• Journal of Animal Science and Technology
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• v.53 no.3
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• pp.195-202
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• 2011

Maintenance of adequate telomere length in developing cells is the most important concern to preserve the integrity of the genome. The length of telomere is strictly regulated by numerous telomere-binding proteins and/or interacting factors. Even though the expression of telomerase in the male reproductive tract has been characterized, developmental expressional profiling of telomerase and other telomere-associated proteins has not been determined in detail. The present study was attempted to examine expression patterns of catalytic subunit (Tert) and RNA component (Terc) of telomerase and two telomerase associated factors, telomerase associated protein 1 (Tep1) and TERF1 (TRF1) interacting nuclear factor 2 (Tinf2) in the testis and seminal vesicle of male rat during postnatal development. The real-time PCR analysis was utilized to quantify mRNA expression of molecules. The abundance of Tep1 mRNA in the testis and seminal vesicle was the highest at 5 months of age. Expressional fluctuation of Tinf2 during postnatal development was found in the testis, while expression of Tinf2 in the seminal vesicle was gradually increased until 5 months of age and then significantly decreased later. mRNA level of Tert gene in the testis was significantly increased at the adult and the elder, while the highest expression of Tert gene in the seminal vesicle was found at 5 months of age. Expression of Terc transcript in the testis and seminal vesicle was the highest at 5 months of age, followed by significant reduction at 1 and 2 years of ages. Such differential gene expression of telomere-associated factors and telomerase components in different male reproductive tissues during postnatal development indicates that maintenance of telomere length would be regulated in tissue- and/or age-specific manners.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.6
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• pp.5-18
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• 1999

This study was attempt to encourage for developing on rehabilitation delivery system and programs as a substitute service instead of hospitalization for accident patients at work, such as hospital based home health care nursing service. It needs vary substitutes service of hospitalization to curtail the length of stay for inpatients who were hospitalized with workers compensation insurance. It focused on developing an estimation of early discharge day of accident inpatients based on a detail statement of treatment for 115 inpatients who were hospitalized at General Hospital in 1997. This study has four specific purpose as follows. First, to find out the status of health service utilization. Second, to estimate the early discharge days and income increasing effect based on the early discharge for those patients. Third, to identify the factors to affect total medical expenditure and the length of stay for those inpatients. Forth, to figure out the need of utilizing home health care nursing service for accident patients. In order to analyze of the length of stay and medical expenditure for inpatients who were hospitalized due to the accident, the authors conducted with micro-analysis and macroanalysis from medical records and medical expenditure records. Micro-analysis was done by nominal group discussion of 4 expertise with the critical criteria. such as a decrease in the amount of treatment after surgery, treatments, tests, drugs and changes in the tests consistency, drug methods, vital signs, start of ROM exercise, doctor's order, patient's outside visiting ability, stable conditions. In addition to identify affected variables for medical expenditure. the length of stay and income effect due to early discharge day, the data was analyzed with multiple regression analysis and linear regression analysis model by SPSS-PC for windows and Excell program. Results of this study as follows. First, the mean length of stay was 37.1 days, whereas the mean length of stay due to early discharge was 28.2 days at the hospital. The estimation of early discharge days were shown that depends on the length of stay. The longer length of stay, the longer length of early discharge days, such as under 7 days length of stay patients was to estimated the mean length of stay was 4.9 days and early discharge days was 4.6. whereas the mean length of stay was 122.6 days and early discharge days was 92.0 respectively. The mean medical expenditure per day were found to be 133.409 Won. whereas the mean medical expenditure per day was shown negative linear trends according to the length of stay at the hospital. The estimation results of the income effect due to 11 early discharge days per bed was around 2,150,000 won. However, it means not the real benefits from early discharge, but the income increasing amount without considering medical prime cost in general hospital. Therefore, it needs further analysis on the cost containments and benefits under the considering as well turn over rates per bed as the medical prime costs. The length of stay was most significant and the sign was positive to the total medical expenditure, as expected. Surgery and patient's residential area also an important variable in explaining medical expenditure. The level of complications was most significant variable in explaining the length of stay. The level of the needs on horne health care nursing service which can be used for early discharge accident patients were shown very high. The needs distribution varied from 65.5% of patients and 88.9% of caregivers, to 96.4% of doctors, and 99.1% of nurses. In addition horne health nurse responded that they can be managed the accident inpatients from early discharge. From these research findings. the following suggestions has been drawn it needs to develop strategies on rehabilitation delivery system in order to focused on consumer's side which is planned for 21 century health policy in Korea. Vary intermediate facilities and horne health care would have been developed in the community based for comprehensive rehabilitation services as a substitutes of hospitalization for shortening the length of stay of hospitalizations. In hospital based horne health care nursing service, it's available immediately to utilize for the patients who wanted rehabilitation services as a substitutes of hospitalization under the cooperations with workers compensation insurance company.

