• Clinical and Experimental Reproductive Medicine
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• 제21권3호
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• pp.227-232
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• 1994

In order to define the clinical characteristics of Korean women with polycystic ovary syndrome, clinical symptoms, biochemical features and ultrasonographic findings were determined in ninety PCO patients. Frequency of clinical manifestations were as follows:acne 42%, overweight 31 %, oily skin 14 %, hirsutism 10%. Relatively low frequencies of hirsutism is recognized in patients with Korean PCO syndrome. Mean(${\pm}$S.E.) of each hormone was:testosterone 1.18${\pm}$1.07ng/ml, LH 21.47${\pm}$${\pm}$2.6mIU/ml, FSH 7.26${\pm}$2.67mIU/ml, LH/FSH ratio 2.94${\pm}$1.29, prolactin 25.48${\pm}$46.33ng/ml, DHEA-S 333.78${\pm}$309.60ng/dl, 17-0HP 1.72${\pm}$1.74ng/ml. Mean 17-OHP after ACTH stimulation test was 5.07${\pm}$12.01ng/ml. Ultrasonographically measured mean ovarian volume were $11.02{\pm}5.92cm^3$ in right and $9.23{\pm}5.64cm^3$ in left and small sized multiple subcapsular follicular cysts were noted in 43 patients (47.9%) with PCO syndrome.

• 고령자･치매작업치료학회지
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• 제12권2호
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• pp.19-28
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• 2018

목적 본 연구는 노인의 장악력을 표준화하고 장악력, 신체계측인자, 우울, 삶의 질 사이에 상관관계를 알아보고자 하였다. 연구방법 연구자는 2016년 국민건강영양조사를 분석에 이용하였으며, 활동제한이 없는 오른손잡이 노인 중 장악력 검사를 완료한 919명의 자료를 분석하였다. 노인 전체, 남성, 여성의 장악력을 65세~69세, 70세~74세, 75세~79세, 80세 이상으로 구분하여 장악력을 표준화하였다. 신체계측인자에는 키. 몸무게, 체질량지수, 허리둘레가 포함되었다. 우울은 PHQ-9로 측정되었고, 삶의 질은 EQ-5D로 평가되었다. 연구결과 노인의 오른손잡이의 비율은 87.8%, 왼손잡이 4.9%, 양손잡이 5.7%로 나타났다. 표준화 결과 및 상관분석에서, 남녀노인 모두 나이가 증가함에 따라 장악력이 감소하였다(p<.01, r=-.308~-.305). 장악력은 키와 가장 높은 상관성을 나타냈다(p<.01, r=.747~.741). 장악력은 우울(p<.01, r=-.172~-.163)과 삶의 질(p<.01, r=.285~.267) 사이에 유의한 상관이 있었다. 결론 본 연구의 결과는 노인의 연령별 장악력 수준을 고려할 때, 키, 우울, 삶의 질에 따라 장악력의 차이가 나타날 수 있음을 고려할 필요가 있음을 시사한다.

• 대한핵의학회지
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• 제38권4호
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• pp.288-293
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• 2004

