• Toxicological Research
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• v.3 no.1
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• pp.33-44
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• 1987

A fertility study was carried out in Sprague Daxley rats which have been given the intravenous or intraperitoneal injections of rHuIFN-${\alpha}$A, a commecially available therapeutic agent, at dose levels of $1{\times}10^5$, $4{\times}10^5$ and $1.2{\times}10^6$ I.U/kg/day. Male rats were treated with rHuIFN-${\alpha}$A from 60 days before pairing and until the completion of mating. Femal rats received rHuIFN-${\alpha}$A for 22days prior to mating and up to day of gestation. All pregnant females were sacrificed on day 20 of gestation and all fetuses were examined for abnormalities. Both the male and female animals treated with rHuIFN-${\alpha}$A did not show any abnormal responses. No abnormal signs were seen in reproducibility for the rats treated with rHuIFN-${\alpha}$A. No External, internal and skeletal anomalies attributable to rHuIFN-${\alpha}$A were observed in the fetuses. It was concluded that rHuIFN-${\alpha}A$ had no harmful effect on mating, fertilization, implantation, or embryonic development.

• Journal of Korean Clinical Nursing Research
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• v.18 no.1
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• pp.52-62
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• 2012

Purpose: This study was done to evaluate the effects of Doin Gigong Exercise on the Recovery from Facial Paralysis, pain and anxiety in patients with Bell's palsy. Methods: A nonequivalent control group posttest-only non-synchronized design was used for this study. Participants were contacted at the oriental medicine ward of D hospital in Busan and assigned to either the experimental group (25) or control group (25). Collected data were analyzed for changes in recovery from facial paralysis, in pain and in anxiety between pre and post Doin Gigong Exercise. Data analysis was done using t-test, Fisher's exact test, $x^2-test$ with the SPSS 12.0 Win program. Results: There were significant decreases in the lip paralysis status pain and in anxiety between pre and post Doin Gigong Exercise. Conclusion: The results indicate that Doin Gigong Exercise is effective for patients with Bell's palsy to decrease lip paralysis, pain and anxiety and therefore, an effective intervention for use with patients with Bell's palsy.

• Toxicological Research
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• v.18 no.2
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• pp.139-147
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• 2002

Hantaan (HTNV) and Puumala (PUUV) viruses cause hemorrhagic fever with renal syndrome in human. In the present study, the repeated dose toxicity of the HTNV-PUUV combination vaccine was evaluated in Sprague-Dawley rats. Animals were injected subcutaneously for 28 days with dosages of 0, 0.017, 0.17 and 1.7 dose/kg body weight per day, respectively. No any significant changes of body weight, food and water consumptions were shown. There were no death and clinical findings during the experimental period. In both male and female rats, there were not significant changes in hematological and serum biochemical analysis, urinalysis, and ophthalmoscopic and histopathological examination. These results indicate that the HTNV-PUUV combination vaccine may have no toxic effects and no observed adverse effect level (NOAEL) may be over 1.7 dose/kg/day at subcutaneous route in rats.

• Korean Journal of Ecology and Environment
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• v.37 no.4 s.109
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• pp.378-384
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• 2004

We investigated the variations of epilithic diatom community and assessed water quality of the water system of Ulleung Island by DAIpo in April, May, July, August, October, and November of 2003, and January and February of 2004. Samples were collected from four sampling stations. Total 95 taxa were identified from this study and dominant species were Nitzschia inconspicua, Achnanthes minutissima, Gomphonema angustum and Cocconeis placentuja var. lineata. The variation of DAIpo values was ranged from 51.14 to 77.77 and the water quality by DAIpo was estimated between ${\alpha}-oligosaprobic$ and ${\beta}- oligosaprobic$ states.

• YAKHAK HOEJI
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• v.40 no.6
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• pp.621-624
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• 1996

Betaine was treated with hydrochloric acid and then with sodium borohydride to give a hydroxy compound 2. The reaction of 2 with thionyl chloride followed by thiourea led a comp ound 5. Oxidation of compound 2 with pyridinium dichromate(PDC) and succesive treatment with Lawesson's reagent also afforded the same compound 5. Cleavage of N-C14 bond compound of 7 was carried out via two reaction sequence from the compound 4. Finally, compound 10 was sythesized by a series of transformations from the compound 4.

