• Nuclear Engineering and Technology
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• 제54권4호
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• pp.1516-1525
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• 2022

Interfacing the output of severe accident analysis with the input of radiological consequence analysis is an important and mandatory procedure at the beginning of Level 3 PSA. Such interfacing between the severe accident analysis code MELCOR and MACCS, one of the most commonly used consequence analysis codes, is relatively tractable since they share the same chemical groups, and the related interfacing software, MelMACCS, has already been developed. However, the linking between MAAP, another frequently used code for severe accident analyses, and MACCS has difficulties because MAAP employs a different chemical grouping method than MACCS historically did. More specifically, MAAP groups by chemical compound, while MACCS groups by chemical element. An appropriate interfacing method between MAAP and MACCS has therefore long been requested by users. This study suggests a way of extracting relevant information from MAAP results and providing proper source term information to MACCS by an appropriate treatment. Various parameters are covered in terms of magnitude and manner of release in this study, and special treatment is made for a bypass scenario. It is expected that the suggested approach will provide an important contribution as a guide to interface MAAP and MACCS when performing radiological consequence analyses.

• 한국안전학회지
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• 제39권1호
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• pp.96-103
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• 2024

The demand for mass calculation of offsite consequence analysis to conduct exhaustive single-unit or multi-unit Level 3 PSA is increasing. In order to perform efficient offsite consequence analyses, the Korea Atomic Energy Research Institute is conducting model optimization studies to minimize the analysis time while maintaining the accuracy of the results. A previous study developed a model optimization method using efficient plume segmentation and verified its effectiveness. In this study, we investigated the possibility of optimizing the model through particle size distribution setting by checking the reduction in analysis time and deviation of the results. Our findings indicate that particle size distribution setting affects the results, but its effect on analysis time is insignificant. Therefore, it is advantageous to set the particle size distribution as fine as possible. Furthermore, we evaluated the effect of multithreading and confirmed its efficiency. Future optimization studies should be conducted on various input factors of offsite consequence analysis, such as spatial grid settings.

• 분석과학
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• 제29권2호
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• pp.65-72
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• 2016

액체섬광계수기(Liquid Scintillation Counter, LSC)를 이용한 토양 중 ²²⁶Ra 분석 방법에 대해 연구하였다. 용융법으로 토양에서 Ra을 추출하고, Ba(Ra)SO₄로 침전시켜 방해핵종과 Ra을 분리하였다. Ba(Ra)SO₄를 산에 녹을 수 있는 Ba(Ra)CO₃로 변환시키고, 라돈 가스를 포집할 수 있는 소수성 섬광용액과 혼합한 다음, LSC로 분석하였다. ²²⁶Ra과 ⁹⁰Sr 표준시료를 이용하여 최적의 PSA(Pulse shape analysis, 파형분석) 준위를 설정하였다. FOM(Figure of merit, 성능지수)이 최대이고 알파선 중첩정도가 최소로 나타나는 PSA 80을 최적값으로 결정하였다. Glass vial을 사용했을 때 계측 효율은 243±2% 이다. 본 연구에서 개발한 분석법은 IAEA-312, IAEA-314, IAEA-315를 이용하여 그 신뢰도를 평가를 하였다. 회수율은 60~82% 이며, 측정값과 참고값과의 상대편의가 10 % 이내였다. 최소검출농도는 토양 1 g, 바탕 계수율 0.02 cpm일 때, 회수율 70 %, 계측시간 30 분을 기준으로 2.1 Bq kg⁻¹ 이다.

• 분석과학
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• 제12권5호
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• pp.428-435
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• 1999

액체섬광계수기를 이용한 수용액시료 중의 미량의 Rn-222 및 Ra-226 농도 측정을 위한 분석방법을 확립하였다. 라돈 분석을 위해 자이렌계열 섬광용액(xylene-based cocktail) 12 mL를 사용하여 물 시료(10mL)내 라돈을 선택적으로 용매 추출하였다. 추출된 라돈을 측정용기 내에서 딸핵종과의 방사 평형을 위해 3시간동안 방치한 후 저준위 액체섬광계수기를 이용하여 계측하였다. Ra-226 분석을 위해서는 화학적 분리과정을 거친 후 자이렌 계열 섬광용액이 포함된 측정용기 내에서 일정 기간동안의 방사평형을 거쳐 생성된 Rn-222 및 알파선 딸핵종을 계측하였다. Rn-222 및 그의 알파선 딸핵종의 계측을 위한 최적 파형분석(PSA) 준위는 바탕시료에 대한 최대 효율값(Figure of Merit)을 조사하여 설정하였다. PSA 준위 100에서 폴리에틸렌 용기와 자이렌계열 섬광용액을 사용하여 준비된 시료를 200분 동안 계측하였을 때 얻어진 검출하한값(MDA)은 알파선의 총 피크영역에서 0.14 Bq/L(3.78 pCi)이었고, Po-214 만의 피크영역에서는 0.06 Bq/L(1.63 pCi)이었다. 섬광용액에 대한 시료의 부피비와 시료용기의 취급 및 시료용기를 통한 라돈기체의 손실등이 계측치에 미치는 영향을 고찰하였다.

