• Journal of Chest Surgery
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• 제32권5호
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• pp.413-421
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• 1999

배경: 폐장의 허혈-재관류 손상은 폐이식에서 발생하는 조기 이식장기 실패의 주요 원인의 하나로 알려져 있다. 최근 갑상선 호르몬의 활성형인 삼요드티로닌 (T3)이 심장을 비롯한 여러 장기의 허혈 손상을 줄여주는 효과가 있음을 시사하는 보고가 있다. 본 연구에서는 이러한 T3의 허혈-재관류 손상에 대한 효과가 폐장의 허혈 손상에도 효과가 있을 것으로 기대하고 덱스트란을 주성분으로 하는 세포외액성 폐보존액에 T3를 추가한 새로운 폐보존액을 제조하여 그 효과를 검증하고자 하였다. 대상 및 방법: 12마리의 황견을 6마리씩 두 군으로 나누어 제 1군에서는 새로 개발한 폐보존액을 사용하고, 제 2군에서는 유로콜린스 용액을 사용하여 폐를 적출 하였다. 적출한 폐장은 각각의 보존액에 담그어 섭씨 4도에서 20시간 보관한 후, 각 군에 6마리씩 총 12례의 좌측 폐이식을 시행하였다. 이식된 좌측폐만의 기능을 관찰하기 위해서 폐이식 후 재관류를 15분시킨 후에 우측 주폐동맥과 우측 주기관지를 결찰하고, 2시간 동안 혈역학적 변수와 가스분석을 시행하고, 측정이 종료된 후 바로 희생하여 폐조직 일부를 떼어내어 조직검사와 수분 함량 및 MDA양을 측정 비교하였다. 결과: 동맥혈 산소분압은 제 1군에서 재관류 후 60분, 90분 120분에 각각 147$\pm$25 mmHg, 148$\pm$22 mmHg, 159$\pm$21 mmHg, 제 2군에서는 각각 133$\pm$26 mmHg, 132$\pm$29 mmHg, 135$\pm$30 mmHg로 제 1군에서 조금 높은 경향을 보였으나 통계적으로 유의성은 없었다. 각 시간에서의 최대 흡기압은 제 1군에서 14.0$\pm$0.5 cmH2O, 14.2$\pm$0.6 cmH2O, 15.7$\pm$0.8 cmH2O, 제 2군에서는 17.8$\pm$2.0 cmH2O, 18.0$\pm$1.9 cmH2O, 19.3$\pm$2.7 cmH2O으로 제 1군에서 조금 낮은 경향을 보였으나 통계적 유의성은 없었다. 동맥혈 이산화탄소 분압은 제 1군에서 각 시간에 27.9$\pm$2.2 mmHg, 27.7$\pm$2.4 mmHg, 28.0$\pm$3.0 mmHg, 제 2군에서는 36.8$\pm$6.0 mmHg, 43.2$\pm$8.1 mmHg, 53.1$\pm$17.4 mmHg로 제 1군에서 유의하게 낮았다 (p<0.05). 폐혈관 저항 및 조직 MDA양은 두 군간에 유의한 차이가 없었다. 폐 조직 수분 함량은 제 1군에서 유의하게 낮았고, 조직학 검사상 폐조직 손상의 정도도 제 1군에서 적었다. 결론: 이상의 결과에서 T3를 포함한 새로 개발한 폐보존액이 유로콜린스 용액과 비교하여 폐보존능이 우수함을 확인할 수 있었고, 이는 T3가 폐이식시 폐장의 효과적 보존에 유용한 역할을 함을 시사하였다.

• 대한수의학회지
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• 제46권2호
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• pp.171-175
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• 2006

Three dogs with suspected patent ductus arteriosus were referred to Veterinary Medical Teaching Hospital of College of Veterinary Medicine, Konkuk University because of cough, shortness of breath, exercise intolerance, and syncope, Continuous murmur and thrill were detected in physical examination. Left ventricular enlargement, cardiomegaly, bulged main pulmonary artey were found in radiography. Tall R wave, wide P wave, atrial fibrillation, and turbulent flow were observed in electrocardiogram and echocardiogram. Thoracotomy was performed at left fourth intercostal space under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. The median (mean ${\pm}$ SD) diameter of patents was $8.0{\pm}2.0mm$. The median operation time was $36{\pm}6.6min$. On examination right after surgery, continuous murmur, thrill, atrial fibrillation, and turbulent flow were disappeared. On 30 days after surgery, clinical signs, left ventricular enlargement, and, bulged main pulmonary artery were disappeared. VHS 12.5 and 13.5, R wave 3.3 and 3.0 mV, and P wave 0.05 and 0.05 sec were decreased to 10.0 and 10.5, 1.8 and 2.0 mV, and 0.04 and 0.04 sec respectively in case 1 and 2. Ratio of aorta and main pulmonary artery in diameter was changed 1 : 1.3 and 1 : 1.6 into 1 : 1.1 and 1 : 1 respectively in case 1 and 2. Mild tear developed during dissection in case 3 and hemorrhage was controlled by vascular Devakey forceps. However, the dog died. On 12 months after surgery, patients (case 1 and case 2) have not showed abnormal signs.