• Structural Engineering and Mechanics
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• v.50 no.3
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• pp.287-304
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• 2014

A computer based iterative numerical procedure has been developed to analyse reinforced high strength concrete columns subjected to horizontal wave loads and eccentric vertical load by taking the material, geometrical and wave load non-linearity into account. The behaviour of the column has been assumed, to be represented by Moment-Thrust-Curvature relationship of the column cross-section. The formulated computer program predicts horizontal load versus deflection behaviour of a column up to failure. The developed numerical model has been applied to analyse several column specimens of various slenderness, structural properties and axial load ratios, tested by other researchers. The predicted values are having a better agreement with experimental results. A simplified user friendly hydrodynamic load model has been developed based on Morison equation supplemented with a wave slap term to predict the high frequency non-linear impulsive hydrodynamic loads arising from steep waves, known as ringing loads. A computer program has been formulated based on the model to obtain the wave loads and non-dimensional wave load coefficients for all discretised nodes, along the length of column from instantaneous free water surface to bottom of the column at mud level. The columns of same size and material properties but having different slenderness ratio are analysed by the developed numerical procedure for the simulated wave loads under various vertical thrust. This paper discusses the results obtained in detail and effect of slenderness in resisting wave loads under various vertical thrust.

• Journal of the Korean Society for Railway
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• v.5 no.3
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• pp.148-157
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• 2002

A health monitoring system becomes a useful tool to obtain information on long term behavior of the important railway structures such as very long span and special type bridges. The health monitoring system not only gives the direct measurement data of the railway bridges but also provides the basic data on the maintenance of the structures. Therefore, periodic calibrations of the health monitoring system will be a necessary step toward precise and accurate assessment of the railway bridges. In this study, the calibration and gauge factor readjustment process made for the health monitoring system installed in the railroad bridges is reviewed and some findings are explained in detail: specifically, the calibrators made for this purpose are illustrated and the regression processes of the calibration on long-term displacement using water level sensor, longitudinal displacement using LVDT sensor, instantaneous displacement using LVDT sensors and accelerometer are described in full length. Based on the regression results, it was found that the gauge factors need to be readjusted according to the regression equation but, since the deviation or shift is not serious so far, long-term observation on each sensor is also recommended. Future work will be concentrated on the long-term analysis of each sensor and on the database creation so that the assessment of the structures is possible.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.13 no.5
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• pp.1-10
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• 2014

This research focuses on the warrants for the Two-Way Left-Turn Lanes (TWLTL). Using a microscopic traffic simulation tool, two key parameters were investigated herewith. One is a wide range of the Design Hourly Volume (DHV), reflective of recent Korean roadway volume characteristics, that is conventionally reduced from the Average Daily Traffic (ADT). The other is driveway spacing, the length of the middle-lane section where two conflicting left-turn demands often compete for space. In addition, unlike previous researches, the way and the procedure the TWLTL operation is realized in the VISSIM S/W with its add-on application such as VISVAP is clearly stated and described in detail. According to the result of simulations for 10 volume scenarios, as expected, the higher the volume level is, the more delay the left-tuner experience. The Level Of Service (LOS) for most cases was in the range of C and D based on the non-signalized intersection LOS criteria. Furthermore, the TWLTL was found operable up to the volume level of 1,116 and 1,860 vph in heavy direction (equivalent of volume level 7) for 3-lane and 5-lane facility respectively, which covers significant portion of existing two to four-lane highway volumes in Korea.

• Earthquakes and Structures
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• v.10 no.2
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• pp.367-388
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• 2016

Eccentrically braced frames (EBFs) represent an attractive lateral load resisting steel system to be used in areas of high seismicity. In order to assess the likely damage for a given intensity of ground shaking, fragility functions can be used to identify the probability of exceeding a certain damage limit-state, given a certain response of a structure. This paper focuses on developing a set of fragility functions for EBF structures, considering that damage can be directly linked to the interstorey drift demand at each storey. This is done by performing a Monte Carlo Simulation of an analytical expression for the drift capacity of an EBF, where each term of the expression relies on either experimental testing results or mechanics-based reasoning. The analysis provides a set of fragility functions that can be used for three damage limit-states: concrete slab repair, damage requiring heat straightening of the link and damage requiring link replacement. Depending on the level of detail known about the EBF structure, in terms of its link section size, link length and storey number within a structure, the resulting fragility function can be refined and its associated dispersion reduced. This is done by using an analytical expression to estimate the median value of interstorey drift, which can be used in conjunction with an informed assumption of dispersion, or alternatively by using a MATLAB based tool that calculates the median and dispersion for each damage limit-state for a given set of user specified inputs about the EBF. However, a set of general fragility functions is also provided to enable quick assessment of the seismic performance of EBF structures at a regional scale.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.2
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• pp.72-81
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• 2016

