• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.314-314
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• 2023

Extreme climate events can have a large impact on human life by hampering social, environmental, and economic development. Global circulation models (GCMs) are the widely used numerical models to understand the anticipated future climate change. However, different GCMs can project different future climates due to structural differences, varying initial boundary conditions and assumptions about the physical phenomena. The multi-model ensemble (MME) approach can improve the uncertainties associated with the different GCM outcomes. In this study, a comprehensive rating metric was used to select the best-performing GCMs out of 11 CMIP5 and 13 CMIP6 GCMs, according to their skills in terms of four temporal and five spatial performance indices, in replicating the 21 extreme climate indices during the baseline (1975-2017) in South Korea. The MME data were derived by averaging the simulations from all selected GCMs and three top-ranked GCMs. The random forest (RF) algorithm was also used to derive the MME data from the three top-ranked GCMs. The RF-derived MME data of the three top-ranked GCMs showed the highest performance in simulating the baseline extreme climate which was subsequently used to project the future extreme climate indices under both the representative concentration pathway (RCP) and the socioeconomic concentration pathway scenarios (SSP). The extreme cold and warming indices had declining and increasing trends, respectively, and most extreme precipitation indices had increasing trends over the period 2031-2100. Compared to all scenarios, RCP8.5 showed drastic changes in future extreme climate indices. The coasts in the east, south and west had stronger warming than the rest of the country, while mountain areas in the north experienced more extreme cold. While extreme cold climatology gradually declined from north to south, extreme warming climatology continuously grew from coastal to inland and northern mountainous regions. The results showed that the socially, environmentally and agriculturally important regions of South Korea were at increased risk of facing the detrimental impacts of extreme climatology.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.285-293
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• 2023

Background: Irritable bowel syndrome (IBS) is a digestive disorder characterized by abdominal discomfort or pain accompanied by a change in stool condition. Owing to its complicated mechanisms, a standard treatment for IBS has not yet been established. Yukgunja-tang (YGT) is a Korean herbal medicine known in Asia to be effective in the treatment of gastrointestinal symptoms. In this study, we will conduct a systematic review of randomized controlled trials (RCTs) to assess the efficacy and safety of YGT in IBS treatment. Methods and analysis: English databases, such as Embase, Medline (via PubMed), Allied and Complementary Medicine Database, and Cochrane Central Register of Controlled Trials, will be searched for articles published up to April 2023. Additional databases, such as five Korean, one Chinese, and one Japanese database, will be included. RCTs and quasi-RCTs will also be included in the assessment of the efficacy of YGT. The overall efficacy rate will be the primary outcome, and data such as IBS quality-of-life measurements, global symptom scores, and adverse events will be the secondary outcomes. Review Manager Version 5.3 will be used for evaluation, and the risk of bias (RoB) will be evaluated using Cochrane Collaboration's RoB tool. The Grading of Recommendations Assessment, Development, and Evaluation approach will be used to score the quality of evidence. Conclusion: This study will demonstrate the efficacy and safety of YGT for treating patients with IBS.

• Physical Therapy Korea
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• v.30 no.4
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• pp.288-305
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• 2023

Background: The compression therapy, which is the standard treatment for lymphedema patients, may be difficult to implement and contraindicated to some patients depending on their health condition. Objects: The purpose of this study is to investigate whether kinesiology taping (KT) can be used effectively and safely in the management of lymphedema as an alternative treatment through systematic review and meta-analysis. Methods: In February 2023, the literature was systematically collected through eight search engines with a combination of terms, 'lymphedema' and 'kinesiology taping.' We qualitatively analyzed the differences and safety of KT methods, and quantitatively meta-analyzed the effects of volume reduction in edema, range of motion (ROM), and pain improvement using Review Manager ver. 5. 4. To assess the risk of bias in the randomized controlled trial (RCT) studies, Risk of Bias was used. Results: A total of 616 articles searched and 20 studies were selected, including 12 RCTs and eight case studies. KT intervention could not replace multilayer compression bandage (MLB), but it demonstrated similar or better results compared to compression garment (CG), with reduced pain and improved intervention comfort. Studies reported skin adverse events ranging from 2.5% to 20.68%, with a total adverse event incidence of 7.7%. There was no significant difference in the application method of KT. As a result of the meta-analysis from the 8 RCTs, the KT intervention showed a mean difference (MD) of -7.18 with a 95% confidence interval (CI) [-12.64 to -1.72] in the volume change of lymphedema, while the pain difference was MD 0.82 with CI 95% [0.50 to 1.15], in comparison to the MLB and CG intervention. Conclusion: KT therapy led to a reduction in edema size, volume, pain, and improved ROM and quality of life. KT may be a viable option for lymphedema patients who have trouble applying traditional compression therapies.

