• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.314-314
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• 2023

Extreme climate events can have a large impact on human life by hampering social, environmental, and economic development. Global circulation models (GCMs) are the widely used numerical models to understand the anticipated future climate change. However, different GCMs can project different future climates due to structural differences, varying initial boundary conditions and assumptions about the physical phenomena. The multi-model ensemble (MME) approach can improve the uncertainties associated with the different GCM outcomes. In this study, a comprehensive rating metric was used to select the best-performing GCMs out of 11 CMIP5 and 13 CMIP6 GCMs, according to their skills in terms of four temporal and five spatial performance indices, in replicating the 21 extreme climate indices during the baseline (1975-2017) in South Korea. The MME data were derived by averaging the simulations from all selected GCMs and three top-ranked GCMs. The random forest (RF) algorithm was also used to derive the MME data from the three top-ranked GCMs. The RF-derived MME data of the three top-ranked GCMs showed the highest performance in simulating the baseline extreme climate which was subsequently used to project the future extreme climate indices under both the representative concentration pathway (RCP) and the socioeconomic concentration pathway scenarios (SSP). The extreme cold and warming indices had declining and increasing trends, respectively, and most extreme precipitation indices had increasing trends over the period 2031-2100. Compared to all scenarios, RCP8.5 showed drastic changes in future extreme climate indices. The coasts in the east, south and west had stronger warming than the rest of the country, while mountain areas in the north experienced more extreme cold. While extreme cold climatology gradually declined from north to south, extreme warming climatology continuously grew from coastal to inland and northern mountainous regions. The results showed that the socially, environmentally and agriculturally important regions of South Korea were at increased risk of facing the detrimental impacts of extreme climatology.

• 대한한방내과학회지
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• 제44권3호
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• pp.285-293
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• 2023

Background: Irritable bowel syndrome (IBS) is a digestive disorder characterized by abdominal discomfort or pain accompanied by a change in stool condition. Owing to its complicated mechanisms, a standard treatment for IBS has not yet been established. Yukgunja-tang (YGT) is a Korean herbal medicine known in Asia to be effective in the treatment of gastrointestinal symptoms. In this study, we will conduct a systematic review of randomized controlled trials (RCTs) to assess the efficacy and safety of YGT in IBS treatment. Methods and analysis: English databases, such as Embase, Medline (via PubMed), Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials, will be searched for articles published up to April 2023. Additional databases, such as five Korean, one Chinese, and one Japanese database, will be included. RCTs and quasi-RCTs will also be included in the assessment of the efficacy of YGT. The overall efficacy rate will be the primary outcome, and data such as IBS quality-of-life measurements, global symptom scores, and adverse events will be the secondary outcomes. Review Manager Version 5.3 will be used for evaluation, and the risk of bias (RoB) will be evaluated using Cochrane Collaboration's RoB tool. The Grading of Recommendations Assessment, Development, and Evaluation approach will be used to score the quality of evidence. Conclusion: This study will demonstrate the efficacy and safety of YGT for treating patients with IBS.

• 한국전문물리치료학회지
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• 제30권4호
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• pp.288-305
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• 2023

Background: The compression therapy, which is the standard treatment for lymphedema patients, may be difficult to implement and contraindicated to some patients depending on their health condition. Objects: The purpose of this study is to investigate whether kinesiology taping (KT) can be used effectively and safely in the management of lymphedema as an alternative treatment through systematic review and meta-analysis. Methods: In February 2023, the literature was systematically collected through eight search engines with a combination of terms, 'lymphedema' and 'kinesiology taping.' We qualitatively analyzed the differences and safety of KT methods, and quantitatively meta-analyzed the effects of volume reduction in edema, range of motion (ROM), and pain improvement using Review Manager ver. 5. 4. To assess the risk of bias in the randomized controlled trial (RCT) studies, Risk of Bias was used. Results: A total of 616 articles searched and 20 studies were selected, including 12 RCTs and eight case studies. KT intervention could not replace multilayer compression bandage (MLB), but it demonstrated similar or better results compared to compression garment (CG), with reduced pain and improved intervention comfort. Studies reported skin adverse events ranging from 2.5% to 20.68%, with a total adverse event incidence of 7.7%. There was no significant difference in the application method of KT. As a result of the meta-analysis from the 8 RCTs, the KT intervention showed a mean difference (MD) of -7.18 with a 95% confidence interval (CI) [-12.64 to -1.72] in the volume change of lymphedema, while the pain difference was MD 0.82 with CI 95% [0.50 to 1.15], in comparison to the MLB and CG intervention. Conclusion: KT therapy led to a reduction in edema size, volume, pain, and improved ROM and quality of life. KT may be a viable option for lymphedema patients who have trouble applying traditional compression therapies.

