• Journal of Dental Anesthesia and Pain Medicine
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• 제22권5호
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• pp.323-338
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• 2022

Burning mouth syndrome (BMS) is a chronic oral disorder of unknown etiology which presents therapeutic challenges. Alpha-lipoic acid (ALA) has been studied as a potential treatment for BMS. The objective of this systematic review and meta-analysis was to evaluate the effectiveness of ALA compared to that of placebo or other interventions in individuals with BMS. Randomized controlled trials (RCT) using ALA to treat BMS were identified from MEDLINE, Cochrane Library, EMBASE, and Web of Science up to February 3, 2021. The assessment of the risk of bias in the included studies was based on the Cochrane guidelines. The primary outcome evaluated was the visual analog scale (VAS) pain intensity. ALA was compared with placebo, clonazepam, gabapentin, pregabalin, ALA plus gabapentin, capsaicin, Biotène^®, and laser therapy. Altogether, 137 records were scanned for inclusion/exclusion, and nine RCTs (two unclear and seven at high risk of bias) were included in the qualitative and quantitative analyses, with a total of 594 patients with BMS included in this review. All studies reported an improvement in VAS pain scores ranging from -0.72 to -2.77. Meta-analysis results showed a non-significant reduction in pain intensity for ALA (P = 0.616) compared to that of placebo on a VAS of 0-10. Patients taking ALA were 1.923 times more likely to show an improvement in self-reported BMS symptoms (P = 0.031) than those in the placebo group. Clonazepam and pregabalin showed a significant VAS pain reduction of 4.08 and 4.68 (P < 0.001), respectively, compared to that with ALA. Although ALA intervention provided a non-significant improvement in the pain score and was more likely to produce a reduction in BMS symptoms, the evidence was of low quality. Further research is needed to establish clear guidelines for the use of ALA for BMS treatment.

• 지능정보연구
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• 제29권2호
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• pp.219-240
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• 2023

사용자가 만족감을 느끼며 상호작용할 수 있는 대화형 인공지능을 개발하기 위한 노력이 이어지고 있다. 대화형 인공지능 개발을 위해서는 사람들의 실제 대화를 반영한 학습 데이터를 구축하는 것이 필요하지만, 기존 데이터셋은 질문-답변 형식이 아니거나 존대어를 사용하여 사용자가 친근감을 느끼기 어려운 문체로 구성되어 있다. 이에 본 논문은 온라인 커뮤니티에서 수집한 30,767개의 질문-답변 문장 쌍으로 구성된 대화 데이터셋(KOMUChat)을 구축하여 제안한다. 본 데이터셋은 각각 남성, 여성이 주로 이용하는 연애상담 게시판의 게시물 제목과 첫 번째 댓글을 질문-답변으로 수집하였다. 또한, 자동 및 수동 정제 과정을 통해 혐오 데이터 등을 제거하여 양질의 데이터셋을 구축하였다. KOMUChat의 타당성을 검증하기 위해 언어 모델에 본 데이터셋과 벤치마크 데이터셋을 각각 학습시켜 비교분석하였다. 그 결과 답변의 적절성, 사용자의 만족감, 대화형 인공지능의 목적 달성 여부에서 KOMUChat이 벤치마크 데이터셋의 평가 점수를 상회했다. 본 연구는 지금까지 제시된 오픈소스 싱글턴 대화형 텍스트 데이터셋 중 가장 대규모의 데이터이며 커뮤니티 별 텍스트 특성을 반영하여 보다 친근감있는 한국어 데이터셋을 구축하였다는 의의를 가진다.

• 한국한의학연구원논문집
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• 제3권1호
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• pp.1-15
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• 1997

