• Journal of Chest Surgery
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• 제30권10호
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• pp.1040-1043
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• 1997

식도암 .수술후 발생한 bronchiolitis obliterans organizing pneumonia환자 1례를 보고하고자 한다. 이 환자는 수술후 4일째부터 미열, 마른기침, 경미한 호흡곤란을 호소하였다 이때 촬영한 단순 흉부 사진과 흉부 컴퓨터 촬영상 폐양측에 반성(Patchy)침습소견이 나타났다. 고식적 치료에도 불구하고 경도의 백혈구 증다증과 함께 호흡기 증상은 더욱 악화되어 호흡부전의 소견을 보였다. 개흉적 폐생검을 실시하였으며, 병리조직검사 상 BOOP라는 진단을 얻었다. 수주간에 걸친 부신피질호르몬치료후 임상적, 생리학적, 그리고 방사선검사에서 많은 호전을 보였다. 이에 우리는 개흉술후 발생될 수 있는 급성호흡부전증에서 BOOP도 그 원인이 될 수 있음을 알았다. 이 경우 부신피질호르몬치료로 좋은 효과를 얻을 수 있으므로 개흉술후 발생되는 급성호 흡부전의 경우 가능한 조속히 조직검사를 시행할 팔요가 있음을 알 수 있었다.

• 한국연소학회지
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• 제18권4호
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• pp.44-52
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• 2013

Important role of chemical interaction in flame extinction was numerically investigated in downstream interaction among lean(rich) and lean(rich) premixed as well as partially premixed $H_2$-air and CO-air flames. The strain rate varied from 30 to $5917s^{-1}$ until interacting flame could not be sustained anymore. Flame stability diagrams mapping lower and upper limit fuel concentrations for flame extinction as a function of strain rate are presented. Highly stretched interacting flames were survived only within two islands in the flame stability map where partially premixed mixture consisted of rich $H_2$-air flame, extremely lean CO-air flame, and a diffusion flame. Further increase in strain rate finally converges to two points. Appreciable amount of hydrogen in the side of lean $H_2$-air flame also oxidized the CO penetrated from CO-air flame, and this reduced flame speed of the $H_2$-air flame, leading to flame extinction. At extremely high strain rates, interacting flames were survived only by a partially premixed flame such that it consisted of a very rich $H_2$-air flame, an extremely lean CO-air flame, and a diffusion flame. In such a situation, both the weaker $H_2$-air and CO-air flames were parasite on the stronger diffusion flame such that it could lead to flame extinction in the situation of weakening the stronger diffusion flame. Particular concerns are focused on important role of chemical interaction in flame extinction was also discussed in detail.

• 한국연소학회지
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• 제18권4호
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• pp.29-36
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• 2013

Numerical study was conducted to clarify effects of added $CO_2$ for the downstream interaction between $H_2$-air and CO-air premixed flames in counterflow configuration. The reaction mechanism adopted was Davis model which had been known to be well in agreement with reliable experimental data. The results showed that both lean and rich flammable limits were reduced. The most discernible difference between the two with and without having $CO_2$ addition into $H_2$-air and CO-air premixtures was two flammable islands for the former and one island for the latter at high strain flame conditions. Even a small amount of $H_2$, in which $H_2$-air premixed flame cannot be sustained by itself, participates in CO oxidation, thereby altering the CO-oxidation reaction path from the main reaction route $CO+O_2{\rightarrow}CO_2+O$ with a very long chemical time in CO-air flame to the (H, O, OH)-related reaction routes including $CO+OH{\rightarrow}CO_2+H$ with relatively short chemical times. This intrinsic nature alters flame stability maps appreciably. The results also showed that chemical effects of added $CO_2$ suppressed flame stabilization. Particularly this phenomenon was appreciable at flame conditions which lean and rich extinction boundary was merged. The detailed discussion of chemical effects of added $CO_2$ was addressed to the present downstream interaction.

