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The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects

  • Min, Jang Hwan;Yun, In Sik;Lew, Dae Hyun;Roh, Tai Suk;Lee, Won Jai
    • Archives of Plastic Surgery
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    • v.41 no.4
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    • pp.330-336
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    • 2014
  • Background For patients with full thickness skin defects, autologous Split-thickness skin grafts (STSG) are generally regarded as the mainstay of treatment. However, skin grafts have some limitations, including undesirable outcomes resulting from scars, poor elasticity, and limitations in joint movement due to contractures. In this study, we present outcomes of Matriderm grafts used for various skin tissue defects whether it improves on these drawbacks. Methods From January 2010 to March 2012, a retrospective review of patients who had undergone autologous STSG with Matriderm was performed. We assessed graft survival to evaluate the effectiveness of Matriderm. We also evaluated skin quality using a Cutometer, Corneometer, Tewameter, or Mexameter, approximately 12 months after surgery. Results A total of 31 patients underwent STSG with Matriderm during the study period. The success rate of skin grafting was 96.7%. The elasticity value of the portion on which Matriderm was applied was 0.765 (range, 0.635-0.800), the value of the trans-epidermal water loss (TEWL) was 10.0 (range, 8.15-11.00)$g/hr/m^2$, and the humidification value was 24.0 (range, 15.5-30.0). The levels of erythema and melanin were 352.0 arbitrary unit (AU) (range, 299.25-402.75 AU) and 211.0 AU (range, 158.25-297.00 AU), respectively. When comparing the values of elasticity and TEWL of the skin treated with Matriderm to the values of the surrounding skin, there was no statistically significant difference between the groups. Conclusions The results of this study demonstrate that a dermal substitute (Matriderm) with STSG was adopted stably and with minimal complications. Furthermore, comparing Matriderm grafted skin to normal skin using Cutometer, Matriderm proved valuable in restoring skin elasticity and the skin barrier.

Transaxillary Subpectoral Placement of Cardiac Implantable Electronic Devices in Young Female Patients

  • Oh, Joo Hyun;Kim, Chae Min;Song, Seung Yong;Uhm, Jae Sun;Lew, Dae Hyun;Lee, Dong Won
    • Archives of Plastic Surgery
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    • v.44 no.1
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    • pp.34-41
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    • 2017
  • Background The current indications of cardiac implantable electronic devices (CIEDs) have expanded to include young patients with serious cardiac risk factors, but CIED placement has the disadvantage of involving unsightly scarring and bulging of the chest wall. A collaborative team of cardiologists and plastic surgeons developed a technique for the subpectoral placement of CIEDs in young female patients via a transaxillary approach. Methods From July 2012 to December 2015, subpectoral CIED placement via an axillary incision was performed in 10 young female patients, with a mean age of 25.9 years and mean body mass index of $20.1kg/m^2$. In the supine position, with the patient's shoulder abducted, an approximately 5-cm linear incision was made along one of the deepest axillary creases. The submuscular plane was identified at the lateral border of the pectoralis major, and the dissection continued over the clavipectoral fascia until the subpectoral pocket could securely receive a pulse generator. Slight upward dissection also exposed an entrance to the subclavian vein, allowing the cardiology team to gain access to the vein. One patient with dilated cardiomyopathy underwent augmentation mammoplasty and CIED insertion simultaneously. Results One case of late-onset device infection occurred. All patients were highly satisfied with the results and reported that they would recommend the procedure to others. Conclusions With superior aesthetic outcomes compared to conventional methods, the subpectoral placement of CIEDs via a transaxillary approach is an effective, single-incision method to hide operative scarring and minimize bulging of the device, and is particularly beneficial for young female or lean patients.

A basic study on mathematics telelearning system (수학과 원격 수업 체제 기초 연구)

  • Kang Wan;Chang Kyung Yoon;Lew Hee Chan;Paik Seok Yoon
    • Journal of Elementary Mathematics Education in Korea
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    • v.2 no.1
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    • pp.61-80
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    • 1998
  • Whereas research on telelearning in educational technology area is lively done, that in mathematics education area is not. Related to the open education, telelearning has 4 models: the distance classroom model, the front-end system design, the knowledge construction model, and the teaching model based on data. S/W, C/W, and H/W are the components of telelearning system. For an effective mathematics telelearning system, H/W and S/W which use multimedia with complex multimode information such as text, graphics, animation, video, and audio are necessary. Examples of telelearning systems on going are MIPOS, SDS telelearning system, telelearning system of the Naechon Elementary School, and Doorae Multimedia Application Development Platform.

