• International Journal of High-Rise Buildings
• /
• v.11 no.2
• /
• pp.137-144
• /
• 2022

As one of the most important vertical transportation equipment in super high-rise buildings, the construction elevator directly affects the project period, cost, and effectiveness. The paper proposes a new construction elevator with single-guide rail and multi-cages. It can solve the problems of single construction elevator capacity shortage and efficacy decrease with height reduction, the occupancy of plan and elevation position of multiple construction elevators, and extension of total construction period by cycling operation of multi-cages on a single-guide rail. The paper focuses on the design and research of the main components of the equipment, such as the rotating guide rail mechanism, vertical bearing mast tie system, segmented electrical power supply system, group control scheduling system, and safety anti-collision system.

• Proceedings of the Korean Society of Broadcast Engineers Conference
• /
• 2021.06a
• /
• pp.81-84
• /
• 2021

In this paper, a rate-distortion optimization (RDO) model is proposed to find the joint bit allocation of geometry data and color data based on geometry-based point cloud compression (G-PCC) of Moving Picture Experts Group (MPEG). The mechanism of the method is to construct the RD models for geometry and color data through the training process. Afterward, two rate-distortion (RD) models are integrated as well as the decision of the parameter λ to obtain the final RDO model. The experimental results show that the proposed method can decrease 20% of the geometry Bjøntegaard delta bit rate and increase 37% of the color Bjøntegaard delta bit rate compared to the MPEG G-PCC TMC13v12.0 software.

• Smart Structures and Systems
• /
• v.10 no.3
• /
• pp.253-269
• /
• 2012

A split spectrum processing (SSP) method is proposed to accurately determine the time-of-flight (ToF) of damage-scattered waves by comparing the instantaneous amplitude variation degree (IAVD) of a wave signal captured from a damage case with that from the benchmark. The fundamental symmetrical ($S_0$) mode in aluminum plates without and with a notch is assessed. The efficiency of the proposed SSP method and Hilbert transform in determining the ToF of damage-scattered $S_0$ mode is evaluated for damage identification when the wave signals are severely contaminated by noise. Broadband noise can overwhelm damage-scattered wave signals in the time domain, and the Hilbert transform is only competent for determining the ToF of damage-scattered $S_0$ mode in a noise-free condition. However, the calibrated IAVD of the captured wave signal is minimally affected by noise, and the proposed SSP method is capable of determining the ToF of damage-scattered $S_0$ mode accurately even though the captured wave signal is severely contaminated by broadband noise, leading to the successful identification of damage (within an error on the order of the damage size) using a triangulation algorithm.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.5
• /
• pp.1771-1777
• /
• 2012

The impact of anatomic resection (AR) as compared to non-anatomic resection (NAR) for hepatocellular carcinoma (HCC) as a factor for preventing intra-hepatic and local recurrence after the initial surgical procedure remains controversial. A systematic review and meta-analysis of nonrandomized trials comparing anatomic resection with non-anatomic resection for HCC published from 1990 to 2010 in PubMed and Medline, Cochrane Library, Embase, and Science Citation Index were therefore performed. Intra-hepatic recurrence, including early and late, and local recurrence were considered as primary outcomes. As secondary outcomes, 5 year survival and 5 year disease-free survival were considered. Pooled effects were calculated utilizing either fixed effects or random effects models. Eleven non-randomized studies including 1,576 patients were identified and analyzed, with 810 patients in the AR group and 766 in the NAR group. Patients in the AR group were characterized by lower prevalence of cirrhosis, more favorable hepatic function, and larger tumor size and higher prevalence of macrovascular invasion compared with patients in the NAR group. Anatomic resection significantly reduced the risks of local recurrence and achieved a better 5 years disease-free survival. Also, anatomic resection was marginally effective for decreasing the early intra-hepatic recurrence. However, it was not advantageous in preventing late intra-hepatic recurrence compared with non-anatomic resection. No differences were found between AR and NAR with respect to postoperative morbidity, mortality, and hospitalization. Anatomic resection can be recommended as superior to non-anatomic resection in terms of reducing the risks of local recurrence, early intra-hepatic recurrence and achieving a better 5 year disease-free survival in HCC patients.

