• 유기물자원화
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• 제22권2호
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• pp.35-43
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• 2014

각기 다른 돈분 처리시스템 운영 과정을 포함하여 액비의 농경지 살포에 따른 옥수수 재배에 대한 환경영향을 분석하기 위하여 전과정 평가방법을 적용하였다. 전과정평가의 첫 번째 부분은 사용될 분석 항목을 구성하는 것으로 돈분 처리시스템 운영에 대한 유입 및 배출에 대한 항목이며, 전과정 영향평가를 위한 다음 단계로서 전체 환경부하를 최종적으로 하나의 지수로 통합하기 위하여, 특정 항목에 대한 자료를 취합하고 분석하는 것이다. 전과정 영향 분석을 위한 실례로서 호기 및 혐기소화시스템 운영부터 호기 및 혐기 액비의 농경지 시용에 대한 옥수수 재배과정에 이르기 까지를 평가하였다. 농업환경영향에 대한 부하량 평가에서, 혐기소화액을 이용한 옥수수 재배에서는 수계부영야화가 7.6배 높았으며, 지구온난화에 대한 생태지표 지수(Eco-indicator value)는 10.9 tonne $CO_2$ eq.로 0.9배 적게 배출하는 것으로 산정되었다.

• Journal of Nutrition and Health
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• 제46권3호
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• pp.239-249
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• 2013

Subclinical vitamin $B_{12}$ deficiency is common in the elderly worldwide. We investigated the change of serum vitamin $B_{12}$ concentration with aging and compared anthropometric data and clinical health indicators between normal (${\geq}$ 340 pg/mL) and low (< 340 pg/mL) serum vitamin $B_{12}$ groups in 470 Korean women aged 65 years and over living in a rural area. Serum vitamin $B_{12}$ concentration showed inverse correlation with age (r = -0.0992, p < 0.05). The normal $B_{12}$ group showed significantly (p < 0.05) higher red blood cell count, hemoglobin, and hematocrit compared to the low $B_{12}$ group, however, no difference in mean corpuscular volume was observed between the two groups. The normal $B_{12}$ group showed significantly lower serum homocysteine concentration (p < 0.01) and prevalence of vitamin D (p < 0.01) or folate deficiency (p < 0.001). Bone mineral density (T-score) was significantly higher (p < 0.05) in the normal $B_{12}$ group, compared with that in the low $B_{12}$ group, and showed positive correlation (r = 0.1490, p < 0.01) with serum vitamin $B_{12}$ concentration after adjusting for age, body weight, and body mass index. No differences in anthropometric data, physical activity, and smoking and drinking habits were observed between the two groups. In conclusion, it could be suggested that older female adults with normal serum vitamin $B_{12}$ level would be less anemic and osteoporotic and more resistant to hyperhomocysteinemia associated chronic diseases than those with low serum vitamin $B_{12}$ level.

• KIEAE Journal
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• 제12권2호
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• pp.65-75
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• 2012

The rapid urbanization caused drastic temperature changes in Korea. Excessive urbanization and development result in unpredictable and abnormal climate change all over the world. These changes are reflected in Korean government policy and research about cities, such that various research endeavors have been undergone recently. There are lots of ways to improve the urban environment; the easiest way to solve the urban heat effect problem is to make green spaces within the city. Even though we can't enlarge green spaces over the city limitlessly, it is desperately need for a methodology to efficiently create green space in limited area. Based on awareness of issues as mentioned earlier, we would like to propose landscaping method that can increase thermal comfort in the same area. For this study, simulating the change of temperature, mean radiant temperature, PMV were done due to number of species planted in apartment complex. To increase the reliability of the simulation, first above all, field measurement for temperature change was performed in apartment complex, where residential building are arranged in the form of ㄷ. And based on this data, Envi-met simulation was performed varying 1-7 kinds of species divided by grass, shrubs, arbor (deciduous, conifers) planted in apartment complex. As a result, there was a change less than $1^{\circ}C$ with the increasing number of species in daytime, but the average radiation temperature about $6-7^{\circ}C$ was reduced. In addition, PMV index was improved by more than 0.5 point. Thermal comfort indicator improved significantly depending on the number of species during the day, on the other hand, there were no significant changes at night. As a consequence, this study has shown that not single-species planting but mixed planting varied the number of species would improve the thermal comfort in the same area of landscaping space at daytime.

