• The Journal of Korean Medicine
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• v.20 no.1 s.37
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• pp.91-105
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• 1999

The effects of Yinjin and Yinjinsaryongsangagambang on a DNA damaging agent, etoposide-induced apoptosis, cell viability, cell cycle progression, and mRNA expression of apoptosis-related genes of human hepatocyte cell line HepG2 were investigated using tryphan blue exclusion assay, MTT assay, flow cytometry, immunocytometric analysis of PCNA, and quantitative RT-PCR analysis. MTT assay showed that Yinjin and Yinjinsaryongsangagambang increases cellular viability of HepG2 cells in a dosage-dependent manner. Stimulation of cell cycle progression by Yinjin or Yinjinsaryongsangagambang was detected by flow cytometric analysis of the DNA content and immunocytometric analysis of PCNA expression. A significant reduction of a DNA-damaging agent, etoposide-induced apoptosis were found in both Yinjin and Yinjinsaryongsangagambang-treated cells in dosage-dependent manner. In overall, 3-fold reduction of apoptosis was recognized in $10.0\;{\mu}g/ml$ of Yinjin or Yinjinsaryongsangagambang-treated cells compared to untreated cells. Although the difference is not significant, Yinjinsaryongsangagambang showed slightly higher effect on the inhibition of apoptosis than Yinjin. From flow cytometric analysis of apoptosis, while 39.9% of untreated cells showed etoposide-induced apoptotic cell death, only 19.6% or 17.4% of Yinjin or Yinjinsaryongsangagambang-treated cells were fond at apoptotic sub G1 phase, respectively. Interestingly, strong induction of Gadd45-mRNA was observed from Yinjin or Yinjinsaryongsangagambang-treated cells. However, no changes in expression levels of p53 and Waf1 were detected, demonstrating that induction of Gadd45 mRNA expression by Yinjin or Yinjinsaryongsangagambang occurs by p53-independent mechanism. Marked mRNA inductions of two apoptosis-inhibiting genes, Bcl-2 and Bcl- XL, were found in both Yinjin or Yinjinsaryongsangagambang-treated HepG2 cells while no changes was detected in expression levels of an apoptosis-promoting gene, Bax.

• Archives of Pharmacal Research
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• v.19 no.5
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• pp.359-367
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• 1996

The pharmacokinetics of LB20304 was investigated following intravenous (IV) and oral administration to rats and dogs. Additionally, in vitro metabolism and serum protein binding studies were also conducted. The total body clearance, apparent volume of distribution, terminal half-life, and extent of bioavailability were 21.8 ml/min/kg, 2265 ml/kg, 93.6 min, and 30.8% for rats; and 7.95 ml/min/kg, 4144 ml/kg, 363 min, and 81.1% for dogs, respectively. LB20304 was stable in the liver microsome containing NADPH generating system and its serum protein binding was 58.5-65.8% for rats, 19.1-29.6% for dogs, and 56.9-59.6% for humans. Its tissue concentration levels in lever, stomach, small intestine, and kidney were 9.5 to 26.1 times greater than plasma level, but the concentration in testis was quite low and that in brain was negligible in rats. The 48 hr urinary recovery of the dose was 44% for IV dosing and 14% for oral dosing, shereas the 48 hr biliary recovery of the dose was 6.4% for IV dosing and 4.5% for oral dosing in rats. In summary, the pharmacokinetic properties of LB20304 were characterized by its good oral absorption, long plasma half-life, and good tissue distribution.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.12
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• pp.61-68
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• 2010

In this paper, we investigate the performance of ARQ-aided Time Switched Transmit Diversity (ARQ-TSTD) applying the multi-level control signaling in the WCDMA LCR-TDD system. Proposed ARQ-TSTD system applies the multi-level control signaling scheme in which the receiver sends the response signal (ACK or NACK signal) to the transmitter and defines NACK2 signal for multi-level control. Transmitter utilize the NACK2 control signal to the postponement of transmission and multi-user scheduling scheme proposed by this paper. Simulation results demonstrate that the proposed postponement of transmission and multi-user scheduling scheme yield about 1.3dB, 1.4dB performance gain respectively, compared with the conventional ARQ-TSTD with antenna switching scheme in tenn of the frame error rate (FER) for mobile speed of 3km/h and FER value of 10%. In addition, 14% and 11.5% of throughput gain respectively is shown when Eb/N0=-3dB.