• 한국산림과학회지
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• 제113권2호
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• pp.210-221
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• 2024

본 연구는 운동처방을 적용한 숲길 걷기 운동이 노인의 신체조성에 미치는 영향을 밝히는 것을 목적으로 수행되었다. 연구대상자는 65세 이상 75세 미만의 노인 44명(평균연령: 69.3±3.1세)으로 하였다. 실험군 22명은 개인의 건강상태 등 을 고려하여 처방된 운동강도를 바탕으로 매주 3회, 회당 1시간 이상의 숲길 걷기를 8주 동안 진행하였다. 대조군 22명은 평소와 같은 생활을 지속하였다. 실험군 및 대조군의 8주 동안의 체성분 변화를 측정하였으며, ①실험군의 숲길 걷기 전후 비교, ②대조군의 사전 사후 측정 결과 비교, ③실험군과 대조군의 변화량(사후-사전) 비교의 3가지 관점에서 분석을 진행하였다. 그 결과, ①실험군에서 체중, 체지방, 체질량 지수에서의 유의한 감소, ②대조군에서 오른팔 근육량 및 비율, 몸통 근육 비율, 왼쪽 다리의 근육량 및 비율, 오른팔 체수분의 유의한 감소가 나타났으며, ③그룹 간 비교결과, 실험군은 체중 및 체지방이 감소한 반면 대조군은 증가하였다는 사실을 알 수 있었다. 결론적으로, 운동처방을 적용한 숲길 걷기는 노인의 신체조성에 긍정적인 영향을 미친다는 것이 밝혀졌다.

• 한국의학물리학회지:의학물리
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• 제19권2호
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• pp.95-101
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• 2008

본 기초연구에서는 강제수영검사(forced swimming test, FST)에 의해 우울증이 유발된 쥐의 해마(hippocampus) 부위에서 뇌 대사물질(brain metabolites)중에 choline 신호의 변화를 관찰하였다. 본 연구의 목적은 우울증이 유발된 쥐에 항우울제인 desipramine-HCl을 투여하여 정상 쥐와 약물을 투여한 쥐 사이의 뇌 대사물질의 차이를 자기공명분광법(magnetic resonance spectroscopy: MRS)을 통하여 알아보는 것이다. 실험대상으로는 6주령의 SD rat을 사용하였으며 우울증을 유발시키고 항우울제의 약물평가를 위한 모델링 방법으로 강제수영검사를 시행하였다. 자기공명분광법을 시행하기 위한 localization 방법으로는 PRESS 펄스시퀀스를 사용하였다(TR: 2,500 ms, TE: 144 ms, averaging: 512, complex data point: 2048, scan time: 25 min). 정상 쥐 그룹과 우울증을 유발시킨 뒤 항우울제를 투여한 쥐 그룹 모두 양쪽 해마부위에서의 NAA/Cr, Cho/Cr 비율(ratio)은 차이가 나지 않았다. 또한 왼쪽 해마에서 정상 쥐와 항우울제를 투여한 쥐 사이에서 NAA/Cr, Cho/Cr 비율도 차이가 나지 않았고, 오른쪽 해마부위에서도 통계적으로 유의한 차이가 없었다. 본 연구를 통하여 anti-immobility효과를 나타내는 항우울제를 투여함으로써 choline 신호가 정상 쥐와 비슷하게 회복되는 것을 관찰하였다. 이는 앞으로의 항우울제 약물 평가에 있어 자기공명분광법을 도입함으로써 기존의 주관적인 판단을 배제할 수 없었던 행동변화분석만으로 항우울제의 효과를 평가하는 방법에 비해 객관적이고 정량적인 분석을 할 수 있다는 점에서 아주 유용한 방법이라 사료된다.

