• Bulletin of the Korean Chemical Society
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• 제27권6호
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• pp.909-917
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• 2006

2,2-Dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyran analogues (eg., 7 and 8) were identified as prolyl 4-hydroxylase inhibitors via a screening process using HSC-T6 and LI 90 cells that express an immortalized rat hepatic stellate cell line and as part of a test of the type I collagen contents employing the ELISA method. A subsequent lead optimization effort based on solid-phase parallel synthesis led to the identification of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans as potent inhibitors of prolyl 4-hydroxylase.

• 대한간호학회지
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• 제42권3호
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• pp.434-442
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• 2012

Purpose: The purpose of this predictive study was to identify factors affecting health related quality of life (HRQoL) in patients with rheumatoid arthritis (RA). Methods: The participants in this study were 131 patients with RA who were recruited from the outpatient clinic of a university hospital in Seoul. Disease activity in rheumatoid arthritis was evaluated by calculating the Disease Activity Score 28. Disability in activities of daily living (ADL) was assessed with the Korean Health Assessment Questionnaire, and depression with The Center for Epidemiologic Studies Depression Scale. HRQoL was evaluated using The Short Form 36 Health Survey. Data were analyzed using descriptive statistics, correlation, and hierarchical multiple regression. Results: Pain, disability in ADL, disease activity, and depression correlated negatively with physical and mental dimensions of HRQoL. But hierachical multiple regression analysis revealed that disability in ADL and depression were the only variables negatively influencing physical and mental QoL after adjustment for influences of sociodemographic variables. Conclusion: Results of this study suggest that disability in ADL and depression, rather than disease activity and pain have profound effects on HRQoL in patients with RA. Further studies are needed to assess the predictive ability of disease activity and pain on HRQoL in this population.

• 한국산업융합학회 논문집
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• 제9권1호
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• pp.61-66
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• 2006

In perspective of saving natural resource and energy, today's automobiles are in process of regenerating by smaller and lighter. In order to achieve the sufficiency on the consumption of the fuel, new mechanism and new assembly are required. Therefore the expectations on the new materials are very high. Especially, AI materials are widely used to reduce the weight. AI that is used in automobiles is mostly casting material, and according to the innovation of technique is in rapid development. AI Die casting is an important field as today's trend of lightweight on automobiles. One of the parts in steering system, Valve Housing plays a role of reduce the operating effort of drivers. Unfortunately, the Valve Housing which is widely reliable to the most automobiles are not developed at this moment in our automobile industry. Therefore, they are produced by casting method which cost three times or even more expensive in production. If Valve Housing, which is a part of steering system is produced by Gravity Casting, the space that manufacturing equipment will be increased, and more time and workers would be brought into service. For such reason, Die Casting would replace Gravity Casting in order to minimize cost of time, manpower, and working space.

• 대한수학교육학회지:학교수학
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• 제15권2호
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• pp.263-288
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• 2013

본 연구는 전통적인 지필평가의 단점을 보완하기 위한 대안평가의 방법 중 하나인 면접평가의 현장 적용에 대한 실천적 방안을 제시하기 위하여 실행된 연구이다. 면접평가에 대한 다양한 이론들을 분석하고, 이를 토대로 수학학습 평가에서 면접평가 현장 적용을 위한 평가도구로서 면접평가 점검목록표 및 채점기준표를 개발하였다. 개발한 면접평가 점검목록표 및 채점기준표를 평가 목적에 따라 학생특성 면접평가와 사고과정 면접평가로 나누어 학교현장에 적용하고 결과를 분석함으로써 현장 적용의 실제적 활용가능성을 모색하고 논의사항을 제시하였다.

• 한국터널지하공간학회 논문집
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• 제9권1호
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• pp.19-28
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• 2007

시설물의 안전성을 위한 유지 관리는 시간과 인력에 따른 경비가 상당히 소모되는 작업이다. 특히 인력에 의한 육안 검사에 의해 이루어지는 터널과 같은 시설물 관리에는 많은 시간과 경비가 요구되고 있으며, 데이터의 보관이나 저장 등에 어려움이 많다. 본 연구에서는 이러한 단점을 극복하기 위하여 최근 신기술로 떠오르는 레이저 스캐닝 기술에 의하여 획득한 데이터를 이용하여 터널의 유지 관리에 필요한 정보를 추출하는 접근방법을 제안하고자 한다. 터널의 레이저 스캐닝 데이터는 시작품으로 제작된 레이저 스캐너를 이용하여 촬영하였으며, 고밀도 점 데이터의 형태로 저장된 자료를 이용하였다. 터널의 스캐닝 데이터의 기하학,광학적 특성을 이용하여 터널 내부에 장착된 시설물들을 제거 한 후, 터널의 라이닝 상에 나타나는 물리적인 손상부위나 균열을 탐지하는 방법을 제시한다. 물리적인 손상부위는 터널의 라이닝이 성립하는 면을 기준으로 근접성을 바탕으로 탐지된다. 이 연구에서는 제안된 알고리즘을 적용하여 현장의 디지털 사진에서 확인할 수 있는 물리적인 손상 부위를 탐지 할 수 있었다.

