• Clinical and Experimental Pediatrics
• /
• 제54권3호
• /
• pp.111-116
• /
• 2011

Childhood chronic myelogenous leukemia (CML) is a rare hematologic disease, with limited literature on the methods of treatment. Previously, allogeneic hematopoietic stem cell transplantation (HSCT) was considered the only curative treatment for this disease. Treatment with imatinib, a selective inhibitor of the BCR-ABL tyrosine kinase (TKI), has resulted in prolonged molecular response with limited drug toxicity. Imatinib is now implemented in the primary treatment regimen for children, but the paucity of evidence on its ability to result in permanent cure and the potential complications that may arise from long-term treatment with TKIs have prevented imatinib from superseding HSCT as the primary means of curative treatment in children. The results of allogeneic HSCT in children with CML are similar to those observed in adults; HSCT-related complications such as transplant-related mortality and graft-versus-host disease remain significant challenges. An overall consensus has been formed with regards to the need for HSCT in patients with imatinib resistance or those with advanced-phase disease. However, issues such as when to undertake HSCT in chronic-phase CML patients or how best to treat patients who have relapsed after HSCT are still controversial. The imatinib era calls for a reevaluation of the role of HSCT in the treatment of CML. Specific guidelines for the treatment of pediatric CML have not yet been formulated, underscoring the importance of prospective studies on issues such as duration of imatinib treatment, optimal timing of HSCT and the type of conditioning utilized, possible treatment pre-and post-HSCT, and the role of second-generation TKIs.

• 대한전기학회논문지:전력기술부문A
• /
• 제48권5호
• /
• pp.658-663
• /
• 1999

2D sliced CT images hardly express the human disease in a space. This space expression can be reconstructed into 3D image by piling up the CT sliced image in succession. In medical image, in order to get the reconstructed 3D images, expensive system or much calculation time is needed. But by changing the method of reconstruction procedure and limit the range, the reconstruction time could be reduced. In this study, to reduce the processing time and memory, we suggested a method of interpolation and ray casting processing at the same time in a limited range. Such a limited range processing have advantages that we could reduce the unnecessary interpolation and ray casting. Through a experiment, it is founded that the reconstruction time and the memory was much reduced.

• Investigative Magnetic Resonance Imaging
• /
• 제25권1호
• /
• pp.53-58
• /
• 2021

Polyarteritis nodosa (PAN) is a systemic vasculitis involving small- and medium-sized arteries, which presents with necrotizing inflammation. PAN occurs as a systemic disease or as a limited form confined to a single organ. Few cases have been reported with single organ involvement, and even fewer have been reported with skeletal muscle involvement. Herein, we report the ultrasonography and magnetic resonance imaging findings in a rare case of PAN with limited muscle involvement in a 66-year-old man.

• 한국식물병리학회지
• /
• 제10권3호
• /
• pp.169-174
• /
• 1994

A new unidentified pear leaf spot disease presumed to first occur in the late 1970's has recently become prevalent over the pear growing areas, and caused the greatest problem for pear production in Korea. The disease began to develop on pear leaves at mid- to late May, peaked at mid- to late une, but stopped further development until September in cool climate. Leaf lesions are 0.9∼2.5 mm in diam., oval or irregular to rectangular in shape, first appeared reddish purple, later changed to dark brown, and to whitish grey in the late season. Lesions were limited to appear only on the mature, hardened leaves, initially from leaf margin or near the leaf veins, and later scattered over the leaf surface. Individual lesions usually did not enlarge, but often coalesced each other, commonly causing shot holes and eventual early falling. The disease was most severe on the major pear cultivars Niitaka and Okusankichi ranged with 4 to 100% infections in trees, depending on the orchards, but not on the cultivar Chojuro. Damages from the disease included lower fruit weight, and higher acid and less sugar content in fruits, resulting in lowering the overall fruit quality. Etiology of the disease including identification of the causal organism is in a separate paper.

• Journal of mucopolysaccharidosis and rare diseases
• /
• 제4권1호
• /
• pp.7-10
• /
• 2018

Rare diseases are life threatening or chronically debilitating diseases with a low prevalence (less than 2,000 people in a population), which includes lysosomal storage diseases. These diseases are often seen as unimportant especially in developing countries, such as Indonesia, due to small number of patients. National Rare Disease Center in Indonesia was pioneered almost 20 years ago and officially established in 2017 by the Indonesian Minister of Health. Lysosomal storage disease become the most commonly found inborn errors of metabolism (IEM) in Indonesia due to easily accessible diagnostic facilities. Currently there are 7 patients receiving ERT in this mixed-donation scheme, one patient with Gaucher disease and 6 patients with MPS type II. Few challenges for ERT in Indonesia include importation through special access scheme, preparation of ERT infusion in intensive care settting, and cost of treatment. Even with limited resources, healthcare professionals in Indonesia have been giving the best care possible for rare disease patients, especially to provide diagnostic facilities through collaboration and treatment options for treatable rare diseases. Improvements in care for rare disease patients are still needed.

