• 대한한방내과학회지
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• 제39권6호
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• pp.1206-1224
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• 2018

Purpose: This systematic review was planned and performed in order to determine the clinical effectiveness of acupuncture for non-alcoholic fatty liver disease (NAFLD). Methods: We searched related randomized controlled trials in several medical online databases, including China National Knowledge Infrastructure (CNKI), Excerpta Medica dataBASE (EMBASE), Public/Publisher MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), National Digital Science Library (NDSL), and Research Information Sharing Service (RISS). NAFLD related outcomes were extracted from the included trials and meta-analyzed. Results: From the 8 included trials, the values of the following examinations were extracted: liver ultrasonography, liver CT, body fat CT, aspartate transaminase (AST), alanine transaminase (ALT), gamma-glutamyltransferase (GGT), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, fasting blood sugar (FBS), hosmeostatic model assessment for insulin resistance (HOMA-IR), weight, body mass index (BMI), waist hip ratio (WHR), obesity degree, body fat mass, body fat rate, leptin, malondialdehyde (MDA), and super oxide dismutase (SOD). In the 4 outcomes, cure rate in liver ultrasonography (RR=1.56; 95%CI=1.05~2.31; P=0.03), cure rate in liver CT (RR=2.23; 95%CI=1.33~3.72; P=0.002), TC (MD=-0.78; 95%CI=-1.41~-0.15; P=0.02), and TG (MD=-2.05; 95%CI=-3.88~-0.21; P=0.03), acupuncture was more effective than the control intervention. Conclusions: In this meta-analysis, acupuncture relieved hepatic steatosis, and reduced TC, and TG in NAFLD patients. more well-planned studies are still needed due to the heterogeneity and the considerable methodological flaws in the analyzed trials.

• 한방재활의학과학회지
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• 제33권3호
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• pp.67-78
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• 2023

Objectives To evaluate the evidence supporting the efficacy and safety of electroacupuncture for lumbar spinal stenosis. Methods We searched eight electronic databases (PubMed, EMBASE, Cochrane Library, Chinese Academic Journals, Research Information Sharing Service, ScienceOn, KMBASE, DBpia) and related two journals up to March 2023. We included randomized controlled trials of testing electroacupuncture for lumbar spinal stenosis patients. The methodological quality of relevant randomized controlled trials assessed by the Cochrane risk of bias tool. Results Among 90 articles that were searched, seven randomized controlled trials involving 474 participants were finally selected in this systematic review. Electroacupuncture was more effective on lumbar spinal stenosis compared with other treatments including analgesics, acupuncture, bed rest and exercise therapy, but showed ambiguous effect compared with physical therapy. Most of the side effects and adverse reactions were reported as minor and temporary. Conclusions Electroacupuncture for lumbar spinal stenosis was more effective than analgesics, acupuncture, bed rest and exercise therapy. In terms of safety, it was limited because there are many papers that do not mention side effects and adverse reactions related to electroacupuncture. Additional studies are needed to determine the effect of electroacupuncture on lumbar spinal stenosis.

• 대한의생명과학회지
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• 제13권4호
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• pp.263-272
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• 2007

Nebulin is a giant actin binding protein (600-900 kDa) which is specific to skeletal muscle. This protein is known to regulate thin filaments length in sarcomere as a molecular template. The C-terminus of nebulin is located in the Z-disc of muscle sarcomere and is bound to other proteins such like myopalladin, titin, archvillin, and desmin. The N-terminus of nebulin binds to tropomodulin at the pointed ends of the thin filaments. In recent research, nebulin not only found in brain but also expressed in heart, stomach, and liver. So, the roles of nebulin in non-muscle tissue have been studied. However, lack of information or studies on nebulin binding proteins and nebulin function in brain are available so far. Therefore, the current study have investigated a novel binding partner of Nebulin C-terminus by using yeast two-hybrid screening with human brain cDNA library. Nebulin C-terminus, containing simple repeats, serine rich and SH3 domain, interacts with osteonectin C-terminal region. The specific interaction of nebulin and osteonectin were confirmed in vitro by using GST pull-down assay and reconfirmed in vivo by using transfected COS-7 cells with EGFP-tagged nebulin and DsRed-tagged osteonectin. Consequently, this study identified SH3 domain in nebulin C-terminus specifically binds to extracellular Ca-binding (EeC domain in osteonectin. Also, nebulin C-terminus fusion protein colocalized with osteonectin EC domain fusion protein in transfected COS-7 cells. The current study found the interaction between nebulin and osteonectin in human brain for the first time and suggested the nebulin in brain may be associated with osteonectin, as a regulator of cell cycle progression and mitosis.

