• Water for future
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• v.24 no.4
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• pp.49-58
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• 1991

Flood routing in the Youngsan River was performed for the flood event of July, 1989 by two finite difference methods. The Saint Venant eq., a kind of hyperbolic partial differential equation is employed as governing equation and the explicit scheme (Leap Frog) and implicit scheme (Preissmann) are used to discretize the GE. As for the external boundary conditions, discharge and tidal elevation are upstream and downstream BC, respectively and estuary dam is included in internal BC. Lateral inflows and upstream discharges are the hourly results from storage function method, At Naju station, a Relatively upstream points in this river, the outputs are interpreted as good ones by comparing two numerical results of FDMs with the observed data and the calibrated results by storage function method. and two computational results are compared at the other sites, from middle stream and downstream points, and thus are considered reliable. Therefore, we can conclude from this research that these numerical models are adaptable in simulating and forecasting the flood in natural channels in Korea as well as existing hydrologic models. And the study about optimal gate control at the flood time is expected as further study using these models.

• Journal of Aerospace System Engineering
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• v.13 no.5
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• pp.32-38
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• 2019

The flying wing configuration with high sweep angles and rounded leading edge represent a complex flow of structures by the leading edge vortex. For control of the tailless flying wing configuration with unstable directional stability, flaperon is used. In this study, we conducted numerical simulations for a non-slender flying wing configuration with a rounded leading edge and analyzed the effect of the sideslip angle and flaperon. Through aerodynamic coefficient analysis, it was found that the effect of AoS on lift and drag coefficient was minimal and the side force and moment coefficient were markedly influenced by AoS. As the sideslip angle increased, the pitch break, which is related to the pitching moment coefficient, was delayed. Through stability analysis, the directional and lateral static stability of the flying wing configuration were increased by flaperon. Also, the structure and behavior of the leading edge vortex were analyzed by observing the contour of the pressure coefficient and the skin friction line.

• Applied Chemistry for Engineering
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• v.29 no.6
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• pp.645-651
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• 2018

Lung cancer has the highest death rate of any cancer diseases in Koreans. However, patients often feel difficult to recognize their disease before facing the terminal diagnosis due to the absence of any significant symptoms. Furthermore, the clear detection of an early cancer stage is usually obscure with existing diagnostic methods. For this reason, extensive research efforts have been made on introducing a wide range of biochemical diagnostic tools for the molecular level analysis of biological fluids for lung cancer diagnoses. A chip-based biosensor, one type of the analytical devices, can be a great potential for the diagnosis, which can be used without any further expensive analytical equipments nor skilled analysts. In this mini review, we highlight recent research trends on searching biomarker candidates and bio-chip sensors for lung cancer diagnosis in addition to discussing their future aspects.

• Archives of Plastic Surgery
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• v.49 no.1
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• pp.61-69
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• 2022

Background Single free flaps are a commonly used reconstructive method for multiple soft tissue defects in digits. We analyzed the flap size, division timing, and degree of necrosis in cases with various types of flap division. Methods We conducted a retrospective review of the medical charts of patients who had undergone single free flap reconstruction for multiple soft tissue defects across their digits from 2011 to 2020. The flap types included were the lateral arm free flap, venous forearm free flap, thenar free flap, hypothenar free flap, anterolateral thigh free flap, medial plantar free flap, and second toe pulp free flap. Flap size, anastomosed vessels, division timing, and occurrence of flap necrosis were retrospectively investigated and then analyzed using the t-test. Results In total, 75 patients were included in the analysis. The success rate of the free flaps was 97.3%. All flaps were successfully divided after at least 17 days, with a mean of 47.17 days (range, 17-243 days) for large flaps and 42.81 days (range, 20-130 days) for the medium and small flaps (P=0.596). The mean area of flap necrosis was 2.38% in the large flaps and 2.58% in the medium and small flaps (P=0.935). Severe necrosis of the divided flap developed in two patients who had undergone flap division at week 6 and week 34. Conclusions In cases where blood flow to the flap has been stable for more than 3 weeks, flap division can be safely attempted regardless of the flap size.