${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$(1445) is a book compiled the medical achievements of China and Choseon in those times and it's our source of pride to have it In this country. It also deserves careful investigation since this book can provide some clues of features of missing books in China and Korea. The extent of accuracy of xylographica of old books determines the possiblity of in depth further study. So authors attempted to investigate the xylographica of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ one of the 3 main books in Korea. Previous investigation done by Miki Sakae and Kim Doo Jong are noticeable. On the basis of their respective works, we analyzed 'Annals of the Choseon Dynasty' to find records related with ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ and estimated the situation of its publication. We tried figure the situation of those times of China, Japan and Korea(including North Korea) and tried to estimate the book's original xylographica as much as we could. By King Sejong's command, the first draft of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ consisted of 365 books was made by collaboration of civil officials and medical officers during the period from 1443 to 1445. And then from 1451(first year of Moonjong's reign) to 1464(l0th year of Sejo's reign) lots of manpowers were employed and through the process of countless erasure, proofreading, arrangement and rearrangement revised version of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ which is called by Sejo text was completed. After 3 years of wood engraving work, the first printed form of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ (alternately called Seongjong text) in folding case consisted of 266 chapters, 264 volumes came into the world in 1477.(8th year of Seongjong's reign). This was 32 years after the initial completion of the edition. So ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ exists in three forms as Sejong text, Sejo text and Seongjong text respectively. Since those texts were plundered during the Japanese invasion of Korea in 1592, none of the original copy remains within korea. The texts were constantly moved to kadeungcheongieong, to Kongdeungpyeongio, Jesookoan of Edo, to East University of department of classic books, to Cheoncho archives, to the Imperial Museum and finally is kept in the royal palace at present. (Doseoryo text Eulhae printing type) Reduced-size republication books of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ in wooden type were imported at the time of 'Byeongja Korea-Japan Treaty in 1876' and of those 2 books, one copy was treasured in the Royal Household of the Yi Dynasty and than was lost during the Korean War circa 1950. The other remaining copy has been kept succesively by Kojong's imperial grant, Royal doctor Hong Cheol Bo, Hong Taek Joo, Hong Ik Pyo the book agent, and now is kept In Yonsei University Library and this is the only existing copy in Korea at present. In 1965, Dongyang Medical college published the transcription version of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ consisting of 11 books and then in 1981 after edition and arrangement by Choonghoa(中華) publishing company, photoprint copy of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ was published in Keumgang(金剛) publishing company In 1991, October Yeokang(驛江) publishing company producd photocopies of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ which were previously translated into Korean by North Korea Institute of Oriental Medicine and then issued by medical publishing company. In China, two institutes, Zhejiang Institute of Traditional Chinese Medicine and Huzhou Traditional Chinese Medical Hospital cooperated to publish a revised and marked text consiting of 11 books by adding marking points to japanse Edohakhoondang text which were used as a reference. Both the korean and chinese texts issued were grounded by the ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ kept in the royal palace. Any further study concerning ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ can acquire its accuracy and objectivity when the japanese text kept in the royal palace is taken as an original copy.

• 동의생리병리학회지
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• 제26권4호
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• pp.551-556
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• 2012

The database for the oriental medicine had been existed in documentation in past times and it has been developed to the database type for random accesses in the information society. However, the aspects of the database are not so diversified and the database for the bio herbal material exists in widened type dictionary style. It is a situation that the database which handles the in-depth raw herbal medicines is not sufficient in its quantity and quality. Korean wild grape is a deciduous plant categorized into the Vitaceae and it was found experimentally that it has various medical effects. It is one of the medical materials with higher potentiality of academic study and commercialization recently because it has a bigger possibility to be applied into diverse industrial fields including the medical product for health, food and beauty. We constituted the cooperative system among the Muju cluster business group for Korean mountain wild grapes, Physiology Laboratory in Kyung Hee University Oriental Medicine and Medical Classics Laboratory in Kyung Hee University Oriental Medicine with a view to focusing on such potentiality and a database for Korean wild grapes was made a touchstone for establishing the in-depth database for the single bio medical materials. First of all, the literatures based on the North East Asia in ancient times had been categorized into the classical literature (Korean literature published by government organization, Korean classical literature, Chinese classical literature and classical literature fro Korean and Chinese oriental medicine) and modern literature (Modern literature for oriental medicine, modern literature for domestic and foreign herbal medicine) to cover the eastern and western research records and writings related to Korean wild grapes and the text-mining work has been performed through the cooperation system with the Medical Classics Laboratory in Kyung Hee University Oriental Medicine. First of all, the data for the experiment and theory for Korean wild grape were collected for the Medline database controlled by the Parliament Library of USA to arrange the domestic and foreign theses with topic for Korean wild grapes and the network hyperlink function and down load function were mounted for self-thesis searching function and active view based on the collected data. The thesis searching function provides various auxiliary functions and the searching is available according to the diverse searching/queries such as the name of sub species of Korean wild grape, the logical intersection index for the active ingredients, efficacy and elements. It was constituted for the researchers who design the Korean wild grape study to design of easier experiment. In addition, the data related to the patents for Korean wild grape which were collected from European Patent Office in response to the commercialization possibility and the system available for searching and view was established in the same viewpoint. Perl was used for the query programming and MS-SQL for database establishment and management in the designing of this database. Currently, the data is available for free use and the address is as follows. http://163.180.41.43:8011/index.html

• 한국전통조경학회지
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• 제31권2호
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• pp.70-81
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• 2013

