• Title/Summary/Keyword: Leaflet

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Outcomes of Mitral Valve Repair: Quadrangular Resection versus Chordal Replacement

  • Park, Kwon-Jae;Woo, Jong Soo;Yi, Jung Hoon;Park, Jong Yoon
    • Journal of Chest Surgery
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    • v.46 no.2
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    • pp.124-129
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    • 2013
  • Background: Mitral valve repair for posterior mitral leaflet (PML) prolapse has been considered to be a standard treatment because of its high success rate and high level of patient satisfaction. The aim of this study was to evaluate the clinical results of two different techniques of PML prolapse, quadrangular resection (QR) and chordal replacement (CR). Materials and Methods: The subjects consisted of 56 patients who had undergone mitral valve repair for PML prolapse between November 1997 and December 2010. The patients were divided into two groups according to surgical technique. Among them, 31 patients underwent QR (group QR) and 25 patients had CR (group CR). We reviewed the medical records of the patients retrospectively to compare the clinical outcomes of both groups. Results: After mitral valve repair, the degree of mitral regurgitation (MR) in both groups decreased to the to a mild degree or less and the amount of remnant MR was slightly higher in the CR group but it was not statistically different. Three patients received mitral valve-related reoperation (2 in the QR group and 1 in the CR group). Freedom from mitral valve-related reoperation at 7 years was 93% for the QR group and 96% for the CR group and was not significantly different between the two groups. Conclusion: Both QR and CR showed excellent long-term results and were considered equally effective methods for PML prolapse.

Structure and Bacterial Cell Selectivity of a Fish-Derived Antimicrobial Peptide, Pleurocidin

  • Yang Ji-Young;Shin Song-Yub;Lim Shin-Saeng;Hahm Kyung-Soo;Kim Yang-Mee
    • Journal of Microbiology and Biotechnology
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    • v.16 no.6
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    • pp.880-888
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    • 2006
  • Pleurocidin, an $\alpha$-helical cationic antimicrobial peptide, was isolated from skin mucosa of winter flounder (Pleuronectes americamus). It had strong antimicrobial activities against Gram-positive and Gram-negative bacteria, but had very weak hemolytic activity. The Gly$^{13,17}\rightarrow$Ala analog (pleurocidin-AA) showed similar antibacterial activities, but had dramatically increased hemolytic activity. The bacterial cell selectivity of pleurocidin was confirmed through the membrane-disrupting and membrane-binding affinities using dye leakage, tryptophan fluorescence blue shift, and tryptophan quenching experiments. However, the non-cell-selective antimicrobial peptide, pleurocidin-AA, interacts strongly with both negatively charged and zwitterionic phospholipid membranes, the latter of which are the major constituents of the outer leaflet of erythrocytes. Circular dihroism spectra showed that pleurocidin-AA has much higher contents of $\alpha$-helical conformation than pleurocidin. The tertiary structure determined by NMR spectroscopy showed that pleurocidin has a flexible. structure between the long helix from $Gly^3$ to $Gly^{17}$ and the short helix from $Gly^{17}$ to $Leu^{25}$. Cell-selective antimicrobial peptide pleurocidin interacts strongly with negatively charged phospholipid membranes, which mimic bacterial membranes. Structural flexibility between the two helices may play a key role in bacterial cell selectivity of pleurocidin.

Tricuspid Papillary Fibroelastoma Mimicking Tricuspid Vegetation in a Patient with Severe Neutropenia

