• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.34-40
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• 2019

Transglutaminase 2 (TGase 2) plays a key role in p53 regulation, depleting p53 tumor suppressor through autophagy in renal cell carcinoma. We found that microtubule-associated protein 1A/1B-light chain 3 (LC3), a hallmark of autophagy, were tightly associated with the level of TGase 2 in cancer cells. TGase 2 overexpression increased LC3 levels, and TGase 2 knockdown decreased LC3 levels in cancer cells. Transcript abundance of LC3 was inversely correlated with level of wild type p53. TGase 2 knockdown using siRNA, or TGase 2 inhibition using GK921 significantly reduced autophagy through reduction of LC3 transcription, which was followed by restoration of p53 levels in cancer cells. TGase 2 overexpression promoted the autophagy process by LC3 induction, which was correlated with p53 depletion in cancer cells. Rapamycin-resistant cancer cells also showed higher expression of LC3 compared to the rapamycin-sensitive cancer cells, which was tightly correlated with TGase 2 levels. TGase 2 knockdown or TGase 2 inhibition sensitized rapamycin-resistant cancer cells to drug treatment. In summary, TGase 2 induces drug resistance by potentiating autophagy through LC3 induction via p53 regulation in cancer.

• Korean journal of applied entomology
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• v.15 no.3 s.28
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• pp.153-159
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• 1976

Present paper was attempted to investigate the effects of the light on the sclerotium formation of some isolates of Sclerotinia sclerotiorum(Lib.) do Bary from lettuce, cucumber and rape. The investigations were performed in the both aspects inducing sclerotial primordia from the mycelial colony and developing such primordia. The cultures were grown on potato-dextrose agar and were treated with day-light fluorescent lamps. In the continuous light illumination for 21 days, numbers of sclerotial primordia and matured sclerotia were increased with increasing the light intensity up to about 500 Lux, but on the contrary the dry-weight of matured sclerotia was decreased. In the 800 Lux illumination, induction of the primordia was extremely depressed, and then matured sclerotia were almost not produced. Short-time illumination for 48 hours, although the light intensity was as high as 5000 Lux, increased the numbers of sclerotial primordia and matured sclerotia. Dry-weight of matured sclerotia, however, was slightly increased only at low intensity of 160 Lux. On the other hand, the light shock which u·as alternatively on-of light every one minute for 48 hours increased the number and dry-weight of sclerotia produced, but the former was more effective at 500 Lux shock and the later more effective at 160 Lux shock.

• Journal of Photoscience
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• v.9 no.2
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• pp.445-447
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• 2002

The compositional changes in mycosporine-like amino acids (MAAs) were investigated in the marine dinoflagellate Scrippsiella sweeneyae exposed to four different spectral compositions and five relative intensities of UV-B (280-320 nm) to UV-A (320-400 nm) + photosynthetically available radiation (PAR: 400-700 nm). Neither dose nor wavelengths of UVR significantly affected the growth rates. UVR caused a significantly increase in cell volume. Cell volume in the >280nm treatment was more than two times greater at 6.8 % of UVR intensity. Production of UVR induced MAAs was dependent on the dose of UVR. However. the induction of MAAs was related to the cell growth. Greater induction of MAAs was observed at shorter wavelengths. The composition of MAAs varied with increasing light intensity of UVR.

• Proceedings of the KIEE Conference
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• 2006.04b
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• pp.344-346
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• 2006

In this paper, a novel algorithm for increasing the steady state efficiency during light load operation of the induction generator that integrated with a wind power generation system is presented. The proposed algorithm based on the flux level reduction, where the flux level is estimated using Support-Vector -Machines for regression (SVR) for the optimum d-axis current of the generator. SVR is trained off-line to estimate the unknown mapping between the system's inputs and outputs, and then is used online to calculate the optimum d-axis current for minimizing generator loss. The experimental results show that SVR can define the flux-power loss accurately and determine the optimum d-axis current value precisely. The loss minimization process is more effective at low wind speed and the percent of power saving can approach to 40%.

