• 정보관리학회지
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• 제18권3호
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• pp.139-158
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• 2001

전통적으로 도서관은 가치 있는 인쇄저널을 선별해 구독하고 소장하고 보존함으로써 비교적 오랜 기간 동안 이용자에게 원문을 제공할 수 있었다. 최근 등장한 전자저널은 시간과 공간의 제약없이 편리하게 이용할 수 있다는 장점이 있는 반면 시간이 경과함에 따라 원문을 이용할 수 있는 가능성이 낮아진다는 단점이 있다. 이는 전통적으로 보존의 기능을 담당했던 도서관이 전자저널 컨텐츠를 보유하고 있지 않다는데서 원인을 찾을 수 있다. 독특한 전자저널의 유통체제로 인하여 컨텐츠 생산자인 출판사나 데이터베이스사가 실제 전자저널의 컨텐츠를 보유하고 서비스하고 있으며 이들의 정책에 따라 전자저널의 영구접속 및 영구이용이 달라질 수밖에 없는 상황에 처하게 된 것이다. 이 연구는 이와 같은 상황을 염두에 두고 외국과 국내의 전자저널 아카이빙 현황을 살펴보았으며 바람직한 전자저널 아카이빙 정책추진 방향을 제안하고자 하였다. 연구결과 출판사의 아카이빙 노력에 전적으로 기대를 걸기보다는 전통적으로 보존기능을 담담했던 도서관이 중심이 되어 아카이빙을 수행하는 것이 바람직하다는 것을 알 수 있었다. 특히 출판계 적극적인 협조하에 국가도서관이 주축이 되어 전자저널 아카이빙에 대한 포괄적인 보존정책을 수립하여 시행하는 것이 보다 현실성이 있으며 각 단위도서관이 적절하게 역할을 분담하여 전자저널 아카이빙에 참여하는 공동 아카이빙 체제를 마련해야 함을 제안할 수 있었다.

• 정보관리학회지
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• 제37권1호
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• pp.23-49
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• 2020

본 연구는 문헌정보학 정규교육과정에서 중점적으로 다뤄야 하는 정보조직분야의 주요 영역을 도출하고, 영역별 내용요소를 제안하였다. 이를 위해 문헌연구, 내용분석, 설문조사 및 전문가평가를 수행하였다. 이를 통해 정보조직분야를 정보조직일반, 분류, 목록, 실습이라는 4영역으로 구성하고, 총 31개의 영역별 내용요소를 제시하였다. 본 연구를 통해 영역별로 도출된 내용요소들은 정보조직분야 교과목에 대한 강의계획안이나 교수 요목을 설계할 때 도움이 될 수 있는 기초자료로 활용할 수 있다. 또한, 본 연구에서 사용한 연구방법을 적용하여 정보조직분야의 주요 영역별 내용요소를 확장할 수 있기 때문에, 정보조직분야 교육내용을 설계를 위한 기초자료로 활용될 수 있을 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9085-9091
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• 2014

Background: Epidemiology studies have shown an inconclusive relationship between phytoestrogen intake and ovarian cancer risk and there have been no relevant meta-analyses directly regarding this topic. The purpose of the present meta-analysis was therefore to investigate any association between phytoestrogen intake and ovarian cancer in detail. Materials and Methods: We conducted a search of PubMed, EMBASE, EBSCO, the Cochrane Library, CNKI and Chinese Biomedical Database (up to April 2014) using common keywords for studies that focused on phytoestrogen and ovarian cancer risk. Study-specific risk estimates (RRs) were pooled using fixed effect or random-effect models. Results: Ten epidemiologic studies were finally included in the meta-analysis. The total results indicated higher phytoestrogen intake was associated with a reduced ovarian cancer risk (RR, 0.70; 95%CI: 0.56-0.87). The association was similar in sensitivity analysis. Meta regression analysis demonstrated sources and possibly types and regions as heterogeneous factors. Subgroup analysis of types, sources and regions showed that isoflavones (RR: 0.63; 95%CI: 0.46, 0.86), soy foods (RR: 0.51; 95%CI: 0.39, 0.68) and an Asian diet (RR: 0.48; 95%CI: 0.37, 0.63) intake could reduce the incidence of ovarian cancer. Conclusions: Our findings show possible protection by phytoestrogens against ovarian cancer. We emphasize specific phytoestrogens from soy foods, but not all could reduce the risk. The habit of plentiful phytoestrogen intake by Asians is worthy to recommendation. However, we still need additional larger well designed observational studies to fully characterize underlying associations.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.713-718
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• 2015