• Korean Journal of Social Welfare
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• v.44
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• pp.178-208
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• 2001

This study concerns the understanding of 'social exclusion' which is getting poplular in Europe as the new term or paradigm in order to resolve poverty problem. As case study on the France, the purpose of this study is to extract the consideration of welfare policy and suggestions as to us. In order to understand comprehensively the concept 'social exclusion' and the situation of the France, this study analyzes the existing researches on its concept and tries to realize a comparative study. Thus, this study indicates that the France is the state which has taken the most interest in 'social exclusion'. The second parti of this study concerns the change of the concept 'social exclusion' and its policies in the France. The concept 'social exclusion' which has used in the 1960's, has settled as the term of policies in the 1980's, thanks to seriousness of poverty and unemployment problem and change of social consciousness (opinion). As policy on the 'social exclusion', there are Revenu minimum d'insertion of the 1988 and law on the social exclusion of the 1998. Through analysis of policies on the 'social exclusion' in the France, we can get the following consideration of welfare policy and suggestions: on the macro level, the necessity to establish the comprehensive perspective on the poverty problem, invention and development of the term as regard to social new problem; on the micro lever, planning of welfare program according to clients needs, importance of perpetual assessing of the existing welfare program and institutions, the institutional establishment of 'reserve budget', the application of decentralization principle and the active participation of the private sector in order to promote the effectiveness and the efficiency of the program and institutions.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.2
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• pp.391-398
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• 2009

In this study, we introduce the design methodology of an optimized fuzzy cascade controller with the aid of hierarchical fair competition-based genetic algorithm(HFCGA) for ball & beam system. The ball & beam system consists of servo motor, beam and ball, and remains mutually connected in line in itself. The ball & beam system determines the position of ball through the control of a servo motor. The displacement change the position of ball leads to the change of the angle of the beam which determines the position angle of a servo motor. Consequently the displacement change of the position of the moving ball and its ensuing change of the angle of the beam results in the change of the position angle of a servo motor. We introduce the fuzzy cascade controller scheme which consists of the outer(1st) controller and the inner(2nd) controller as two cascaded fuzzy controllers, and auto-tune the control parameters(scaling factors) of each fuzzy controller using HFCGA. The inner controller controls the position of lever arm which corresponds to the position angle of a servo motor and the outer controller decides the set-point value of the inner controller. HFCGA is a kind of parallel genetic algorithms(PGAs), and helps alleviate the premature convergence being generated in conventional genetic algorithms (GAs). For a detailed comparative analysis from the viewpoint of the performance results and the design methodology, the proposed method for the ball & beam system which is realized by the fuzzy cascade controller based on HFCGA, is presented in comparison with the conventional PD cascade controller based on serial genetic algorithms.

• International Journal of Precision Engineering and Manufacturing
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• v.8 no.2
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• pp.70-74
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• 2007

This paper describes the development of a nano-positioning system for nanoscale science and engineering. Conventional positioning systems, which can be expensive and complicated, require the use of laser interferometers or capacitive transducers to measure nanoscale displacements of the stage. In this study, a new self-displacement sensing (SDS) nano-stage was developed using mechanical magnification of its displacement signal. The SDS nano-stage measured the displacement of its movement using a position-sensitive photodiode (PSPD), a laser source, and a hinge-connected rotating mirror plate. A beam from a laser diode was focused onto the middle of the plate with the rotating mirror. The position variation of the reflected beam from the mirror rotation was then monitored by the PSPD. Finally, the PSPD measured the amplified displacement as opposed to the actual movement of the stage via an optical lever mechanism, providing the ability to more precisely control the nanoscale stage. The displacement amplification process was modeled by structural analysis. The simulation results of the amplification ratio showed that the distance variation between the PSPD and the mirror plate as well as the length L of the mirror plate could be used as the basic design parameters for a SDS nano-stage. The PSPD was originally designed for a total travel range of 30 to 60 mm, and the SDS nano-stage amplified that range by a factor of 15 to 25. Based on these results, a SDS nano-stage was fabricated using principle of displacement amplification.

• Journal of the Korean Society of Safety
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• v.26 no.4
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• pp.41-46
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• 2011

The purpose of this paper is to analyze the causes of accidents related to the 3 phase 170 kV gas insulated switchgear of a power system collected from accident sites to secure data for the prevention of similar accidents and provide important points of view regarding diagnosis for the prevention of accidents involving gas insulated switchgears. The analysis results of the causes of accidents involving gas insulated switchgears showed deformation of the manipulation lever installed at the S-phase, disconnection of the insulation rod connection, melting of the upper conductor, a damaged tulip, damage to the lower spacer and the spacer at the breaker, etc. It is believed from this result that the potential for accidents has expanded due to accumulated energy as a result of repeated deterioration. The carbonization depth of a GIS was formed near the screw (T2, T3) used to secure the lower pole of the S-phase tulip. It is not known what has caused the screws to be extruded and melted. However, it is thought that an unbalanced electromagnetic force, micro-discharge, surface discharge, etc., have occurred at that point. In addition, even though 16 years have passed since its installation, there was no installation defect, act of arson, accidental fire, etc. General periodical inspection and diagnosis failed to find the factors causing the accidents. As a system contained in a closed metal container, it has a high risk factor. Therefore, it is necessary to design, install and operate a GIS in accordance with the standard operational procedure (SOP). In addition, it is necessary to apply conversion technology for periodical SF6 gas analysis and precision safety diagnosis. It is expected that tracking and managing these changes in characteristics by recording the results on the history card will provide a significant accident prevention effect.

