• BMB Reports
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• v.37 no.1
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• pp.11-27
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• 2004

The introduction of molecular markers in genetic analysis has revolutionized medicine. These molecular markers are genetic variations associated with a predisposition to common diseases and individual variations in drug responses. Identification and genotyping a vast number of genetic polymorphisms in large populations are increasingly important for disease gene identification, pharmacogenetics and population-based studies. Among variations being analyzed, single nucleotide polymorphisms seem to be most useful in large-scale genetic analysis. This review discusses approaches for genetic analysis, use of different markers, and emerging technologies for large-scale genetic analysis where millions of genotyping need to be performed.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.13 no.3
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• pp.1-9
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• 2014

This study deals with development of Integrated Transportation Analysis System for Large-scale event. Based on case studies, the requirements of the system were defined and the direction of development was established. The large-scale events that require fast and accurate transportation policy were selected. The data warehouse and data mart were developed by integrating the large-scale event data and the traffic data. Business intelligence system was designed and developed users to allow timely decisions.

• Proceedings of the KSME Conference
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• 2001.06e
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• pp.94-99
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• 2001

The numerical simulation of the particle dispersion in the vortical flows provides insight into the mechanism of particle-fluid interaction. The simulation results show that the mixing layers are characterized by the large-scale vortical structures undergoing pairing process. The particle dispersion is strongly influenced by the large-scale structures and the particle sizes. The analysis shows that the mixing layers grows like a step-function.

• 한국전산유체공학회:학술대회논문집
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• 2006.10a
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• pp.208-208
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• 2006

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.7
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• pp.904-913
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• 2020

As the data volumes and complexity rapidly increase, data-intensive science handling large-scale scientific data needs to investigate new techniques for intelligent storage and data distribution over networks. Recently, Named Data Networking (NDN) and data-intensive science communities have inspired innovative changes in distribution and management for large-scale experimental data. In this article, analysis on NDN testbeds for large-scale scientific data such as climate science data and High Energy Physics (HEP) data is presented. This article is the first attempt to analyze existing NDN testbeds for large-scale scientific data. NDN testbeds for large-scale scientific data are described and discussed in terms of status, NDN-based application, and features, which are NDN testbed instance for climate science, NDN testbed instance for both climate science and HEP, and the NDN testbed in SANDIE project. Finally various issues to prevent pitfalls in NDN testbed establishment for large-scale scientific data are analyzed and discussed, which are drawn from the descriptions of NDN testbeds and features on them.

• Interaction and multiscale mechanics
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• v.5 no.1
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• pp.27-40
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• 2012

The two-dimensional incompressible flow of a linear viscoelastic fluid we considered in this research has rapidly oscillating initial conditions which contain both the large scale and small scale information. In order to grasp this double-scale phenomenon of the complex flow, a multiscale analysis method is developed based on the mathematical homogenization theory. For the incompressible flow of a linear viscoelastic Maxwell fluid, a well-posed multiscale system, including averaged equations and cell problems, is derived by employing the appropriate multiple scale asymptotic expansions to approximate the velocity, pressure and stress fields. And then, this multiscale system is solved numerically using the pseudospectral algorithm based on a time-splitting semi-implicit influence matrix method. The comparisons between the multiscale solutions and the direct numerical simulations demonstrate that the multiscale model not only captures large scale features accurately, but also reflects kinetic interactions between the large and small scale of the incompressible flow of a linear viscoelastic fluid.

• Structural Engineering and Mechanics
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• v.41 no.4
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• pp.559-573
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• 2012

An adaptive modeling and simulation technique is introduced for the effective and reliable fluid-structure interaction analysis using MSC/Dytran for large-scale complex pressurized liquid containment. The proposed method is composed of a series of the global rigid sloshing analysis and the locally detailed fluid-structure analysis. The critical time at which the system exhibits the severe liquid sloshing response is sought through the former analysis, while the fluid-structure interaction in the local region of interest at the critical time is analyzed by the latter analysis. Differing from the global coarse model, the local fine model considers not only the complex geometry and flexibility of structure but the effect of internal pressure. The locally detailed FSI problem is solved in terms of multi-material volume fractions and the flow and pressure fields obtained by the global analysis at the critical time are specified as the initial conditions. An in-house program for mapping the global analysis results onto the fine-scale local FSI model is developed. The validity and effectiveness of the proposed method are verified through an illustrative numerical experiment.

• Journal of Information Management
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• v.43 no.4
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• pp.31-48
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• 2012

Social network analysis was performed on 545 job descriptions in 32 university libraries in Seoul, and drew the job distribution and their relations. Furthermore, for finding the differences according to scale of libraries, this study performed secondary analysis by dividing them two groups. Results show that large scale library show lower density and loose connectivity than small scale library. And while jobs of small scale library were clustered 3 groups, large scale university cluster 4 groups containing 1 technical job and 3 diverse user services. And the jobs that has high specificity, such as catalog or classification, shows high degree centrality in the case of small scale library. Whereas in large scale library they show lower degree centrality, so it can be said that these jobs were performed somewhat independently in large scale libraries.

• Proceedings of the SAREK Conference
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• 2008.11a
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• pp.334-339
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• 2008

Nowadays national research and development fund is continuously increased. And the evaluation on the feasibility of R&D budget investment was carried out. Through this study it was possible that a business feasibility evaluation of large scale research project. Also the benefit of research project about large scale plant(A plant) is $2.67{\sim}3.76$ times of research funds, and the R&D fund pay-back period is $6{\sim}8$ years. And also there is employment effect as $1,200{\sim}2,200$ every year, and $22,000{\sim}35,000$ within 20 years after research project.

• International Journal of High-Rise Buildings
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• v.4 no.1
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• pp.75-83
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• 2015

In the present study, the preliminary results of a large-scale seismic response analysis of a super-high-rise steel frame considering soil-structure interaction are presented. A seismic response analysis under the excitation of the JR Takatori record of the 1995 Hyogoken-Nanbu earthquake is conducted. Precise meshes of a 31-story super-high-rise steel frame and a soil region, which are constructed completely of hexahedral elements, are generated and combined. The parallel large-scale simulation is performed using K computer, which is one of the fastest supercomputers in the world. The results are visualized using an offline rendering code implemented on K computer, and the feasibility of using a very fine mesh of solid elements is investigated. The computation performance of the analysis code on K computer is also presented.