• 대한후두음성언어의학회지
• /
• 제7권1호
• /
• pp.27-31
• /
• 1996

The voice of aged persons is known generally to be somewhat different from that of other adults, suggesting that laryngeal change occurs with advancing age. However, because knowledge of the voice characteristics of aged persons is limited, it is difficult to judge whether their voices arc normal. Chart review and laryngoscopic examination from ninety-one patients with hoarseness over the age of 60(1st group) and one hundred sixteen patients with hoarseness below the age of 50(2nd group) were done to define aging related voice disorders. The following results were obtained. 1) Associated diseases related to laryngeal disease were hypertension(12%), pulmonary disease(4.4%), thyroid disease(1.1%) in 1st group and hypertension(9.5%), thyroid disease(1.7%) in 2nd group. 2) The underlying diseases causing hoarseness in order of frequency were benign vocal fold lesion(37.7%), inflammatory disease(36.8%), functional dysphonia(17%) in 1st group and benign vocal fold lesion(43.6%), functional dysphonia(26.3%), inflammatory disease(16.5%) in 2nd group. 3) In stroboscopic findings, atrophy and sulcus of vocal cords are more prevalent in males than in females and edema of vocal cords is more common in females. Generally the voice characteristics of aged persons depend on the mass of the vocal folds which may be decreased through atrophy or be increased by edema. However, other factors such as systemic diseases, drug side effects and compensatory mechanism to presbylaryngis must be taken into account in diagnosing and treating voice disorders in aged persons.

• 대한한의학원전학회지
• /
• 제36권4호
• /
• pp.69-91
• /
• 2023

Objectives : This study investigates the association between disease behind the Beijing Epidemic of 1232 and fever causing internal damages as mentioned in the Neiwaishang Bianhuolun. Methods : In order to narrow the fever causing diseases in the Neiwaishang Bianhuolun, the retrospective diagnostic method was used in analysis. Disease behind the 1232 Beijing Epidemic and the fever causing internal damages were categorized. Results : Fever causing diseases in the Neiwaishang Bianhuolun could be categorized as infectious disease, inflammatory disease, irritable bowel syndrome, and fever of unknown origin. The Beijing Epidemic was limited in scale with high fatality, of which possible diseases include infectious disease and inflammatory disease with epidemic medium. Fever from internal damage has a mild prognosis, is non-epidemic, and lacks accompanying symptoms such as acute stomachache, even when it happens with external damage. This narrows the possible diseases to IBS and fever of unknown origin. Conclusions : Among internal damage fever cases treated by Li Dongyuan, there were infectious diseases from the 1232 epidemic and inflammatory diseases with mild prognosis.

• 산업융합연구
• /
• 제21권2호
• /
• pp.111-116
• /
• 2023

최근 바이러스 감염병 및 새로운 질병은 한 지역에 국한되는 것이 아니라 전 세계적으로 확산되어 경제적, 사회적으로 심각한 피해를 일으키고 있다. 또한, 새로운 질병의 발현 주기가 짧고, 확산 속도도 빨라지고 있다. 질병에 대한 확산을 막기 위해 격리, 폐쇄 등 질병 발생 후 수동적인 형태의 대응이 우선시 되고 있다. 이러한 형태의 대응은 질병 확산 방지에 근본적인 대응으로는 부족한 부분이 많이 있다. 이에, 본 연구에서는 새로운 질병 발생 정보를 포함한 질병 예방 모니터링 시스템을 제안한다. 본 연구에서는 IoMT 환경 구축을 통해 질병 정보와 사용자의 정보를 수집한다. devices를 이용한 정보 수집은 사용자의 생체정보와 질병 서버에 등록된 데이터를 수집하고 분류한다. IoMT 환경에서는 사용자의 데이터를 수집하여 사용자 질병 감염 여부를 평가하여 사용자에게 제공한다. 본 연구를 통해 개인의 질병 증상 정보를 제공하고, 질병 확산에 대한 능동적인 대응 방법을 제공할 수 있다.

• 대한핵의학회:학술대회논문집
• /
• 대한핵의학회 2002년도 제41차 추계학술대회
• /
• pp.24.2-24.2
• /
• 2002

• 보건행정학회지
• /
• 제30권3호
• /
• pp.277-285
• /
• 2020

Chronic diseases as well as a growing population of older adults are currently the leading cause of ill health and economic burden worldwide. Managing those diseases in one-on-one medical consultations poses substantial challenges due to limited time and resources in the current health care system. Various approaches have been taken to manage these conditions, most with limited success. Shared medical appointments (SMAs) are an innovative care delivery option to make the testing of alternative care modalities a prime concern. SMAs are individual medical consultations carried out in a group of patients with similar diseases by providing education, medication management, and disease monitoring. SMAs, since their initial conceptualization in 1998, have gained much popularity and adopted as one of the standard processes in many countries. Accumulated evidence-based studies show outcomes for increasing access to care, behavioral change facilitated through self-management education, maintained/better outcomes, physician productivity, and enhanced resource management. This review summarizes current evidence regarding the existing status of SMAs abroad. An extensive literature search was conducted on major electronic databases including PubMed and Google Scholar. This study suggests to explore and exploit the SMAs which have unique potential as a healthcare delivery innovation in Korea.