• 한국방사선학회논문지
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• 제17권3호
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• pp.315-325
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• 2023

본 연구는 복부 비만도에 따라 콩팥 크기의 상관관계를 분석하여 3차원 전산화단층영상(3-Dimensional Computed Tomography, 3D CT)의 콩팥 크기 계측으로 복부 비만도를 예측하고자 하였다. 대상자는 전주 예수병원 건강의학센터에서 종합검진을 받은 자로 기저질환이 없는 건강한 성인 178명으로 하였다. 복부 비만도는 CT의 배꼽 주변의 횡단면에서 내장지방 면적, 피하지방 면적, 비만도로 구분하여 측정하였다. 복부 비만도 간에 따라 분류한 콩팥 크기의 평균 비교는 일원배치 분산분석(One-way analysis of variance, ANOVA) 및 Scheffe 사후 검정을 통해 시행하였다. 모든 계측 값의 상관관계는 Pearson 상관분석 하였다. 그 결과 복부 비만도에 따른 콩팥 크기 ANOVA 분석 결과는 다음과 같다. 내장 지방도 간에 따른 콩팥 계측치의 평균은 모든 콩팥 계측치에서 유의한 차이가 있었다(p<0.05). 피하 지방도 간에 따른 콩팥 계측치의 평균은 3D CT 우측 콩팥 너비 계측 시 중증 비만군에서 유의한 차이를 보였다(p<0.05). 비만도 간에 따른 콩팥 계측치의 평균은 3D CT 우측 콩팥 너비와 좌측 콩팥 너비 계측 시 중증 비만군에서 유의한 차이를 보였다(p<0.05). 콩팥 계측치와 CT 복부 비만도 간의 Pearson 상관분석 결과 내장지방 면적은 3D CT 좌측 콩팥 너비와 상대적으로 높은 양의 상관관계(r=0.467)를 보였으며 피하지방 면적은 3D CT 우측 콩팥 너비와 양의 상관관계(r=0.249)를 보였다. 비만도에서는 3D CT 좌측 콩팥 너비와 양의 상관관계(r=0.291)를 보였다.

• 대한핵의학회지
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• 제23권2호
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• pp.155-163
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• 1989

Regional cerebral perfusion was evaluated in 15 normal controls by single photon emission computed tomography using $^{99m}Tc$ HM-PAO. For quantitative analysis, 13 pairs of homologous region of interest (ROI) were drawn on three transverse slices matching the vascular territories and cerebral cortices, and normal values of 3 semiqunatitative indices including 'Right to left ratio'(R/L ratio), 'Regional index'(RI), and 'Region to cerebellum ratio'(R/cbll ratio) were calculated. Mean values of R/L ratios of homotogous regions were ranged from 0.985 to 1.023, and mean ${\pm}2$ s.d. of all regions did not exceed 11% of mean. Significant difference of RIs (mean count per voxel of a ROI/mean count per voxel of total ROIs) between regions were found (p<0.001) with highest values in occipital cortex and cerebellum. After attenuation correction, RIs in deep gray, cranial portion of anterior cerebral artery and vascular territories in the 2nd slice increased significantly (p < 0.05-0.001), but vise versa in other ROIs. Region to cerebellum ratios also showed regional difference similar to RIs.

• 대한정형도수물리치료학회지
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• 제8권2호
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• pp.31-43
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• 2002

The subjects of this study were 15 woman soccer players and 15 untrained woman students at H-Cheju University. Each subject was measured on the muscle strength and peak torque of knee extensors and knee flexors with isokinetic load ($60^{\circ}$/sec, $180^{\circ}$/sec). The results were as follows: 1. There was no significant difference between right and left leg strength measured isokinetically in each group. 2. The peak torque of knee extensors and flexors was significantly higher in scoccer players than untrainded students (p<0.001). 3. For the angle of knee joint showing the highest peak torque, there was significant difference between soccer players and untrained students in knee extensors(p<0.05) and right flexors (p<0.01). 4. For knee H/Q ratio, there was significant difference between two groups(p<0.05). 5. For the total work and average power at $180^{\circ}$/sec, there was significant difference between two groups in knee extensors(p<0.001) and flexors(p<0.01). 6. In soccer players at $60^{\circ}$/sec, there were significant correlations between peak torque and height and between peak torque and weight.(p<0.001). 7. For the muscular contraction velocity at $60^{\circ}$/sec, there was significant difference between two groups in flexors (p<0.01). 8. For the muscular indurance at $180^{\circ}$/sec in extensors and flexors, there was no significant difference between two groups(p<0.05). In conclusion, there were significantly higher in peak torque, contraction velocity, knee joint's angle with the highest peak torque, H/Q ratio, total work and average power in woman scoccer player than general students. But there was no significant difference in muscular endurance. Soccer performance is based on the various components including muscular endurance that is one of the most important components. So it is necessary that the training method to improve the various components (especially including muscular endurance) should be done.

