Browse > Article
http://dx.doi.org/10.7314/APJCP.2015.16.2.713

DNA Repair Gene Polymorphisms Do Not Predict Response to Radiotherapy-Based Multimodality Treatment of Patients with Rectal Cancer: a Meta-analysis  

Guo, Cheng-Xian (Center of Clinical Pharmacology, the Third Xiangya Hospital)
Yang, Guo-Ping (Center of Clinical Pharmacology, the Third Xiangya Hospital)
Pei, Qi (Department of Pharmacy, the Third Xiangya Hospital, Central South University)
Yin, Ji-Ye (Institute of Clinical Pharmacology, Central South University)
Tan, Hong-Yi (Center of Clinical Pharmacology, the Third Xiangya Hospital)
Yuan, Hong (Center of Clinical Pharmacology, the Third Xiangya Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.2, 2015 , pp. 713-718 More about this Journal
Abstract
Background: A number of association studies have been carried out to investigate the relationship between genetic polymorphisms in DNA repair genes and response to radiotherapy-based multimodality treatment of patients with rectal cancer. However, their conclusions were inconsistent. The objective of the present study was to assess the role of DNA repair gene genetic polymorphisms in predicting genetic biomarkers of the response in rectal cancer patients treated with neoadjuvant chemoradiation. Materials and Methods: Studies were retrieved by searching the PubMed database, Cochrane Library, Embase, and ISI Web of Knowledge. We conducted a meta-analysis to evaluate the association between genetic polymorphisms and the response in rectal cancer treated with neoadjuvant chemoradiation by checking odds ratios (ORs) and 95% confidence intervals (CIs). Results: Data were extracted from 5 clinical studies for this meta-analysis. The results showed that XRCC1 RS25487, XRCC1 RS179978, XRCC3 RS861539, ERCC1 RS11615 and ERCC2 RS13181 were not associated with the response in the radiotherapy-based multimodality treatment of patients with rectal cancer (p>0.05). Conclusions: This study shows that DNA repair gene common genetic polymorphisms are not significantly correlated with the radiotherapy-based multimodality treatment in rectal cancer patients.
Keywords
DNA repair genes; genetic polymorphism; response; rectal cancer; meta-analysis;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Wood RD, Mitchell M, Sgouros J, et al (2001). Human DNA repair genes. Science, 291, 1284-9.   DOI   ScienceOn
2 Yu Z, Chen J, Ford BN, et al (1999). Human DNA repair systems: an overview. Environ Mol Mutagen, 33, 3-20.   DOI
3 Balboa E, Duran G, Lamas MJ, et al (2010). Pharmacogenetic analysis in neoadjuvant chemoradiation for rectal cancer: high incidence of somatic mutations and their relation with response. Pharmacogenomics, 11, 747-61.   DOI
4 Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101.   DOI
5 Borchiellini D, Etienne-Grimaldi MC, Thariat J, et al (2012). The impact of pharmacogenetics on radiation therapy outcome in cancer patients. A focus on DNA damage response genes. Cancer Treat Rev, 38, 737-59.   DOI
6 Bouzourene H, Bosman FT, Seelentag W, et al (2002). Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer, 94, 1121-30.   DOI
7 Camma C, Giunta M, Fiorica F, et al (2000). Preoperative radiotherapy for resectable rectal cancer: A meta-analysis. JAMA, 284, 1008-15.   DOI
8 Cecchin E, Agostini M, Pucciarelli S, et al (2010). Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. Pharmacogenomics J, 11, 214-26.