Background: A number of association studies have been carried out to investigate the relationship between genetic polymorphisms in DNA repair genes and response to radiotherapy-based multimodality treatment of patients with rectal cancer. However, their conclusions were inconsistent. The objective of the present study was to assess the role of DNA repair gene genetic polymorphisms in predicting genetic biomarkers of the response in rectal cancer patients treated with neoadjuvant chemoradiation. Materials and Methods: Studies were retrieved by searching the PubMed database, Cochrane Library, Embase, and ISI Web of Knowledge. We conducted a meta-analysis to evaluate the association between genetic polymorphisms and the response in rectal cancer treated with neoadjuvant chemoradiation by checking odds ratios (ORs) and 95% confidence intervals (CIs). Results: Data were extracted from 5 clinical studies for this meta-analysis. The results showed that XRCC1 RS25487, XRCC1 RS179978, XRCC3 RS861539, ERCC1 RS11615 and ERCC2 RS13181 were not associated with the response in the radiotherapy-based multimodality treatment of patients with rectal cancer (p>0.05). Conclusions: This study shows that DNA repair gene common genetic polymorphisms are not significantly correlated with the radiotherapy-based multimodality treatment in rectal cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.595-600
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• 2015

Background: Accumulating evidence suggests that metformin possesses anticarcinogenic properties, and its use is associated with favorable outcomes in several cancers. However, it remains unclear whether metformin influences prognosis in prostate cancer (PCa) with concurrent type 2 diabetes (T2D). Materials and Methods: We searched PubMed, EMBASE, and the Cochrane Library from database inception to April 16, 2014 without language restrictions to identify studies investigating the effect of metformin treatment on outcomes of PCa with concurrent T2D. We conducted a meta-analysis to quantify the risk of recurrence, progression, cancer-specific mortality, and all-cause mortality. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated. Publication bias was assessed by Begg's rank correlation test. Results: A total of eight studies fulfilled the eligibility criteria. We found that diabetic PCa patients who did not use metformin were at increased risk of cancer recurrence (RR, 1.20; 95%CI, 1.00-1.44), compared with those who used metformin. A similar trend was observed for other outcomes, but their relationships did not reach statistical significance. Funnel plot asymmetry was not observed among studies reporting recurrence (p=0.086). Conclusions: Our results suggest that metformin may improve outcomes in PCa patients with concurrent T2D. Well-designed large studies and collaborative basic research are warranted.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4339-4347
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• 2014

Purpose: This study aimed at exploring treatment delay (TD) among cancer patients in China with an attempt to develop a practical methodology facilitating frontline Chinese clinicians in promoting earlier cancer diagnosis and treatment. Materials and Methods: The study comprised framework development, qualitative interviews and paired factor rating. Framework development utilized systematic literature review, soft systems thinking and consensus groups. Qualitative interviews employed a checklist of open questions soliciting information about all the domains included the framework from cancer patients drawn via stratified randomized sampling of inpatients at 10 hospitals in Hefei, China. Paired factor rating used a self-developed computer aid and the interviewed patients as referring cases to weigh the relative importance of the factors listed in the framework in terms of their contributions to specific components of total delay (TD). Results: a) A conceptual framework was proposed consisting of a 6-step path to TD and 36 category determinants. b) A total of 227 patients were interviewed; their TD was 267.3 mean or 108 median days ranging from 0 to 2475 days; average appraisal, illness, behavioral, preparation and treatment delay accounted for 52.1%, 9.4%, 0.30%, 8.8% and 29.4% of the TD respectively. Individual side factors were rated substantially more important than environmental side factors (60% vs. 40%); most influential TD factors included cancer symptoms, overall health, family relations and knowledge about cancer and health. Conclusions: The framework proposed together with the interviewing and rating approaches used provide a potential new methodology for understanding cancer patients' TD and promoting earlier cancer treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3917-3921
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• 2016

Background: The association between calcium channel blockers (CCBs) and survival in cancer patients remains unclear and the results of related studies are conflicting. The objective of the study was to investigate the association between calcium channel blockers (CCBs) use and survival in cancer patients. Materials and Methods: We searched PubMed, EMBASE, Web of Science and Cochrane Library for studies published before January 2016 with the terms related to CCBs and survival in cancer patients. The information was reviewed and extracted by two evaluators independently. Data of publications was extracted and calculated into hazard ratios (HRs) for overall survival (OS). Statistical analysis was performed by using Review Manager 5.3. Results: There were 11 studies included in our meta-analysis. Analysis of all studies showed that CCBs use was not associated with survival in cancer patients (HR=1.07; 95% CI: 0.91-1.25; P=0.42). No association between CCBs use and overall survival in cancer patients was existed whether in Asian (HR=1.18, 95% CI: 0.72-1.93; P=0.52) or Caucasian population (HR=1.03, 95% CI: 0.89-1.20; P=0.66). Conclusions: There is no evidence that CCBs use is associated with a better or worse outcome of survival in cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.3823-3827
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• 2016

