• Journal of Korea Game Society
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• v.20 no.2
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• pp.91-100
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• 2020

Life-and-death problem in Go is a fundamental problem to be overcome for implementing a computer Go. To solve it, an important consideration is to find out who surrounds or is surrounded between black and white players. To figure out the boundary between black and white groups, we applied an influence function and a contour tracing algorithm. We found that applying the Moore-neighbor tracing among various contour tracing algorithms can create boundaries, and also suggested the possibility of tremendously reducing the search space of a game tree.

• BMB Reports
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• v.35 no.1
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• pp.61-66
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• 2002

The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-${\kappa}B$ and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.

• Journal of Korean Public Health Nursing
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• v.34 no.2
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• pp.211-224
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• 2020

Purpose: This study was conducted to investigate death attitude, death anxiety, and knowledge toward advance directives of nursing students. Method: Participants were 157 nursing undergraduates in Korea. The students responded to a self-reporting questionnaire that included demographics, Death Attitude Profile-Revised (DAP-R), Revised Death Anxiety Scale (RDAS), and knowledge toward advance directives. The data collection period was December, 9-13, 2019. Data were analyzed by descriptive test, independent t-test, one-way ANOVA, and Pearson's correlation coefficient with SPSS/WIN 23.0. Results: The mean scores for death attitude, death anxiety, and knowledge toward advance directives were 2.70±0.58, 2.45±0.49, and 7.94±2.04, respectively. Knowledge toward advance directives was significantly different according to age, grade, and experience of end-of-life care education. Death attitude was significantly associated with death anxiety (r=. 27, p<.001). Conclusion: Knowledge toward advance directive was relatively low compared to the findings of previous studies. Therefore, nursing colleges need to include legal and institutional aspects when writing written letters on advance directive, death attitude, and ethical approaches to death anxiety.

• Journal of Digital Convergence
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• v.15 no.8
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• pp.257-265
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• 2017

The purpose of this study was to investigate the degree of awareness of the concept of 'hospice palliative medical care' and decision of 'life-prolonging medical care' by the general public subjects. A survey was conducted on 346 participants and officials who participated in an event held in September 2016. As a result of the research, the subjects' responses results to the life-prolonging medical care decision showed that people with religion wanted natural death compared to people without religion, and had more active attitude toward decisions related to dignity death. Religion is an important factor that can influence perceptions of life and death, believing that afterlife is after death, so it is possible to take a more firm stance on the extension of meaningless life at the last minute. Therefore, in order to stabilize the hospice care and prescription medical decision law to the general public and to improve the quality of the death and the dignity of life, it is necessary to develop awareness through various educational programs in consideration of age, education level. In addition, education and promotion should be strengthened so that the general public can fully understand the knowledge of hospice palliative care and health care and government standardization and policies for hospice personnel and breeding programs will be urgent.

• Korean Journal of Adult Nursing
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• v.18 no.5
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• pp.746-759
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• 2006

Purpose: This study was designed to systematically explore and elicit information about terminally ill cancer patients' and primary family caregivers' subjectivity of death. Method: Using Q-methodology, 21 terminally ill cancer patients and 19 primary family caregivers sorted 40 statements during personal interviews. Results: The results of this study show that terminally ill cancer patients have four factors ('Attachment to life', 'Hope for heaven', 'Resignation to reality', 'Avoidance of pain') of response and primary caregivers have four factors('Dependence on religion', 'Faithfulness to reality', 'Obedience to fate', 'Agony of reality'). Comparing the subjectivities of death of terminally ill cancer patients and primary family caregivers, 'Hope for heaven' and 'Dependence on religion' reveal the similarities of their outlook. On the other hand, 'Attachment to life', 'Resignation to reality', 'Avoidance of pain', 'Faithfulness to reality', 'Obedience to fate', 'Agony of reality' reveals different aspects of their outlook. The group of terminally ill cancer patients and their families divided into four types. Type A was 'Attachment to life and Agony of reality', type B was 'Attachment to life and Obedience to fate', type C was 'Hope for heaven and Dependence on religion' and type D was 'Resignation to reality and Faithfulness to reality'. The positive group was C or 'Hope for heaven and Dependence on religion'. Conclusion: There are significant differences found in the subjective structure of death among terminally ill cancer patients and primary family caregivers. Therefore, it is necessary to develop an individualized nursing intervention for terminally ill cancer patients and family caregivers.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.101-105
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• 2016

