• Title/Summary/Keyword: Leech

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The Relationship between Explanation and Patient Compliance in Hirudotherapy

  • Kim, Kwang Seog;Sim, Ho Seup;Shin, Jun Ho;Hwang, Jae Ha;Lee, Sam Yong
    • Archives of Craniofacial Surgery
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    • v.18 no.3
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    • pp.179-185
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    • 2017
  • Background: The use of leeches can effectively increase the salvage rate of flap congestion. However, the first reaction from patients and carers in using leeches in clinical fields is strong aversion. This can be due to the fact that development of our culture from agriculture to industrial society, coming across leeches became fairly rare. Also because of the biological traits that leeches carry; staying attached to a leg or other body parts of the host, sucking blood, and leaving wounds. Methods: This study was conducted through questionnaires, divided into many subgroups. We scaled the compliance of the two therapies, with or without leech. Maximum scale of 10 showing no rejective response to the therapy and minimum scale of 0 showing the greatest rejective response. Results: Overall subjects' compliance was improved after explaining the benefits of hirudotherapy. Irrelevant to the explanation, there was no significant difference in general compliance between male and female. Young-aged group and medical personnel or people studying medicine showed higher compliance over older-aged group and the general public. Conclusion: In the terms of general social cognition, recognizing leech as a therapeutic material may not be welcomed at first, but provided with proper information and explanations, overall compliance of patients and carers can be improved and consequently result in superior outcomes in flap salvage.

A New Record of Roeselia triangulalis (Lepidoptera: Nolidae) from Korea

  • Choi, Sei-Woong
    • Animal Systematics, Evolution and Diversity
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    • v.27 no.3
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    • pp.274-276
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    • 2011
  • A nolid species, Roeselia triangulalis (Leech) is reported for the first time from Korea. Two males were collected from Jeju Island, South Korea. Roeselia triangulalis can be distinguished by the bipectinate male antennae, broad frons, long labial palpi, costally dark brownish spot and the rounded dark brownish postmedial line of forewing. In the male genitalia, the long saccus, the slender valve with distally expanded and spine-like harpe and long spinular cornutus of vesica are distinguishing characters. In the female genitalia, the simple sterigma, the long ductus bursae and the large ovate corpus bursae with a lip-shaped signum are distinguishing characters. Diagnosis and description of the species are given with the figures of the male genitalia.

A Study on Economic Analysis of R&D Output -With Respect to Hirudin- (연구개발제품(硏究開發製品)의 경제성분석(經濟性分析) 연구(硏究) - 히루딘을 중심으로 -)

  • Hyeon, Byung-Hwan;Lim, Jae-Hwan
    • Korean Journal of Agricultural Science
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    • v.24 no.1
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    • pp.55-62
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    • 1997
  • Hirudin is a potent thrombin inhibitor originally derived from the medicinal leech. Leeches were commonly used at the turn of the century for bloodletting and are still used today in some countries. So, hirudin is being developed as a alternative to heparin which has several shortcomings. This study is intended to analyze R&D trends, potential market for hirudin and existing anticoagulant drug market. Anticoagulant drug market in Korea is estimated by over 1,200 billion won in 2010 and revenues in the world market are forecasted to reach 1.62 billion dollar in 1999.

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Evaluation of Anticoagulant Activity of Recombinant Hirudin (유전자 재조합에 의해 제조된 하루딘의 항응고 작용)

  • 김영식;엄은미;정정숙;정춘식;정기화;손정훈;최의성;이상기
    • Biomolecules & Therapeutics
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    • v.1 no.2
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    • pp.166-170
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    • 1993
  • Hirudin is a potent inhibitor of thrombin, which was originally obtained from the medicinal leech (Hirudo medicinalis) Now it is being produced through the recombinant technology on a large scale. Recombinant hirudin has been assayed for the anticoagulant activity by the measurement of clotting time and the inhibition of thrombin actvity using a chromogenic substrate. The assay range of partial thromboplastin time and thrombin time is within $0.2{\sim}1.0 {\mu}g/mι.$ Thrombin time is more sensitive to the measurement of clot. Ex vivo study showed the level of hirudin in rat plasma was highest in 10 min and then it was eliminated slowly. The half-life of r-hirudin was 80~110 min depending on the assay methods. Intraveneous injection of russel viper venom was used for thrombus induction combined with vents cava ligation. Inhibition of venous thrombosis was observed with i.v. hirudin. It was dependent on the concentration of hirudin.

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Cases of space design education by the media of Language (언어를 매개로 한 공간디자인 교육사례)

  • Yim, Eun-Young
    • Proceedings of the Korean Institute of Interior Design Conference
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    • 2007.05a
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    • pp.95-96
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    • 2007
  • Language is the method for communication. Semantician, G. Leech categorized the function of language as informational, expressive, directive, aesthetic and phatic one. Therefore, language can be defined as the social symbol system and the media for communication. Space, also, performs the role of symbol, information and communication. Space can be the media for the communication and the design can be logical construction process by it's arbitrary interpretation. The researcher considered the common points between verbal language and visual language as the tools for the mutual communication, tried to transit them into the 'space' as object language after analyzing 'image of poetry' as meta language, so that the old perspective of space design as function can be renewed as information system of the significant meaning delivery in the context of language's multiplicity, expandibility and changeability.