• Journal of the Korea Institute of Building Construction
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• v.24 no.3
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• pp.363-370
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• 2024

The escalating frequency and intensity of natural disasters and extreme weather events due to climate change have caused increasingly severe damage to societal infrastructure and buildings. Government agencies and private companies are actively working to evaluate these damages, but existing technologies and methodologies often fall short of meeting the practical demands for accurate assessment and prediction. This study proposes a novel approach to assess building damage resulting from natural disasters, focusing on typhoons-one of the most devastating natural hazards experienced in the country. The methodology leverages deep learning algorithms to evaluate typhoon-related damage, providing a comprehensive framework for assessment. The framework and outcomes of this research can provide foundational data for the evaluation of natural disaster-induced damage over the entire life cycle of buildings and can be applied in various other industries and research areas for assessing risk of damage.

• The Journal of the Convergence on Culture Technology
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• v.10 no.3
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• pp.379-390
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• 2024

We looked at the background of how Western dance (Dance Sports, Social Dance) was first introduced as social dance in the past in Korean society with Confucian culture. In addition, we look into the social aspects of dance at the time, such as the spread of social dancing before the Korean War, the path through which the social dancing craze developed in the 1950s after the Korean War, and the decadent trend immediately after the Korean War, and how it transformed into a negative cultural phenomenon. We reexamined the series of events along with their social background. And now, social dance and dance sports have undergone such a significant change in perception in Korean society that they have become an indispensable element of life, to the point where the sentence is no longer unfamiliar in our country. Dancesport is an artistic indoor sport that combines elements of dance and sport. We also studied what changes have occurred in Korean society, including modern artistic elements.

• Reproductive and Developmental Biology
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• v.35 no.3
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• pp.281-285
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• 2011

In the present study, we identified differentially methylated region (DMR) upstream of Dnmt1o and Dnmt1s gene in early porcine embryos. Porcine Dnmt1o had at least one DMR which was located between -530 bp to -30 bp upstream from transcription start site of the Dnmt1o gene. DNA methylation analyses of Dnmt1o revealed the DMR to be hypomethylated in oocytes, whereas it was highly methylated in sperm. Moreover, the DMR upstream of Dnmt1o was gradually hypermethylated from oocytes to two cells and dramatically changed in the methylation pattern from four cells to BL stages in an in vivo. In an IVF, the methylation status in the DMR upstream of Dnmt1o was hypermethylated from one cell to eight cells, but demethylated at the Morula and BL stages, indicating that the DNA methylation pattern in the Dnmt1o upstream ultimately changed from stage to stage before the implantation. Next, to elucidate whether DNA methylation status of Dnmt1s upstream is stage-by-stage changed in during porcine early development, we analyzed the dynamics of the DNA methylation status of the Dnmt1s locus in germ cell, or one cell to BL cells. The Dnmt1s upstream was highly methylated in one and eight cells, while less methylated in two, four, morula, and BL cells. Taken together, our data demonstrated that DNA methylation and demethylation events in upstream of Dnmt1o/Dnmt1s during early porcine embryos dramatically occurred, and this change may contribute to the maintenance of genomewide DNA methylation in early embryonic development.

• Journal of The Korean Society of Agricultural Engineers
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• v.60 no.5
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• pp.135-147
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• 2018

The objective of this study was to analyze the characteristics of combined 1D/2D inundation simulation of riverside farmland using the Hydrologic Engineering Center - River Analysis System (HEC-RAS). We compared and analyzed inundation simulation results between 1D and combined 1D/2D hydraulic simulation using HEC-RAS. Calibration and validation of stream stage were performed using three rainfall events. The coefficient of determination ($R^2$) and root mean square error (RMSE) between simulated and observed stream stage were 0.935 - 0.957 and 0.250 m - 0.283 m in calibration and validation, respectively. The inundation area showed no significant difference in 1D and combined 1D/2D simulation ($8.48km^2$ in 1D simulation, $8.75km^2$ in combined 1D/2D simulation). The average inundation depth by 1D simulation was 1.4 m deeper than combined 1D/2D simulation. In the lower inundation depth, the inundation area by combined 1D/2D simulation was larger than inundation area by 1D simulation. As the inundation depth increased, the inundation area by 1D simulation became wider. In the case of the 1D/2D combined simulation, low elevation areas along the river bank were inundated widely. Compared to 1D/2D combined simulation, the flood radius in some sections was longer in 1D simulation. In the 1D analysis, because the low altitude riverside farmlands are also assumed to stream, it is calculated that riverside farmlands have the same stage as the mainstream when the stream is overflowed. Therefore, the inundation area seems to be overestimated in those sections. In other regions, the inundation areas tend to be broken depending on overflow by each stream cross-section. In the case of river flooding, the overflow is expected to flow to the lower area depending on the terrain, such as the results of the combined 1D/2D simulation. It is concluded that the results of combined 1D/2D inundation simulation reflected the topographical characteristics of low-lying farmland.

