• Journal of Animal Science and Technology
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• 제53권3호
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• pp.195-202
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• 2011

Maintenance of adequate telomere length in developing cells is the most important concern to preserve the integrity of the genome. The length of telomere is strictly regulated by numerous telomere-binding proteins and/or interacting factors. Even though the expression of telomerase in the male reproductive tract has been characterized, developmental expressional profiling of telomerase and other telomere-associated proteins has not been determined in detail. The present study was attempted to examine expression patterns of catalytic subunit (Tert) and RNA component (Terc) of telomerase and two telomerase associated factors, telomerase associated protein 1 (Tep1) and TERF1 (TRF1) interacting nuclear factor 2 (Tinf2) in the testis and seminal vesicle of male rat during postnatal development. The real-time PCR analysis was utilized to quantify mRNA expression of molecules. The abundance of Tep1 mRNA in the testis and seminal vesicle was the highest at 5 months of age. Expressional fluctuation of Tinf2 during postnatal development was found in the testis, while expression of Tinf2 in the seminal vesicle was gradually increased until 5 months of age and then significantly decreased later. mRNA level of Tert gene in the testis was significantly increased at the adult and the elder, while the highest expression of Tert gene in the seminal vesicle was found at 5 months of age. Expression of Terc transcript in the testis and seminal vesicle was the highest at 5 months of age, followed by significant reduction at 1 and 2 years of ages. Such differential gene expression of telomere-associated factors and telomerase components in different male reproductive tissues during postnatal development indicates that maintenance of telomere length would be regulated in tissue- and/or age-specific manners.

• 가정간호학회지
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• 제6권
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• pp.5-18
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• 1999

This study was attempt to encourage for developing on rehabilitation delivery system and programs as a substitute service instead of hospitalization for accident patients at work, such as hospital based home health care nursing service. It needs vary substitutes service of hospitalization to curtail the length of stay for inpatients who were hospitalized with workers compensation insurance. It focused on developing an estimation of early discharge day of accident inpatients based on a detail statement of treatment for 115 inpatients who were hospitalized at General Hospital in 1997. This study has four specific purpose as follows. First, to find out the status of health service utilization. Second, to estimate the early discharge days and income increasing effect based on the early discharge for those patients. Third, to identify the factors to affect total medical expenditure and the length of stay for those inpatients. Forth, to figure out the need of utilizing home health care nursing service for accident patients. In order to analyze of the length of stay and medical expenditure for inpatients who were hospitalized due to the accident, the authors conducted with micro-analysis and macroanalysis from medical records and medical expenditure records. Micro-analysis was done by nominal group discussion of 4 expertise with the critical criteria. such as a decrease in the amount of treatment after surgery, treatments, tests, drugs and changes in the tests consistency, drug methods, vital signs, start of ROM exercise, doctor's order, patient's outside visiting ability, stable conditions. In addition to identify affected variables for medical expenditure. the length of stay and income effect due to early discharge day, the data was analyzed with multiple regression analysis and linear regression analysis model by SPSS-PC for windows and Excell program. Results of this study as follows. First, the mean length of stay was 37.1 days, whereas the mean length of stay due to early discharge was 28.2 days at the hospital. The estimation of early discharge days were shown that depends on the length of stay. The longer length of stay, the longer length of early discharge days, such as under 7 days length of stay patients was to estimated the mean length of stay was 4.9 days and early discharge days was 4.6. whereas the mean length of stay was 122.6 days and early discharge days was 92.0 respectively. The mean medical expenditure per day were found to be 133.409 Won. whereas the mean medical expenditure per day was shown negative linear trends according to the length of stay at the hospital. The estimation results of the income effect due to 11 early discharge days per bed was around 2,150,000 won. However, it means not the real benefits from early discharge, but the income increasing amount without considering medical prime cost in general hospital. Therefore, it needs further analysis on the cost containments and benefits under the considering as well turn over rates per bed as the medical prime costs. The length of stay was most significant and the sign was positive to the total medical expenditure, as expected. Surgery and patient's residential area also an important variable in explaining medical expenditure. The level of complications was most significant variable in explaining the length of stay. The level of the needs on horne health care nursing service which can be used for early discharge accident patients were shown very high. The needs distribution varied from 65.5% of patients and 88.9% of caregivers, to 96.4% of doctors, and 99.1% of nurses. In addition horne health nurse responded that they can be managed the accident inpatients from early discharge. From these research findings. the following suggestions has been drawn it needs to develop strategies on rehabilitation delivery system in order to focused on consumer's side which is planned for 21 century health policy in Korea. Vary intermediate facilities and horne health care would have been developed in the community based for comprehensive rehabilitation services as a substitutes of hospitalization for shortening the length of stay of hospitalizations. In hospital based horne health care nursing service, it's available immediately to utilize for the patients who wanted rehabilitation services as a substitutes of hospitalization under the cooperations with workers compensation insurance company.