  • Choi, Kuk Bin;Kim, Hwan Wook;Kim, Do Yeon;Jo, Keon Hyon;Choi, Hang Jun;Hong, Seok Beom
    • Journal of Chest Surgery
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    • v.49 no.3
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    • pp.195-198
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    • 2016
  • We report a 72-year-old male with known myelodysplastic syndrome who presented to the emergency department with a 7-day history of fever and dyspnea. Echocardiography revealed a round echogenic mass $13{\times}16mm$ in size attached to the atrial side of the tricuspid valve. Considering the high risk of infective endocarditis in the patient with a low absolute neutrophil count ($130/mm^3$), emergency surgery was performed. Intraoperatively, a single gelatinous neoplasm was resected, and subsequent reconstruction of the involved leaflet was accomplished using autologous pericardium. The tumor was pathologically confirmed as papillary fibroelastoma with no evidence of infective endocarditis. Papillary fibroelastoma is a rare cardiac neoplasm that occurs in either the mitral or aortic valves. Interestingly, a few cases of tricuspid valve papillary fibroelastoma have been reported so far. Similar echocardiographic findings between vegetation and tricuspid valve neoplasm make it difficult to distinguish these two disease entities.

Assessment of Waste Management Practices , Source - reduction Programs and Related Tasks in Elementary School Foodservice in Seoul and Kyonggi Province Areas (서울.경기지역 초등학교 급식소의 쓰레기 감량화 프로그램 및 관리업무영역 규명)

  • Ryu, Gyeong;Gwak, Dong-Gyeong;Choe, Eun-Hui
    • Journal of the Korean Dietetic Association
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    • v.7 no.4
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    • pp.410-425
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    • 2001
  • This study was designed to assess the waste management practices, source-reduction programs and related tasks in elementary school foodservice in Seoul. and Kyonggi Province Areas. A questionnaire mailed to 910 school foodservice managers in Seoul and Kyonggi province: a 202% (N=184) response rate was obtained. About 83.7% of school foodservice managers were responsible for managing solid waste. Most foodservice operations take the responsibility of food waste but not packaging wastes. The average disposal cost per month per person was about 19 won and income was about 35 won. Leftovers were mainly disposed with platewaste. Platewaste was reused for the livestook feed(68.0%), and some platewaste was composted(11.6%). Source reduction programs implemented in half of school foodservice operations were adjustment of portion size', checking the plate waste', 'working with classroom teachers on waste reduction campaign', 'providing information leaflet on food waste minimization', posting education materials, 'classroom instruction about food waste minimization', and 'improving cooking method. According to factor analysis based on importance rating. slid waste management activities of elementary school foodservice operations were divided to 7 dimensions such as communication and cooperation with others', 'employee training', 'product quality control, 'yield control', plate waste control', 'purchasing', and 'public relations'. As a result of Important-Performance Analysis(IPA), sine dimensions such as 'communication and cooperation with others' and 'plate waste control were identified in Focus Here' quardrant area which need more enhanced performance.

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Pulsatile Blood Flows Through a Bileaflet Mechanical Heart Valve with Different Approach Methods of Numerical Analysis : Pulsatile Flows with Fixed Leaflets and Interacted with Moving Leaflets

  • Park, Choeng-Ryul;Kim, Chang-Nyung;Kwon, Young-Joo;Lee, Jae-Won
    • Journal of Mechanical Science and Technology
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    • v.17 no.7
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    • pp.1073-1082
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    • 2003
  • Many researchers have investigated the blood flow characteristics through bileaflet mechanical heart valves using computational fluid dynamics (CFD) models. Their numerical approach methods can be classified into three types; steady flow analysis, pulsatile flow analysis with fixed leaflets, and pulsatile flow analysis with moving leaflets. The first and second methods have been generally employed for two-dimensional and three-dimensional calculations. The pulsatile flow analysis interacted with moving leaflets has been recently introduced and tried only in two-dimensional analysis because this approach method has difficulty in considering simultaneously two physics of blood flow and leaflet behavior interacted with blood flow. In this publication, numerical calculation for pulsatile flow with moving leaflets using a fluid-structure interaction method has been performed in a three-dimensional geometry. Also, pulsatile flow with fixed leaflets has been analyzed for comparison with the case with moving leaflets. The calculated results using the fluid-structure interaction model have shown good agreements with results visualized by previous experiments. In peak systole. calculations with the two approach methods have predicted similar flow fields. However, the model with fixed leaflets has not been able to predict the flow fields during opening and closing phases. Therefore, the model with moving leaflets is rigorously required for advanced analysis of flow fields.

