• Nuclear Engineering and Technology
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• v.54 no.4
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• pp.1516-1525
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• 2022

Interfacing the output of severe accident analysis with the input of radiological consequence analysis is an important and mandatory procedure at the beginning of Level 3 PSA. Such interfacing between the severe accident analysis code MELCOR and MACCS, one of the most commonly used consequence analysis codes, is relatively tractable since they share the same chemical groups, and the related interfacing software, MelMACCS, has already been developed. However, the linking between MAAP, another frequently used code for severe accident analyses, and MACCS has difficulties because MAAP employs a different chemical grouping method than MACCS historically did. More specifically, MAAP groups by chemical compound, while MACCS groups by chemical element. An appropriate interfacing method between MAAP and MACCS has therefore long been requested by users. This study suggests a way of extracting relevant information from MAAP results and providing proper source term information to MACCS by an appropriate treatment. Various parameters are covered in terms of magnitude and manner of release in this study, and special treatment is made for a bypass scenario. It is expected that the suggested approach will provide an important contribution as a guide to interface MAAP and MACCS when performing radiological consequence analyses.

• Journal of the Korean Society of Safety
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• v.39 no.1
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• pp.96-103
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• 2024

The demand for mass calculation of offsite consequence analysis to conduct exhaustive single-unit or multi-unit Level 3 PSA is increasing. In order to perform efficient offsite consequence analyses, the Korea Atomic Energy Research Institute is conducting model optimization studies to minimize the analysis time while maintaining the accuracy of the results. A previous study developed a model optimization method using efficient plume segmentation and verified its effectiveness. In this study, we investigated the possibility of optimizing the model through particle size distribution setting by checking the reduction in analysis time and deviation of the results. Our findings indicate that particle size distribution setting affects the results, but its effect on analysis time is insignificant. Therefore, it is advantageous to set the particle size distribution as fine as possible. Furthermore, we evaluated the effect of multithreading and confirmed its efficiency. Future optimization studies should be conducted on various input factors of offsite consequence analysis, such as spatial grid settings.

• Analytical Science and Technology
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• v.29 no.2
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• pp.65-72
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• 2016

This study presented an analytical method for detecting radium in soils using a liquid scintillation counter (LSC). The isotope ²²⁶Ra was extracted from soil using the fusion method and then separated from interfering radionuclides using the precipitation method. Radium was coprecipitated as sulfate salts with barium (Ba) and then converted into Ba(Ra)CO₃, which is soluble in an acidic solution. The isotope ²²²Rn, the decay progeny of ²²⁶Ra, was trapped in a water immiscible cocktail and analyzed by LSC. The pulse shape analysis (PSA) level was estimated using ⁹⁰Sr and ²²⁶Ra standard solutions. The figure of merit was the highest at PSA 80, while the alpha spillover was the lowest at PSA 80. The counting efficiency was 243 ± 2% in a glass vial. This analytical method was verified with International Atomic Energy Agency (IAEA) reference materials, including IAEA-312, IAEA-314, and IAEA-315. The recovery ranged from 60–82%, while the relative bias between the measured value and the recommended value was less than 10%. The minimum detectable activity was 2.1 Bq kg⁻¹ with dry mass 1 g, the background count rate of 0.02 cpm, the recovery rate of 70% and counting time of 30 min.

• Analytical Science and Technology
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• v.12 no.5
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• pp.428-435
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• 1999

A method for measuring Rn-222 and Ra-226 in aqueous sample using liquid scintillation counting technique has been studied. The Rn-222 was extracted easily from the water sample (10 mL) by 12 mL of xylene based organic scintillant. After radioactive equilibrium between Rn-222 and its alpha emitting decay products for three hours, the alpha activity from Rn-222 and its decay products were measured in a scintillation vial using the Wallae $1220^{TM}$ Quantulus liquid scintillation counter. Ra-226 concentration in aqueous sample was determined, after isolation of Ra-226 from the sample matrix, by extraction the ingrowth of the Rn-222 and its alpha emitting decay products with xylene based organic scintillant. The optimum pulse-shape analysis (PSA) value was evaluated by the figure of merit (FM) criterion. Minimum detectable activity (MDA) is about 0.14 Bq/L (3.78 pCi) for the region of Rn-222 and its alpha emitting decay products and 0.06 Bq/L (1.63 pCi) for the region of Po-214 respectively, with 200 min, counting time at PSA level 100 in the low-diffusion polyethylene vial and xylene based cocktail solution. Experiment on the optimum sample-cocktail volume ratio, the influence of agitation and the diffusion of radon from vial were carried out.