• Nutrition Research and Practice
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• v.16 no.1
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• pp.60-73
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• 2022

BACKGROUND/OBJECTIVES: The extract from Dendropanax morbifera exhibited diverse therapeutic potentials. We aimed to evaluate the efficacy and safety of D. morbifera leaf extract for improving metabolic parameters in human. SUBJECTS/METHODS: A 12-week, double blind, placebo-controlled and randomized trial included a total of 74 adults, and they were assigned to the placebo group (n = 38) or 700 mg/day of D. morbifera group (n = 36). The efficacy endpoints were changes in glycemic, lipid, obesity, and blood pressure (BP) parameters, in addition to the prevalence of metabolic syndrome (MetS) and the numbers of MetS components. Safety was assessed by monitoring adverse events (AEs). RESULTS: After 12 weeks of treatment, the hemoglobin A1c (HbA1c) level significantly decreased in the D. morbifera group compared to that of the placebo group (difference: -0.13 ± 0.20% vs. 0.00 ± 0.28%, P = 0.031; % of change: -2.27 ± 3.63% vs. 0.10 ± 5.10%, P = 0.025). The homeostatic model assessment for insulin resistance level also decreased significantly from its baseline in the D. morbifera group. The systolic BP of D. morbifera group decreased significantly than that of placebo group (difference: -3.9 ± 9.8 mmHg vs. 3.3 ± 11.7 mmHg, P = 0.005; % of change: -2.8 ± 7.7% vs. 3.3 ± 10.2%, P = 0.005). However, the lipid parameters and body composition including body weight did not differ between the groups. The prevalence of MetS (36.8% vs. 13.9%, P = 0.022) and the incidence of MetS (10.5% vs. 13.9%, P = 0.027) at 12 weeks was significantly lower in the D. morbifera group than it was in the placebo group. No serious AEs occurred in either group. CONCLUSIONS: Supplementation with D. morbifera extracts over a 12-week period improved metabolic parameters such as HbA1c and BP and reduced the prevalence of MetS.

• Journal of The Geomorphological Association of Korea
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• v.17 no.1
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• pp.49-57
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• 2010

To evaluate physical characteristics of open rainfall in Korea, terminal velocity of raindrop and drop size distributions (DSD) were continuously measured using by laser-optical disdrometer around Gosam reservoir, Anseong-si, Gyeonggi-do during three rainfall events from 2008 to 2009. The relationships between kinetic energies (KE, Jm^-2mm^-1; KER, Jm^-2h^-1) and rainfall intensity were obtained, respectively. Moreover, we compared the rainfall intensity from a disdrometer with the rainfall intensity from a tipping bucket raingauge to transform the kinetic energy of rainfall using the data from a tipping bucket raingauge. Therefore, the established relationships between kinetic energies (KE and KER) and rainfall intensity could be a useful model to consider the kinetic energy of raindrop using the rainfall intensity below 40mmh^-1 of max 5-min rainfall intensity in the middle of South Korea. However, to better examine the relationship between kinetic energy and rainfall intensity, further measurement will be required.

• Journal of Life Science
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• v.18 no.9
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• pp.1219-1224
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• 2008

The embryonic zebrafish (Danio rerio) is rapidly becoming an important model organism for studies of early events in vertebrate development. Neural crest-derived pigment cell precursors of the embryonic zebrafish give rise to melanophores, xanthophores, and/or iridophores. Cell-signaling mechanisms related to the development of pigmentation and pigment pattern formation remain obscure. In this study, zebrafish embryos were treated with various signaling-related molecules - LiCl (an inositol-phosphatase inhibitor), forskolin (a protein kinase-A activator), a combination of LiCl/forskolin, and LiCl/heparin (an IP3 inhibitor) in order to identify the mechanisms involved in pigmentation. LiCl treatment resulted in ultrastructural and morphological alterations of melanophores. To identify the possible proteins responsible for this ultrastructural and morphological change, phosphorylation patterns in vitro and in vivo were analyzed. LiCl and LiCl/forskolin treatment elicited dramatic increases in the phosphorylation of a 55-kDa protein which was inhibited by heparin treatment. LiCl treatment also induced phosphorylation of a 55-kDa protein in melanophores purified from adult zebrafish. Collectively these results suggest that a LiCl-induced 55-kDa phosphoprotein plays a role in melanophore morphology and ultrastructure and ultimately effects gross pigmentation.