• Structural Engineering and Mechanics
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• 제50권3호
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• pp.287-304
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• 2014

A computer based iterative numerical procedure has been developed to analyse reinforced high strength concrete columns subjected to horizontal wave loads and eccentric vertical load by taking the material, geometrical and wave load non-linearity into account. The behaviour of the column has been assumed, to be represented by Moment-Thrust-Curvature relationship of the column cross-section. The formulated computer program predicts horizontal load versus deflection behaviour of a column up to failure. The developed numerical model has been applied to analyse several column specimens of various slenderness, structural properties and axial load ratios, tested by other researchers. The predicted values are having a better agreement with experimental results. A simplified user friendly hydrodynamic load model has been developed based on Morison equation supplemented with a wave slap term to predict the high frequency non-linear impulsive hydrodynamic loads arising from steep waves, known as ringing loads. A computer program has been formulated based on the model to obtain the wave loads and non-dimensional wave load coefficients for all discretised nodes, along the length of column from instantaneous free water surface to bottom of the column at mud level. The columns of same size and material properties but having different slenderness ratio are analysed by the developed numerical procedure for the simulated wave loads under various vertical thrust. This paper discusses the results obtained in detail and effect of slenderness in resisting wave loads under various vertical thrust.

• 한국철도학회논문집
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• 제5권3호
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• pp.148-157
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• 2002

A health monitoring system becomes a useful tool to obtain information on long term behavior of the important railway structures such as very long span and special type bridges. The health monitoring system not only gives the direct measurement data of the railway bridges but also provides the basic data on the maintenance of the structures. Therefore, periodic calibrations of the health monitoring system will be a necessary step toward precise and accurate assessment of the railway bridges. In this study, the calibration and gauge factor readjustment process made for the health monitoring system installed in the railroad bridges is reviewed and some findings are explained in detail: specifically, the calibrators made for this purpose are illustrated and the regression processes of the calibration on long-term displacement using water level sensor, longitudinal displacement using LVDT sensor, instantaneous displacement using LVDT sensors and accelerometer are described in full length. Based on the regression results, it was found that the gauge factors need to be readjusted according to the regression equation but, since the deviation or shift is not serious so far, long-term observation on each sensor is also recommended. Future work will be concentrated on the long-term analysis of each sensor and on the database creation so that the assessment of the structures is possible.

• 한국ITS학회 논문지
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• 제13권5호
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• pp.1-10
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• 2014