목적: 삼상골스캔상의 증가된 손목과 손의 관절의 증가된 섭취는 반사성교감신경 이영양증후군의 소견이다. 반신마비성 반사성교감신경 이영양증후군 환자에서의 병측 견관절 섭취 증가는 드물지 않은 소견으로서 이번 연구에서는 이런 환자들에서의 견관절 섭취의 임상적 의미를 알고자 연구를 시행하였다. 대상 및 방법 : 뇌졸중으로 반신마비가 된 환자 중 임상적으로 반사성교감신경 이영양증후군으로 진단된 23명의 환자를 대상으로 하였다(남:녀=16:7, 좌:우=11:12). 평균나이는 $63{\pm}10$세였다. 10명의 정상 자원자의 데이터를 대조군으로 사용하였다(평균 나이 $60{\pm}5$, 남:녀=1:9). 삼상골스캔은 뇌졸중 발병 후 $59{\pm}32$ 일에 시행하였다. 관심영역을 그려서 삼상의 양손의 우/좌 섭취비를 각각 구하였고, 이를 지연 영상에서의 견관절 섭취 우/좌 섭취비와 비교하였다. 손의 관심 영역은 손목을 포함하였다. 검사의 예민도는 정상 대조군의 데이터를 이용하여 결정하였다. 결과: 관류 영상과 혈액 풀 영상, 지연 영상의 손의 우/좌 섭취비를 이용한 삼상골스캔의 민감도는 각각 45%, 76%, 78%이었다. 지연 영상의 견관절 섭취비를 이용한 민감도는 74%이었다. 지연영상의 손 우/좌 섭취비와 견관절 우/좌 섭취비는 유의한 상관관계를 보였다(Spearman's R=0.824, p<0.001). 결론 : 지연 영상에서의 견관절 섭취는 지연 영상의 손 섭취와 유의한 상관 관계를 보였다. 병측 견관절 섭취 증가 소견은 반신마비성 반사성교감신경 이영양증후군 환자의 진단에 도움을 주는 소견이다.민감도는 스캐너의 횡축방향 708.6 (2D), 2931.3 (3D) counts/sec/MBq, 횡축방향 중심에서 10cm 벗어난 지점에서 728.7 (2D), 3398.2 (3D) counts/sec/MBq 이었다. 산란 분획은 0.19 (2D), 0.49 (3D)이었고 최고 참 계수율과 NECR은 2차원 영상 획득 모드에서 40.1 kBq/mL 일 때 64.0 kcps, 40.1 kBq/mL 일 때 49.6 kcps, 3차원 영상 획득 모드에서 4.76 kBq/mL 일 때 53.7 kcps, 4.47 kBq/mL 일 때 26.4 kcps이었다. 결론: 이 실험에서 NEMA NU2-2001로 측정한 PET스캐너의 물리적 특성은 PET스캐너에 대한 객관적 평가 및 최적화 된 영상 획득과 분석에 유용할 것이다.로 사료되었다.률 또한 신경회로망(59%)과 핵의학 전문가(72%)의 진단 성적이 거의 다르지 않았다. 결론: 이 연구에서 개발한 간질병소 국소화를 위한 신경회로망 시스템은 측두엽간질 감별 진단에 도움이 될 것으로 기대된다. 생체광학 영상을 이용한 다약제내성 유전자 및 Pgp 발현 연구는 아직 시작단계이나, 분자 생물학적 영상법의 발전과 함께 MRI 기술등에도 이용될 수 있으므로 향후 많은 연구가 있을 것으로 기대된다.{\mu}M$에서는 각각 40%와 5%만 섭취되었다. MTT assay상 K562(Adr)세포에서는 verapamil $100{\mu}M$ 이상에서는 유의하게 낮았으나 다른 세포는 $200{\mu}M$까지에도 차이가 없었다. PKC 아형의 분석상 PKC $\varepsilon$이

• 한국조경학회지
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• 제35권1호
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• pp.1-8
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• 2007

The purpose of this study is to suggest the minimum distance needed between landscape trees and apartment buildings. in order for the trees to grow soundly and maintain constant growth. Therefore, this study investigated and analyzed the present conditions of the green-spaces contiguous to apartment buildings and the trees inside the apartment complex. The following general problems were identified : (1) the tree growth conditions, (2) the planting intervals, and (3) the planting methods in the apartment complexes. The method of this study was to survey areas, measure the trees and analyze the results. Ten apartment complexes located in Seoul were randomly selected for this study. To analyze the greens contiguous to the building of each apartment complex, the greens were divided into three types, including the front greens, the side greens, and the rear greens. The study surveyed the width of all contiguous greens and the distance from trees to my given building. Four representative sites were specifically investigated to measure the crown widths, heights, and diameters of the trees. These investigations were carried out over 3 months from August to December 2006. According to the results of the study, it was found that the greens are narrower in width and the more closer to a building. The study identified a correlation between the tree and the passage of time after the completion of construction of an apartment complex, showing that the malformation of the trees worsened as time passed. As a result of measuring the right crown and left crown width with the tree trunk as the center, a broad difference was found between coniform trees and trees that tend to branch out more. For example, the ratio of the width of the Acer palmatum is 1:6. However, the ratio of the Metasequoia glyptostroboide is 1:1.7. Based on the overall analysis, it was concluded that the maintained minimum width must be greater than one meter over the green space according to the 'Landscape Standard 2000'. However, that is only applicable to cases such as apartment buildings that present no obstacles. In conclusion having greens placed within one meter of width to a building is not an appropriate environment for the healthy growth of trees. To create sound green spaces, sustainable, long-term growth rate and size should be considered. It is necessary to prepare new standards for the computation of planting trees and the measurement of square landscapes. Wall greenery and shrubberies could be an alternative in the case of a narrow-width green space.