• 대한한방부인과학회지
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• 제34권4호
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• pp.46-61
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• 2021

Objectives: The purpose of this review is to overview the studies of traditional herbal medicine for chronic pelvic inflammatory disease. Methods: We searched relevant studies using seven databases (The Journal of Korean obstetrics & gynecology, National Digital Science Library (NDSL), Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS), Pubmed, Cochrane, Chinese National Knowledge Infrastructure (CNKI)). Data retrieval was carried out on April 5, 2021 and the papers published from January 1, 2015 to March 31, 2021 were included. The risk of bias was assessed by using Cochrane's risk of bias tool. Results: 524 studies were searched in domestic and foreign databases, and 7 studies were finally selected. In all studies, the treatment group was treated with oral traditional herbal medicine and the control group was treated with western medicine. Although the evaluation index was slightly different for each study, all studies used total efficacy rate index. In all 7 studies, the treatment group was more effective than the control group. Conclusions: Traditional herbal medicine can be an effective option in treating chronic pelvic inflammatory disease. Further high quality studies which include large number should be carried out to confirm the evidence and safety of traditional herbal medicine treatment.

• 한국융합학회논문지
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• 제9권9호
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• pp.9-14
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• 2018

본 연구는 학술논문의 출현순서에 따른 저자키워드의 중요도를 측정해보고자 하는 연구이다. 이를 위해 학술논문 저자키워드의 출현순서를 측정한 후 네트워크 분석 방법의 연결정도중심성, 근접중심성, 매개중심성, 위세중심성 지수를 사용하여 저자키워드의 중요도를 측정해보았으며 다음으로 각각의 네트워크지수 값과 저자키워드의 출현순서와의 상관관계 분석을 수행하여 출현순서의 특징을 살펴보고자 하였다. 연구결과 연결정도중심성, 근접중심성, 매개중심성, 위세중심성 모두 4번 째 출현순서가 높은 군집의 논문수가 많은 것으로 나타났다. 다음으로 상관관계 분석결과 근접중심성을 제외한 연결정도중심성, 매개중심성, 위세중심성의 경우 출현순서의 뒷부분으로 갈수록 지수 값이 모두 높아지는 것을 볼 때 네트워크 상에서 상대적으로 중요한 용어가 뒷부분에 위치한다는 것을 알 수 있다. 본 연구는 대략적으로 연구자들의 저자키워드 부여 행태를 살펴볼 수 있었다는 점에서 의의를 지닌다. 향후 저자키워드의 전개양상을 심층적으로 살펴 보기 위해서는 상황적 요인, 행동, 심리 등을 파악하여 보완하는 후속 연구가 반드시 필요하다.

• 한방재활의학과학회지
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• 제34권2호
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• pp.29-49
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• 2024

Objectives The purpose of this study is to systemically review the recent studies in the Korean medicine treatments for torticollis. Methods We search the clinical studies from January 1, 2018 to December 31, 2023. The studies were searched through 10 databases (Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, Research Information Sharing Service, Korean Medical Database, ScienceON, PubMed, Cochrane Library, Embase, Wanfang Data, China National Knowledge Infrastructure). Results A total of 19 studies were included in the study. 12 studies were case report studies, 5 studies were randomized controlled trials, 2 studies were non-randomized controlled trials. Of the 19 interventions, Chuna was the most used in this study and of the 28 evaluation tools, Sternocleidomastoid thickness was the most used in this study except efficiency rate. All 19 studies had improvements after treatment, and 8 studies had statistically significant improvements. As a result of the study, we found that Chuna, GB, GB20, BL10, Glycyrrhiza uralensis were commonly used Korean medicine treatments for torticollis. Conclusions We analyzed the Korean medicine treatments for torticollis. Through this study, we found that the Korean medicine was effective for torticollis. However, more research is needed to confirm the more detailed effect.