본 연구는 미시적 교통류 시뮬레이션 모형을 이용하여 양방향 좌회전차로의 설치기준과 관련된 두 개의 주요한 파라미터를 분석하고 평가하는데 초점을 맞추고 있다. 첫째는 통상적으로 평균 일교통량(ADT)에 기반을 두고 산정되지만 최근 우리나라 도로교통량의 시간변화 특성을 반영한 설계시간 교통량(DHV)의 범위에 대한 분석이며, 다른 하나는 양방향 좌회전차로 내의 구간으로써 양방향 좌회전 수요가 공간점유를 위해 서로 경쟁하면서 상충이 유발되는 부분인 접근로 간격에 관한 것이다. 이에 더해 VISSIM S/W에 VISVAP과 같은 추가 기능 프로그램을 사용하여 TWLTL의 작동을 구현하는 구체적 방법과 절차에 대해 선행 연구들과는 달리 충실히 설명하고자 하였다. 10개의 교통량 수준 시나리오로 수행한 모의실험 결과에 따르면 통과 교통량이 많을수록 좌회전 차량이 경험하는 지체는 예상대로 견조히 증가하였다. 시나리오 대부분에 대한 지체 값이 비신호교차로 서비스수준을 기준으로 LOS C와 D의 범위에 있는 것으로 나타났으며, 교통량 수준 7(중방향으로 3차로 시설 경우 1,116대/시, 5차로 시설은 1,860대/시)까지 양방향 좌회전 차로가 운영가능하다는 것을 알 수 있었다. 이 범위의 교통량은 우리나라 2차로 및 4차로도로 교통량의 상당 부분을 포함하는 것으로 향후 양방향 좌회전차로의 도입 가능성을 한 층 높이는 것이라고 판단하고 있다.

• Earthquakes and Structures
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• 제10권2호
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• pp.367-388
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• 2016

Eccentrically braced frames (EBFs) represent an attractive lateral load resisting steel system to be used in areas of high seismicity. In order to assess the likely damage for a given intensity of ground shaking, fragility functions can be used to identify the probability of exceeding a certain damage limit-state, given a certain response of a structure. This paper focuses on developing a set of fragility functions for EBF structures, considering that damage can be directly linked to the interstorey drift demand at each storey. This is done by performing a Monte Carlo Simulation of an analytical expression for the drift capacity of an EBF, where each term of the expression relies on either experimental testing results or mechanics-based reasoning. The analysis provides a set of fragility functions that can be used for three damage limit-states: concrete slab repair, damage requiring heat straightening of the link and damage requiring link replacement. Depending on the level of detail known about the EBF structure, in terms of its link section size, link length and storey number within a structure, the resulting fragility function can be refined and its associated dispersion reduced. This is done by using an analytical expression to estimate the median value of interstorey drift, which can be used in conjunction with an informed assumption of dispersion, or alternatively by using a MATLAB based tool that calculates the median and dispersion for each damage limit-state for a given set of user specified inputs about the EBF. However, a set of general fragility functions is also provided to enable quick assessment of the seismic performance of EBF structures at a regional scale.

• 산업경영시스템학회지
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• 제39권2호
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• pp.72-81
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• 2016

There can be included a variety of uncertainties in all measurement results whether we can perceive or not on the causes. These uncertainties may end up in lowering the reliability of measurement results and also deteriorate the level of quality. For the purpose, we tried to combine the strengths of measurement uncertainty and measurement system analysis together to present a practical flowchart so as to verify those potential variation factors in general measurement processes. As a case study, we did an experiment and gathered data on the length between two holes of an engine cylinder head which is a core part for vehicles with a coordinate measuring machine and estimated nine uncertainty factors of it. Consequently, it was identified that the four primary factors among the nine which were related to the measurement standard, random errors or spread of the repeat measurements, differences between the coefficients of thermal expansion and the environment especially had been the influence around the laboratory. Since it is impossible to analyze the equipment and appraisal variations respectively through the only measurement uncertainty, we have used the measurement system analysis following the flowchart. Showing the result of being just about 0.5% lower for the appraisal variation, and the equipment variation occupied about 7% for the total Gage R&R. Through this research, we have come to a conclusion that much more detail analysis on variation factors can be possible to be identified in measurement processes by using the developed flowchart which is composed of measurement uncertainty and measurement system analysis. Therefore, we expect engineers who are involved in quality and measurements to utilize this developed method.