Smoking Cessation Intervention in Rural Kerala, India: Findings of a Randomised Controlled Trial

  • Jayakrishnan, Radhakrishnan;Uutela, Antti;Mathew, Aleyamma;Auvinen, Anssi;Mathew, Preethi Sara;Sebastian, Paul
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6797-6802
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    • 2013
  • Background: Prevalence of tobacco use is higher in the rural than urban areas of India. Unlike tobacco cessation clinics located in urban areas, community-based smoking cessation intervention has the potential to reach a wider section of the community to assist in smoking cessation in the rural setting. The present study aimed to assess the effectiveness of a cessation intervention in rural Kerala state, India. Materials and Methods: Current daily smoking resident males in the age group 18-60 years from four community development blocks in rural Kerala were randomly allocated to intervention and control groups. The intervention group received multiple approaches in which priority was given to face-to-face interviews and telephone counselling. Initially educational materials on tobacco hazards were distributed. Further, four rounds of counselling sessions were conducted which included a group counselling with a medical camp as well as individual counselling by trained medical social workers. The control group received general awareness training on tobacco hazards along with an anti-tobacco leaflet. Self-reported smoking status was assessed after 6 and 12 months. Factors associated with tobacco cessation were estimated using binomial regression method. Results: Overall prevalence of smoking abstinence was 14.7% in the intervention and 6.8% in the control group (Relative risk: 1.85, 95% CI: 1.05, 3.25). A total of 41.3% subjects in the intervention area and 13.6% in the control area had reduced smoking by 50% or more at the end of 12 months. Lower number of cigarettes/ bidi used, low nicotine dependence and consultation with a doctor for a medical ailment were the statistically significant predictors for smoking cessation. Conclusions: Rigorous approaches for smoking cessation programmes can enhance quit rates in smoking in rural areas of India.

Status survey on short-term agricultural machinery rental system for efficient operation (농업기계 단기임대사업의 효율적 운영을 위한 실태조사 연구)

  • Hong, Soon-Jung;Huh, Yun-Kun;Chung, Sun-Ok;Shin, Seung-Yeoub
    • Korean Journal of Agricultural Science
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    • v.38 no.3
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    • pp.583-591
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    • 2011
  • Status survey on short-term agricultural machinery rental business was conducted to provide basic data for effective and sustainable implementation of the rental system. Selected survey samples were 34 rental management institutions such as city and county level government offices and agricultural technology development centers, and Primary Agricultural Cooperatives. Survey was conducted through mailing of questionnaire papers and direct interviews with the officers in charge of the agricultural machinery short-term rental management. Number of agricultural machinery retained by the 34 management institutions for the machinery rental business was 3,699, and numbers of the machinery were 1630 for upland crops, 929 for rice, 542 for orchard farming, 274 for animal husbandry, and 324 for common use. Regarding size of warehouse for rental agricultural machinery, 50% of the institutes were less than 660 $m^2$, 26.5% were greater than 993 $m^2$, and 23.5% were between 663 and 990 $m^2$. Institutes maintaining machinery washing facilities were only 10 (29%) among the 34 rental management institutions. Agricultural machinery rental business was advertised to farmers by 91% of the institutes, and the methods were leaflet (35.2%), village broadcasting (26.5%), call-up education (23.6%), and TV and radio (14.7%). Major contents of the advertisement were rental procedure (52.9%), rental machinery (26.5%), and rental cost (20.6%).

A new species of Potentilla (Rosaceae): P. baekdusanensis M. Kim (양지꽃속(장미과)의 신종: 백두산양지꽃(Potentilla baekdusanensis M. Kim))

  • JO, Hyun;SHIN, Changkeun;SEO, Eunkyoung;KIM, Muyeol
    • Korean Journal of Plant Taxonomy
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    • v.48 no.1
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    • pp.37-42
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    • 2018
  • A new species, Potentilla baekdusanensis M. Kim, is described here. It is found in Baekdusan Mt., Korea. Potentilla baekdusanensis shares several characteristics (pinnately compound leaves, pubescent leaf blades and leaf petioles, different leaflets size, and absent stolons) with the related species P. fragarioides. However, this new species has small plants with short and curved hairs, 7 leaflets, small lower leaflets, a glabrous leaflet margin, and yellow petals with a reddish yellow base. In contrast, P. fragarioides are large plants with long and straight hairs, 9-15 leaflets, large lower leaflets, a ciliate leaf margin, and yellow petals without a reddish yellow base.