• Archives of Plastic Surgery
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• 제37권5호
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• pp.547-554
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• 2010

Purpose: The purpose of this study is to delineate the optimal time of venous revascularization for preventing the flap necrosis due to venous occlusion, and to clarify the usefulness of tissue oxygen pressure ($TcpO_2$) in the determination of the point of time for venous revascularization. Methods: Thirty-six, $3{\times}3\;cm$ sized epigastric island flap was elevated in left abdomen of male Sprague-Dawley rat weighing 250 gram. Flaps were randomly assigned to six groups of six flaps according to the duration of venous occlusion with microvascular clamp; 10 minutes in the group I as the control, 60 minutes in the group II, 2 hours in the group III, 3 hours in the group IV, 4 hours in the group V, and 6 hours in the group VI, respectively. Just before removal of clamp after flap was reposed in situ, the ratio of $TcpO_2$ (tissue oxygen pressure) of the island flap to that of right abdomen was calculated in each group, and tissue specimen was harvested from the distal area of the flap for histological evaluation of vascular change. Five days later, survival area of the flap was estimated, and evaluated the correlation between the tissue oxygen pressure and the rate of flap survival. Results: The $TcpO_2$ and the survival rate of flap were decreased proportionally with the duration of venous occlusion. The ratio of the $TcpO_2$ of the flap is decreased abruptly to below sixty percentile compared to the $TcpO_2$ of normal tissue, and the survived area of the flap is decreased to nine-tenth of the designed size after three hours of total venous occlusion. Histologically, the number of congested vessels was increased according to venous occluded time, and proportionally increased after 3-hours of occlusion significantly. Conclusion: There is a close correlation between the $TcpO_2$ and the survival rate of flaps according to the duration of venous occlusion. Therefore, the $TcpO_2$ represents the hemodynamic changes within the flap, and thought to be an alternative effective tool in the flap monitoring for venous revascularization.

• 한국통신학회논문지
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• 제31권1C호
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• pp.26-35
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• 2006

본 논문에서는 지능적인 경로 계획을 위한 스테레오 카메라 기반의 공간좌표 검출 기법을 이용한 자율 이동 로봇 시스템을 제안하였다. 우선 스테레오 카메라로부터 입력된 영상 중 좌 영상에 YCbCr 컬러 모델 및 무게 중심법을 이용하여 이동중인 보행자의 얼굴 영역과 중심좌표를 검출하고, 검출된 좌표 값에 따라 스테레오 카메라의 능동적인 로봇 제어를 통해 이동하는 보행자를 실시간적으로 검출하게 된다. 다음으로, 로봇구동에 의해 추적 제어된 스테레오 카메라의 좌, 우 영상간의 시차정보와 스테레오 카메라 내부 변환관계를 통해 깊이 정보를 검출한 후, 검출된 깊이 지도로부터 각 열에 존재하는 최소값을 이용한 2차원 공간좌표를 검출하여 이동 로봇과 보행자간의 거리와 위치좌표는 물론 다른 물체들과의 상대 거리를 산출하게 되며, 산출된 위치 좌표를 토대로 이동 로봇의 지능적인 경로 추정 및 판단에 따라 자율적인 주행을 수행하게 된다. 실시간적으로 입력되는 240 프레임의 스테레오 영상을 사용한 실험결과, 이동 로봇과 전방에 존재하는 장애물간의 거리 및 보행자와 장애물간 상대거리의 계산치와 측정치간의 오차가 평균 $2.19\%$와 $1.52\%$이하로 각각 유지됨으로써 경로 계획을 위한 공간좌표 검출에 기반을 둔 실질적인 이동 로봇 시스템의 구현 가능성을 제시하였다.