• The Journal of Korean Physical Therapy
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• 제27권3호
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• pp.169-173
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• 2015

Purpose: This study aimed to improve the asymmetrical weight-bearing ratio, by applying different repetitive sit-to-stand training methods to the paretic-side foot of hemiplegic patients, as well as to provide the necessary information for applying balance training with hemiplegic patients. Methods: The subjects were divided into two groups: a spontaneous foot group and an asymmetrical foot group. They all performed repetitive sit-to-stand training five times a week for a total of six weeks. The sit-to-standing movement was studied using standardized clinical tests. The Biodex Balance System, Time up and go test (TUG), 5 times sit-to-stand test (5XSST), and functional reach test (FRT) were used to measure the static and dynamic standing balance of the patients. Results: In the balance system measurement, the results for the overall index, ant-post index, med-lat index, fall risk index, 5XSST, and FRT after the training differed significantly between the comparison groups (p<0.05). In the evaluation of dynamic balance, the differences in TUG did not differ significantly between the comparison groups after the training (p>0.05). Conclusion: The study found that the asymmetrical group showed significant increases in static and dynamic balance in comparison to the spontaneous group after repetitive sit-to-stand training. Based on this result, it is clear that training in an asymmetrical position with the paretic foot back can increase the left-right stability limit and the anterior-posterior stability limit, thus improving balance control.

• Advances in pediatric surgery
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• 제9권2호
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• pp.89-93
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• 2003

A lipomatous lesion of the cord is an accidentally encountered structure during the operative repair of inguinal hernia. This lesion has been reported as a lipoma of the cord in adults. However, there is only a limited number of reports in the pediatric age group. To evaluate the prevalence of this lesion in children and in order to review the surgical signiticancies, 600 hernia operations in 411 children during a period of 4 years from January, 2000 to December, 2003 in the Division of Pediatric Surgery, Department of Surgery, the Catholic University of Korea, were included in this study. There was a total of 31 (5.2 %) lipomatous lesions in 25 (6.1 %) cases; 3 cases in infants, 17 between 1 to 4 years, and 5 above 5 years of age. Male was more prevalent (male to female ratio 14:11). The laterality of clinical hernia with the lesions was 10 in the right, 13 in the left and 2 in both sides. The patients with ipsilateral lesions to the hernia were 14, contralateral in 5 and bilateral in 6 cases. Excluding 1 case of bilateral lesions in bilateral hernia, 10 lesions were contralateral to the clinical hernias. In 1 case, lipomatous lesion was the sole finding with nonsignificant patent processus vaginalis. Every lesion was suture ligated and resected with gentle traction of the dissected hernia sac. It has not been clearly defined whether the lesion is a stopper or a provocator of the hernia development. However, removal is highly recommended to make a differential diagnosis from the recurrent inguinal hernia in future. The term "lipomatous lesion" seems to be pathologically accurate and must be differentiate from the true lipomas.

• 한국축산식품학회지
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• 제35권2호
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• pp.171-178
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• 2015

This study aimed to investigate the effects of Lactobacillus plantarum FH185 on the reduction of adipocyte size and gut microbial changes in mice with diet-induced obesity. The strain was found to have a lipase inhibitory activity of 70.09±2.04% and inhibited adipocyte differentiation of 3T3-L1 cells (18.63±0.98%) at a concentration of 100 µg/mL. To examine the effect of the strain supplementation on gut microbial changes in mice with diet-induced obesity, male C57BL/6J mice were fed on four different diets (i.e., A, normal diet (ND); B, high-fat diet (HFD); C, HFD with ABT-3 (10⁹ CFU/day); and D, HFD with L. plantarum FH185 (10⁹ CFU/day)) for 6 wk. According to the results of fecal pyrosequencing, the ratio of Firmicutes to Bacteroidetes in groups C and D was lower than in the control groups at the phylum level. At the family level, Lactobacillaceae in groups C and D was observed to dominate, while Lachnospiraceae in groups A and B was observed to dominate. At the genus level, Lactobacillus in groups C and D was comparatively higher than in groups A and B. To examine the effects of strain supplementation on the reduction of adipocyte size, the left and right epididymal fat pads were quickly isolated after the animals were sacrificed, and the adipocyte sizes were measured. In groups A, C and D, the percentage of 2,000 m² of adipocyte was higher than in the other size of adipocyte, while the percentage of over 5,000 m² of adipocyte was highest in group B. The mean adipocyte size of group D was significantly larger than that of group A, but smaller than that of group B.