• 대한물리치료과학회지
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• 제18권4호
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• pp.31-46
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• 2011

The purpose of this survey was to give data and information about type and needs of Home Physical Therapy, Visiting Physical Therapy and School Physical Therapy for physical and nurse. The subjects were 154(99 physical therapists and 55 nurses) who were working at geriatric rehabilitation hospitals and children hospitals. The period of questionary collection was from the 15 of August to the 15th of September 2011. And data was analysis from 99 articles such as journals related to physical therapy, and searched with keyword 'home and visiting physical therapy' by web site and Korea National Assembly Library from 1991 to 2011. The data was analysis with percentage, mean, standard deviation and ANOVA by SPSS PC 12.0. The results were as follows; 1. The definition of 'Home Physical Therapy' has been community based on physical therapy service for the patient who had diagnosis by medical doctor, has been based on medical law. The definition of 'Visiting Physical Therapy' has been community based on physical therapy service at home for the patient who had diagnosis by medical doctor, for the national basic living security, and senior citizen over 65 years who lives alone, has been based on law for community health and law of long term health insurance. The definition of 'School Physical Therapy' has been school based on physical therapy service at school after class for the disabled children who are studying at school, has been based on special education law article 28. 2. As for the knowledge of the Home and Visiting and School Physical Therapy, both groups PT and nurse were 'I do not know'125(81.3%) of the difference the concept of 3 definitions, so it means to need education and information about the different concept of three physical therapy. As for the needs of home and visiting physical therapy, both groups of PT and Nurse were 'needs' 151(98.1%). Physical therapist showed of 'Needs' on visiting physical therapy 35(35.4%), home physical therapy 32(32.3%), and schole physical therapy 32(32.3%). Nurse showed of 'Needs' on home physical therapy 23(41.8%). visiting physical therapy 19(34.5%), school physical therapy 13(23.6%). Therefore it is necessary to have home and visiting physical therapy as for the elderly and disabled person. 3. As for the qualification of Home and Visiting physical therapist, both PT and nurse groups showed as follows; take post graduation education program for home and visiting therapy after became PT : home physical therapist 108(70.1%), visiting physical therapist 106(68.8%). So it means education center or university can be developed post graduation program for home and visiting physical therapist. 4. As for the 'Needs' of school physical therapy, both groups of PT and nurse showed as follows; 'Needs' 142(92.2%), 'Needs superviser education program' 148(96.1%), in PT group showed 'I will participate of education program' 92(92.9%). 5. As for the present states of research papers or report of home, visiting, and school physical therapy was as follows; the 103 papers for 8 fields about' the needs of home and visiting physical therapy' from 1991 to 2011, the 13 papers for 2 fields about school physical therapy from 2001 to 2011, so total papers were 114 articles.

• 한국수자원학회논문집
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• 제55권4호
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• pp.301-308
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• 2022

조류는 수생태계에서 소비자의 에너지를 공급하여 생태계 내 없어서는 안 될 1차 생산자로서 크게 녹조류, 남조류, 규조류로 나뉘어진다. 남조류의 경우 수온이 상승하여 여름철 발생하여 과대 증식하여 녹조현상의 주원인이 되며, 최근 기후 변화로 인해 녹조현상의 발생시기의 변화와 빈도수가 늘고 있는 추세이다. 기존의 조류 조사 방식은 채수 및 센서를 통한 측정으로 이루어지고 있으며 시간, 비용 및 인력의 한계가 나타난다. 이러한 기존 모니터링 방법의 한계를 극복 하기위해 위성영상이나 무인항공기(Unmanned Aearial Vehicles, UAV), 등 탑제체를 운용한 다중분광 및 초분광과 같은 분광기기를 이용하여 원격 모니터링을 수행하는 연구가 진행되어 왔다. 본 연구에서는 조류 배양액 및 하천수 채수를 통한 실험실 규모의 실험을 통해 원격 모니터링의 종 구분에 대한 가능성에 대하여 확인 해보고자 하였다. 초분광 영상을 취득하기 위해 400-1000 nm에서 분석할 수 있는 초분광 센서를 활용하였다. 채수한 하천수의 조류 종 구분을 위한 분광특성을 추출하기 위해 GF/C필터를 이용하여 여과를 진행하여 시료를 제조하여 영상을 수집하였다. 수집된 영상을 방사보정 및 Base (하천수 및 배양보존액 통칭) 제거를 진행하였고 조류의 분광 정보 추출 과정을 통해 시료별 분광 정보를 추출, 분석하여 조류의 분광특성을 파악, 비교분석하여 하천·호소에서의 초분광영상 기반 원격탐사 모니터링의 적용성을 검토하고자 하였다.