• Nuclear Engineering and Technology
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• v.53 no.10
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• pp.3298-3313
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• 2021

The objective of this study is to estimate the occurrence probabilities of severe accident phenomena based on a fuzzy elicitation technique. Normally, it is difficult to determine these probabilities due to the lack of information on severe accident progression and the highly uncertain values currently in use. In this case, fuzzy set theory (FST) can be best exploited. First, questions were devised for expert elicitation on technical issues of severe accident phenomena. To deal with ambiguities and the imprecision of previously developed (reference) probabilities, fuzzy aggregation methods based on FST were employed to derive the occurrence probabilities of severe accidents via four phases: 1) choosing experts, 2) quantifying weighting factors for the experts, 3) aggregating the experts' opinions, and 4) defuzzifying the fuzzy numbers. In this way, this study obtained expert elicitation results in the form of updated occurrence probabilities of severe accident phenomena in the OPR-1000 plant, after which the differences between the reference probabilities and the newly acquired probabilities using fuzzy aggregation were compared, with the advantages of the fuzzy technique over other approaches explained. Lastly, the impact of applying the updated severe accident probabilities on containment integrity was quantitatively investigated in a Level 2 PSA model.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.14 no.2
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• pp.49-58
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• 2018

The regulatory periodic inspection program (PSI) conducted at every overhaul period is the most important process for confirming the safety of nuclear power plants. The PSI for operating nuclear power plants in Korea mainly consist of component level performance check that had been developed based on deterministic approach putting the same degree of importance to all the inspection items. This inspection methodology is likely to be effective for preoperational inspection. However, once the plant is put into service, the PSI must be focused on whether to minimize the risk of accident using defense-in-depth concept and risk insight. The incorporation of defense-in-depth concept and risk insight into the deterministic based safety inspection has not been well studied so far. In this study, two track approaches are proposed to make sure that core damage be avoided: one is to secure success path and the other to block the failure path in a specific event tree of PSA. The investigation shows how to select safety important components and how to set up inspection group to ensure that core damage would not occur for a given initiating event, which results in strengthening defense-in-depth level 3.

• IMMUNE NETWORK
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• v.1 no.3
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• pp.260-265
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• 2001

Transforming growth $factor-{\beta}1$ ($TGF-{\beta}1$) is a multipotent growth factor affecting development, homeostasis and tissue repair. Many kinds of malignant tissues were reported to overexpress transforming growth $factor-{\beta}1$ ($TGF-{\beta}1$) gene. However, a little work has been done on the circulating $TGF-{\beta}1$ and the association of $TGF-{\beta}1$ with progression in patients with malignant tumors. In this study, we measured the plasma level of $TGF-{\beta}1$ in gastric cancer and prostate cancer patients and evaluated the utility of plasma $TGF-{\beta}1$ as a possible tumor marker. We used Enzyme-linked immunosorbent assay (ELISA) system in order to measure plasma $TGF-{\beta}1$ level in 134 gastric cancer patients, 50 prostate cancer patients and 290 normal controls. And the tumor marker, carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), was compared with $TGF-{\beta}1$ in the aspects of sensitivity and specificity. The mean plasma $TGF-{\beta}1$ levels were $1.219{\pm}0.834$ (0.272-5.772) ng/mL in normal controls, $5.964{\pm}3.218$ (0.845-18.124) ng/mL in gastric cancer and $4.140{\pm}2.345$ (1.108-13.302) ng/mL in prostate cancer. In gastric cancer patients difference in plasma $TGF-{\beta}1$ level was not detected according to cancer stage. In comparison with other tumor marker (CEA, PSA) $TGF-{\beta}1$ is more potent in sensitivity. These results indicate that the plasma $TGF-{\beta}1$ level can be a potent tumor marker in gastric cancer and prostate cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8699-8703
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• 2014

