Archives of Plastic Surgery

  • 제41권4호
  • /
  • Pages.330-336
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  • 2014
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  • 2234-6163(pISSN)
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  • 2234-6171(eISSN)
대한성형외과학회 (Korean Society of Plastic and Reconstructive Surgeons)
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The Use of Matriderm and Autologous Skin Graft in the Treatment of Full Thickness Skin Defects

  • Min, Jang Hwan (Department of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine) ;
  • Yun, In Sik (Department of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine) ;
  • Lew, Dae Hyun (Department of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine) ;
  • Roh, Tai Suk (Department of Plastic and Reconstructive Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Lee, Won Jai (Department of Plastic and Reconstructive Surgery, Severance Hospital, Yonsei University College of Medicine)
  • 투고 : 2014.01.22
  • 심사 : 2014.02.27
  • 발행 : 2014.07.15
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Background For patients with full thickness skin defects, autologous Split-thickness skin grafts (STSG) are generally regarded as the mainstay of treatment. However, skin grafts have some limitations, including undesirable outcomes resulting from scars, poor elasticity, and limitations in joint movement due to contractures. In this study, we present outcomes of Matriderm grafts used for various skin tissue defects whether it improves on these drawbacks. Methods From January 2010 to March 2012, a retrospective review of patients who had undergone autologous STSG with Matriderm was performed. We assessed graft survival to evaluate the effectiveness of Matriderm. We also evaluated skin quality using a Cutometer, Corneometer, Tewameter, or Mexameter, approximately 12 months after surgery. Results A total of 31 patients underwent STSG with Matriderm during the study period. The success rate of skin grafting was 96.7%. The elasticity value of the portion on which Matriderm was applied was 0.765 (range, 0.635-0.800), the value of the trans-epidermal water loss (TEWL) was 10.0 (range, 8.15-11.00)$g/hr/m^2$, and the humidification value was 24.0 (range, 15.5-30.0). The levels of erythema and melanin were 352.0 arbitrary unit (AU) (range, 299.25-402.75 AU) and 211.0 AU (range, 158.25-297.00 AU), respectively. When comparing the values of elasticity and TEWL of the skin treated with Matriderm to the values of the surrounding skin, there was no statistically significant difference between the groups. Conclusions The results of this study demonstrate that a dermal substitute (Matriderm) with STSG was adopted stably and with minimal complications. Furthermore, comparing Matriderm grafted skin to normal skin using Cutometer, Matriderm proved valuable in restoring skin elasticity and the skin barrier.