• Nuclear Engineering and Technology
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• 제53권10호
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• pp.3298-3313
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• 2021

The objective of this study is to estimate the occurrence probabilities of severe accident phenomena based on a fuzzy elicitation technique. Normally, it is difficult to determine these probabilities due to the lack of information on severe accident progression and the highly uncertain values currently in use. In this case, fuzzy set theory (FST) can be best exploited. First, questions were devised for expert elicitation on technical issues of severe accident phenomena. To deal with ambiguities and the imprecision of previously developed (reference) probabilities, fuzzy aggregation methods based on FST were employed to derive the occurrence probabilities of severe accidents via four phases: 1) choosing experts, 2) quantifying weighting factors for the experts, 3) aggregating the experts' opinions, and 4) defuzzifying the fuzzy numbers. In this way, this study obtained expert elicitation results in the form of updated occurrence probabilities of severe accident phenomena in the OPR-1000 plant, after which the differences between the reference probabilities and the newly acquired probabilities using fuzzy aggregation were compared, with the advantages of the fuzzy technique over other approaches explained. Lastly, the impact of applying the updated severe accident probabilities on containment integrity was quantitatively investigated in a Level 2 PSA model.

• 한국압력기기공학회 논문집
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• 제14권2호
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• pp.49-58
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• 2018

The regulatory periodic inspection program (PSI) conducted at every overhaul period is the most important process for confirming the safety of nuclear power plants. The PSI for operating nuclear power plants in Korea mainly consist of component level performance check that had been developed based on deterministic approach putting the same degree of importance to all the inspection items. This inspection methodology is likely to be effective for preoperational inspection. However, once the plant is put into service, the PSI must be focused on whether to minimize the risk of accident using defense-in-depth concept and risk insight. The incorporation of defense-in-depth concept and risk insight into the deterministic based safety inspection has not been well studied so far. In this study, two track approaches are proposed to make sure that core damage be avoided: one is to secure success path and the other to block the failure path in a specific event tree of PSA. The investigation shows how to select safety important components and how to set up inspection group to ensure that core damage would not occur for a given initiating event, which results in strengthening defense-in-depth level 3.

• IMMUNE NETWORK
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• 제1권3호
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• pp.260-265
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• 2001

Transforming growth $factor-{\beta}1$ ($TGF-{\beta}1$) is a multipotent growth factor affecting development, homeostasis and tissue repair. Many kinds of malignant tissues were reported to overexpress transforming growth $factor-{\beta}1$ ($TGF-{\beta}1$) gene. However, a little work has been done on the circulating $TGF-{\beta}1$ and the association of $TGF-{\beta}1$ with progression in patients with malignant tumors. In this study, we measured the plasma level of $TGF-{\beta}1$ in gastric cancer and prostate cancer patients and evaluated the utility of plasma $TGF-{\beta}1$ as a possible tumor marker. We used Enzyme-linked immunosorbent assay (ELISA) system in order to measure plasma $TGF-{\beta}1$ level in 134 gastric cancer patients, 50 prostate cancer patients and 290 normal controls. And the tumor marker, carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), was compared with $TGF-{\beta}1$ in the aspects of sensitivity and specificity. The mean plasma $TGF-{\beta}1$ levels were $1.219{\pm}0.834$ (0.272-5.772) ng/mL in normal controls, $5.964{\pm}3.218$ (0.845-18.124) ng/mL in gastric cancer and $4.140{\pm}2.345$ (1.108-13.302) ng/mL in prostate cancer. In gastric cancer patients difference in plasma $TGF-{\beta}1$ level was not detected according to cancer stage. In comparison with other tumor marker (CEA, PSA) $TGF-{\beta}1$ is more potent in sensitivity. These results indicate that the plasma $TGF-{\beta}1$ level can be a potent tumor marker in gastric cancer and prostate cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8699-8703
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• 2014