The number of deaths is often measured to monitor the population health status and priority of health problems. However, number of years of life lost (YLL) is a more appropriate indicator in some cases. We have calculated the YLL of adult cancers and its trend over the past few years in Yazd to provide planners with baseline data. Data obtained from death registration system were used to calculate the YLL, based on each individual's age at death, and the standardized expected YLL method was applied with a discount rate of 0.03, an age weight of 0.04, and a correction factor of 0.165. All data were analyzed and prepared in Epi6 and Excel 2007. A total of 3,850 death records were analyzed. Some 550 patients in Yazd province aged ${\geq}20$ die annually due to cancer (male: female ratio 1.3). The average ages at death in lung, CNS, breast cancer and leukemia cases were 68.5, 59, 58.7 and 61, respectively. The age group of 40-59 with 21 % had the highest cancer mortality percentage. Premature cancer deaths have caused 40,753 YLL (5,823 YLL annually). Females lose on average more life years to cancer than do men (11.6 vs 9.8 years). Lung cancer (12.1%), CNS tumors (11.7%) and leukemia (11.4 %) were the leading causes terms of YLL due to all cancers in both sexes. From 2004 to 2010, cancer-caused YLL as a fraction of all YLL increased from 12.8 to 15.2 %. This study can help in the assessment of health care needs and prioritization. Cancer is the major cause of deaths and the trend is increasing. The use of YLLs is a better index for measurement of premature mortality for ranking of diseases than is death counts. Longer periods of observation will make these trends more robust and will help to evaluate and develop, better public health interventions.

• Journal of Microbiology and Biotechnology
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• v.18 no.6
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• pp.1197-1202
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• 2008

Recent studies provide some evidence that the HtrA2 protein is intimately associated with the pathogenesis of neurodegenerative disorders and that endoplasmic reticulum (ER) quality control and ER stress-associated cell death play critical roles in neuronal cell death. However, little is known about the intimate relationship between HtrA2 and ER stress-associated cellular responses. In the present study, we have demonstrated that the HtrA2 protein level was gradually and significantly increased by up to to-fold in the mitochondria under tunicamycin (Tm)-induced ER stress, which eventually promoted cell death through the release of HtrA2 into the cytoplasm. Using an ecdysone-inducible mammalian expression system, we demonstrate that the extent of cell death in 293-HtrA2 cells was approximately 20 times higher under Tm-induced ER stress, indicating that the increase in the HtrA2 protein level in the mitochondria itself is necessary but not sufficient for the promotion of cell death. Taken together, these results suggest that HtrA2 may serve as a mediator of ER stress-induced apoptosis and ER-mitochondrial cross-talk in some cellular processes.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.676-683
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• 2016

This study examined the relationships between self-esteem, and the awareness of biomedical ethics and the quality of life and death attitude, as well as the factors influencing the death attitude among 130 nursing students in college. The data were analyzed using an independent t-test, one-way ANOVA, Pearson correlation coefficients, and multiple regression with the SPSS Win 14.0 Program. Significant positive correlations were observed between the self-esteem and death attitude, between the awareness of biomedical ethics and the death attitude. The predictors for the death attitude were self-esteem (${\beta}=.25$) and awareness of biomedical ethics (${\beta}=.11$). The model explained 21.2% (F=10.4, p<.001) of the variance. The findings indicated that more study will be needed to explore the factors influencing the death attitude and to develop education programs for reinforcing a positive death attitude among college nursing students.

• The Journal of the Korea Contents Association
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• v.15 no.12
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• pp.294-303
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• 2015

The purpose of this study was to examine the effects end-of-life care education using self-reflection diary on spirituality, death orientation, and attitudes toward nursing care of the dying patients in nursing students. This study adopted nonequivalent control group pretest-posttest design and the subjects consisted of 69 in the experimental group and 68 in the control group. The education was performed for 100 minutes a session, once a week for 12 weeks. Data was collected using a structured questionnaire consisting of general characteristics, spirituality, death orientation, and attitudes toward nursing care of the dying patients. Collected data was analyzed for frequency, percentage, ${\chi}^2$ test, Fisher's exact test and t-test using SPSS/WIN 21.0 computed program. There were statistically significant differences in spirituality and attitudes toward nursing care of the dying patients between the experimental group and the control group. Regarding death orientation, our result showed no significant differences between two groups. These findings suggest that end-of-life care education using self-reflection diary was effective in enhancing the spirituality and attitudes toward nursing care of the dying patients in nursing students.

• The Plant Pathology Journal
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• v.39 no.6
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• pp.584-591
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• 2023

Active plant immune response involving programmed cell death called the hypersensitive response (HR) is elicited by microbial effectors delivered through the type III secretion system (T3SS). The marine bacterium Hahella chejuensis contains two T3SSs that are similar to those of animal pathogens, but it was able to elicit HR-like cell death in the land plant Nicotiana benthamiana. The cell death was comparable with the transcriptional patterns of H. chejuensis T3SS-1 genes, was mediated by SGT1, a general regulator of plant resistance, and was suppressed by AvrPto1, a type III-secreted effector of a plant pathogen that inhibits HR. Thus, type III-secreted effectors of a marine bacterium are capable of inducing the nonhost HR in a land plant it has never encountered before. This suggests that plants may have evolved to cope with a potential threat posed by alien pathogen effectors. Our work documents an exceptional case of nonhost HR and provides an expanded perspective for studying plant nonhost resistance.