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참고문헌

  1. Cervelli V, Brinci L, Spallone D, et al. The use of MatriDerm (R) and skin grafting in post-traumatic wounds. Int Wound J 2011;8:400-5. https://doi.org/10.1111/j.1742-481X.2011.00806.x
  2. Yannas IV, Burke JF, Gordon PL, et al. Design of an artificial skin. II. Control of chemical composition. J Biomed Mater Res 1980;14:107-32. https://doi.org/10.1002/jbm.820140203
  3. Juhasz I, Kiss B, Lukacs L, et al. Long-term followup of dermal substitution with acellular dermal implant in burns and postburn scar corrections. Dermatol Res Pract 2010;2010:210150.
  4. Eming SA, Yarmush ML, Morgan JR. Enhanced function of cultured epithelium by genetic modification: Cell-based synthesis and delivery of growth factors. Biotechnol Bioeng 1996;52:15-23. https://doi.org/10.1002/(SICI)1097-0290(19961005)52:1<15::AID-BIT2>3.0.CO;2-1
  5. Myers S, Navsaria H, Sanders R, et al. Transplantation of keratinocytes in the treatment of wounds. Am J Surg 1995;170:75-83. https://doi.org/10.1016/S0002-9610(99)80258-X
  6. Philandrianos C, Andrac-Meyer L, Mordon S, et al. Comparison of five dermal substitutes in full-thickness skin wound healing in a porcine model. Burns 2012;38:820-9. https://doi.org/10.1016/j.burns.2012.02.008
  7. Burke JF, Yannas IV, Quinby WC Jr, et al. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg 1981;194:413-28. https://doi.org/10.1097/00000658-198110000-00005
  8. van Zuijlen PP, van Trier AJ, Vloemans JF, et al. Graft survival and effectiveness of dermal substitution in burns and reconstructive surgery in a one-stage grafting model. Plast Reconstr Surg 2000;106:615-23. https://doi.org/10.1097/00006534-200009010-00014
  9. Sinha UK, Shih C, Chang K, et al. Use of AlloDerm for coverage of radial forearm free flap donor site. Laryngoscope 2002;112:230-4. https://doi.org/10.1097/00005537-200202000-00006
  10. Wainwright DJ. Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns. Burns 1995;21:243-8. https://doi.org/10.1016/0305-4179(95)93866-I
  11. Yim H, Cho YS, Seo CH, et al. The use of AlloDerm on major burn patients: AlloDerm prevents post-burn joint contracture. Burns 2010;36:322-8. https://doi.org/10.1016/j.burns.2009.10.018
  12. Haslik W, Kamolz LP, Nathschlager G, et al. First experiences with the collagen-elastin matrix Matriderm as a dermal substitute in severe burn injuries of the hand. Burns 2007;33:364-8. https://doi.org/10.1016/j.burns.2006.07.021
  13. Jones I, Currie L, Martin R. A guide to biological skin substitutes. Br J Plast Surg 2002;55:185-93. https://doi.org/10.1054/bjps.2002.3800
  14. Middelkoop E, de Vries HJ, Ruuls L, et al. Adherence, proliferation and collagen turnover by human fibroblasts seeded into different types of collagen sponges. Cell Tissue Res 1995;280:447-53. https://doi.org/10.1007/BF00307818
  15. de Vries HJ, Middelkoop E, Mekkes JR, et al. Dermal regeneration in native non-cross-linked collagen sponges with different extracellular matrix molecules. Wound Repair Regen 1994;2:37-47. https://doi.org/10.1046/j.1524-475X.1994.20107.x
  16. De Vries HJ, Mekkes JR, Middelkoop E, et al. Dermal substitutes for full-thickness wounds in a one-stage grafting model. Wound Repair Regen 1993;1:244-52. https://doi.org/10.1046/j.1524-475X.1993.10410.x
  17. Enomoto DN, Mekkes JR, Bossuyt PM, et al. Quantification of cutaneous sclerosis with a skin elasticity meter in patients with generalized scleroderma. J Am Acad Dermatol 1996;35:381-7. https://doi.org/10.1016/S0190-9622(96)90601-5
  18. Janzekovic Z. A new concept in the early excision and immediate grafting of burns. J Trauma 1970;10:1103-8. https://doi.org/10.1097/00005373-197012000-00001
  19. De Vries HJ, Zeegelaar JE, Middelkoop E, et al. Reduced wound contraction and scar formation in punch biopsy wounds. Native collagen dermal substitutes. A clinical study. Br J Dermatol 1995;132:690-7.
  20. Oliveira GV, Chinkes D, Mitchell C, et al. Objective assessment of burn scar vascularity, erythema, pliability, thickness, and planimetry. Dermatol Surg 2005;31:48-58. https://doi.org/10.1097/00042728-200501000-00010
  21. van Zuijlen PP, Angeles AP, Kreis RW, et al. Scar assessment tools: implications for current research. Plast Reconstr Surg 2002;109:1108-22. https://doi.org/10.1097/00006534-200203000-00052
  22. Ryssel H, Gazyakan E, Germann G, et al. The use of MatriDerm in early excision and simultaneous autologous skin grafting in burns: a pilot study. Burns 2008;34:93-7. https://doi.org/10.1016/j.burns.2007.01.018
  23. Hamuy R, Kinoshita N, Yoshimoto H, et al. One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation. Wound Repair Regen 2013;21:141-54. https://doi.org/10.1111/j.1524-475X.2012.00864.x
  24. Jeon H, Kim J, Yeo H, et al. Treatment of diabetic foot ulcer using matriderm in comparison with a skin graft. Arch Plast Surg 2013;40:403-8. https://doi.org/10.5999/aps.2013.40.4.403
  25. Bloemen MC, van Gerven MS, van der Wal MB, et al. An objective device for measuring surface roughness of skin and scars. J Am Acad Dermatol 2011;64:706-15. https://doi.org/10.1016/j.jaad.2010.03.006

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  5. The effect of a collagen-elastin matrix on adhesion formation after flexor tendon repair in a rabbit model vol.136, pp.7, 2016, https://doi.org/10.1007/s00402-016-2472-2
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  11. Regenerative medicine: Clinical applications and future perspectives vol.5, pp.1, 2014, https://doi.org/10.1016/j.jmau.2016.05.002
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  16. Potential applications of human artificial skin and electronic skin (e-skin): a review vol.7, pp.1, 2018, https://doi.org/10.1680/jbibn.17.00002
  17. Physical Properties of Implanted Porous Bioscaffolds Regulate Skin Repair: Focusing on Mechanical and Structural Features vol.7, pp.6, 2014, https://doi.org/10.1002/adhm.201700894
  18. The treatment of post-traumatic facial skin defect with artificial dermis vol.19, pp.1, 2018, https://doi.org/10.7181/acfs.2018.19.1.35
  19. Approaches to cutaneous wound healing: basics and future directions vol.374, pp.2, 2018, https://doi.org/10.1007/s00441-018-2830-1
  20. Skin graft using MatriDerm® for plantar defects after excision of skin cancer vol.11, pp.None, 2014, https://doi.org/10.2147/cmar.s198568
  21. A clinical trial with a novel collagen dermal substitute for wound healing in burn patients vol.8, pp.3, 2020, https://doi.org/10.1039/c9bm01209e
  22. On skin substitutes for wound healing: Current products, limitations, and future perspectives vol.8, pp.1, 2014, https://doi.org/10.1142/s2339547820300024
  23. Acellular dermal matrix reconstruction of a nail bed avulsion in a 13-year-old child vol.13, pp.9, 2014, https://doi.org/10.1136/bcr-2020-236253
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  26. From Grafts to Human Bioengineered Vascularized Skin Substitutes vol.21, pp.21, 2014, https://doi.org/10.3390/ijms21218197
  27. 3D printing of bioreactors in tissue engineering: A generalised approach vol.15, pp.11, 2014, https://doi.org/10.1371/journal.pone.0242615
  28. Extra-wound fixation: a modified tie-over dressing technique for skin graft vol.29, pp.suppl12, 2014, https://doi.org/10.12968/jowc.2020.29.sup12.s23
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  30. A Prototype Skin Substitute, Made of Recycled Marine Collagen, Improves the Skin Regeneration of Sheep vol.11, pp.5, 2014, https://doi.org/10.3390/ani11051219
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