18-fluoro-2-deoxyglucose positron emission tomography-computed tomography ($^{18}F$-FDG PET/CT) scans are commonly used for the staging and restaging of various malignancies, such as head and neck, breast, colorectal and gynecological cancers. However, the value of FDG PET/CT for detecting prostate cancer is unknown. The aim of this study was to evaluate the clinical value of incidental prostate $^{18}F$-FDG uptake on PET/CT scans. We reviewed $^{18}F$-FDG PET/CT scan reports from September 2009 to September 2013, and selected cases that reported focal/diffuse FDG uptake in the prostate. We analyzed the correlation between $^{18}F$-FDG PET/CT scan findings and data collected during evaluations such as serum prostate-specific antigen (PSA) levels, digital rectal examination (DRE), transrectal ultrasound (TRUS), and/or biopsy to confirm prostate cancer. Of a total of 18,393 cases, 106 (0.6%) exhibited abnormal hypermetabolism in the prostate. Additional evaluations were performed in 66 patients. Serum PSA levels were not significantly correlated with maximum standardized uptake values (SUVmax) in all patients (rho 0.483, p=0.132). Prostate biopsies were performed in 15 patients, and prostate cancer was confirmed in 11. The median serum PSA level was 4.8 (0.55-7.06) ng/mL and 127.4 (1.06-495) ng/mL in the benign and prostate cancer groups, respectively. The median SUVmax was higher in the prostate cancer group (mean 10.1, range 3.8-24.5) than in the benign group (mean 4.3, range 3.1-8.8), but the difference was not statistically significant (p=0.078). There was no significant correlation between SUVmax and serum PSA, prostatic volume, or Gleason score. $^{18}F$-FDG PET/CT scans did not reliably differentiate malignant or benign from abnormal uptake lesions in the prostate, and routine prostate biopsy was not usually recommended in patients with abnormal FDG uptake. Nevertheless, patients with incidental prostate uptake on $^{18}F$-FDG PET/CT scans should not be ignored and should be undergo further clinical evaluations, such as PSA and DRE.

• Food Science and Biotechnology
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• 제16권3호
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• pp.457-462
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• 2007

Histone acetyltransferase (HAT) is a family of enzymes that regulate histone acetylation. Dysfunction of HAT plays a critical role in the development of cancer. Here we have screened the various plant extracts to find out the potent HAT inhibitors. The bellflower (Platycodon grandiflorum) root have exhibited approximately 30% of the inhibitory effects on HAT activity, especially p300 and CBP (CREB-binding protein) at the concentration of $100\;{\mu}g/mL$. The cell viability was decreased approximately 52% in LNCaP cell for 48 hr incubation. Furthermore, mRNA level of 3 androgen receptor target genes, PSA, NKX3.1, and TSC22 were decreased with bellflower root extract treatment ($100\;{\mu}g/mL$) in the presence of androgen. In ChIP assay, the acetylation of histone H3 and H4 in PSA promoter region was dramatically repressed by bellflower root treatment, but not TR target gene, Dl. Therefore, the potent HAT inhibitory effect of bellflower root led to the decreased transcription of AR target genes and prostate cancer cell growth with the repression of histone hyperacetylation.

• Journal of Radiation Protection and Research
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• 제28권3호
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• pp.189-197
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• 2003

Level 3 PSA(사고결말분석)는 원자력 발전소의 사고 시 누출된 방사성 핵종으로 인해 야기되는 환경 및 인체에 미치는 영향(공중위험도)을 평가하는 것이다. 본 논문에서는 원자력 발전소의 중대사고시 환경으로 방출되는 방사성물질의 방출특성과 그 결과로 인체에 미치는 영향에 대하여 확률론적 사고영향분석코드인 MACCS를 이용하여 평가하였다. 이러한 평가는 관련 변수들의 상대적 중요도를 파악하는데 유용할 뿐만 아니라 소외리스크(Offsite Risk)를 최소화시키기 위한 대책개발에 있어 중요한 지표가 될 수 있다. 특히 방출고도, 열 함량, 방출기간의 3가지 중요 변수를 선정하여, 이들 변수들의 변화에 따라 영향을 받는 조기사망자 수와 암 사망자 수의 변화를 분석하였다. 또한, 참조원전의 위험성 평가를 위하여 IPE(Individual Plant Examination)에서 제시된 STC(Source Term Category) 19가지 시나리오에 대한 각 사고별 빈도와 MACCS코드를 수행한 결과값을 이용하여 참조원전의 위험성 평가를 수행하였다.