• Journal of Microbiology
• /
• v.43 no.6
• /
• pp.529-536
• /
• 2005

Viral infection causes stress to the endoplasmic reticulum (ER). The response to endoplasmic reticulum stress, known as the unfolded protein response (UPR), is designed to eliminate misfolded proteins and allow the cell to recover. The role of hepatitis C virus (HCV) non-structural protein NS4B, a component of the HCV replicons that induce UPR, is incompletely understood. We demonstrate that HCV NS4B could induce activating transcription factor (ATF6) and inositol-requiring enzyme 1 (IRE1), to favor the HCV subreplicon and HCV viral replication. HCV NS4B activated the IRE1 pathway, as indicated by splicing of X box-binding protein (Xbp-1) mRNA. However, transcriptional activation of the XBP-1 target gene, EDEM (ER degradation-enhancing $\alpha-mannosidase-like$ protein, a protein degradation factor), was inhibited. These results imply that NS4B might induce UPR through ATF6 and IRE1-XBP1 pathways, but might also modify the outcome to benefit HCV or HCV subreplicon replication.

• Journal of Haehwa Medicine
• /
• v.13 no.2
• /
• pp.231-249
• /
• 2004

This study analyzed the contents of the research papers concerning the common cold recorded in Chinese medical journal published over the period between 2000 and 2004. As a result, the following conclusion was drawn. 1. Among the clinical research papers, There are a lot of treatment papers of traditional chinese medicine in the method of treatment. There are a lot of papers about Feng-Re-Xing(風熱型) and Xu-Zheng-Xing(虛證型) in the Bian-Zheng-Lei-Xing(辨證類型) 2. "Zhong-Yi-Xu-Zheng-Bian-Zheng-Can-Kao-Biao-Zhun" ("中醫虛證辨證參考標準"), "Zhong-Yi-Nei-Ke-Wu-Ban-Jiao-Cai"("中醫內科五版敎材"), "Zhong-Hua-Ren-Min-Gong-He-Guo-Zhong-Yi-Yao-Hang-Ye-Biao-Zhun"("中華人民共和國醫藥行業標準"), "Gan-Mao-Zhen-Duan-Biao-Zhun"("感冒診斷漂準"), "Zhong-Yi-Bing-Zheng-Zhen-Duan-Liao-Xiao-Biao-Zhun"("中醫病證診斷療效標準"), "Quan-Guo-Gao-Deng-Yi-Xue-Yuan-Xiao-Zhong-Yi-Zhuan-Ye-Jiao-Cai"("全國高等醫藥院校中醫專業敎材") are used as the criterion for diagnosis in Chinese medicine. 3. It is mainly used "Zhong-Yi-Bing-Zheng-Zhen-Duan-Liao-Xiao-Biao-Zhun"("中醫病證診斷療效標準") as the criterion for treatment effect evaluation, and symptom of traditional chinese medicine, the frequency and the duration of common cold, measurement of immunologic function are used as assistant evaluation indicator. 4. The research papers reported that the use of prescriptions such as Chai-Qi-Fang-Jiao-Tang, Tui-Re-He-Ji(退熱合劑), Ti-Xu-Gan-Mao-He-Ji(體虛感冒合劑), Yu-Ping-Feng-San-He-Gui-Zhi-Tang(玉屛風散合桂枝湯), Chai-Guan-Jie-Re-Ke-Li(柴貫解熱顆粒), Hu-Qin-He-Ji(蒿芩合劑), Lian-Hua-Feng-Cha(蓮花峰茶), Kang-Gan-He-Ji(抗感合劑), Bing-Du-He-Ji(病毒合劑), Zhong-Gan-Ling-Pian(重感靈片) led to the high efficacy 5. The pharmacological research papers reported that Yu-Ping-Feng-San(玉屛風散) have influence on IgA, phagocytic function of macrophage, the total number of splenocyte and PEC.

• Smart Structures and Systems
• /
• v.6 no.7
• /
• pp.835-849
• /
• 2010

This study investigated propagation characteristics of piezo-activated guided waves in an aluminium rectangular-section tube for the purpose of damage identification. Changes in propagating velocity and amplitude of the first wave packet in acquired signals were observed in the frequency range from 50 to 250 kHz. The difference in guided wave propagation between rectangular- and circular-section tubes was examined using finite element simulation, demonstrating a great challenge in interpretation of guided wave signals in rectangular-section tubes. An active sensor network, consisting of nine PZT elements bonded on different surfaces of the tube, was configured to collect the wave signals scattered from through-thickness holes of different diameters. It was found that guided waves were capable of propagating across the sharp tube curvatures while retaining sensitivity to damage, even that not located on the surfaces where actuators/sensors were attached. Signal correlation between the intact and damaged structures was evaluated with the assistance of a concept of digital damage fingerprints (DDFs). The probability of the presence of damage on the unfolded tube surface was thus obtained, by which means the position of damage was identified with good accuracy.

