• 대한의용생체공학회:의공학회지
• /
• 제37권4호
• /
• pp.147-151
• /
• 2016

Tibial defect, or fracture is very routine musculoskeletal case which brings fully uncomfortable and painful situations to patient. Moreover, it has long hospitalization period because of its risk of non-union. There are many studies using ultrasound, vibration, and laser for bone regeneration to figure out fast bone healing. Among them, Low Level Laser Therapy (LLLT) is already known that it is very easy to treat and may have positive effect for bone regeneration. However, LLLT has uncertain energy dose because of scattering and absorption of laser in tissue. In this study, we used interstitial LLLT to treat tibial defect in animal study. The Interstitial LLLT can overcome some limitations caused by laser scattering or absorption in tissue medium. The results were evaluated using u-CT which can calculate X-ray attenuation coefficient and bone volume of bone defect area. These results showed that interstitial LLLT may affect fast bone healing process in early phase.

• 한국광학회:학술대회논문집
• /
• 한국광학회 2007년도 동계학술발표회 논문집
• /
• pp.155-156
• /
• 2007

• 한국광학회:학술대회논문집
• /
• 한국광학회 2008년도 동계학술발표회 논문집
• /
• pp.155-156
• /
• 2008

• 한국광학회:학술대회논문집
• /
• 한국광학회 2006년도 동계학술발표회 논문집
• /
• pp.359-360
• /
• 2006

Functional photoacoustic tomography is a new non-invasive imaging modality, and it is emerging as a very practical method for imaging biological tissue structures by means of laser-induced ultrasound. Structures with high optical absorption, such as blood vessels, can be imaged with the spatial resolution of ultrasound, which is not limited by the strong light scattering in biological tissues. By varying wavelengths of the laser light and acquiring photoacoustic images, optical absorption spectrum of each image pixel is found. Since the biochemical constituents of tissues determine the spectrum, useful functional information like oxygen saturation ($SO_2$) and total haemoglobin concentration (HbT) can be extracted. In this study, as a proof-of-principle experiment, hypoxic brain tumor vasculature and traumatic brain injury (TBI) of small animal brain are imaged with functional photoacoustic tomography. High resolution brain vasculature images of oxygen saturation and total hemoglobin concentration are provided to visualize hypoxic tumor vasculature, and hemorrhage on the cortex surface by the TBI.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
• /
• pp.369-369
• /
• 2016

A nanostructure composite is a highly suitable substance for photoacoustic ultrasound generation. This allows an input laser beam (typically, nanosecond pulse duration) to be efficiently converted to an ultrasonic output with tens-of-MHz frequency. This type of energy converter has been demonstrated by using a carbon nanotube (CNT)-polydimethylsiloxane (PDMS) composite film that exhibit high optical absorption, rapid heat transition, and mechanical durability, all of which are necessary properties for high-amplitude ultrasound generation. In order to develop the CNT-PDMS composite film, a high-temperature chemical vapor deposition (HTCVD) method has been commonly used so far to grow CNT and then produce a CNT-PDMS composite structure. Here, instead of the complex HTCVD, we use a mixed solution of hydrophobic multi-walled CNT and dimethylformamid (DMF) and fabricate a solution-processed CNT-PDMS composite film over a spherically concave substrate, i.e. a focal energy converter. As the solution process can be applied over a large area, we could easily fabricate the focal transmitter that focuses the photoacoustic output at the moment of generation from the CNT-PDMS composite layer. With this method, we developed photoacoustic energy converters with a large diameter (>25 mm) and a long focal length (several cm). The lens performance was characterized in terms of output pressure amplitude for an incident pulsed laser energy and focal spot dimension in both lateral and axial. Due to the long focal length, we expect that the new lens can be applied for long-range ultrasonic treatment, e.g. biomedical therapy.

• Journal of Oral Medicine and Pain
• /
• 제30권4호
• /
• pp.401-410
• /
• 2005

본 연구는 온열요법이 표층부 혈류량과 피부 온도에 미치는 영향을 평가하기 위해, 건강한 성인 20명(남성: 10명, 여성: 10명)을 대상으로 습열요법과 초음파요법 적용전후의 전이부 표층부 혈류량과 피부 온도를 각각 laser doppler flowmetry와 접촉식온도계를 사용하여 측정함으로써 다음과 같은 결론을 얻었다. 1. 습열요법과 초음파요법 모두에서, 표층부 혈류량과 피부 온도는 적용전보다 적용후에 유의하게 증가하였다. 2. 습열요법을 시행한 경우, 초음파요법에 비해 적용직후 표층부 혈류량과 피부 온도의 증가량이 유의하게 더 컸으며, 증가된 상태도 더 오래 유지되었다. 3. 온열요법 적용전 표층부 혈류량과 피부 온도는 남성이 여성에 비해 더 높았다. 4. 온열요법 적용전후 표층부 혈류량과 피부 온도의 변화량은 남녀간의 유의한 차이가 없었다.