• 조명전기설비학회논문지
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• 제20권10호
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• pp.82-93
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• 2006

본 논문에서는 인버터 구동 고압유도전동기 운전시 스위칭 서지로 인하여 고압유도 전동기 단자에서 발생하는 과도과전압을 저감하기 위한 필터로 인버터 출력단자에서 dv/dt를 저감하는 LCR 필터와 전동기 입력단자에서 케이블과 유도전동기 특성임피던스를 매칭시키는 RC필터에 대한 과도과전압 저감특성을 분석하였다. 이 필터를 고압에 대용량 유도전동기에 적합하도록 EMTP(ElectroMagnetic Transients Program)를 이용하여 모델링 및 케이블 영향에 의한 필터의 과도과전압 저감효과를 전압파형과 고조파 스펙트럼으로 비교분석하고, 이를 토대로 고압 대용량 유도전동기에 사용될 필터를 제시하였다. 인버터 스위칭 서지에 의한 과도과전압은 유도전동기 고정자 권선에 심각한 전압 스트레스를 발생시켜 절연파괴를 일으키는 주요원인이 된다. 이러한 과도과전압을 저감위한 필터설계는 고압유도전동기 시스템에서 필수적인 요소임을 보였다. 또한 제시된 필터는 과도과전압을 효과적으로 저감시키는 것을 EMTP 시뮬레이션을 통하여 입증하였다.

• 한국해안해양공학회지
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• 제16권4
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• pp.213-223
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• 2004

마산만 연안유역의 지하수 유출량을 Darcy 방법을 이용하여 추정하였다. 지하수위, 관정의 위치, 투수계수, 대수층 두께, 해안선 길이 정보를 이용하여 추정한 지하수 유출량은 강우량 대비 1.65%정도이다. 마산만 유역의 암반층을 통한 지하수 유출량은 $0.7\times10^4$ $m^2/year$정도로 추정되었으며, 충적층을 통한 지하수 유출량은 $1.0\times10^7$$m^3/year$정도로 추정되어 암반층을 통한 유출량은 무시할 만한 정도로 파악되었다. 한편, 한국해양연구원(2003)에서 방사성 동위원소를 이용하여 추정한 지하수 유출량은 본 연구에서 추정한 지하수 유출량의 20배 정도에 해당하지만, 이는 연안 대수층으로 침입한 재순환 해수의 영향으로 파악되었으며, 해안선에 근접한 관측정의 운영을 통하여 지하수위 및 염도 변화를 지속적으로 관측하여 재순환해수의 정량적인 영향분석을 보다 상세하게 연구할 필요가 있는 것으로 판단된다.

• 한국발생생물학회지:발생과생식
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• 제7권1호
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• pp.35-40
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• 2003

성선자극호르몬 분비호르몬은 시상하부에서 분비되며, 포유동물의 생식에 중추적인 역할을 담당한다. 골든 햄스터는 계절적으로 번식하는 포유동물이며, 생식 활동은 광주기(하루 중 낮의 길이)에 의해 결정된다. 장주기(12.5 시간 이상의 빛)는 생식 능력을 유지시키지만, 단주기(12시간 이하의 빛)는 생식 기능을 억제한다. 성선자극호르몬 분비호르몬과 광주기의 상호 관계를 자세히 조사하기 위하여 랫트 성선자극호르몬 분비호르몬 cDNA를 포함하는 벡터를 여러 농도로 골든 햄스터의 수컷에 주입하고 단주기에 유지하여 생식 활동을 개별적으로 조사하였다. 벡터를 고농도로 처리한 그룹의 골든 햄스터는 기타 실험 그룹에 비해 정소 퇴화가 의미있게(P<0.05) 가속되었다. GnRH의 맥동적 분비가 생식 능력을 유지하는 관점에서 보면, GnRH-cDNA를 포함하는 벡터는 GnRH를 일정하게 고농도로 분비했다고 사료된다. 이 결과는 GnRH를 포함하는 벡터가 뇌하수체 전엽을 desensitization시켜 정소 퇴화를 가속시켰음을 암시한다.