• 대한기계학회논문집B
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• 제34권7호
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• pp.729-738
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• 2010

질소로 희석된 부탄 층류 부상 화염에서 발생할 수 있는 화염진동 메커니즘을 살펴보기 위하여 실험적 연구를 수행하였다. 화염 진동은 층류 자유제트 부상 화염에서 5가지 영역으로 구분되었다: 화염 안정화 영역 (I), 열손실에 의한 진동 (II), 열손실에 의한 진동과 부력에 의한 진동이 혼재된 영역 (III),열손실에 의한 진동과 화염날림 직전의 진동이 혼재된 영역 (IV), 그리고 열손실에 의한 진동, 부력에 의한 진동 및 화염날림 직전의 진동이 모두 혼재된 영역(V). 각각의 화염진동의 특성을 규명하기 위해 화염의 시간에 따른 부상 높이 변화에 대한 FFT분석을 수행하였고 각 영역에 관련된 무차원 변수와 스트라훌 수의 조합으로 특성화 작업을 수행하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1405-1410
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• 2016

Background: The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Bone Metastases Module (EORTC QLQ-BM22) is a recently designed supplement to EORTC Quality of Life Questionnaire-C30 (EORTC QLQ-C30). Additional psychometric properties, especially using confirmatory factor analysis (CFA) and the Rasch model, are warranted. Materials and Methods: A total of 573 patients with bone metastases were enrolled from eight countries with a mean${\pm}$SD age of $55.8{\pm}13.7years$. Slightly more than two thirds of them were female (n=383; 66.8%). CFA was used to examine the BM22 framework; Rasch models were applied to understand misfit items and differential item functioning (DIF). Results: The fit indices were satisfactory in CFA (comparative fit index=0.972, Tucker-Lewis index=0.964, root mean square error of approximation=0.076, and standardized root mean square residual=0.045). All items fit well in the Rasch models (mean square values were between 0.5 and 1.5), and only one item (number 17) displayed DIF across gender. However, there were six DIF items across Canada and Taiwan, ten across Canada and Iran, and six across Taiwan and Iran. Conclusions: The BM22 has satisfactory psychometric properties, and could assess the QoL of patients with bone metastases specifically focusing on their symptoms. Clinicians may want to use it to capture the underlying QoL for patients with bone metastases. However, the score of item 17 should be interpreted with caution when comparing male and female patients. In addition, researchers should note that variation in DIF items may occur when conducting an international study.

• 대한토목학회논문집
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• 제34권3호
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• pp.773-784
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• 2014

본 연구는 우리나라의 극한강우와 극한홍수를 모의하기 위한 MBLRP 포아송 클러스터 강우생성모형의 적용성을 평가하였다. 국내 61개의 기상청 지상기상관측시스템의 강우량 관측지점에 대하여 고립입자 군집화 최적화(ISPSO) 기법을 적용하여 모형의 매개변수를 추정하고, 추정된 매개변수를 바탕으로 각 강우관측지점에서 100년치의 가상 강우시계열을 생성하였다. 생성된 강우시계열을 이용하여 확률강우량 및 확률홍수량을 산정하고 이 값들을 관측치에 근거하여 산정된 값들과 비교하였다. 비교 결과, 모형에 의한 확률강우량은 관측치보다 평균적으로 20~42% 작았으며, 강우의 재현기간이 증가할수록 과소산정되는 정도가 증가하였다. 확률홍수량의 경우, 모형에 의한 값이 관측치에 근거한 값보다 31%에서 50% 작았으며, 이 과소산정량은 홍수의 재현기간의 증가 및 유역의 불투수도의 증가와 함께 증가하였다.

• 한국연소학회지
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• 제20권1호
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• pp.6-14
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• 2015

Numerical study was conducted to clarify effects of added $H_2O$ for the downstream interaction between $H_2$-air and CO-air premixed flames in counterflow configuration. The reaction mechanism adopted was Davis model which had been known to be well in agreement with reliable experimental data. The results showed that both lean and rich flammable limits were reduced in increase of strain rate. The most discernible difference between the two with and without having $H_2O$ and/or $H_2$ addition into $H_2$-air and CO-air premixtures was two flammable islands for the former and one island for the latter at high strain flame conditions. Even a small amount of $H_2$, in which $H_2$-air premixed flame cannot be sustained by itself, participates in CO oxidation, thereby altering the CO-oxidation reaction path from the main reaction route $CO+O_2{\rightarrow}CO_2+O$ with a very long chemical time in CO-air flame to the OH-related reaction routes including $CO+OH{\rightarrow}CO_2+H$ with very short chemical times. This intrinsic nature alters flame stability maps appreciably. The results also showed that chemical effects of added $H_2O$ help lean flames at relatively low strain rate be sustained, and suppress the flame stabilization at high strain rates.