There can be included a variety of uncertainties in all measurement results whether we can perceive or not on the causes. These uncertainties may end up in lowering the reliability of measurement results and also deteriorate the level of quality. For the purpose, we tried to combine the strengths of measurement uncertainty and measurement system analysis together to present a practical flowchart so as to verify those potential variation factors in general measurement processes. As a case study, we did an experiment and gathered data on the length between two holes of an engine cylinder head which is a core part for vehicles with a coordinate measuring machine and estimated nine uncertainty factors of it. Consequently, it was identified that the four primary factors among the nine which were related to the measurement standard, random errors or spread of the repeat measurements, differences between the coefficients of thermal expansion and the environment especially had been the influence around the laboratory. Since it is impossible to analyze the equipment and appraisal variations respectively through the only measurement uncertainty, we have used the measurement system analysis following the flowchart. Showing the result of being just about 0.5% lower for the appraisal variation, and the equipment variation occupied about 7% for the total Gage R&R. Through this research, we have come to a conclusion that much more detail analysis on variation factors can be possible to be identified in measurement processes by using the developed flowchart which is composed of measurement uncertainty and measurement system analysis. Therefore, we expect engineers who are involved in quality and measurements to utilize this developed method.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.20 no.10
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• pp.82-93
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• 2006

In this paper, filters are designed to reduce transients overvoltage in inverter fed high-voltage large-capacity induction motor drive system. Design issues for a LCR filter at the inverter output terminals to reduce the dv/dt of the inverter output pulse and a RC filter at the induction motor input terminals to match the characteristic impedance between cable and induction motor are examined in detail. These filters are modeled to be suitable to high-voltage large-capacity induction motor. The performance of the filter is evaluated through simulation using EMTP(ElectroMagnetic Transients Program). We presented filters that used high voltage large-capacity induction Motor on the basis of this. Effect of the filter is analyzed for variation of the cable length. Characteristics of filters are analyzed to reduce harmonic in voltage waveform of induction motor input terminal. The switching surge voltage became the major cause to occur the insulation failure by serious voltage stress in the stator winding of induction motor. Filter for to mitigate transients overvoltage presents a required component in drive system of high-voltage large-capacity induction motor. Also, proposed filters are proved through simulation using EMTP.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.16 no.4
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• pp.213-223
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• 2004

The discharges of groundwater flow were estimated using Darcy's method along the coastal zone in the Masan Bay. The estimates using the information, i.e., groundwater level, location of the observation well, hydraulic conductivity, the thickness of the aquifer, and coastline length, were 1.65% of the precipitation of the watershed. The estimated groundwater discharges through fractured rock aquifer and the aquifer with sedimentary material were $0.7\times10^4$$m^2/year$and $1.0\times10^7$$m^3/year$ respectively. Whereas, the discharge estimated by KORDI (2003) using isotopes method is about 20 times larger than the estimates from this study because of the influence of the re-circulated seawater through the coastal zone aquifer. In order to quantify this effect in detail, the groundwater levels and salinity changes in the observation wells located in the coastal zone should be continuously monitored and analyzed.

• Development and Reproduction
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• v.7 no.1
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• pp.35-40
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• 2003

Gonadotropin releasing hormone(GnRH), which is secreted from the hypothalamus, has a pivotal role in the reproduction of mammals. Golden hamsters are seasonal breeding mammal and their sexual activity is determined by photoperiod(length of light per day). Long photoperiod(LP, $\leq$ 12.5 hours of light) maintains the reproductive activity and short photoperiod(SP, $\leq$ 12 hours of light) suppresses it. In order to investigate in detail, the sexual activity was individually examined in SP-housed male golden hamsters received a vector at three different concentrations which contains rat GnRH cDNA. The gonadal regression was significantly(P<0.05) accelerated by the highest concentrations of the vector at 8 and 10 weeks after the treatment in comparison to the other groups. In the light of pulsatile release of GnRH in maintaining reproductive activity, the vector containing GnRH cDNA might secrete the GnRH in a constant high level. These results suggest that the GnRH-containing vector might desensitize the anterior pituitary, leading to acceleration or testicular regression.