• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제14권1_2호
• /
• pp.105-116
• /
• 1992

저자들은 악안면부에 발생한 종양 절제 후 광배근피판(유정 피판, 5례 : 유리 피판, 1례)으로 재건하여 5례에서 성공하였다. 큰 피판 형성의 잠재성은 두경부에서 충분한 종물제거와 재건을 가능하게 하였으며, 피판 형성이 빠르고 용이하며 긴 혈판경(약 45cm)을 채득할 수 있었다. 공여부 합병증과 기능 상실이 적어 두경부의 커다란 결손부 재건에 매우 유용한 피판으로 판단되었으며, 경부곽청술 후 노출되는 심부 조직에 대해 심미적이며 기능적인 보호를 제공할 수 있었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권10호
• /
• pp.5973-5981
• /
• 2013

At present, the most common cause of cancer-related death in women is breast cancer. In a large proportion of breast cancers, there is the overexpression of human epidermal growth factor receptor 2 (HER2). This receptor is a 185 KDa growth factor glycoprotein, also known as the first tumor-associated antigen for different types of breast cancers. Moreover, HER2 is an appropriate cell-surface specific antigen for passive immunotherapy, which relies on the repeated application of monoclonal antibodies that are transferred to the patient. However, vaccination is preferable because it would stimulate a patient's own immune system to actively respond to a disease. In the current study, several bioinformatics tools were used for designing synthetic peptide vaccines. PEPOP was used to predict peptides from HER2 ECD subdomain III in the form of discontinuous-continuous B-cell epitopes. Then, T-cell epitope prediction web servers MHCPred, SYFPEITHI, HLA peptide motif search, Propred, and SVMHC were used to identify class-I and II MHC peptides. In this way, PEPOP selected 12 discontinuous peptides from the 3D structure of the HER2 ECD subdomain III. Furthermore, T-cell epitope prediction analyses identified four peptides containing the segments 77 (384-391) and 99 (495-503) for both B and T-cell epitopes. This work is the only study to our knowledge focusing on design of in silico potential novel cancer peptide vaccines of the HER2 ECD subdomain III that contain epitopes for both B and T-cells. These findings based on bioinformatics analyses may be used in vaccine design and cancer therapy; saving time and minimizing the number of tests needed to select the best possible epitopes.

• 한국산림과학회지
• /
• 제108권4호
• /
• pp.600-609
• /
• 2019

본 연구는 우리나라 소나무와 일본잎갈나무의 지역별 형상비를 고려한 임분 밀도 관리의 필요성과 관리 방안을 제시하기 위하여 수행되었다. 전국을 대상으로 소나무 2,112본, 일본잎갈나무 2,030본을 벌채하여 흉고직경 및 수고, 지하고를 측정하고 지역별 형상비(수고/흉고직경)를 비교 분석하였다. 소나무의 형상비는 강원지방 소나무 72.3%, 중부지방소나무 64.0%, 소나무 평균 70.8%로 강원지방소나무가 중부지방소나무에 비하여 높게 나타났다. 지역별로는 영주 78.4%, 영월 77.5%순으로 높게 나타났으며, 직경별로는 소경목 90.4%, 중경목 71.7%, 대경목 56.1%로 나타났다. 형상비는 밀도가 높아질수록 수간의 직경에 대한 수고의 비율(형상비)이 높아지며, 70% 이하면 안정성이 높으나 80%를 초과하면 풍해 및 폭설피해로 위험해지기 때문에 일부 지역에서는 임분 밀도관리가 필요하다. 일본잎갈나무의 전체 평균 형상비는 90.6%이며, 지역별로는 평창 108.5%, 영주 105.4%, 단양 100.5% 순으로 나타났다. 경급별로는 소경목 104.9%, 중경목 92.7%, 대경목 73.4%로 전체적으로 일본잎갈나무의 형상비가 80% 이상으로 풍해 및 폭설피해의 위험에 노출되어 있어 빠른 시일 내에 적정 임분 밀도의 관리의 시업이 요구되어 진다.