Background: To investigate the association circumcision with prostate cancer. Materials and Methods: We searched PubMed, EMBASE, the Cochrane Library, and Chinese biomedicine literature database up to August 2015. All case-control studies were identified in which investigated the association circumcision with prostate cancer. Three authors independently assessed study quality and extracted data. All data were analyzed using RevMan 5.3 and STATA version 11.0. Results: Six case-control studies met the inclusion criteria. The pooled meta-analysis showed that there was a lower incidence of circumcision in prostate cancer patients compared with control (OR=0.90, 95% confidence interval [CI] 0.82-0.98, P=0.01). The results of meta-analysis also showed that no significant difference was found between circumcision and less aggressive prostate cancer (OR=0.93, 95% CI 0.83-1.04, P=0.19); however, there was a lower incidence of circumcision in more aggressive prostate cancer compared with control (OR =0.84, 95% CI 0.72-0.97, P=0.02). The Egger's results did not show any evidence of publication bias(P=0.798). Conclusions: In summary, within the limits of available data, male with circumcision appears to have a lower incidence of prostate cancer. In the future, high-quality multicenter studies are needed to thoroughly verify the outcome.

• Journal of Radiation Protection and Research
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• 제41권2호
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• pp.123-131
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• 2016

Background: With the increase in the number of particle accelerator facilities under either operation or construction, the accurate calculation using Monte Carlo codes become more important in the shielding design and radiation safety evaluation of accelerator facilities. Materials and Methods: The calculations with different physics models were applied in both of cases: using only physics model and using the mix and match method of MCNPX code. The issued conditions were the interactions of 600 MeV proton and $290MeV{\cdot}n^{-1}$ oxygen with a carbon target. Both of cross-section libraries, JENDL High Energy File 2007 (JENDL/HE-2007) and LA150, were tested in this calculation. In the case of oxygen ion interactions, the calculation results using LAQGSM physics model and JENDL/HE-2007 library were compared with D. Satoh's experimental data. Other Monte Carlo calculations using PHITS and FLUKA codes were also carried out for further benchmarking study. Results and Discussion: It was clearly found that the physics models, especially intra-nuclear cascade model, gave a great effect to determine proton-induced secondary neutron spectrum in MCNPX code. The variety of physics models related to heavy ion interactions did not make big difference on the secondary particle productions. Conclusion: The variations of secondary neutron spectra and particle transports depending on various physics models in MCNPX code were studied and the result of this study can be used for the shielding design and radiation safety evaluation.

• Journal of Radiation Protection and Research
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• 제41권2호
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• pp.155-159
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• 2016

Background: Nuclear reactors produce a great number of antielectron neutrinos mainly from beta-decay chains of fission products. Such neutrinos have energies mostly in MeV range. We are interested in neutrinos in a region of keV, since they may take part in special weak interactions. We calculate reactor antineutrino spectra especially in the low energy region. In this work we present neutrino spectrum from a typical pressurized water reactor (PWR) reactor core. Materials and Methods: To calculate neutrino spectra, we need information about all generated nuclides that emit neutrinos. They are mainly fission fragments, reaction products and trans-uranium nuclides that undergo negative beta decay. Information in relation to trans-uranium nuclide compositions and its evolution in time (burn-up process) were provided by a reactor code MVP-BURN. We used typical PWR parameter input for MVP-BURN code and assumed the reactor to be operated continuously for 1 year (12 months) in a steady thermal power (3.4 GWth). The PWR has three fuel compositions of 2.0, 3.5 and 4.1 wt% $^{235}U$ contents. For preliminary calculation we adopted a standard burn-up chain model provided by MVP-BURN. The chain model treated 21 heavy nuclides and 50 fission products. The MVB-BURN code utilized JENDL 3.3 as nuclear data library. Results and Discussion: We confirm that the antielectron neutrino flux in the low energy region increases with burn-up of nuclear fuel. The antielectron-neutrino spectrum in low energy region is influenced by beta emitter nuclides with low Q value in beta decay (e.g. $^{241}Pu$) which is influenced by burp-up level: Low energy antielectron-neutrino spectra or emission rates increase when beta emitters with low Q value in beta decay accumulate Conclusion: Our result shows the flux of low energy reactor neutrinos increases with burn-up of nuclear fuel.