An overview of the structural requirements of passenger carrying rolling stock according to EN12663 and prEN15227 (EN12663과 prEN15227에 따른 객차의 구조적 요구사항 검토)

  • Ainoussa, Amar;Chang, D.S.;Paik, J.S.
    • Proceedings of the KSR Conference
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    • 2007.11a
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    • pp.816-823
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    • 2007
  • As the South Korean rolling stock industry is developing designs for full compliance with the European Standards, it is fitting to take a look at these two core standards. The paper presents an overview of the load cases and structural requirements developed in Europe for the design of safe and compatible rolling stock vehicles. These load cases and structural requirements have been compiled into two standards namely EN12663 and EN15227. Standard EN12663 was developed as a reference design requirements standard. The work was mandated and sponsored by the European Committee for Standardization and Standard issuing National Institutions. EN12663 specifies a series of proof and fatigue load cases for European rolling stock regulations compliant vehicle designs. As EN12663 does not address the crashworthiness issue, a dedicated crashworthiness standard, EN15227, was therefore developed in a similar manner through industry wide consultations managed by a Trans-European working group of experienced engineers and specialists. In both standards, the vehicle and/or trains are grouped into categories reflecting the vehicle types and/or their indented operational function. EN15227, developed to complement EN12663, addresses the "passive" crashworthiness capability of the vehicles and trains. EN15227 specifies reference crash scenarios similar to those found in the Technical Specification for Interoperability (TSI) of high speed trains operating in Europe. The overview also touches on a general comparison with the corresponding British Group Standard (GM/RT2100) and also the UIC leaflet based load cases. The exercise is extended to pertinent design load cases specified by the Federal Railroad Administration (FRA) in the US.

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Posterior Left Ventricular Wall Rupture After Mitral Valve Replacement (승모판 치환술후 발생한 좌심실 후벽 파열)

  • 강면식
    • Journal of Chest Surgery
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    • v.25 no.11
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    • pp.1254-1260
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    • 1992
  • Rupture of the posterior left ventricular wall following mitral valve replacement is a rare but fatal complication. Over a 10 year period from August 25 1980 to November 27 1990, we have experienced 6 such patients among 884 cases of mitral valve replacement with 4 deaths and 2 survivors. One patient had a type I rupture and another a type II rapture with the remaining four patients having suffered type III ruptures. All of the ruptures were dis covered intraoperatively enabling prompt reinstitution of the cardiopulmonary bypass and subsequent cardioplegic arrest prior to repair. Overzealous removal of calcified valve leaflets seemed to be responsible for the single type I rupture, and untethering of the so called ventricular loop appeared to be the main mechanism responsible for the type III ruptures. The single type II rupture that had occurred seemed to have been caused by inadvertent laceration of the papillary muscle with resultant rupture of the posterior LV wall at the base of the papillary muscle. Among the type III ruptures, 2 patients required intraaortic balloon pump[IABP] support only for mechanical assistance and 1 patient required both the IABP and the Biomedicus LV assist device for successfull weaning following repair of the LV rupture Another patient with a type II rupture also required the circulatory assistance of both the IABP and the bio-medicus LV assist device for weaning from the bypass. Attention to meticulous technical considerations such as avoiding over aggressive removal of heavily calcified valvular tissue, preservation of as much mural leaflet tissue and chordal stuctures as possible seemed helpful in preventing this catastrophic complication from occurring. Fusion and fibrous stricture of the chordal structures appeared particularly conducive to the type II ruptures as a result of the increased susceptibility to papillary injury during operation.

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