9 DerSimonian R, Kacker R (2007). Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials, 28, 105-14.   DOI   ScienceOn
10 Cheng XD, Lu WG, Ye F, et al (2009). The association of XRCC1 gene single nucleotide polymorphisms with response to neoadjuvant chemotherapy in locally advanced cervical carcinoma. J Exp Clin Cancer Res, 28, 91.   DOI
11 DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88.   DOI
12 Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34.   DOI
13 Gordon MA, Gil J, Lu B, et al (2006). Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation. Pharmacogenomics, 7, 67-88.   DOI
14 Grimminger PP, Brabender J, Warnecke-Eberz U, et al (2010). XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer. J Surg Res, 164, 61-6.   DOI
15 Hoeijmakers JH (2001). Genome maintenance mechanisms for preventing cancer. Nature, 411, 366-74.   DOI
16 Hu-Lieskovan S, Vallbohmer D, Zhang W, et al (2011). EGF61 polymorphism predicts complete pathologic response to cetuximab-based chemoradiation independent of KRAS status in locally advanced rectal cancer patients. Clin Cancer Res, 17, 5161-9.   DOI
17 Jemal A, Siegel R, Xu J, et al (2010). Cancer statistics. CA Cancer J Clin, 60, 277-300.   DOI
18 Kapiteijn E, Marijnen CA, Nagtegaal ID, et al (2001). Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med, 345, 638-46.   DOI
19 Kockerling F, Reymond MA, Altendorf-Hofmann A, et al (1998). Influence of surgery on metachronous distant metastases and survival in rectal cancer. J Clin Oncol, 16, 324-9.
20 Kerns SL, Ostrer H, Rosenstein BS (2014). Radiogenomics: using genetics to identify cancer patients at risk for development of adverse effects following radiotherapy. Cancer Discov, 4, 155-65.   DOI
21 Lamas MJ, Duran G, Gomez A, et al (2012). X-ray crosscomplementing group 1 and thymidylate synthase polymorphisms might predict response to chemoradiotherapy in rectal cancer patients. Int J Radiat Oncol Biol Phys, 82, 138-44.   DOI
22 Mahimkar MB, Samant TA, Kannan S, et al (2012). Polymorphisms in GSTM1 and XPD genes predict clinical outcome in advanced oral cancer patients treated with postoperative radiotherapy. Mol Carcinog, 51, 94-103.   DOI
23 Mandard AM, Dalibard F, Mandard JC, et al (1994). Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer, 73, 2680-6.   DOI
24 Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
25 Masson M, Niedergang C, Schreiber V, et al (1998). XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol, 18, 3563-71.   DOI
26 Metzger R, Warnecke-Eberz U, Alakus H, et al (2012). Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: ERCC1 gene polymorphisms for prediction of response and prognosis. J Gastrointest Surg, 16, 26-34.   DOI
27 Rajput A, Bullard Dunn K (2007). Surgical management of rectal cancer. Semin Oncol, 34, 241-9.   DOI
28 Roh MS, Colangelo LH, O'Connell MJ, et al (2009). Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03. J Clin Oncol, 27, 5124-30.   DOI
29 Read TE, McNevin MS, Gross EK, et al (2001). Neoadjuvant therapy for adenocarcinoma of the rectum: tumor response and acute toxicity. Dis Colon Rectum, 44, 513-22.   DOI
30 Rodel C, Martus P, Papadoupolos T, et al (2005). Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol, 23, 8688-96.   DOI
31 Sauer R, Becker H, Hohenberger W, et al (2004). Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med, 351, 1731-40.   DOI
32 Shen MR, Jones IM, Mohrenweiser H (1998). Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res, 58, 604-8.
33 Szkandera J, Absenger G, Liegl-Atzwanger B, et al (2013). Common gene variants in RAD51, XRCC2 and XPD are not associated with clinical outcome in soft-tissue sarcoma patients. Cancer Epidemiol, 37, 1003-9.   DOI
34 Terrazzino S, Agostini M, Pucciarelli S, et al (2006). A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation. Pharmacogenet Genomics, 16, 817-24.   DOI
35 Thompson LH, West MG (2000). XRCC1 keeps DNA from getting stranded. Mutat Res, 459, 1-18.   DOI
36 Vecchio FM, Valentini V, Minsky BD, et al (2005). The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys, 62, 752-60.   DOI