoir. The UFCA mixes water by circulation of surface and bottom water layers. The circulation supplies oxygen to bottom of the reservoir, resulting in water quality improvement. With a UFCA in use, we surveyed the changes of temperature, pH, transparency, depth, conductivity, DO, COD, BOD, T-N, T-P and Chlorophyll-a for 7 months from Feb. to Aug. in 2004 in our experimental reservoir. There was little difference in the surface and bottom temperatures of the reservoir because of water mixing by the UFCA. However, pH was changed from 7 to 9. The transparency of water was about 80 cm through the all periods. Conductivity was $150\;{\mu}S/cm$ in early Feb., but increased to $270\;{\mu}S/cm$ in early March. Little change was seen in DO with depth, but it was maintained above 6 mg/l in June and July. BOD increased from 2.1 to 12.2 mg/l. The study reservoir did not undergo any eutrophication during the period of our experiment, but the comparison reservoir had an algae-bloom. The COD in the experimental reservoir increased from 5.4 to 14.5 mg/l. The COD concentration of the experimental reservoir was higher than comparison reservoir at the beginning of the study but in August this situation was reversed. SS concentration increased from 13.5 to 23.5 mg/l in Feb., but it fell from between 8.5 to 11.2 mg/l in July. T-N was increased from 1.3 to 4.9 mg/l. It increased up to 3 times in the rainy season as compared to other components. However the comparison reservoir increased up to 40 times higher than the experimental reservoir in the same period. T-P increased from 0.04 to 0.17 mg/l. The ratio of T-N to T-P increased from 20:1 to 40:1 which means that T-P was a growth limiting factor for algae and aquatic plants. Chlorophyll-a increased from 20 to 120 mg/l, and its concentration was correlated with T-P, such that Chlorophyl-a concentration increased with increased of T-P concentration. The concentrations of COD, T-N, T-P and other parameters were higher in the experimental reservoir than in the comparison reservoir but this situation was reversed in July, when the most severe eutophication occurred. The results show that overall the experimental reservoir was greatly remedied by UFCA. The UFCA accelerated the degradation of aquatic organic materials through effective supply of air with up-flow and circulation of water. We conclude that the UFCA can be very effective in aspect of the remediation of water quality incontaminated reservoirs and lakes.

• Journal of Ginseng Research
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• v.12 no.1
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• pp.1-10
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• 1988

Panax ginseng seedlings were grown at various temperature regimes from 15 to $30^{\circ}C$ for 19 days under dark and the linear relationship between various regrowth efficiencies and thermal stress indices, cumulative superoptimum temperatures corrected with factors. Gross growth efficiency(shoot weight l root weight loss) was 37.5 % at the optimum temperature $15^{\circ}C$/$15^{\circ}C$, and 12.3% at the highest temperature, $30^{\circ}C$/$30^{\circ}C$ while net growth efficiency (shoot weight + Sm)l(root loss-Rm), which corrected by maintenance respiration for shoot(Sm) and root(Rm) was 39.6% and 16.7 at optimum and highest temperature respectively. All growth efficiencies showed negative correlations (p = 0.001) with all thermal stress indices and negative(p = 0.001) with shoot growth(St). When growth temperature difference in a day was nil or above $15^{\circ}C$ growth efficiency decreased greatly. Thermal stress indices showed negative correlation with root dry matter loss(RDL) but positive with Rm. St showed positive correlation with RDL. Thermal stress appeared to inhibit substrate supply for shoot growth resulting in the extremely low growth efficiency comparing with other crops that seems to be main rate limiting factor of slow growth, Thus it is necessary that growth efficiency and thermal stress must be elucidated in terms of metabolic pathway.