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Reconstruction of Mandible Defect after Tumor Ablation Surgery : Versatility of Fibular Free Flap Design (광범위 종양절제술 후 발생한 하악 결손의 재건 : 결손부위에 따른 비골 유리 피판의 다양한 디자인)

  • Seul Chul-Hwan;Lee Young-Dae;Tark Kwan-Chul;Lew Dae-Hyun
    • Korean Journal of Head & Neck Oncology
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    • v.21 no.2
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    • pp.190-195
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    • 2005
  • Background and Objectives: Fibula is the flap of choice for reconstruction of wide mandible defects after tumor ablation surgery. In mandible reconstruction, restoring the mandible frame to provide mandibular contour and dental arch while restoring masticatory function are important. Even though vascularized fibula can be osteotomized freely, proper design and flap insetting is not easy because of its three dimensional structure and difference in design according to the defect sites. We reviewed patients who underwent mandible reconstruction with fibular flaps according to the defect sites and suggest proper modification methods of fibular flap according to the various defects sites after tumor ablation surgery. Materials and Methods: Twelve consecutive mandible reconstruction with fibular free flaps were performed for defects after tumor ablation surgery. Patients were classified into 4 groups according to the type of mandibular defect(Group 1 : defect on central segment including symphysis, Group 2 : defect on lateral segment(with or without central segment) confined to body, Group 3 : defect on body and ascending ramus that does not include the condyle, Group 4 : defect including the condyle). Results: We suggest different modification methods of fibular free flap for each patient group. Group 1, 3 ; contour by using multiple closing wedge osteotomy. Group 2 ; single or double barrel reconstruction without wedge osteotomy. Group 4 ; contour using single or multiple wedge osteotomy and condylar reconstruction with costochondral graft. Conclusion: Fibular free flaps can be contoured to any desired shape after multiple osteotomies to restore various mandibular defects. It is a reliable and versatile method for reconstruction of mandibular defects after tumor ablation surgery.

Reconstruction of Soft Tissue Deficit After Parotidectomy by Sternocleidomastoid Muscle Flap (이하선종양 적출술후 흉쇄유돌근을 이용한 함몰기형교정의 임상적 고찰)

  • Choi Hee-Yoon;Chung Hyo-Gyeong;Lee Young-Mann;Lew Jai-Mann
    • Korean Journal of Head & Neck Oncology
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    • v.3 no.1
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    • pp.37-54
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    • 1987
  • The aim of surgery for all parotid masses is directed toward total removal of the tumor with adequate safe margins of adjacent normal tissue and preservation of the facial nerve whenever possible. Reconstructive procedures following parotidectomy for benign or low grade malignant lesions are most commonly necessary if soft tissue deficits appear at the angle of the mandible below the earlobe as a major cosmetic deformity. This is a report of Z4 cases with a diagnosis of parotid tumor who were treated using various surgical procedures at Department of Plastic and Reconstructive Surgery, Hanyang University Hospital over the period of 4 years from January, 1983 to December, 1986. Among 24 cases, 11 cases were reconstructed by Sternocleidomastoid muscle flap at the same time that extirpative surgery is outlined. The advantage of Sternocleidomastoid muscle flap is the coverage of the facial nerve, so adhesion between the facial nerve and skin was prevented. Absorption and loss of bulk was not found such as dermofat graft. It was a simple method. Neither donor site defect nor sternocleidomastoid muscle deformity was developed. Sternocleidomastoid muscle flap have been found satisfactory in maintaining filled-out soft tissue hollows with good result cosmetically and functionally.

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Chronic Wound Treatment Using rh PDGF (재조합 인체 혈소판 성장인자(rh PDGF)를 이용한 만성 창상의 치료)

  • Jeong, Wong-Ki;Lew, Dae-Hyun;Park, Beyoung-Yun
    • Archives of Reconstructive Microsurgery
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    • v.11 no.2
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    • pp.173-178
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    • 2002
  • Wound healing is the result of interaction of normal cellular and biochemical responses that restore the interrupted anatomical structure in limited period. When any response of them is impaired, it results in chronic wound. The factors that influence the wound healing process is not only limited to the fundamental disease of the individual but also the local factors, especially various growth factors secreted from the various cells involved in tissue regeneration have important role. Recent reports that the chronic wounds are depleted of these growth factors have led active studies on the alteration of local wound environment with manipulation of the growth factors and the its application in management of chronic wounds. We investigated the effect on the chronic wounds in 10 patients with various pathologic conditions to suggest the appropriate application and guideline of the indication. The chronic wounds resulting from various causes in 10 patients were treated with rhPDGF gel and good wound care. All the chronic wounds were located on the lower extremity and the average diameter was 2.5 cm. 7 patients were completely cured within 8 weeks, however the patient who received previous radiation therapy the healing was delayed to 14 weeks. Two patients with vascular ulcer were not cured with rhPDGF alone. Local application of rhPDGF has yielded complete cure of the chronic wound in 70% of the patients within 2 months. The author suggests that it would be an effective alternative treatment modality of chronic wound when it is applied with good wound care and appropriate indication.