• Korean Journal of Applied Biomechanics
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• v.17 no.3
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• pp.189-195
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• 2007

The purpose of this study was to analyze the effects of shoes with curved out-sole on the pressure, reaction force(sum of pressure) on foot and relations between the rolling speeds and pronation of foot. The foot pressure, reaction force and pressure center on the foot surface of shoe were measured with NOVEL padar system, and 3 type shoes were used to compare the position and speed of pressure center and the foot reaction force, which were s(target) shoe with soft cushions in middle part of out-sole and curved out-sole, m shoes with two type- soft, hard, hardness out-sole and curved out-sole and n shoes with flat out-sole. The subjects were 13 female university students, had weared the 3 type shoes for 6 weeks on two-weeks shifts for adaptation before experiment and put on 3-type shoes repeatedly and randomly and walked on treadmill with 3.5km/h and 80 steps/min. The data were captured with 30Hz and readjusted with 5kgf threshold reaction force. The results can be summarized as follow. 1. There were no difference in maximum reaction force on initial contact period and total foot impact, but statistical difference in maximum reaction force on takeoff period : s, m, n in ascending order. 2. There were some difference in rolling speeds for support periods. At initial contact, the rolling speed of s shoes was fastest but at periods between first and second maximum reaction force, that of m shoes fastest. 3. There was a negative relation between rolling speeds and the length of lever arm on initial reaction force related to pronation. It seems shoes with various curved shapes and hardness could make effects on the rolling features and the rolling speed also have some relationships with walking efficiency, absortion of impact and pronation.

• Journal of Welding and Joining
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• v.30 no.4
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• pp.31-37
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• 2012

In recent years, a demand for precision-welding is increasing in wide industrial fields for getting a high quality welded structures. Although laser welding is commonly used for precision-welding, gas tungsten arc (GTA) welding is also attempted as a precision-welding due to the cost benefit. However, welding heat causes an uneven temperature distribution leading to welding deformation. Since it causes geometric errors and degrades product quality, welding distortion recently rises as an important issue in the field of automobile parts. To control welding deformation, it is needed to design in shapes that can maximize stiffness against deformation during welding; control the welding sequence; minimize heat input; and weld allowing reverse deformation; etc. Thus it is necessary to find the one, among such approaches, that can minimize the deformation range by mathematical analysis and understand how effective it would be when it is actually used in industrial fields. This study performs analyses by numerical calculations and experiments for the De-Tent Lever, one of transmission part that requires precision the most among automobile parts, as the subject of experiment. Decrease in welding deformation is required for this part, since there is currently a trouble in guaranteeing precision due to angular deformation by welding between boss and plate. Finally the ways to minimize welding deformation has been suggested in this study through analyses on it.

• Economic and Environmental Geology
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• v.32 no.6
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• pp.669-688
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• 1999

The Yeongju granitoid batholith is a plutonic complex of huge area (1180km2) intruding the metamorphic rocks of the Yeongnam massif. The batholith, which is divided into fivelithofacies, consists of three separate plutons. The oldest Buseok pluton comprises four lithofacies: hornblende biotite tonalite, porphyrotoc biotite granodiorite, equigranular biotite grandiorite and biotite granite. The middle Chunyang pluton has been called as Chunyang granite that ranges in compostion from granodiorite to granite. The youngest Jangsu pluton is intrusions that has lithofacies of two mica granite. The contact between Buseok pluton and the rest two plutons shows obvious intrusive relations, but relation between the Chunyang and the Jangsu pluton is far away, so gives no indication of relative ages. Changes in nextures and micristructures, as well as in the mineral contents, take place between rock types og the plutons. only the Buseok pluton shows faliations of two type: magmatic foliation and regional mylonal foliation. K-Ar age deteminations fall into 171.7$\pm$3.2~162.3$\pm$3.1 Ma in the Buseok pluton, 153.9$\pm$2.9 Ma in the Chunyang pluton and 145.3$\pm$2.7 Ma in the jangsu Pluton. The batholith presents three separate intrusive phases which range in composition from tonalite to granite to granite. Each intrusive phase apperars to have been intruded in a pulse from an underlying, differentiating magma. The petrochemical data showthat three plutons are within the diagnostic range for continental arc orogenic tectonic setting, whereas Jangsu pluton approaches postorogenic setting. The data suggest that three plutons are calc-aclkalline series, and that temporal compositional variations change progerssively from tonalite through grandiorite to granite between the intrusive phases. so we consider that the magmas for all the phases were probably derived from a differentiation by fractional crystallization of a parental magma. The tonalite magma of the Buseok phase was tapped was tapped from a chamber deep in the crust, and then would have to rise at a rapid rate to its final level of emplacement. The tonalite magma in the chamber was gradually enolved through granodiorite magma into granite magma by fractional crystallization. The magmas of the younger phases were respectively tapped with temporal interval from a evolved magma of the chamber that rose into a shallower lever in the crust, and rose to their present level of emplacement.