• 환경영향평가
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• 제13권6호
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• pp.295-305
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• 2004

After the Rio declaration on environment and development in 1992, developed countries are undertaking "environmentally sustainable transportation (EST)" projects. To meet the needs for EST, current transportation policies in Korea are rapidly reforming and one of its concerns is modernizing and upgrading railway freight system. Planning new railroad construction projects is increasing and subsequent environmental impact assessment (EIA) demands improvements, especially in both the EIA and decision making systems. In this paper, we discuss the present status of EIA for railroad construction projects, especially, by analyzing the EIA documents for the last six years. The EIA for railroad construction projects accounts for only 4.9% of total 918 project EIAs during 1998-2003, and the portion is gradually increasing. Major environmental concerns for EIA in railroad construction projects were geomorphological and ecological changes, protection of rare organisms, air pollution, water pollution, waste management, and noise, etc. We compared characteristics of environmental impacts of railroad construction with those of vehicle road construction, based on environmental and construction-planning indicators appeared in Environmental Impact Statements. Railroad construction usually requires longer tunnels and bridges for a given length than those for vehicle road construction. In addition, the amounts of geomorphological and ecological changes (road-cutting, embankment, devegetation, etc.) in railroad construction were generally less than 50% of those in vehicle road construction. To develop environmentally friendly railway systems, monitoring studies for environmental impacts of railroads such as habitat fragmentation and road kills, dispersal of alien plants, tunnelling effects on groundwater and vegetation, and noise impacts are highly recommended.

• 한국축산식품학회지
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• 제32권5호
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• pp.598-603
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• 2012

Beef qualities which can be properly predicted by time-temperature integrator (TTI), a chromatic indicator, were selected in terms of its similarity of temperature dependence between beef qualities and TTI, denoted by Arrhenius activation energy ($E_a$). The high similarity is required to afford accurate prediction. A devised enzymatic TTI based on laccase (an oxidase), which catalyses the oxidation on 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) producing color development, was applied. The factors of beef quality, such as volatile basic nitrogen (VBN), pH, color (CIE $L^*$, $a^*$), Warner-Bratzler shear force (WBSF), Pseudomonas spp. count, and lactic acid bacteria (LAB) count were considered for the selection. $E_a$ (55.48 kJ/mol) of the TTI was found to be similar to those of the beef qualities (all referred) in the order of LAB count (53.54 kJ/mol), CIE $a^*$ value (61.86 kJ/mol), pH (65.51 kJ/mol), Pseudomonas spp. Count (44.54 kJ/mol), VBN (67.98 kJ/mol), WBSF (40.67 kJ/mol), and CIE $L^*$ value (33.72 kJ/mol). The beef qualities with more similar $E_a$ to that of the TTI showed less difference between real and TTI predicted levels. In conclusion, it was found out that when applying TTI to food packages, their $E_a$ similarity should be checked to assure accurate estimation of food quality levels from TTI response.

• 한국환경보건학회지
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• 제45권3호
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• pp.213-221
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• 2019

Objective: This study was performed to evaluate gender and age differences in hygienic behavior among the general population, focusing on hand-washing habits and the microbial load of hands. Methods: A self-administered questionnaire survey and a separate microbial examination were performed. The Pearson's correlation between hand-washing habits and microbial load was analyzed. Results: In the questionnaire survey on hand-washing habits, gender differences were found in hand-washing frequency, use of hand-washing agents, and hand drying methods (p<0.05). Age differences were found in numbers of washing parts of the hands and also in hand drying methods (p<0.05). Females showed better habits washing hands than did males, as did older people compared to younger. In the microbial examination of indicator bacteria on their hands, younger people tended to show a higher load of total aerobic bacteria than did the older, and females showed a higher load of total coliforms than did males (p<0.05). There were significant relationships between the load of total aerobic bacteria and hand-washing frequency, duration, and method of turning-off water (p<0.05). Conclusions: Although females were expected to show a better practice of hand-washing than were males based on the survey results, they showed a higher level of total coliforms in the hand examination. The older age group showed better hand-washing habits than did the younger age group and had less total aerobic bacteria on their hands. These inter-gender and age differences highlight the need for development and implementation of gender-and age-specific educational programs or campaigns.