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Preservice Teachers' Writing Performance Producing Proofs and Counterexamples about Limit of Sequence (예비교사들을 대상으로 한 증명활동과 반례생성 수행결과 분석 : 수열의 극한을 중심으로)

  • Lee, Jeong-Gon;Lew, Hee-Chan
    • Journal of Educational Research in Mathematics
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    • v.21 no.4
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    • pp.379-398
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    • 2011
  • In learning environment at mathematics education, prove and refute are essential abilities to demonstrate whether and why a statement is true or false. Learning proofs and counter examples within the domain of limit of sequence is important because preservice teacher encounter limit of sequence in many mathematics courses. Recently, a number of studies have showed evidence that pre service and students have problem with mathematical proofs but many research studies have focused on abilities to produce proofs and counter examples in domain of limit of sequence. The aim of this study is to contribute to research on preservice teachers' productions of proofs and counter examples, as participants showed difficulty in writing these proposition. More importantly, the analysis provides insight and understanding into the design of curriculum and instruction that may improve preservice teachers' learning in mathematics courses.

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Re-Interpretation on the Korean Middle Grades Mathematics Textbooks of the 1st Curriculum (제 1차 교육과정에 따른 중학교 수학교과서의 현대적 재조명)

  • Ban, Eun Seob;Lew, Hee Chan
    • School Mathematics
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    • v.16 no.1
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    • pp.83-110
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    • 2014
  • This study analyzed the mathematics textbooks of middle grades in the first Korean curriculum, based on the modern trends of mathematics education curriculum, comparing with present Korean curriculum's other textbooks and the American textbook, MiC. The mathematics textbooks in the first Korean curriculum are based on various situations in our real life and introduce mathematical concepts throughout a set of mathematics problems. The textbooks present mathematical concepts with connected knowledge and include mathematical activities which make students use mathematical table, graph and formula at the same time. And students are actively required to discuss together during the mathematics problem solving process. As the results of this modern review on Korean 1st curriculum and middle grades mathematics textbooks, it would provide preliminary data and meaningful implications for the next curriculum and concomitant instructional materials.

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A Study on the Features of Digilog in Contemporary Fashion (현대 패션에 나타난 디지로그의 특징)

  • Lew, Chahyang;Suh, Seunghee
    • Journal of Fashion Business
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    • v.21 no.5
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    • pp.61-77
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    • 2017
  • Fashion companies are increasingly becoming aware of the importance of Digilog as a response strategy to an emotional stimulus, in order to win the hearts of consumers, because the Digilog provides a new type of emotional value. The features of Digilog found in modern fashion are characterized as follows: first, the "Fashion Image of Hybrid Nature" expresses nature in a new light or reinterprets existing expressions of nature, by using cutting-edge technology based on the psychological desire to return to, adapt with, and harmonize with nature. Second, the "Fashion Image of Nostalgia," which exhibits past forms of regressive fashion, is a fashion code that can be understood as a social trend. It has a digital exterior, with retro materials and old perfumes that reflect psychological comfort, as its expressive medium. Third, the "Lifestyle through the Technique of Interaction" is the sharing of information through consumer participation and delivery, or its interaction. Fourth, the "Fashion Design through the Technique of Customizing" allows consumers to actively participate in the design process. It reflects the consumer's desire to personally design fashion products. Fifth, the "Emotion Sharing through the Technique of Storytelling," which focuses on intangible values, is based on the sentiment of communication between the consumer and the brand, thereby satisfying the inner values as well as the aesthetic demands of consumers. This study confirmed that digital fashion, which uses digital technology based on analog sentiments, has opened up a new environment for fashion culture and has also widened the boundaries of fashion.

Studies on the Toxigenic Fungi Isolated from Local Grains and Foodstuffs (수종(數種) 곡류(穀類) 및 식품(食品)에서 분리(分離)한 진균(眞菌)의 유독성(有毒性)에 관(關)한 연구(硏究))

  • Koh, Choon-Myung;Choi, Tae-Kyung;Lew, Joon
    • The Journal of the Korean Society for Microbiology
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    • v.10 no.1
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    • pp.39-58
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    • 1975
  • These studies were carried out to detect the presence of mycotoxin producing fungi in various kind of grains and foodstuffs in Korea. The experiments were divided into three parts: bacteriologic, toxicologic and electron microscopic studies. The results were summarized as follows: 1. From the 133 various samples, 426 colonies of fungi were isolated. In 405 of 426 colonies, it was possible to identify 17 genera. Among the identified strains, the predominant genera were Penicillium, Aspergillus and Alternaria. 2. In cytotoxicity test, 20 strains showed mild to severe toxic effects in mice and 24 strains showed toxic effects on HeLa cells among the 107 strains of experiments. 3. In electron microscopic studies of liver cells from animal which had been treated with toxin like substances, the liver cells showed the cytoplasmic changes: dilatation of endoplasmic reticulum, swelling of mitochondria, disappearance of mitochondrial cristae, increased number of lipid and glycogen particles. Nucleus and nuclear envelope alterations were also noted. 4. In fine structure of HeLa cells treated with culture filtrates of mycotoxin producing fungi and experimental strains had been noted a certain specific changes induced by culture filtrates. These alterations showed the disappearance of golgi complex, endoplasmic reticulum vacuolization and mitochondrial changes. 5. As a mass screening, the cytotoxicity tests of HeLa cells and histopathologic study of mice liver cells treated with toxin-like substances, employed are feasible to detect mycotoxin producing fungi.

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