• Journal of Microbiology and Biotechnology
• /
• v.32 no.9
• /
• pp.1134-1145
• /
• 2022

SCO6993 (606 amino acids) in Streptomyces coelicolor belongs to the large ATP-binding regulators of the LuxR family regulators having one DNA-binding motif. Our previous findings predicted that SCO6993 may suppress the production of pigmented antibiotics, actinorhodin, and undecylprodigiosin, in S. coelicolor, resulting in the characterization of its properties at the molecular level. SCO6993-disruptant, S. coelicolor ΔSCO6993 produced excess pigments in R2YE plates as early as the third day of culture and showed 9.0-fold and 1.8-fold increased production of actinorhodin and undecylprodigiosin in R2YE broth, respectively, compared with that by the wild strain and S. coelicolor ΔSCO6993/SCO6993⁺. Real-time polymerase chain reaction analysis showed that the transcription of actA and actII-ORF4 in the actinorhodin biosynthetic gene cluster and that of redD and redQ in the undecylprodigiosin biosynthetic gene cluster were significantly increased by SCO6993-disruptant. Electrophoretic mobility shift assay and DNase footprinting analysis confirmed that SCO6993 protein could bind only to the promoters of pathway-specific transcriptional activator genes, actII-ORF4 and redD, and a specific palindromic sequence is essential for SCO6993 binding. Moreover, SCO6993 bound to two palindromic sequences on its promoter region. These results indicate that SCO6993 suppresses the expression of other biosynthetic genes in the cluster by repressing the transcription of actII-ORF4 and redD and consequently negatively regulating antibiotic production.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.3
• /
• pp.1925-1929
• /
• 2013

Background: As a negative regulator of P53, MDM2 plays an important role in carcinogenesis; a polymorphism in its promoter region. SNP309 T>G, is known to increase the expression of MDM2, thus being considered related to higher susceptibility to neoplasia. However, no agreement has been achieved regarding its effects on gastric cancer. Methods: The present systematic meta-analysis was performed based on comprehensive literature search from Pubmed, Web of science and CBM databases. Results: It was suggested from 6 independent studies that the GG genotype is associated with a significantly increased risk of gastric cancer (Recessive: OR = 1.43, 95% CI = 1.08-1.91, P = 0.013), and subgroup analysis also confirmed the relationship (English publications-recessive model: OR = 1.45, 95% CI = 1.10-1.91, P = 0.009; Studies in China-recessive model: OR = 1.58, 95% CI = 1.08-2.30, P = 0.017). No publication bias was detected. Conclusion: The meta-analysis indicated a significant inverse association between GG genotype carriage and elevated risk of gastric cancer. However, more studies and detailed information are needed to fully address the topic.

• The Korean Journal of Physiology and Pharmacology
• /
• v.24 no.1
• /
• pp.39-46
• /
• 2020

Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential to delay AD development. The plant sterol β-Sitosterol has a potential role in inhibiting the production of platelet Aβ, suggesting that it may be useful for AD prevention. In the present study, we aimed to investigate the effect and mechanism of β-Sitosterol on deficits in learning and memory in amyloid protein precursor/presenilin 1 (APP/PS1) double transgenic mice. APP/PS1 mice were treated with β-Sitosterol for four weeks, from the age of seven months. Brain Aβ metabolism was evaluated using ELISA and Western blotting. We found that β-Sitosterol treatment can improve spatial learning and recognition memory ability, and reduce plaque load in APP/PS1 mice. β-Sitosterol treatment helped reverse dendritic spine loss in APP/PS1 mice and reversed the decreased hippocampal neuron miniature excitatory postsynaptic current frequency. Our research helps to explain and support the neuroprotective effect of β-Sitosterol, which may offer a novel pharmaceutical agent for the treatment of AD. Taken together, these findings suggest that β-Sitosterol ameliorates memory and learning impairment in APP/PS1 mice and possibly decreases Aβ deposition.