• Journal of Microbiology and Biotechnology
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• v.33 no.8
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• pp.1091-1100
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• 2023

Human papillomavirus (HPV) types 16 and 18 are the major causes of cervical lesions and are associated with 71% of cervical cancer cases globally. However, public health infrastructures to support cervical cancer screening may be unavailable to women in low-resource areas. Therefore, sensitive, convenient, and cost-efficient diagnostic methods are required for the detection of HPV16/18. Here, we designed two novel methods, real-time ERA and ERA-LFD, based on enzymatic recombinase amplification (ERA) for quick point-of-care identification of the HPV E6/E7 genes. The entire detection process could be completed within 25 min at a constant low temperature (35-43℃), and the results of the combined methods could be present as the amplification curves or the bands presented on dipsticks and directly interpreted with the naked eye. The ERA assays evaluated using standard plasmids carrying the E6/E7 genes and clinical samples exhibited excellent specificity, as no cross-reaction with other common HPV types was observed. The detection limits of our ERA assays were 10⁰ and 10¹ copies/µl for HPV16 and 18 respectively, which were comparable to those of the real-time PCR assay. Assessment of the clinical performance of the ERA assays using 114 cervical tissue samples demonstrated that they are highly consistent with real-time PCR, the gold standard for HPV detection. This study demonstrated that ERA-based assays possess excellent sensitivity, specificity, and repeatability for HPV16 and HPV18 detection with great potential to become robust diagnostic tools in local hospitals and field studies.

• IMMUNE NETWORK
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• v.21 no.1
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• pp.11.1-11.10
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• 2021

Coronavirus causes an infectious disease in various species and crosses the species barriers leading to the outbreak of zoonotic diseases. Due to the respiratory diseases are mainly caused in humans and viruses are replicated and excreted through the respiratory tract, the nasal fluid and sputum are mainly used for diagnosis. Early diagnosis of coronavirus plays an important role in preventing its spread and is essential for quarantine policies. For rapid decision and prompt triage of infected host, the immunochromatographic assay (ICA) has been widely used for point of care testing. However, when the ICA is applied to an expectorated sputum in which antigens are present, the viscosity of sputum interferes with the migration of the antigens on the test strip. To overcome this limitation, it is necessary to use a mucolytic agent without affecting the antigens. In this study, we combined known mucolytic agents to lower the viscosity of sputum and applied that to alpha and beta coronavirus, porcine epidemic diarrhea virus (PEDV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively, spiked in sputum to find optimal pretreatment conditions. The pretreatment method using tris(2-carboxyethyl)phosphine (TCEP) and BSA was suitable for ICA diagnosis of sputum samples spiked with PEDV and MERS-CoV. This sensitive assay for the detection of coronavirus in sputum provides an useful information for the diagnosis of pathogen in low respiratory tract.

• Journal of East-West Nursing Research
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• v.13 no.2
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• pp.160-169
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• 2007

Background: Hwa-Byung is known as a specific Korean cultural syndrome which corresponds to DSM-IV(MMPI). Some Korean women who have experienced heart aching anger(Hwa-Byung) complain physical pains as well as psychological problems. As for these physical pains, upper limb arthropathy(e.g. golf elbow pains, tennis elbow pains, or shoulder-joint pains) have not been paid attentions. In spite of not having done her excessive physical endeavor or exercise, some Korean middle aged women complain those arthropathy pains. And they go round orthopedics, pain clinics, and oriental medicine clinics. Purpose: This study was practiced in Severance Oriental Medicine Clinic. The oriental medicine doctor had a question about the major origin of upper limb pains which were not caused by excessive physical endeavor. To answer the question, this study has been practiced. In the process of interview with some those women, the major cause of those syndromes has been revealed as Hwa-Byung. The purpose of this study is to discover the meanings of the women's life who have been experienced Hwa-Byung with upper limb arthropathy. Results: These upper limb arthropathy can be explained by meridian theory. Shoulder-joint pain and golf elbow with Hwabyung can be explained by Heart meridian of hand-shoyin and the points of these pains are in the flow of this meridian. Tennis elbow with Hwabyung can be explained by Small intestine meridian of hand-taiyang and this point is in the flow of this meridian. The results of interview with 9 middle aged women was analyzed and interpreted according to Spradley's method of ethnography. The analysis revealed three core cultural themes : 1) There are certainly external cause to provoke Hwa-Byung. A patricentric family system, husband's playing around with another woman, cruel treatment by husband's family, or financial failure may be present anteriorly. 2) The chief existing condition is the discord between husband and wife. The stoppage of mutual communication, lacking in understanding, unfeeling, heartless, or unsympathetic is an major phenomenon of married life. So the important factor is not the sexual relations or problems but the discords of communication. 3) The feeling of anger, the sense of nihility, the desire to escape, and the effort to forgiveness coexist together. At a glance, they seemed to be a process. For example, anger seemed to present at first, then nihility seemed at second, then escape seemed at third, and then forgiveness seemed at last. But at point of visiting clinic to be treated, they are mixed up together as if in a jumble.

