• Annals of Clinical Neurophysiology
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• v.10 no.1
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• pp.29-32
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• 2008

Although various criteria on the diagnosis of diabetic neuropathy are applied from trial to trial, being tailored in concert with its purpose, the utmost evidences of the diagnosis are subjective symptoms and objective signs of neurologic deficit. The application and interpretation of auxiliary electrophysiological test including nerve conduction study (NCS) should be made on the context of clinical pictures. The evaluation of the functions of small, thinly myelinated or unmyelinated nerve fibers has been increasingly stressed recently with the advent of newer techniques, e.g., measurement of intraepidermal fiber density, quantitative sensory testing, and autonomic function test. And the studies with those techniques have shed light to the nature of the evolution of diabetic neuropathy. The practical application of these techniques to the diagnosis of diabetic neuropathy in the individual patients, however, should be made cautiously due to several shortcomings: limited accessibility, wide overlapping zone between norm and abnormality with resultant unsatisfactory sensitivity and specificity, difficulty in performing subsequent tests, unproven quantitative correlation with clinical deficit, and invasiveness of some technique. NCS, as an extension of clinical examination, is still the most reliable electrophysiological test in evaluating neuropathy and gives the invaluable information about the nature of neuropathy, whereas the newer techniques need more refinement of the procedure and interpretation, and the accumulation of large scaled data of application to be considered as established diagnostic tools of peripheral neuropathy.

• Journal of Microbiology and Biotechnology
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• v.27 no.1
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• pp.72-76
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• 2017

Detection of exon 19 deletion mutation in the epidermal growth factor receptor (EGFR) gene, which results in increased and sustained phosphorylation of EGFR, is important for diagnosis and treatment guidelines in non-small-cell lung cancer. Here, we have developed a simple and convenient detection system using the interaction between G-quadruplex and fluorophore thioflavin T (ThT) for discriminating EGFR exon 19 deletion mutant DNA from wild type without a label and quencher. In the presence of exon 19 deletion mutant DNA, the probe DNAs annealed to the target sequences were transformed into G-quadruplex structure. Subsequent intercalation of ThT into the G-quadruplex resulted in a light-up fluorescence signal, which reflects the amount of mutant DNA. Due to stark differences in fluorescence intensity between mutant and wild-type DNA, we suggest that the induced G-quadruplex structure in the probe DNA can report the presence of cancer-causing deletion mutant DNAs with high sensitivity.

• Journal of the Korean Graphic Arts Communication Society
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• v.13 no.2
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• pp.47-53
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• 1995

Photosensitive resin of azide type is good for resolution and inner solvent, but it is really problem to development of practical use because fanctional groups of polymer has many hydrophilic radicals. By careful attention to this point, this study was investigated synthesis term, photo property and development property of composed photosensitive resin of azida type, it is to this effect. 1) H-NMR spectrum of compared DABCI showed amion redical by $\delta$6.0~6.1ppm to substitude for azide radical by amino radical by $\delta$8.9~9.45ppm, and FT-IR absorption spectra showed the absorption bends at 2100cm. 2)FT-IR absorption spectra of PHS1-DAB, PHS2-DAB, CMM-DAB and CHM-DAB showed azida radical pick to be lost at after irradiation by UV light. 3) According to exposuer change of PHS1-DAB, PHS2-DAB, CMM-DAB and CHM-DAB, absorption maximum value of UV spectrum change was 280nm. 4) to compared relative sensitivity of compared photosensitive resin, PHS2-DAB was the best and to compared insolubility rate of compared photosensitive resin, CMM-DAB was the lower. 5)Solubility if NaOH was the best by 1.0mol/$\ell$ and solubility of developing solution of ethanol to water was it in the ratio of 4 to 1.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.8 no.2
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• pp.240-244
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• 2007

Non-intrusive methods based on active remote IR illumination fur eye tracking is important for many applications of vision-based man-machine interaction. One problem that has plagued those methods is their sensitivity to lighting condition change. This tends to significantly limit their scope of application. In this paper, we present a new real-time eye detection and tracking methodology that works under variable and realistic lighting conditions. Based on combining the bright-pupil effect resulted from IR light and the conventional appearance-based object recognition technique, our method can robustly track eyes when the pupils are not very bright due to significant external illumination interferences. The appearance model is incorporated in both eyes detection and tracking via the use of support vector machine and the mean shift tracking. Additional improvement is achieved from modifying the image acquisition apparatus including the illuminator and the camera.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.4
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• pp.1784-1788
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• 2012

In this paper we considered condition for keep standard error probability in optical transmission system that applied on-off keying transmission which are modulated amplitude along the signal. we calculated received sensitivity of receiver in on-off keying transmission for optical detector have quantum efficiency belong 1 in optical transmission system. For BT is over 30, the number of photon is belong 10000 for maintain standard error probability. also we considered Also, we install a preamplifier to the receiver for considering the low output may be used with a light that was able to get results.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.29 no.6
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• pp.8-13
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• 2015