• 폴리머
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• 제39권2호
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• pp.346-352
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• 2015

폴리알파올레핀(PAO)은 유동점, 점도지수, 열/산화 안정성이 광유 기반의 윤활유보다 우수한 합성 윤활유이다. 본 연구에서는 1-펜텐, 1-헥센, 1-옥텐, 및 1-도데센을 단량체로 사용하고 세가지 종류의 알루미늄계 루이스 산촉매로 양이온 중합을 수행하여 다양한 PAO를 합성하였다. PAO 중합 성능과 제조된 PAO의 분자량, 동점도, 유동점과 점도지수를 다양한 중합 조건에서 조절할 수 있었다. 알킬 알루미늄 할라이드계 촉매가 기존의 $AlCl_3$계 촉매에 비하여 촉매 성능이 우수하였다. PAO의 미세구조를 비행-시간형 질량분석기(TOF-MS) 해석을 통하여 PAO의 미세구조와 윤활유로의 성능(점도지수, 유동점)과의 상관관계를 규명하였다. 특히, PAO의 점도지수는 알파 올레핀의 탄소수 증가에 따라 상승하여, PAO의 분지길이가 점도지수와 밀접한 상관관계가 있음을 확인하였다.

• Archives of Pharmacal Research
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• 제20권2호
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• pp.128-137
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• 1997

The effects of cylindan, a polysaccharide isolated from the basidiocarps of Agrocybe cylindracea, on murine sarcoma 180 tumor and murine immune cells were examined after intraperitoneal administration. Cylindan exhibited a marked life extension effect in mice against ascite forms of sarcoma 180 and Lewis lung carcinoma at a dose of 50 mg/kg/day, although it did not show any direct cytotoxicity against sarcoma 180, X5563, and MM46 murine tumor cells. Cylindan increased numbers of bone marrow stem cells as well as peritoneal exudate cells in flow cytometry using monoclonal antibodies. The tumor bearing mice group apparently showed the increase of macrophages and cytotoxic T lymphocytes in mouse spleen cells during the early stage of tumor growth. But during the later stage, the control group decreased immune cells and cylindan restored the decreased immune cells in the tumor bearing mice to the normal level. In non-specific immune response, cylindan stimulated the bacterial phagocytosis and acid phosphatase production in macrophages. It also activated components of the alternative complement pathway and natural killer activity against YAC-1 lymphoma. In number of plasma cells as token of stimulation of the differentiation of B lymphocytes. In cellular immunity, cylindan restored the depressed response of delayed type hypersensitivity in the tumor bearing mice to 60% of the normal level and increased the interleukin-2 (IL-2) responsiveness in the IL-2 dependent CTLL-2 cells. These results suggest that cylindan did not show direct cytotoxic effects on tumor cells but restored the decreased immune response of the tumor bearing mice.

• BMB Reports
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• 제54권10호
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• pp.497-504
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• 2021

EGR1 (early growth response 1) is dysregulated in many cancers and exhibits both tumor suppressor and promoter activities, making it an appealing target for cancer therapy. Here, we used a systematic multi-omics analysis to review the expression of EGR1 and its role in regulating clinical outcomes in breast cancer (BC). EGR1 expression, its promoter methylation, and protein expression pattern were assessed using various publicly available tools. COSMIC-based somatic mutations and cBioPortal-based copy number alterations were analyzed, and the prognostic roles of EGR1 in BC were determined using Prognoscan and Kaplan-Meier Plotter. We also used bc-GenEx-Miner to investigate the EGR1 co-expression profile. EGR1 was more often downregulated in BC tissues than in normal breast tissue, and its knockdown was positively correlated with poor survival. Low EGR1 expression levels were also associated with increased risk of ER+, PR+, and HER2- BCs. High positive correlations were observed among EGR1, DUSP1, FOS, FOSB, CYR61, and JUN mRNA expression in BC tissue. This systematic review suggested that EGR1 expression may serve as a prognostic marker for BC patients and that clinicopathological parameters influence its prognostic utility. In addition to EGR1, DUSP1, FOS, FOSB, CYR61, and JUN can jointly be considered prognostic indicators for BC.