18-fluoro-2-deoxyglucose positron emission tomography-computed tomography ($^{18}F$-FDG PET/CT) scans are commonly used for the staging and restaging of various malignancies, such as head and neck, breast, colorectal and gynecological cancers. However, the value of FDG PET/CT for detecting prostate cancer is unknown. The aim of this study was to evaluate the clinical value of incidental prostate $^{18}F$-FDG uptake on PET/CT scans. We reviewed $^{18}F$-FDG PET/CT scan reports from September 2009 to September 2013, and selected cases that reported focal/diffuse FDG uptake in the prostate. We analyzed the correlation between $^{18}F$-FDG PET/CT scan findings and data collected during evaluations such as serum prostate-specific antigen (PSA) levels, digital rectal examination (DRE), transrectal ultrasound (TRUS), and/or biopsy to confirm prostate cancer. Of a total of 18,393 cases, 106 (0.6%) exhibited abnormal hypermetabolism in the prostate. Additional evaluations were performed in 66 patients. Serum PSA levels were not significantly correlated with maximum standardized uptake values (SUVmax) in all patients (rho 0.483, p=0.132). Prostate biopsies were performed in 15 patients, and prostate cancer was confirmed in 11. The median serum PSA level was 4.8 (0.55-7.06) ng/mL and 127.4 (1.06-495) ng/mL in the benign and prostate cancer groups, respectively. The median SUVmax was higher in the prostate cancer group (mean 10.1, range 3.8-24.5) than in the benign group (mean 4.3, range 3.1-8.8), but the difference was not statistically significant (p=0.078). There was no significant correlation between SUVmax and serum PSA, prostatic volume, or Gleason score. $^{18}F$-FDG PET/CT scans did not reliably differentiate malignant or benign from abnormal uptake lesions in the prostate, and routine prostate biopsy was not usually recommended in patients with abnormal FDG uptake. Nevertheless, patients with incidental prostate uptake on $^{18}F$-FDG PET/CT scans should not be ignored and should be undergo further clinical evaluations, such as PSA and DRE.

• Food Science and Biotechnology
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• v.16 no.3
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• pp.457-462
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• 2007

Histone acetyltransferase (HAT) is a family of enzymes that regulate histone acetylation. Dysfunction of HAT plays a critical role in the development of cancer. Here we have screened the various plant extracts to find out the potent HAT inhibitors. The bellflower (Platycodon grandiflorum) root have exhibited approximately 30% of the inhibitory effects on HAT activity, especially p300 and CBP (CREB-binding protein) at the concentration of $100\;{\mu}g/mL$. The cell viability was decreased approximately 52% in LNCaP cell for 48 hr incubation. Furthermore, mRNA level of 3 androgen receptor target genes, PSA, NKX3.1, and TSC22 were decreased with bellflower root extract treatment ($100\;{\mu}g/mL$) in the presence of androgen. In ChIP assay, the acetylation of histone H3 and H4 in PSA promoter region was dramatically repressed by bellflower root treatment, but not TR target gene, Dl. Therefore, the potent HAT inhibitory effect of bellflower root led to the decreased transcription of AR target genes and prostate cancer cell growth with the repression of histone hyperacetylation.

• Journal of Radiation Protection and Research
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• v.28 no.3
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• pp.189-197
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• 2003

The Level 3 PSA being termed accident consequence analysis is defined to assess effects on health and environment caused by radioisotopes released from severe accidents of nuclear power plants. In this study consequence analysis on health effects depending on release characteristics of radioisotopes has been peformed using the 3 MACCS code in severe accidents. The results of this study may contribute to identifying the relative importance of various parameters occurred in consequence analysis as well as to assessing risk reduction accident management strategies. Especially three parameters for the purpose of consequence analysis, such as the release height, the heat content, and the duration time, are used to analyze the variation of early fatalities and latent cancer fatalities. Also, in this study risk assessment using the concept, 'products of uncertainty and consequences', has been performed using consequence of MACCS and frequency on source term category 19 scenarios from IPE (Individual Plant Examination) analysis.