• Asian-Australasian Journal of Animal Sciences
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• 제32권7호
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• pp.956-965
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• 2019

Objective: The main goal of this study was to provide a morphological indicator that could be used to select high-quality oocytes of appropriate meiotic and developmental capabilities in pig. The higher quality of immature oocytes, the higher success rates of in vitro maturation (IVM) and in vitro fertilization (IVF). Thus, prior to the IVM culture, it is important to characterize oocytes morphologically and biochemically in order to assess their quality. Two of the largest indicators of oocyte quality are the presence of cumulus cells and status of chromatin. To investigate the effects of porcine oocyte chromatin configurations on the developmental capacity of blastocysts, we assessed oocyte chromatin status according to follicle size and measured the developmental potency of blastocysts. Methods: To sort by follicle size, we divided the oocytes into three groups (less than 1 mm, 1 to 3 mm, and more than 3 mm in diameter). To assess chromatin configuration, the oocytes were assessed for their stages (surrounded nucleolus [SN] germinal vesicle [GV], non-surrounded nucleolus [NSN] GV, GV breakdown, metaphase I [MI], pro-metaphase II [proMII], and metaphase II [MII]) at different maturation times (22, 44, and 66 h). To assess the development rate, oocytes of each follicle size were subjected to parthenogenetic activation for further development. Finally, GV oocytes were grouped by their chromatin configuration (SN, SN/NSN, and NSN) and their global transcriptional levels were measured. Results: SN GV oocytes were more suitable for IVF than NSN GV oocytes. Moreover, oocytes collected from the larger follicles had a greater distribution of SN GV oocytes and a higher developmental capacity during IVM, reaching MII more quickly and developing more often to blastocysts. Conclusion: Porcine oocytes with high-level meiotic and developmental capacity were identified by analyzing the relationship between follicle size and chromatin configuration. The porcine oocytes from large follicles had a significantly higher SN status in which the transcription level was low and could be better in the degree of meiotic progression and developmental capacity.

• 한국해양학회지:바다
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• 제5권4호
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• pp.305-319
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• 2000

동해 북동쪽에 위치한 홋카이도섬 서부해역에서 채취된 중력시추코아 GH98-1223의 45개 퇴적물 시료들로부터 휴면포자를 제외한 총 31속 50종 1아종의 규조류가 동정되었다. 최대 산출종은 Thalassionema nitzschioides로 전시료에서 29${\sim}$59%의 높은 산출빈도를 나타냈으며, 그 외에 비교적 개체 보존이 양호한 Denticulopsis seminae와 Pseudoeunotia doliolus를 비롯한 대부분의 종들은 평균 산출빈도가 5% 이내로 매우 낮게 나타났다 전 시료에서 한류종의 산출빈도가 난류종보다 상대적으로 우세하였으며, 수직분포는 각 종의 생태적 특성에 따라 차이가 있으나 대부분의 층준에서 난류종과 한류종의 산출빈도는 서로 상반되는 경향을 보였다. 대표적인 한류종인 D. seminae와 난류종으로 쿠로시오해류(Kuroshio Current)의 지류인 대마난류(Tsushima Warm Current)의 지시종인 P doliolus의 전체적인 변화양상은 뚜렷하게 상반되며, 이것은 규조온도지수(T$_d$)의 수직적인 변화와도 서로 일치한다. 규조온도지수는 150 cm깊이를 기준으로 코아의 상부에서는 평균 이상의 높은 수치를 나타내며 하부에서는 평균 이하의 낮은 수치를 나타내는데, 이러한 경향은 동해의 북부지역에 위치한 본 연구지역에 대마난류의 영향이 홀로세의 후빙기를 거치면서 점차적으로 증가된 것을 지시하고 있다. 또한, 하층부에서 규조온도지수는 지그재그형의 변화를 나타내는데 이는 규조류가 서식하는 해수의 환경이 불안정하였다는 것을 의미한다. 생산성과 용승의 정도를 지시하는 Chaetoceros resting spores는 5.3${\sim}$40% 정도의 산출빈도를 보이는데 , 최대값은 80 cm 보다 상층부에서 나타났다. 퇴적물의 생물 기원물질의 상대적인 양을 예측하는데 이용되는 Chaetoceros resting spores/Chaetoceroe vegetative cells도 80 cm 보다 상층에서는 높게 나타나 규조온도지수 분포와도 일치하는 경향을 보인다. 이상의 규조군집 분석 결과에 의하면, 홀로세의 후빙기동안 본 연구 지역인 동해 북동부에는 대마 난류의 유입이후 현재와 유사한 환경이 우세하게 발달했으나, 난류종 P. doliolus의 변화는 동해내에서 대마난류의 세기가 반복되었음을 지시하고 있다.