• 한국건축시공학회지
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• 제24권3호
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• pp.363-370
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• 2024

기후 변화에 따른 자연재해와 이상기상의 빈도 및 심도가 날로 증가하면서, 사회기반시설과 건축물에 미치는 영향도 점차 커지고 있다. 이러한 문제에 대응하기 위해 다양한 정부 기관과 민간 부문에서는 이로인한 피해를 정확히 평가하려는 노력을 기울이고 있지만, 현실에 부합하는 정밀한 피해 예측과 평가는 여전히 도전적인 과제로 남아 있으며, 현재의 기술 수준으로는 부족함이 많다. 이러한 배경 하에, 본 연구는 우리나라에서 발생하는 주요 자연재해 중 하나인 태풍에 의한 건축물 피해를 분석하여, 해당 피해를 정확히 평가할 수 있는 방법론을 제시하고자 한다. 딥러닝 알고리즘을 활용한 평가 방식과 프레임워크를 도입하여, 태풍으로 인한 건물 피해 평가에 관한 연구를 진행하였다. 본 연구의 결과는 건물의 수명주기 전반에 걸친 자연재해 피해 평가에 필요한 기본 데이터를 제공하고, 다양한 산업 및 연구 영역에서 위험 평가에 활용이 가능하다.

• 문화기술의 융합
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• 제10권3호
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• pp.379-390
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• 2024

유교문화를 가진 한국사회의 서양 춤(Dance Sports, Social Dance)이 과거의 사교댄스 이름으로 도입되었던 최초 배경을 살펴보았다. 또한 한국전쟁 이전 사교댄스의 보급 경위와 한국전쟁 이후 1950년대를 중심으로 사교댄스 열풍이 일었던 경로와 6·25전쟁 직후의 퇴폐풍조 등 당시의 춤바람 사회 단면을 알아보고, 부정적 문화현상으로 변천되었던 일련의 사건들을 사회적 배경과 함께 재조명 해 보았다. 그리고 현재 우리나라에서 낯설지 않은 문장이 될 정도로 사교 Dance와 Dance Sports는 한국 사회에서 크나큰 인식변화를 거치며 삶에서 뺄 수 없는 하나의 요소가 되었다. 댄스스포츠(Dancesport)는 댄스(Dance)와 스포츠(Sport) 두 가지 요소가 결합된 예술적 실내 스포츠라고 하며 현재 근대 예술적 요소를 포함한 한국 사회에 어떤 변화를 주었는가를 연구를 했다.

• Reproductive and Developmental Biology
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• 제35권3호
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• pp.281-285
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• 2011

In the present study, we identified differentially methylated region (DMR) upstream of Dnmt1o and Dnmt1s gene in early porcine embryos. Porcine Dnmt1o had at least one DMR which was located between -530 bp to -30 bp upstream from transcription start site of the Dnmt1o gene. DNA methylation analyses of Dnmt1o revealed the DMR to be hypomethylated in oocytes, whereas it was highly methylated in sperm. Moreover, the DMR upstream of Dnmt1o was gradually hypermethylated from oocytes to two cells and dramatically changed in the methylation pattern from four cells to BL stages in an in vivo. In an IVF, the methylation status in the DMR upstream of Dnmt1o was hypermethylated from one cell to eight cells, but demethylated at the Morula and BL stages, indicating that the DNA methylation pattern in the Dnmt1o upstream ultimately changed from stage to stage before the implantation. Next, to elucidate whether DNA methylation status of Dnmt1s upstream is stage-by-stage changed in during porcine early development, we analyzed the dynamics of the DNA methylation status of the Dnmt1s locus in germ cell, or one cell to BL cells. The Dnmt1s upstream was highly methylated in one and eight cells, while less methylated in two, four, morula, and BL cells. Taken together, our data demonstrated that DNA methylation and demethylation events in upstream of Dnmt1o/Dnmt1s during early porcine embryos dramatically occurred, and this change may contribute to the maintenance of genomewide DNA methylation in early embryonic development.

• 한국농공학회논문집
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• 제60권5호
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• pp.135-147
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• 2018

The objective of this study was to analyze the characteristics of combined 1D/2D inundation simulation of riverside farmland using the Hydrologic Engineering Center - River Analysis System (HEC-RAS). We compared and analyzed inundation simulation results between 1D and combined 1D/2D hydraulic simulation using HEC-RAS. Calibration and validation of stream stage were performed using three rainfall events. The coefficient of determination ($R^2$) and root mean square error (RMSE) between simulated and observed stream stage were 0.935 - 0.957 and 0.250 m - 0.283 m in calibration and validation, respectively. The inundation area showed no significant difference in 1D and combined 1D/2D simulation ($8.48km^2$ in 1D simulation, $8.75km^2$ in combined 1D/2D simulation). The average inundation depth by 1D simulation was 1.4 m deeper than combined 1D/2D simulation. In the lower inundation depth, the inundation area by combined 1D/2D simulation was larger than inundation area by 1D simulation. As the inundation depth increased, the inundation area by 1D simulation became wider. In the case of the 1D/2D combined simulation, low elevation areas along the river bank were inundated widely. Compared to 1D/2D combined simulation, the flood radius in some sections was longer in 1D simulation. In the 1D analysis, because the low altitude riverside farmlands are also assumed to stream, it is calculated that riverside farmlands have the same stage as the mainstream when the stream is overflowed. Therefore, the inundation area seems to be overestimated in those sections. In other regions, the inundation areas tend to be broken depending on overflow by each stream cross-section. In the case of river flooding, the overflow is expected to flow to the lower area depending on the terrain, such as the results of the combined 1D/2D simulation. It is concluded that the results of combined 1D/2D inundation simulation reflected the topographical characteristics of low-lying farmland.