• 한국임상수의학회지
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• 제24권2호
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• pp.154-159
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• 2007

The objective of this retrospective study was to investigate the prevalence of retinal diseases in dogs presented to the Veterinary Medical Teaching Hospital, Seoul National University from April 2004 to December 2005. Sixty-five dogs (120 eyes) with retinal diseases involving blindness were included in this study. Age, breed, and gender data for all breeds were collected from medical records documenting vision loss. Generalized progressive retinal atrophy (gPRA) was the most common manifestation. Other prevalent findings included sudden acquired retinal degeneration (SARD) and retinal detachment (RD). Bilateral gPRA was found in 32 dogs with a female-to-male ratio of 1 : 1. The mean $age{\pm}SD$ of all dogs in this group was $4.66{\pm}2.30$ years with a range of 3 to 12 years. Breeds with highest prevalence of gPRA were Miniature Schnauzer (24/32, $mean{\pm}SD$ age: $3.79{\pm}0.78$ yr) and Poodle (2/32, $6.50{\pm}0.71$ yr). Twelve dogs (24 eyes) were diagnosed with SARD bilateraly, ranging from 3 to 13 years of age ($mean{\pm}SD:\;6.91{\pm}2.61$ yr). There were no abnormalities in fundus of 11 dogs at presentation. Electroretinography (ERG) without anesthesia was performed in 7 dogs, and all response was totally extinguished. Retinal detachment was identified in 21 dogs (32 eyes): 11 bilateral and 10 unilateral (7 right eye, 3 left eye). The most common breed was Shih Tzu (15/21, $mean{\pm}SD$ age: $4.39{\pm}3.24$ yr). Four other breeds comprised the remaining 6 cases (8 eyes). The everall mean age of the group was: $4.18{\pm}2.89$ years (range 0.8 to 14 years) with a female-to-male ratio of 1 : 1.1 (10 females, and 11 males).

• 대한통합의학회지
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• 제9권4호
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• pp.291-298
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• 2021

Purpose: The Pedisole is a newly developed shoe-mounted wearable assessment system for analyzing balance and gait. This study aimed to determine the reliability and validity of the parameters provided by the system for static balance and gait analysis of healthy adults. Methods: This study included 38 healthy adults (22.4±1.9 years) with no history of injury in the lower limbs. All participants were asked to perform balance and gait tasks for undertaking measurements. For analysis of balance, both the smart Pedisole and Pedoscan systems were concurrently used to analyze the path length of the center of pressure (COP) and the weight ratio of the left and right for 10 s. Gait was measured using the smart Pedisole and GaitRite walkway systems simultaneously. The participants walked at a self-selected preferred gait speed. The cadence, stance time, swing time, and step time were used to analyze gait characteristics. Using the paired t-test, the intra-class coefficient correlation (ICC) was calculated for reliability. The Spearman correlation was used to assess the validity of the measurements. In total, data for balance from 36 participants and the gait profiles of 37 participants were evaluated. Results: There were significant differences between the COP path lengths (p<.050) derived from the two systems, and a significant correlation was found for COP path length (r=.382~.523) for static balance. The ICC for COP path length and weight ratio was found to be greater than .687, indicating moderate agreement in balance parameters. The ICC of gait parameters was found to be greater than .697 except for stance time, and there was significant correlation (r=.678~.922) with the GaitRite system. Conclusion: The newly developed smart insole-type Pedisole system and the related application are useful, reliable, and valid tools for balance and gait analysis compared to the gold standard Pedoscan and the GaitRite systems in healthy individuals.

• Journal of Chest Surgery
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• 제54권2호
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• pp.106-116
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• 2021

Background: We evaluated the mid-term outcomes and angiographic patency of redo coronary artery bypass grafting (CABG). Methods: Of 2,851 patients who underwent isolated CABG at Seoul National University Hospital from 2000 to 2017, 88 underwent redo CABG. Patients' mean age at redo CABG was 66.0±8.0 years. The mean interval between the first-time and redo CABG was 113.0±62.4 months. The mean follow-up duration was 86 months. Early and mid-term clinical outcomes were evaluated. Angiographic patency rates were evaluated early (1-2 days), 1 year, and 5 years after surgery. Comparative analyses between on-pump and off-pump CABG were also performed. Results: The culprits for reoperation were previous grafts (65.6%), native coronary vessels (17.8%), and both (16.7%). Off-pump CABG was performed in 75 cases (85.2%), and the mean number of distal anastomoses was 1.8±0.8. The saphenous vein (39.7%) was used most frequently, followed by the right internal thoracic artery (28.4%), right gastroepiploic artery (21.3%), left internal thoracic artery (7.8%), and radial artery (2.8%). Operative mortality was 1.1%. The overall survival, cumulative incidence of cardiac death, and cumulative incidence of major adverse cardiac events were 71.3%,12.0%, and 23.3% at 5 years after surgery, respectively. The overall angiographic patency rates were 95.7%, 90.1%, and 92.2% on early, 1-year, and 5-year angiograms, respectively. The angiographic patency rates of saphenous vein grafts were 93.1%, 85.6%, and 91.3% on early, 1-year, and 5-year angiograms, respectively. No significant differences in clinical outcomes or angiographic patency rates were observed between the on-pump (n=13) versus off-pump (n=75) groups. Multivariable analysis revealed that age (hazard ratio [HR], 1.07; p=0.005) and chronic kidney disease (HR, 3.85; p=0.001) were risk factors for all-cause mortality. Conclusion: Redo CABG could mostly be performed using the off-pump technique and did not show increased operative mortality and morbidities.