논산 강경읍 소재, 죽림서원과 임리정 그리고 팔괘정의 입지 및 조형 특성을 검토하는 한편, 이들 3개 공간의 상호 관련성을 "사계연보(沙溪年譜) 죽림서원도록(竹林書院都錄) 임리정기(臨履亭記) 죽림서원묘정비(竹林書院廟庭碑) 남유록(南遊錄) 당시 상소기록" 등의 문헌을 통해, 추론한 결과는 다음과 같다. 육현(六賢)을 모신 죽림서원은 강당이 배제된 채 '홍살문-외삼문-동재(헌장당(憲章堂)) 서재-내삼문(신문(神門))-사우(죽림사(竹林祠))'의 위계를 보인다. 죽림서원과 각각 50m와 100m 거리를 두고 조영된 사계 김장생의 임리정과 우암 송시열의 팔괘정은 좌향은 물론 규모 지붕 및 평면 창호 편액 등 세부 의장까지 거의 동일시되고 있음이 주목된다. 특히 임리정과 팔괘정은 죽림서원을 중심으로 암괴로 구성된 부지여건을 고려한다면 최대한의 좌우대칭을 유지하며 사우를 위요한 형상이다. 죽림서원은 인조반정 후 정치적 여건 등으로 서원건립이 재추진되면서 율곡 우계를 향사한 묘우(廟宇) 단일 건물만을 우선 영건하고, 기존 강학당으로 쓰던 임리정을 더해 황산서원이라 통칭한 것으로 보인다. 이와 같은 현상은 최소한 중건 이후, 양정(兩亭)을 서원의 강학당으로 존치 활용함으로써 서원 구성의 기본적 질서인 좌우대칭적 규범을 최대한 도모하기 위한 필연적 결과이다. 결국 시대차를 두고 이루어진 임리정과 사우의 영건으로 초래된 황산서원의 위계와 시각배치상의 불균형을 바로 잡기 위한 고육지책이 바로 황산 몽괘벽(夢卦壁) 아래 영건된 팔괘정이다. 이와 같은 추론을 종합해 볼 때 죽림서원은 사우를 새로 건립하고, 기존 강학당으로 쓰던 임리정과 이후 중건을 통해 보완된 팔괘정을 강당의 성격을 갖춘 공간으로 통합해 완성된 '사우 중심의 서원'으로, 팔괘정의 영건과 임리정과의 조형적 일치는 죽림서원의 강당으로서의 기능과 역할을 보정할 의도 하에 이루어진 결과로 판단된다. 본 연구는 기존의 누정의 기능과 역할이 서원 강학당의 보완적 시설로서 영건되고 존립되었다는 사실을 밝힌 것으로서, 서원과 누정의 상호 보완적 기능을 조명하는 계기가 될 것을 기대한다.

• 기록학연구
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• 제44호
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• pp.51-99
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• 2015

기록평가의 목적은 점차 기록의 선별에서 일종의 주제기반의 수집으로 옮겨가고 있다. 특히 현재의 디지털 기술과 웹의 양 질적 발달은 물리적 수집이 아닌 의미적 수집, 즉 데이터의 연계를 통한 수집을 가능하게 하는 원동력이 되고 있다. 이러한 환경하에서 유네스코를 필두로 국제적으로 '기록유산'에 대한 개념정립이 이루어지고 있다. 이러한 동향을 반영하고 있는 것이 캐나다의 LAC인데, 최근 토탈아카이브즈 정신을 부흥시키고자 새로운 평가방법이자 수집방법을 개발하고 있다. 이것이 'Whole-of-Society 접근법'이다. 이 접근법의 특징은 크게 세가지이다. 첫 번째, 기록유산을 대상으로 하며, 물리적 수집이 아니라 의미적 수집을 목적으로 한다. 또한 그 대상이 기록유산이기 때문에 반드시 기록유산기관 간의 협력이 전제되어야 한다. 마지막으로 이미 발생한 사건에 대한 기록화뿐만 아니라 동시대적 사건에 대한 기록화도 가능하다는 것이다. 평가방법으로서의 'Whole-of-Society 접근법'은 사회이론에 착안하여 사회 구성요소를 식별하는 방식이다. 수집방법으로서의 'Whole-of-Society 접근법'은 디지털기록을 대상으로 하나, 아날로그기록의 소장주체로 안내하는 방식으로 그 대상이 확장된다. 이때의 디지털기록이란 '디지털화된(Digitized)' 기록유산과 '본래 디지털인(Born-Digital)' 기록유산을 포함한다. 그리고 평가 단계에서 식별한 사회 구성요소를 메타데이터 요소로 매핑한 다음, 링크드오픈 데이터로 구축함으로써 데이터 간의 연계를 통한 의미적 수집을 실현한다. 마지막으로 이 연구에서는 국내 평가체계는 그 목적이 선별에 비교적 국한되어 있어 사회의 기록화를 실현하기 어렵다는 한계를 지적하였다. 이러한 한계를 극복하기 위하여 Whole-of-Society 접근법을 적용하여 가이드라인을 제시한다. 가이드라인은 총 8단계를 거치는데, 1단계부터 4단계는 기록화 대상의 선정과 기술이며 5단계부터 8단계는 디지털 환경에서 의미적 수집을 위한 준비절차라 할 수 있다. 한편 가이드라인의 실행을 위한 선행과제를 점검하며 국가기록원의 역할을 촉구한다.