• 비파괴검사학회지
• /
• 제32권4호
• /
• pp.388-392
• /
• 2012

본 연구에서는 표면파의 음향비선형 특성 측정을 위해 선 배열 레이저 빔을 이용하여 협대역의 표면파를 발생시키고 레이저 TWM(Two-Wave Mixing) 방식으로 수신하는 완전 비접촉 측정 방법이 도입되었다. 이 기술은 알루미늄 합금의 소성변형과 음향비선형 특성과의 상관성을 조사하는데 적용되었다. 그 결과, 재료의 소성변형에 따라 음향 비선형성이 비례적으로 증가하는 것으로 나타났으며, 이는 접촉식 PZT 탐촉자 수신 방법으로 측정한 결과와 동일한 경향이다.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
• /
• pp.377-377
• /
• 2016

Under nanosecond-pulsed laser irradiation, light-absorbing thin films have been used for photoacoustic transmitters for ultrasound generation. Especially, nanostructured absorbers are attractive due to high optical absorption and efficient thermoacoustic energy conversion: for example, 2-dimensional (2-D) gold nanostructure array, synthetic gold nanoparticles, carbon nanotubes (CNTs), and reduced graphene oxides. Among them, CNT has been used to fabricate a composite film with polydimethylsiloxane (PDMS) that exhibits excellent photoacoustic conversion performance for high-frequency, high-amplitude ultrasound generation. Previously, CNT-PDMS nanocomposite films were made by using a high-temperature chemical vapor deposition (HTCVD) process for CNT growth. However, this approach is not suitable to fabricate large-area CNT films (>several cm2). This is because a chamber dimension of HTCVD is limited and also the process often causes nonuniform CNT growth when the film area increases. As an alternative approach, a solution-based process can be used to overcome these issues. We develop PDMS composite transmitters, based on the solution process, using several nanostructured light-absorbers such as CNTs, nanoink powders, and imprinted regular arrays of gold nanostructure. We compare fabrication processes of each composite transmitters and photoacoustic output performance.

• Medical Lasers
• /
• 제8권1호
• /
• pp.35-38
• /
• 2019

Thread-lifting is a minimally invasive procedure that shows good results and fewer complications as compared with those results and complications of standard surgery. Many procedures and techniques have been developed to create a younger appearance of facial/neck skin for aging people, and the demand for an improved aesthetic appearance is increasing. Since the incidence of side effects is much less than that of non-absorbable threads, which can lead to complications such as foreign body reactions, polydioxanone (PDO) threads are predominantly used for face lift procedures. A 66-year-old woman presented to our clinic with inflamed palpable masses. She had undergone a face lift with absorbable threads in our clinic 5 months previously. Excisional biopsy was performed with the patient under local anesthesia. During the operation, any threads were not detected and there was both fibrotic scar tissue and granulomatous tissue. For effectively promoting healing and managing the scars, treatment with LDM^®-MED was performed on the day after surgery. The treatment was performed according to the author's protocol. Although foreign body granuloma as a complication after using non-absorbable thread types have been previously reported, it is relatively rare to find this type of complication after using absorbable thread. In this report, we present a case in which a 66-year-old female with foreign body granuloma after undergoing a face lift using absorbable threads was treated with the application of dual-frequency ultrasound, which promoted wound healing.

• 비파괴검사학회지
• /
• 제25권2호
• /
• pp.103-109
• /
• 2005

섬유강화복합재료의 품질향상을 위하여 제조공정중에 발생하게 되는 층간 분리 및 기공 등의 결함이 온라인상에서 검출되어야 한다. 일반적으로 섬유강화복합재료의 비파괴 평가에 있어서 초음파 평가기법이 널리 이용되고 있으나 기존의 초음파 평가 기법은 초음파 전파를 위하여 접촉이 이루어져야 하는 단점이 있다. 따라서 기존의 초음파 평가기법은 비접촉의 기법이 아니므로 제조공정중에 적용할 수 없다. 비접촉식의 초음파 평가 기법을 구현하기 위하여 광학적 기법의 레이저 기법이 적용되었으며 본 연구에서는 레이저 유도 초음파 발생 기법과 레이저 간섭계를 이용한 수신기법이 섬유강화 복합재료 판재에서 적용되었다. 레이저 유도 초음파는 펄스레이저에 의한 복합재료 표면의 순간적인 가열과 이에 의한 열변형으로 발생되어 전파되며 본 연구에 가속도계, AE센서 등 주파수 범위가 다른 수신센서를 이용하여 전파방향 변화에 따른 유도 초음파를 수신하였으며 수신된 유도초음파의 전파방향에 따른 전파속도를 비교하였다. 또한 비접촉 수신기법으로 레이저 간섭계를 이용하여 탄소섬유강화 복합재료에서의 초음파를 수신하고 그 주파수 특성을 분석하였다.