• 대한핵의학회지
• /
• 제32권4호
• /
• pp.365-373
• /
• 1998

목적: 일반 감마카메라는 그 크기(${\sim}500mm$ 폭)가 전신영상 획득에 적합하도록 설계되어있어 유방영상 획득에는 비 이상적이다. 이 연구의 목적은 물리적 영상 저하요인인 배후 방사능과 광자감쇠 효과를 최소화하여 높은 공간분해능과 시스템 민감도를 가지며 유방영상에 적합하도록 소형화된 저가-고성능유방암 진단전용 소형 감마카메라 개발이다. 대상 및 방법: 크기가 $60 mm{\times}60 mm{\times}6 mm$인 NaI(T1) 섬광결정을 위치민감형 광전자증배관에 접합시켜 감마선 측정신호인 $X^+,\;X^-,\;Y^+,\;Y^-$를 얻은 다음, 증폭기 등을 포함한 전자회로(nuclear instrument modules, NIM)를 통하여 검출기로부터 발생하는 위치신호와 트리거 신호를 처리하였다. 이 신호들을 아날로그-디지털 변환기와 앵거로직을 사용하여 분석한 후 감마카메라 영상을 구성하여 일반 개인용컴퓨터에 표현하는 시스템을 개발하였다. 개발된 감마카메라의 1차적인 성능을 평가하기 위해 Tc-99m 점선원을 이용하여 내인성 계수율과 플러드 영상을 획득하였다. 또한 일정간격의 구멍이 있는 구멍 마스크와 직경 2, 3, 4, 5, 6, 7 mm 크기의 구모양에 방사능 용액을 채울 수 있는 유방모형을 제작하여 평행구멍형조준기를 장착하고 영상을 획득하였다. 결과: 개발된 감마카메라는 약 $8{\times}10^3 counts/sec/{\mu}Ci$의 계수율을 보였으며, 공간왜곡은 관찰되나 양질의 플러드 영상과 구멍 마스크 영상을 획득할 수 있었고, 유방모형에 위치한 방사능 분포를 정확하게 영상화할 수 있을 뿐 아니라 최소 2 mm의 방사능 위치를 판별할 수 있는 영상을 획득하였다. 결론: NaI(T1)-위치민감형 광전자증배관를 이용하여 유방영상에 적합한 소형감마카메라를 개발하였다. 추후 선형성, 장균일도 및 불응시간에 대한 보정 알고리즘을 완성하여 적용하고, 정상작동 여부를 검사하기 위한 정도관리 방법을 설정하면, 유방 신티그라피의 정확도를 높이는데 기여할 것이다.

• Journal of Korean Neurosurgical Society
• /
• 제61권4호
• /
• pp.525-529
• /
• 2018

Objective : To evaluate the efficacy of fractionated stereotactic radiosurgery (FSRS) performed using the Novalis $Tx^{(R)}$ system (BrainLAB AG, Feldkirchen, Germany; Varian Medical Systems, Palo Alto, CA, USA) for brain metastases. Methods : Between March 2013 and July 2016, 23 brain metastases patients were admitted at a single institute. Twenty-nine lesions too large for single session stereotactic radiosurgery or located in the vicinity of eloquent structures were treated by FSRS. Based on the results obtained, we reviewed the efficacy and toxicity of FSRS for the treatment of brain metastases. Results : The most common lesion origin was lung (55%) followed by breast (21%). Median overall survival was 10.0 months (95% confidence interval [CI], 4.9-15.0), and median progression-free survival was 10.0 months (95% CI, 2.1-13.9). Overall survival rates at 1 and 2 years were 58.6% and 36.0%, respectively. Local recurrence and neurological complications affecting morbidity each occurred in two cases. Conclusion : FSRS using the $Novalis-Tx^{(R)}$ system would appear to be an effective, safe noninvasive treatment modality for large and eloquently situated brain metastases. Further investigation is required on a larger number of patients.

• 셀메드
• /
• 제2권4호
• /
• pp.33.1-33.3
• /
• 2012

Menorrhagia (kasrate tams) is the most common gynecologic complaint in contemporary gynecology, affecting 10 to 15% of the adult female population. It can occur at any age. In the Unani system of medicine, since antiquity, dry cupping therapy (hijamat bila shurt) has been used to treat menorrhagia. An effort was made to evaluate the usefulness of dry cupping on excessive menstrual blood loss in menorrhagia with a well validated menstrual pictogram. This study was conducted on 15 patients at the National Institute of Unani Medicine, Hospital Bangalore, from January 2010 and July 2010. Unmarried or married patients aged 17 - 47 year with a history of excessive or prolonged bleeding per vaginum were included. Two large cups (with 5.7 cm internal diameter) were applied below each breast for 15 min, only once during the menstrual period when the patient reported to the outpatient department. If the menstrual flow was not reduced, the next day again dry cupping was repeated. The outcome was to assess the efficacy of dry cupping on the reduction in the amount of menstrual blood loss. The data was analyzed by the Wilcoxon matched test. The mean scores of menstrual blood loss before and after the treatment was 400.26 (277.95) and 48.4 (32.082) ml respectively, p = 0.002, considered statistically significant. A dry cupping therapy is a useful treatment modality in decreasing the amount of menstrual blood flow in menorrhagia. Further randomized controlled clinical trials and validation are needed in a large population.