• Journal of Plant Biology
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• v.19 no.1
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• pp.14-18
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• 1976

Inhibition of flowering in Lemna perpusilla 6746 by 30 mM sucrose was reversed by the addition of acetylcholine (>$10^{-4}M) supplemented with 10^{-4}M$ ascorbic acid to 1/10-strength Hunter's growth medium. The reversible effect of acetylcholine was found to be greater at early stages of flowering than in the later period. Promotive effects of both acetylcholine ($10^{-3}M) and eserine(10^{-5}M$) on flowering in the short-day plant under various photoperiodic conditions were studied. It was indicated that the application decreased length of the critical dark period for the floral induction, and it was also shown that the endogenous status of acetylcholine was involved in the floral response which had a correlation with phytochrome. Interruption of inductive dark periods by red irradiation (1min) immediately followed by far-red light (1 min) completely inhibited flowering, while the addition of acetylcholine and eserine to the medium under the same condition slightly promoted flowering, indicating possible involvement of phytochrome system in acetylcholine activity for photoperiodic sensitivity of floral response in Lemna perpusilla 6746.

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.2077-2078
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• 2011

Now a days, the induction motor is widely used in industry automation. Without monitoring the motor fault, maintenance cost is increased undesirably high. The slip frequency is included in the feature frequency, so rotating rotor speed is needed. In this paper, a sensorless motor speed estimation method, rotor slot harmonic(RSH) method is suggested and a solution of rotor bar diagnosis is proposed for motor running with light-load. When the rotor is rotating, it shows the harmonic signal of back-emf voltage related with number of rotor slot. So from the power spectrum of current signal, we can find the rotor speed.

• The Transactions of the Korean Institute of Electrical Engineers
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• v.36 no.1
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• pp.3-8
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• 1987

The conventional autosequentially commutated current-fed inverter (ASCI) is widely employed with the induction motor drives for speed control. Howener, this inverter has a limit of high power and high frequency indution motor drives. One of the limitations is to be found in the commutation capacitors in the main circuit of this inverter. A new current-fed gate turn-off thyristor (GTO) inverter is developed. This inverter is composed of the main GTO bridge configuration and the improved energy rebound circuit (ERC)without the commutation capacitor. This inverter works stable at high frequency from light load to heavy one. The improved ERC is used not only to rebound the load reactive power to the dc link, but also to return the power in the load to the ac source. The new GTO inverter circuit and the characteristics of the inverter induction motor drives are explained and analyzed.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.1661-1666
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• 2009

This paper is analyzed the effect on characteristics of thrust force of linear induction motor(LIM) by arc type tester. Many kinds of tester have a rotational shape because of a finite length of railroad. Whereas effects by using rotational type tester are generally unknown. For reason of that, this paper is analyzed the effect on characteristics by rotational type tester using 2D finite element method(FEM), and then is compared a thrust force between linear type tester and rotational type tester. Analysis model is decided by numerical modeling for fitting the LIM for propulsion system of light rail, and it is changed to proper arc model. And then we analyzed the arc and the linear model. Consequently, arc type tester is not only useful experiment but also efficient simulation method, and small error is occurred between linear and arc model.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2008.10a
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• pp.307-310
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• 2008

This paper is proposed the vector control of 3-phase induction motor drive system by photovoltaic generation. For performance of vector control using a current control voltage source inverter(CC-VSI). CC-VSI is controlled by torque and flux producing component of motor current, relating with current and voltage value of photovoltaic arrays at maximum power point that varies follow different level of insolation. The MPPT using a DC-DC converter controlled the duty cycle to track maximum power from PV under different insolation conditions. The simulation results are shown that the characteristics and performance of drive system, which varies as each conditions of light by expresses in voltage($V_{dq}$), current($I_{dq}$), speed of motor and torque.

• The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.8 no.4
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• pp.46-54
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• 1994

Exhbitlon hghting design be done aftrr due consideration of the photochermcal reaction and h ~ ~ i i tc~.fficits~ upn exposure to light. In this study the balanced judgement is as follows. The most light-susceptible material shouid be illu~stratrui less than 50[k] (illurnlnance-hours per year : 120, 000k.h)and the illuminance of moderately sensitive rriatcrinl k 200[1x] (illuminance hours per year : 480, 0001x.h). Moreover to minimize damage the sources of light shoulcl not only contribute as little as heat possible but remove ultraviolt radiation by filters. Also the sources of light must have good color rendering and low color temperature.