• Journal of Soil and Groundwater Environment
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• v.6 no.4
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• pp.83-95
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• 2001

In this study, the contaminated status of groundwater under Ponchon Basin, Kwangju-city was analyzed by hydrogeological survey. Though the distribution of groundwater hydraulic head was similar with the ground elevation, the flow system of groundwater was changed due to overpumping in the industrial area. Paddy field and residential area which were located in the north part of the basin had relatively high concentrations of Cl, N $a^{+}$ and N $O_3$$^{[-10]}$ in the groundwater. Southern part of the basin which most industrial area occupied had relatively high concentrations of HC $O_3$, $Ca^{2+}$, $Mg^{2+}$ and Zn. Groundwater was contaminated by C $l^{[-10]}$ and N $O_3$$^{[-10]}$ due to the infiltration of domestic sewage and factory wastewater. In the Cl case, C $l^{[-10]}$ had a tendency of distribution over the water shed along with the contaminated source. The drawdown of groundwater due to overpumping caused more vertical movement of contaminant than lateral movement. If the overpumping continues in the industrial area, the groundwater flow system will be more affected and the groundwater will be lowered in the north part of basin. It is clear that contamination by C $l^{[-10]}$ and N $O_3$$^{[-10]}$ due to domestic sewage and factory wastewater will spread through the whole basin area.rea.

• Ocean and Polar Research
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• v.39 no.2
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• pp.85-106
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• 2017

The Lago Sofia conglomerate in southern Chile is a deep-marine gravelly deposit, which is hundreds of meters thick and kilometers wide and extends laterally for more than 100 km, filling the foredeep trough of the Cretaceous Magallanes Basin. For understanding the depositional processes and environments of this gigantic deep-sea conglomerate, detailed analyses on sedimentary facies, architecture and paleoflow patterns were carried out, highlighting the differences between the northern (Lago Pehoe and Lago Goic areas) and southern (Lago Sofia area) parts of the study area. The conglomerate bodies in the northern part occur as relatively thin (< 100 m thick), multiple units intervened by thick mudstone-dominated sequences. They show paleoflows toward ENE and S to SW, displaying a converging drainage pattern. In the southern part, the conglomerate bodies are vertically interconnected and form a thick (> 400 m thick) conglomerate sequence with rare intervening fine-grained deposits. Paleoflows are toward SW. The north-to-south variations are also distinct in sedimentary facies. The conglomerate bodies in the southern part are mainly composed of clast-supported conglomerate with sandy matrix, which is interpreted to be deposited from highly concentrated bedload layers under turbidity currents. Those in the northern part are dominated by matrix- to clast-supported conglomerate with muddy matrix, which is interpreted as the products of composite mass flows comprising a turbidity current, a gravelly hyperconcentrated flow and a mud-rich debris flow. All these characteristics suggest that the Lago Sofia conglomerate was formed in centripetally converging submarine channels, not in centrifugally diverging channels of submarine fans. The tributaries in the north were dominated by mass flows, probably affected by channel-bank failures or basin-marginal slope instability processes. In contrast, the trunk channel in the south was mostly filled by tractive processes, which resulted in the vertical and lateral accretion of gravel bars, deposition of gravel dunes and filling of scours and channels, similar to deposits of terrestrial gravel-bed rivers. The trunk channel developed along the axis of foredeep trough and its confinement within the trough is probably responsible for the thick, interconnected channel fills. The large-scale architecture of the trunk-channel fills shows an eastward offset stacking pattern, suggesting that the channel migrated eastwards most likely due to the uplift of the Andean Cordillera.

• Journal of the Korean Association of Geographic Information Studies
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• v.18 no.1
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• pp.156-169
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• 2015

This study was to evaluate the RCP climate change impact on hydrological components in the Imha-Dam watershed using SWAT(Soil and Water Assessment Tool) Model. The model was calibrated for six year(2002~2007) and validated for six year(2008~2013) using daily observed streamflow data at three watershed stations. The overall simulation results for the total released volume at this point appear reasonable by showing that coefficient of determination($R^2$) were 0.70~0.85 and Nash-Sutcliffe model efficiency(NSE) were 0.67-0.82 for streamflow, respectively. For future hydrologic evaluation, the HadGEM3-RA climate data by scenarios of Representative Concentration Pathway(RCP) 4.5 and 8.5 of the Korea Meteorological Administration were adopted. The biased future data were corrected using 34 years(1980~2013, baseline period) of weather data. Precipitation and temperature showed increase of 10.8% and 4.9%, respectively based on the baseline data. The impacts of future climate change on the evapotranspiration, soil moisture, surface runoff, lateral flow, return flow and streamflow showed changes of +11.2%, +1.9%, +10.0%, +12.1%, +18.2%, and +11.2%, respectively.