• 한국해양학회지
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• 제29권3호
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• pp.228-238
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• 1994

제4기 동안에 일어난 해수면 변화는 지역적 그리고 나아가 전 지구 기후변화에 좋 은 지시자가 되고 있다. 세계 해수면은 제 4기 동안 매우 불규칙하게 변해왔는데 여기 에 대한 정밀한 수학적 접근은 어려운 실정이었다. 이 연구에서 처음으로 세계 해수면 변동자료에 확율 프랙탈을 적용하여 제4기 해수면 변동을 재구성 하였다. 미국 대서양 연안에 위치한 허드슨만과 델라웨어 해안의 홀로세 해수면 변화에 대한 프랙탈 차원을 상자 계산 방법으로 측정한 결과, 허드슨만 해수면 분노는 프랙탈 차원이 1,358이고 델라웨어 해수면 변화는 1,346이다. 프랙탈 내삽함수의 역산 방법 (IFIF)의 유효성이 허드슨만과 델라웨어 해수면의 내삽에 의해서 검증되었고, IFIF에 의해서 두지역에서 의 합리적인 해수면들이 복원되었다. 델라웨어 해수면 자료는 허드슨 해수면 자료보다 IFIF의 내삽에 대해 통계적 오차가 적게 나타나는데, 이는 델라웨어 해수면 자료가 허 드슨 자료보다 더 신빙성이 높다는 것을 의미한다. IFIF는 한국 해안의 해수면을 추정 하는 데도 이용되었는데, 한국 해안의 해수면 자료는 허드슨만이나 델라웨어 지역보다 자료가 충분치 못하다. 따라서 IFIF 의 적용 통계 오차가 적은 텔라웨어 해수면 자료 에서 구한 프랙탈 차원을 사용하여 한국 해안에 대한 IFIF의 수직 비율 인자를 계산하 였다.함수(FIF)를 한국 해안과 미국 대서양 연안의 고해수면의 재구성에 적용한 결과,한국의 고해수면은 미국의 고해수면과 다른 변화를 보였다.8000년 전부터 현재까지 두지역의 해수면은 비교해 보면 한국 해수면이 미국 해수면 보다 훨씬 높았다.

• IMMUNE NETWORK
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• 제23권4호
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• pp.35.1-35.16
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• 2023

Defining the molecular dynamics associated with T cell differentiation enhances our understanding of T cell biology and opens up new possibilities for clinical implications. In this study, we investigated the dynamics of CD5 expression in CD8⁺ T cell differentiation and explored its potential clinical uses. Using PBMCs from 29 healthy donors, we observed a stepwise decrease in CD5 expression as CD8⁺ T cells progressed through the differentiation stages. Interestingly, we found that CD5 expression was initially upregulated in response to T cell receptor stimulation, but diminished as the cells underwent proliferation, potentially explaining the differentiation-associated CD5 downregulation. Based on the proliferation-dependent downregulation of CD5, we hypothesized that relative CD5 expression could serve as a marker to distinguish the heterogeneous CD8⁺ T cell population based on their proliferation history. In support of this, we demonstrated that effector memory CD8⁺ T cells with higher CD5 expression exhibited phenotypic and functional characteristics resembling less differentiated cells compared to those with lower CD5 expression. Furthermore, in the retrospective analysis of PBMCs from 30 non-small cell lung cancer patients, we found that patients with higher CD5 expression in effector memory T cells displayed CD8⁺ T cells with a phenotype closer to the less differentiated cells, leading to favorable clinical outcomes in response to immune checkpoint inhibitor (ICI) therapy. These findings highlight the dynamics of CD5 expression as an indicator of CD8⁺ T cell differentiation status, and have implications for the development of predictive biomarker for ICI therapy.