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The Effects of Live Leech (Hirudo Medicinalis) Therapy on Diabetic Foot: a Clinical Case Report

  • Na, Hyun-Jong
    • The Journal of Korean Medicine
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    • v.24 no.4
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    • pp.136-138
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    • 2003
  • Purpose : A clinical case of diabetic foot-wound repair using Hirudo medicinalis therapy and its application is reported and discussed. Methods : The subject was a sixty-six-year-old woman diagnosed with a non-healing wound indicating the amputation of her right diabetic foot. Instead, Hirudo medicinalis therapy was performed twelve times over forty days, twice a week. The transition of wound closure was observed with the naked eye, and the plethysmogram was measured at the beginning and end of the treatment period. Results : The wound contracted with decreased exudate, collagen-like connective tissue sprouted, and then the wound gradually closed. The initial value (-0.08) of the dicrotic elastic index rose to -0.03. Conclusion : Hirudo medicinalis therapy had a positive effect on the wound repair, without a negative effect on the circulation, allowing the foot to be saved. It is necessary to investigate its wound repair mechanism for the further development of the Sahyul method.

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Gene Expression and Secretion of the Anticoagulant Hirudin in Saccharomyces cerevisiae

  • Sohn, Jung-Hoon;Lee, Sang-Kwon;Choi, Eui-Sung;Rhee, Sang-Ki
    • Journal of Microbiology and Biotechnology
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    • v.1 no.4
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    • pp.266-273
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    • 1991
  • Hirudin, a 65-amino acid protein isolated from the salivary gland of the bloodsucking leech, Hirudo medicinalis, is a potent thrombin-specific inhibitor and blocks the thrombin-mediated conversion of fibrinogen to fibrin in clot formation. We have studied the gene expression and secretion of hirudin in yeast. Saccharomyces cerevisiae. A gene coding for hirudin was synthesized based on the amino acid sequence and cloned into a yeast expression vector $YEG{\alpha}-1$ containing the ${\alpha}-mating$ factor pre-pro leader sequence and galactose-inducible promoter, GALl0. Recombinant S. cerevisiae was found to secrete biologically active hirudin into the extracellular medium. The secreted recombinant hirudin was recovered from the culture medium and purified with ultrafiltration and reverse phase high performance liquid chromatography. Approximately 1 mg of hirudin per liter was produced under suboptimal culture conditions and brought to about 90% purity in two steps of purification.

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A New Record of Disparia diluta from Korea, with Note on Disparia nihonica (Lepidoptera: Notodontidae)

  • Kwon, Young-Dae;Ji, Eun-Mi;Park, Kyu-Tek
    • Animal Systematics, Evolution and Diversity
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    • v.26 no.1
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    • pp.35-37
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    • 2010
  • A notodontid moth, Disparia diluta (Hampson, 1910) is reported for the first time from the Korean peninsula. At the same time, taxonomical note for D. nihonica (Wileman, 1911) is given. The male genitalia of D. nihonica (Wileman) were erroneously illustrated as those of Neodrymonia delia (Leech) by Tshisjakov and Kwon (1999), and Schintlmeister (2008) cited D. nihonica (Wileman) to be distributed in the Korean peninsula, based on the illustration.

Taxonomic Studies on Three Caeneressa Species (Lepidoptera: Syntominae) from India with Special Reference to Their External Genitalia

  • Kirti, Jagbir Singh;Singh, Navneet;Joshi, Rahul
    • Animal Systematics, Evolution and Diversity
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    • v.30 no.1
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    • pp.33-38
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    • 2014
  • Caeneressa diaphana muirheadi (Felder) and Caeneressa brithyris (Druce) have been recorded for the first time from India. Further, a new combination viz. Caeneressa melaena (Walker) comb. nov., has also been proposed on the basis of external genitalic features. With these records, genus Caeneressa will be represented by five species from India, Caeneressa diaphana (Kollar), Caeneressa diaphana muirheadi (Felder), Caeneressa brithyris (Druce), Caeneressa melaena (Hampson) and Caeneressa swinhoei (Leech). The studied material was collected from North-Eastern states of India. Caeneressa brithyris (Druce) was collected near riverside at low altitude whereas the other two species were collected at high altitude.

Preliminary Study on the Korean Cochylidae(Lepidoptera with Ten Unrecorded Species from Korea (한국산 Cochylidae(가는잎말이나방과 : 신칭)에 관하여 -미기록 10종의 발표와 함께-)

  • Park Kyu-Tek
    • Korean journal of applied entomology
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    • v.15 no.2 s.27
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    • pp.69-74
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    • 1976
  • Only twe species of the family Cochylidae were previously reported from Korea by foreign entomologsts, but this family has not been known in Korea to date. In this paper, I deal with ten species newly recorded from Korea.

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