• Journal of Preventive Medicine and Public Health
• /
• 제48권1호
• /
• pp.1-9
• /
• 2015

The purpose of the present review is to give an overview of the association between alcohol intake and the risk of developing cancer. Two large-scale expert reports; the World Cancer Research Fund (WCRF)/American Institute of Cancer Research (AICR) report from 2007, including its continuous update project, and the International Agency for Research of Cancer (IARC) monograph from 2012 have extensively reviewed this association in the last decade. We summarize and compare their findings, as well as relate these to the public health impact, with a particular focus on region-specific drinking patterns and disease tendencies. Our findings show that alcohol intake is strongly linked to the risk of developing cancers of the oral cavity, pharynx, larynx, oesophagus, colorectum (in men), and female breast. The two expert reports diverge on the evidence for an association with liver cancer and colorectal cancer in women, which the IARC grades as convincing, but the WCRF/AICR as probable. Despite these discrepancies, there does, however, not seem to be any doubt, that the Population Attributable Fraction of alcohol in relation to cancer is large. As alcohol intake varies largely worldwide, so does, however, also the Population Attributable Fractions, ranging from 10% in Europe to almost 0% in countries where alcohol use is banned. Given the World Health Organization's prediction, that alcohol intake is increasing, especially in low- and middle-income countries, and steadily high in high-income countries, the need for preventive efforts to curb the number of alcohol-related cancers seems growing, as well as the need for taking a region- and gender-specific approach in both future campaigns as well as future research. The review acknowledges the potential beneficial effects of small doses of alcohol in relation to ischaemic heart disease, but a discussion of this lies without the scope of the present study.

• 한국환경과학회지
• /
• 제26권7호
• /
• pp.803-815
• /
• 2017

In this study of the oak wilt disease that has occurred in a large scale in a protected area located near South Korea's metropolitan region, a detailed analysis has been conducted on the terrain, species and Diameters at Breast Height (DBH) of infected trees to identify the distribution of infection properties in the affected area. Taking into consideration the distribution of oak tree vegetation, a total of 4,640 quadrats in a size of 10 m by 10 m, have been set; and oak tree species, the DBH and infection damage per quadrat have been investigated. Geological properties have been analyzed according to elevation, slope, aspect and micro topography while a weighted value has been given according to the degree of infection in order to calculate an infection index. Through correlation analysis, the infection ratio of seriously-damaged and withered trees and the infection index have been analyzed with regards to the geological properties, tree species and DBH. The analysis shows that the disease tends to affect an area with medium elevation rather than those in the highest or lowest areas and that serious damage has been observed at rugged spots with a steep gradient (more than $30^{\circ}$). Although there has been no distinct tendency with regards to aspect, the infection ratio is relatively high in areas facing the north while the seriously-damaged and withered ratio are high in areas facing the south. In terms of micro topography, more damage has been spotted in valley terrain. Quercus mongolica has sustained more damage than other species. When it comes to the DBH, as seen in previous studies, large trees have suffered severe damage, but the analysis has also revealed conspicuous damage to medium trees with a DBH of 15-20 cm, which had not previously been considered at high risk.

• 한국환경과학회지
• /
• 제29권5호
• /
• pp.519-529
• /
• 2020

The purpose of this study was to provide basic health care data for the climate aspects of park re-cultivation by evaluating air ions according to the type of vegetation in the valley and upper slopes of the mountain park. Simple negative or positive air ions were expected to show the same tendencies, so they were analyzed in terms of correcting the air ion index. By analyzing the air ions according to the topography, it was found that valley > slope in terms of the air ion index. When analyzing air ions according to tree species, we found that evergreen conifers in the valley > the deciduous broad-leaved trees in the valley > the evergreen conifers in the slope = the deciduous broad-leaved trees in the slope. For DBH(Diameter at breast height), the valley large pole > slope large pole > slope medium hard wood, while crown density was analyzed as valley dense > slope dense> valley proper > slope proper. Layered structure analysis showed that the multi-layer structure of the valley > multi-layer structure of the slope = the single-layer structure of the valley > the single-layer structure of the slope. The correlation coefficient was determined according to vegetation type and air ion index in the order of DBH > crown density > layer structure > geomorphic structure. In this study, limits exist except for ridge line, valley, and slopes in urban mountain parks. Therefore, analysis should be made considering both topographical structure and various vegetation types in future studies of air ions.

• 한국의류산업학회지
• /
• 제7권4호
• /
• pp.419-425
• /
• 2005

The purpose of this study is to analyze the physical characteristic by directly measuring the wheelchair using disabled women. The subjects were 103 disabled women of wheelchair used women and between 20 - 55 years of age. The result of this study is as follow. There was a remarkable difference in the physical characteristic of wheelchair using disabled women due to their cause of disability. The cause of disability was classified into the 4 groups; poliomyelitis, spiral cord injury, muscular dystrophy, cerebral palsy. Poliomyelitis disability generally had a large horizontal area due to their strong upper body. People with spiral cord injury disability was shown to have the largest height, cervical height, waist back length, crotch length, knee length, The group of muscular dystrophy disabled people have the shortest length of body and also lean. The cebral palsy group of disabled people has an average length and height size body. A comparison of anthropometric measurements of wheelchair using disabled women with National Anthropometric Survey Korea(1997) was significant difference. People with poliomyelitis disability was shown to have a larger waist back length, neck point to breast point compared to normal women, but stature, crotch length was shorter compared to normal women. People with spiral cord injury disability had a similar in the vertical area. The group of muscular dystrophy and cebral palsy disabled people was short and smaller in general compared to a normal woman.