• Journal of Chest Surgery
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• 제41권1호
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• pp.1-11
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• 2008

배경: Damus-Kaye-Stansel (DKS) 술식은 체심실유출로 협착과 폐동맥고혈압을 완화하기 위하여 근위주폐동맥을 대동맥에 문합시키는 고식적수술이다. 본 연구는 DKS 술식의 적응증, 결과 및 결과에 영향을 주는 요인, 그리고 반월판막 기능과 DKS 경로의 장기 결과들을 알아보고자 하였다. 대상 및 방법: 1994년 5월에서 2006년 4월 사이에 본원에서 DKS 술식을 시행받은 28명의 임상기록을 토대로 후향적으로 분석하였다. 수술시 연령은 중앙값 5.3개월($13일{\sim}38.1$개월), 체중은 중앙값 5.0 kg ($2.9{\sim}13.5\;kg$)이었고, 술전 체심실 유출로 압력차는 $25.3{\pm}15.7\;mmHg$ ($10{\sim}60\;mmHg$)였다. 18명은 초기고식적 수술로 폐동맥교약술을 시행하였으며, 술전 진단은 양대혈관 우심실 기시증이 9명, 심실-대혈관연결 불일치가 있는 양방실판막 좌심실유입이 6명, 그 외 기능성 단심실이 5명, Criss-cross 심장이 4명, 완전 방실중격 결손증이 3명, 그리고 좌심 저형성증후군의 이형이 1명이었다. 수술방법은 팻취를 이용한 측단문합이 14명, 고전적 측단문합이 6명, Lamberti 방법이 3명, 그 외가 5명이었으며, 양방향성 상대정맥 폐동맥 단락술을 6명에서, 폰탄수술을 2명에서 같이 시행하였다. 결과: 병원내 사망은 4명(14.3%)이었고, 평균 $62.7{\pm}38.9$개월 ($3.3{\sim}128.1$개월)의 추적관찰기간 동안 만기사망은 3명(12.5%)이었으며, 10년 누적 생존율은 $71.9{\pm}9.3%$였다. 다변량 분석에서 우심실형 단심실(위험도=13.960, p=0.006)과 일차 DKS 술식의 시행(위험도=6.767, p=0.042)이 사망의 유의한 인자였다. DKS 술식 후 4명은 단계적 양심실성 교정을, 그리고 13명은 폰탄수술까지 시행하였으며, 체심실 유출로 협착은 1명 이외에는 발생하지 않았다. 중등도 이상의 반월판막역류나, 반월판막에 대한 재수술은 없었으나, DKS경로에 의한 폐동맥협착으로 인한 재수술이 고전적 측단문합을 시행했던 1례(3.6%)에서 필요하였다. DKS경로나 반월판막에 대한 재수술의 자유도는 10년에 87.5%였다. 결론: DKS 술식은 체심실 유출로 협착을 동반한 환자군에서 유용한 방법이며, 출생직후 양심실교정이 어려웠던 일부 환자군에서 단계적 양심실 교정을 안전하게 시행할 수 있었다. 체심실유출로 협착이 심하지 않은 경우에 DKS 술식전에 폐동맥 교약술을 시행하여 폐혈관 저항을 감소시킨 후 DKS 술식의 성공률을 향상시킬 수 있었다. DKS 술식후 반월판막기능, DKS 경로와 체심실유출로협착의 완화에 대한 장기 결과는 만족할만하다.