• 한국학교수학회논문집
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• 제16권2호
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• pp.289-318
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• 2013

본 연구는 전통적인 지필평가에서 수학적 과정 요소를 평가하기 어려운 단점을 보완하기 위하여 대안평가의 방법 중 하나인 관찰 평가의 현장 적용에 대한 실천적 방안을 제시한 연구이다. 수학 학습 평가에서의 관찰평가 현장 적용의 활성화 방안을 모색하고자 관찰평가에 대한 다양한 이론들을 분석하여 평가도구를 개발하였다. 또한 개발한 도구를 학교현장에 적용하고 그 결과를 분석함으로써 학교 현장에서 지속 가능하고 실행 가능한 활용 방안을 제시하였다. 이러한 연구 결과는 학교 현장에서 관찰 평가를 실행하고자 하는 교사들에게 유용한 지침이 될 것이다.

• 한방재활의학과학회지
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• 제28권2호
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• pp.21-35
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• 2018

Objectives The objective of this study is to determine the antimicrobial effect of Daehwanggyeonu-san(Dahwangqianniu-san,DGE) and synergistic effects with antibiotics oxacillin, ampicillin, and gentamicin against Methicillin-Resistant Staphylococcus aureus(MRSA). Methods The antibacterial activity of DGE extract was evaluated againest MRSA strains by using the Disc diffusion method, broth microdilution method(minimal inhibitory concentration; MIC), checkerboard dilution test. The checkerboard dilution test was used to examined synergetic effect of oxacillin, ampicillin, gentamicin, ciprofloxacin with DGE extract. Results DGE showed antimicrobial activity against MRSA with an MIC value of $125{\sim}250{\mu}g/mL$. In the checkerboard test, the interation of DGE with all tested antibiotics produced almost synergy or partial synergy against MRSA. Conclusions This study shows that DGE reduced the MICs of several antibiotics tested, and a remarkable antibacterial effect of DGE, with membrane permeability enhancers and ATP synthase inhibitors. This study can be a valuable source for the development of a new drug with low MRSA resistance.

• 대한족부족관절학회지
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• 제10권1호
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• pp.24-30
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• 2006

Purpose: To present our treatment protocol and surgical outcome for patients with congenital brachymetatarsia in which treatment was decided according to the number of affected rays. Materials and Methods: Sixty-nine metatarsals in 44 patients with single or multiple congenital brachymetatarsia were included in the study. When a single ray was affected in a foot, we performed a one-stage lengthening using an intercalary autogenous iliac bone graft. We overcame excessively short rays by the double level lengthening at the metatarsal and proximal phalanx as one stage. When multiple rays were affected in one foot, we performed a one-stage combined shortening and lengthening procedure without an iliac bone graft. Results: All patients were satisfied with the cosmetic and functional results. The average length gain by one-stage lengthening in 56 metatarsals of 38 patients was 14 (6-21) mm. Six patients with a combined shortening and lengthening procedure regained a nearly normal parabola of the involved foot. Neurovascular complication was not identified. Conclusion: Satisfactory results were achieved for the treatment of patients with congenital brachymetatarsia, by individualizing the surgical options according to the number of affected rays and general foot appearance.

• 대한세포병리학회지
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• 제16권1호
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• pp.47-51
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• 2005

Plasmablastic lymphoma (PBL) is a recently described aggressive B-cell neoplasm, which usually manifests as a localized disease of the oral mucosa in individuals infected with human immunodeficiency virus (HIV). Recently we encountered a case of plasmablastic lymphoma manifesting in the left maxillary sinus and cervical lymph node of a previously healthy HIV-negative man, 48 years of age. we conducted a fine-needle aspiration smear of the cervical lymph node, and this was found to be highly cellular with numerous large cells exhibiting eccentrically positioned nuclei, prominent nucleoli, and moderate quantities of basophilic cytoplasm. A biopsy of the mass in the maxillary sinus evidenced diffuse growth of similar plasmablastic cells. These tumor cells were negative for the leukocyte common antigens, CD20, CD3, CD30, and EMA. However, the cells tested positive for CD79a and CD138/syndecan-1. The tumor cells also exhibited L-light-chain restriction. The Ki-67 proliferation index was measured at almost 100%. The patient was diagnosed with plasmablastic lymphoma. After three cycles of combination chemotherapy and radiotherapy, the patient went into complete remission, and currently remains in this state.

• 한국지구과학회지
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• 제25권8호
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• pp.764-773
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• 2004

산불지역 토양의 침식양상을 구분하기위하여 강원도 강릉시 사천면 일대의 산불지역 토양을 조사하였다. 토양은 유기물의 분포양상 및 토양층의 두께, 토양층 발달의 완전성(성숙도)를 근거로 5개 유형으로 구분하였다. 침식 현상은 토양의 유형에 따라 다르게 나타났다. 나뭇잎, 낙엽층, 뿌리, 재 그 밖의 유기물의 피복이 토양의 색과 영상 이미지 반사에 영향을 미치는 중요한 요인이었다. 침식양상의 차이를 보이는 5개 유형의 토양의 Landsat ETM 영상은 토양 유형별로 상이한 반사특성을 보였다. 산불지역 토양의 정규식생지수(NDVI)와 무감독 분류는 토양유형에 따른 Landsat ETM 영상 차이를 잘 반영하기 못하였으나, 최대우도법에 의한 감독분류 기법의 적용시 산불지역에서 침식형태에 따른 토양유형 구분이 가능하였다. 본 연구는 산불지역에서 침식현상을 파악하고 예측하는데 Landsat ETM 영상의 활용이 매우 효과적임을 보여주었다.