• 대한원격탐사학회지
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• 제33권2호
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• pp.189-199
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• 2017

본 연구는 텍스트 마이닝 기법을 활용하여 환경 분야에서 ICT의 활용 연구동향을 정량적으로 분석하였다. 이를 위해 환경 분야 키워드 38개, ICT 관련 키워드 16개를 바탕으로 국가과학기술정보센터(NDSL)에서 최근 20년(1996년-2015년)의 논문 359편을 수집하였다. 해당 논문을 대상으로 환경 분야 및 ICT 관련 자연어를 처리하여 말뭉치(Corpus)단위로 분류체계를 재구성하였다. 전술된 분류체계의 키워드를 바탕으로 텍스트 마이닝 분석 기법인 빈도 분석, 키워드 분석, 키워드 간 연관규칙을 확인하였다. 그 결과 '환경 일반' 및 '기후' 분야의 키워드 출현 빈도가 전체의 77 %, ICT는 '공공융합서비스' 및 '산업융합서비스'가 약 30 %의 비율을 차지하였다. 시계열 분석을 통해 환경 분야에서의 ICT 활용 연구는 최근 5년(2011년-2015년)사이에 급증하여 과거(1996년-2010년)과 비교하여 약 2배 이상 관련 연구가 증가된 것으로 나타났다. 키워드 간 연관 규칙을 생성하여 환경 분야를 기준으로 나타내었을 때, '환경 일반'은 16개, '기후'는 '14'개의 ICT 기반 기술을 주로 활용하고 있는 것으로 확인하였다.

• 지능정보연구
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• 제14권3호
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• pp.59-76
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• 2008

본 논문에서는 실시간 동적 환경에 효과적인 L-CAA 에이전트 구조를 제안한다. L-CAA 에이전트 구조는 변화하는 환경에 대한 적응성을 높이기 위해, 선행 연구를 통해 개발된 행위기반 에이전트 구조인 CAA에 강화학습 기능을 추가하여 확장한 것이다. 안정적인 성능을 위해 L-CAA 구조에서는 행위 선택과 실행을 학습에 전적으로 의존하지 않고 학습을 보조적으로 이용한다. L-CAA에서 행위 선택 메커니즘은 크게 두 단계로 나뉜다. 첫 번째 단계에서는 사용자가 미리 정의한 각 행위의 적용 가능 조건과 효용성을 검사함으로써 행위 라이브러리로부터 실행할 행위들을 추출한다. 하지만 첫 번째 단계에서 다수의 행위가 추출되면, 두 번째 단계에서는 강화학습의 도움을 받아 이들 중에서 실행 할 하나의 행위를 선택한다. 즉, 강화학습을 통해 갱신된 각 행위들의 Q 함수값을 서로 비교함으로써, 가장 큰 기대 보상값을 가진 행위를 선택하여 실행한다. 또한 L-CAA에서는 실행 중인 행위의 유지 가능 조건을 지속적으로 검사하여 환경의 동적 변화로 인해 일부 조건이 만족되지 않는 경우가 발생하면 현재 행위의 실행을 즉시 종료할 수 있다. 그 뿐 아니라, L-CAA는 행위 실행 중에도 효용성이 더 높은 다른 행위가 발생하면 현재의 행위를 일시 정지하였다가 복귀하는 기능도 제공한다. 본 논문에서는 L-CAA 구조의 효과를 분석하기 위해, 대표적인 동적 가상환경인 Unreal Tournament 게임에서 자율적으로 동작하는 L-CAA 기반의 에이전트를 구현하고, 이를 이용한 성능 실험을 전개해본다.