• Nutrition Research and Practice
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• 제16권1호
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• pp.60-73
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• 2022

BACKGROUND/OBJECTIVES: The extract from Dendropanax morbifera exhibited diverse therapeutic potentials. We aimed to evaluate the efficacy and safety of D. morbifera leaf extract for improving metabolic parameters in human. SUBJECTS/METHODS: A 12-week, double blind, placebo-controlled and randomized trial included a total of 74 adults, and they were assigned to the placebo group (n = 38) or 700 mg/day of D. morbifera group (n = 36). The efficacy endpoints were changes in glycemic, lipid, obesity, and blood pressure (BP) parameters, in addition to the prevalence of metabolic syndrome (MetS) and the numbers of MetS components. Safety was assessed by monitoring adverse events (AEs). RESULTS: After 12 weeks of treatment, the hemoglobin A1c (HbA1c) level significantly decreased in the D. morbifera group compared to that of the placebo group (difference: -0.13 ± 0.20% vs. 0.00 ± 0.28%, P = 0.031; % of change: -2.27 ± 3.63% vs. 0.10 ± 5.10%, P = 0.025). The homeostatic model assessment for insulin resistance level also decreased significantly from its baseline in the D. morbifera group. The systolic BP of D. morbifera group decreased significantly than that of placebo group (difference: -3.9 ± 9.8 mmHg vs. 3.3 ± 11.7 mmHg, P = 0.005; % of change: -2.8 ± 7.7% vs. 3.3 ± 10.2%, P = 0.005). However, the lipid parameters and body composition including body weight did not differ between the groups. The prevalence of MetS (36.8% vs. 13.9%, P = 0.022) and the incidence of MetS (10.5% vs. 13.9%, P = 0.027) at 12 weeks was significantly lower in the D. morbifera group than it was in the placebo group. No serious AEs occurred in either group. CONCLUSIONS: Supplementation with D. morbifera extracts over a 12-week period improved metabolic parameters such as HbA1c and BP and reduced the prevalence of MetS.

• 한국지형학회지
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• 제17권1호
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• pp.49-57
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• 2010

한반도 중부에서의 강우사상 동안의 강우입자의 물리적 특성을 규명하고 강우강도와 강우에너지와의 관계를 도출하기 위해 2008년부터 2009년 사이에 3회에 걸쳐 경기도 안성시 고삼저수지 인근에서 laser-optical disdrometer를 이용하여 강우입자의 크기와 종말속도를 측정하였다. 측정된 강우입자의 크기분포와 강우입자의 종말속도를 이용하여 강우강도와 강우운동에너지 함유량(KE, Jm^-2mm^-1)과의 관계와 강우강도와 운동에너지 소비율(KER, Jm^-2h^-1)의 관계를 각각 제안하였다. 그리고 tipping-bucket 강우계로 측정한 강우강도를 disdrometer 의 강우강도로 보정해주는 관계도 제안하였다. 그리하여 본 연구에서 제안된 강우강도와 강우의 운동에너지와의 관계는 한반도 중부지방에서 5분 강우강도가 최대 40mmh^-1 아래인 경우에 강우강도를 이용하여 강우의 운동에너지로 변환하고자 할 때 유용한 모델이 될 수 있을 것으로 판단된다.

• 생명과학회지
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• 제18권9호
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• pp.1219-1224
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• 2008

Neural crest는 신경계의 발생과정에서 생긴 특정화된 외배엽으로서 말초신경계(peripheral nervous system)의 모든 sensory cells과 fibers, 자율신경계의 대부분의 peripheral cells, unipolar spinal ganglion cell, cranial sensory ganglia, peripheral nerve의 neurolemmal sheath cells, ganglia의 capsule cells, sympathetic ganglia, chromaffin cells, pigment cell 등이 분화한다. Fish의 경우는 melanin을 가지고 있는 melanophores, yellow pigment를 가지고 있는 xanthopores, reflecting platelets를 가지고 있는 iridophores등 3가지의 pigment-producing cell을 가지고 있다. 다양한 pigement들의 deposition, distribution에 의해 Fish와 amphibian에서 볼 수 있는 수많은 color와 pattern이 만들어지게 된다. Embryonic neural crest가 patterning을 연구하기에 아주 좋은 모델임에도 불구하고, choromatophores의 cell-signaling mechanism에 관한 연구는 거의 없는 실정이다. 본 연구에서는 melanosomes의 melanocyt로의 이동기작과 이들의 dentiritic processe를 밝히기 밝히기 위해 phosphorylaion assay와 투과형 전자 현미경(transmission electron microscope)등을 이용한 다양한 실험들을 토대로, Lithium에 의해 유도되는 morphological alteration에 IP cell signaling pathway에 의해 조절되는 단백질의 하나인 55-kDa단백질의 인산화가 중요한 역할을 함을 밝혔다.