• Journal of the Korean institute of surface engineering
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• v.44 no.6
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• pp.239-245
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• 2011

Magnesium alloys is the lightest by structural metals, but it is not good corrosion resistant because of pit, void. Particularly, AZ31B magnesium alloy sheets that have slag, scratch by rolling process indicate some defects. The objective of this research is to perform uniform plating on AZ31B by studying etching and zincate process. Especially, zincate treatment by zinc salt and pyrophosphate is the most important in the decoration plating. Dissolution of magnesium is reduced by the formation of uniform zinc conversion layer during strick and post process, which decreases defects for plating process.

• International Journal of Contents
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• v.6 no.1
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• pp.59-64
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• 2010

Recently, biological researches are required to deal with a large scale of data. While scientists used classical experimental approaches for researches in the past, it is possible to get more sophisticated observations easily with the convergence of information technologies and biology. The study on diseases is one of the most important issues of the life science. Conventional services and databases provide users with information such as classification of diseases, symptoms, and medical treatments through the Web. However, it is hard to connect or develop them for other new services because they have independent and different criteria. It may be a factor that interferes the development of biology. In this paper, we propose integrated data structures for the disease databases. We also design and implement a novel directory system for diseases as an infrastructure for developing the new diseases services.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.170-170
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• 2001

This study was designed to evaluate a repeated intravenous dose toxicity of a new anticancer agent, SB extracted from Pulsatilla korean Nakai in Beagle dogs. Animals were intravenously injected with dosages of 0, 0.062, 0.25, and 1 mg/kg of SB everyday for 13 weeks, respectively. There were no dose-related changes in clinical signs, body weight changes, food and water consumptions, opthalmoscopy, and urine analysis. There were somewhat significant differences compared with control group in organ weight, biochemical examination, and hematology findings of animals treated with SB. However, these changes were not dose-related changes. Gross and histopathological findings revealed no evidence of specific toxicity related to SB. These indicate that intraveous maximum tolerated dose value of SB may be over 1mg/kg in rats.

• Child Health Nursing Research
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• v.9 no.4
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• pp.368-375
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• 2003

Purpose: The purpose of this study was to determine rate of breastfeeding practice at 3 months and to examine predictors for breastfeeding practice. Method: Study subjects were 114 mothers who gave birth at one hospital in Busan area. Data regarding breastfeeding practice and potentially related factors to breastfeeding were collected through a self-administered questionaire at 1 weeks and a telephone survey at 3 months. Logistic regression was used to identifiy significant the predictors on breastfeeding practice. Result: Rate of breastfeeding practice was 46.5% at three months of postpartum. The significant predictors for performing breastfeeding were lower the experience of breastfeeding trouble problem(OR=.88 compared with breastfeeding women, 95% CI; 78-.99), higher first breastfeeding satisfaction (OR=1.81 compared with non-breastfeeding women, 95% CI; 1.08-3.32), higher breastfeeding confidence(OR=1.84 compared with non-breastfeeding women, 95% CI; 1.08-3.32). Conclusion: The findings suggest the necessity of support program for mothers during the positive postpartum period to provide correct information about breastfeeding knowledge and attitude and to teach problem-solving skills for any breastfeeding problems for highere rate of breastfeeding practice

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.3
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• pp.40-51
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• 2008

This research presents a new active auxiliary resonant snubber with for induction heating PWM high frequency inverter solving the problem of induction heating PWM high frequency inverter circuit which is using widely in the practical application of an induction heating apparatus, the soft switching operation and power control are impossible when the lowest power supply in the active auxiliary resonant snubber with for induction heating PWM high frequency inverter. The inverter circuit which is attempted by the on-off operation of a switch has the effect of reducing the power loss due to soft switching and high frequency switching. This confirms that power regulation is possible on a continuous basis from 0.25[kW] to 2.84[kW] where the duty factor(D) changes from 0.08 to 0.3 under zero current switching which operates by an asymmetrical pulse width modulating control. The power conversion efficiency is 95[%]. Due to these results, the active auxiliary resonant snubber for an induction heating PWM high frequency inverter is considered effective as a source of induction heating.