Recently, Illumination industry of LED module has been focused to industry technology for energy conservation of nation. The LED device is excellent to power efficiency due to semiconductor light source element. And the application to the lighting circuit technology can be designed to the sensitive lighting system for human sensitivity control. In this paper, as a process for analyzing the operating temperature of standardized electronic device including LED device has analyzed about fusing character with in designed micro fuse for electronic device protection from the over current. Using the de-rating technique, which is performed to micro fuse fusing test in the range of $-30^{\circ}C{\sim}120^{\circ}C$ thermostatic chamber. To the output data in each temperature zone, it is performed to first-order linear fitting. Additionally, applying the resistance temperature coefficient and statistical data for the reliable analysis has derived to the metal element resistance of micro fuse with temperature change of the thermostatic chamber. As a research result, The changed temperature effect of thermostatic chamber was confirmed regarding fusing time change.

• Korean Journal of Optics and Photonics
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• v.8 no.2
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• pp.161-164
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• 1997

A new hybrid, heterodyne, fiber-optic electric field sensor scheme is presented. In this scheme, a dual polarization, dual frequency, stabilized He-Ne laser is used for the light source of the interferometer, Probe beam is delivered to the sensor head using polarization maintaining fiber. In the sensor head, $LiTaO_3$ electro-optic crystal is used for sensing element. Phase retardation is induced on the dual frquency, dual polarization probe beam due to applied electric field across the crystal. Induced phase retardation is demodulated by in-phase and quadrature demodulation technique. In this way, we can obtain optimum sensitivity for electric field measurement regardless a quasi-static phase difference between two polarization components.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.2331-2336
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• 2005

This paper proposes a new haptic device using a parallel mechanism with gimbal type actuators. This device has three legs actuated by 2-DOF gimbal mechanisms, which make the device simple and light by fixing all the actuators to the base. Three extra sensors are placed at passive joints to obtain a unique solution of the forward kinematics problem. The proposed haptic device is developed for an operator to use it on a desktop in due consideration of the size of an average Korean. The proposed haptic device has a small workspace for on operator to use it on a desktop and more sensitivity than a serial type haptic device. Therefore, the motors of the proposed haptic device are fixed at the base plate so that the proposed haptic device has a better dynamic bandwidth due to a low moving inertia. With this conceptual design, optimization of the design parameters is carried out. The objective function is defined by the fuzzy minimum of the global design indices, global force/moment isotropy index, global force/moment payload index, and workspace. Each global index is calculated by a SVD (singular value decomposition) of the force and moment parts of the jacobian matrix. Division of the jacobian matrix assures a consistency of the units in the matrix. Due to the nonlinearity of this objective function, Genetic algorithms are adopted for a global optimization.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.7
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• pp.1-14
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• 1996

Effects of the external optical feedback on the optical transmission characteristics were evaluated for 3 kinds of commercialized DFB-LD modules for 2.5Gbps optical communication systems. As a result, intensity noise induced by external optical feedback via generating the external cavity modes deteriorated the transmission performances of sthe DFB-LD modules as much as 1.5dB, 1.2dB, and 1.0dB for the maximum feedback ratio of -8.8dB which corresponds to the worst reflection along the fiber transmission line. Additional penalty of 0.5dB was occurrred when state of polarization of feedback light was adjusted. From the experiments evaluating the isolation ratio of the single polarization optical isolator, decrease of the polarization dependent isolation ratio as much as 10dB from that of specification and the effective isolation ratio as much as 20dB from that of specification was mjor cause of high sensitivity of DFB-LD modules to external feedback. It was suggested that polarization independent optical isolator or single polarization optical isolator with isolation ratio specification of more than 40dB is required for 2.5Gbps DFB-LD modules with complete suppression of external feedback effects.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.111-111
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• 2014

Intensity interferometry, based on the Hanbury Brown--Twiss effect, is a simple and inexpensive method for optical interferometry at microarcsecond angular resolutions. Motivated by recent technical developments, we argue that the sensitivity of large modern intensity interferometers can be improved by factors up to approximately 25,000, corresponding to 11 photometric magnitudes, compared to the pioneering Narrabri Stellar Interferometer of the 1970s when resolving. Our approach, based on spectrally resolved light, permits the construction of large optical interferometers at the cost of (very) long-baseline radio interferometers. Realistic intensity interferometers are able to spatially resolve main-sequence O-type stars in the Magellanic Clouds. Multi-channel intensity interferometers can address a wide variety of science cases: (i) linear radii, effective temperatures, and luminosities of stars; (ii) mass-radius relationships of compact stellar remnants; (iii) stellar rotation; (iv) stellar convection and the interaction of stellar photospheres and magnetic fields; (v) the structure and evolution of multiple stars; (vi) direct measurements of interstellar distances; (vii) the physics of gas accretion onto supermassive black holes; and (viii) calibration of amplitude interferometers by providing a sample of calibrator stars.