• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 학술회의 논문집 정보 및 제어부문 B
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• pp.823-825
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• 2003

A sensor system was designed to measure real time vibro displacement of civil structure. The He-Ne laser is used for the displacement measuring method, because it guarantees short time stabilization, long time output power stability. Also, it guarantees simple maintenances and repairs under actual using condition. The line CCD image sensor(Tcd-142d) is used to detect the displacement of Ne-Ne laser responding to the vibro of civil structure. For accurate measurement and comparison, CDP-50 is used. Usually CDF-50 (Strain type displacement device) is used for the standard correction device of optical measurement equipments. The data processing part is consists of Optical sensor part, Wireless data transmission device, DAQp-1200, and LapView program. The displacement data of vibro from optical sensor part inputted to wireless data transmission device and then transmitted to DAQp-1200 in main control room. DAQp-1200 performs A/D conversion for the receiving data. After that the converted data inputted to computer system using LapView program for user display. The significance of this paper is to develope a convenient, accurate and lost saving real time displacement measurement system for the civil structure.

• Radiation Oncology Journal
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• 제31권2호
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• pp.57-65
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• 2013

Beta-lapachone (${\beta}$-Lap; 3,4-dihydro-2, 2-dimethyl-2H-naphthol[1, 2-b]pyran-5,6-dione) is a novel anti-cancer drug under phase I/II clinical trials. ${\beta}$-Lap has been demonstrated to cause apoptotic and necrotic death in a variety of human cancer cells in vitro and in vivo. The mechanisms underlying the ${\beta}$-Lap toxicity against cancer cells has been controversial. The most recent view is that ${\beta}$-Lap, which is a quinone compound, undergoes two-electron reduction to hydroquinone form utilizing NAD(P)H or NADH as electron source. This two-electron reduction of ${\beta}$-Lap is mediated by NAD(P)H:quinone oxidoreductase (NQO1), which is known to mediate the reduction of many quinone compounds. The hydroquinone forms of ${\beta}$-Lap then spontaneously oxidizes back to the original oxidized ${\beta}$-Lap, creating futile cycling between the oxidized and reduced forms of ${\beta}$-Lap. It is proposed that the futile recycling between oxidized and reduced forms of ${\beta}$-Lap leads to two distinct cell death pathways. First one is that the two-electron reduced ${\beta}$-Lap is converted first to one-electron reduced ${\beta}$-Lap, i.e., semiquinone ${\beta}$-Lap $(SQ)^{{\cdot}-}$ causing production of reactive oxygen species (ROS), which then causes apoptotic cell death. The second mechanism is that severe depletion of NAD(P)H and NADH as a result of futile cycling between the quinone and hydroquinone forms of ${\beta}$-Lap causes severe disturbance in cellular metabolism leading to apoptosis and necrosis. The relative importance of the aforementioned two mechanisms, i.e., generation of ROS or depletion of NAD(P)H/NADH, may vary depending on cell type and environment. Importantly, the NQO1 level in cancer cells has been found to be higher than that in normal cells indicating that ${\beta}$-Lap may be preferentially toxic to cancer cells relative to non-cancer cells. The cellular level of NQO1 has been found to be significantly increased by divergent physical and chemical stresses including ionizing radiation. Recent reports clearly demonstrated that ${\beta}$-Lap and ionizing radiation kill cancer cells in a synergistic manner. Indications are that irradiation of cancer cells causes long-lasting elevation of NQO1, thereby sensitizing the cells to ${\beta}$-Lap. In addition, ${\beta}$-Lap has been shown to inhibit the repair of sublethal radiation damage. Treating experimental tumors growing in the legs of mice with irradiation and intraperitoneal injection of ${\beta}$-Lap suppressed the growth of the tumors in a manner more than additive. Collectively, ${\beta}$-Lap is a potentially useful anti-cancer drug, particularly in combination with radiotherapy.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.80-80
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• 2003

${\beta}$-lapachone(${\beta}$-Lap), a natural o-naphthoquinone, presents in the bark of the Lapacho tree. ${\beta}$-Lap is cytotoxic against a variety of human cancer cells and it potentiates the anti-tumor effect of Taxol. In addition, ${\beta}$-Lap has been reported to radiosensitize cancer cells by inhibiting the repair of radiation-induced DNA damage.In the present study, we investigated the cytotoxicity of ${\beta}$-Lap against RKO human colorectal cancer cells as well as the combined effect of ${\beta}$-LaP and ionizing radiation. An incubation of RKO cells with 5 ${\mu}$M of ${\beta}$-Lap for 4 h killed almost 90％ of the clonogenic cells. An incubation of RKO cells with 5 ${\mu}$M of ${\beta}$-Lap for 4 h or longer also caused massive apoptosis. Unlike other cytotoxic agents, ${\beta}$-Lap did not increase the expression of p53 and p21 and it suppressed the NFkB expression. The expression of Caspase 9 and 3 was minimally altered by ${\beta}$-Lap. Radiation and ${\beta}$-Lap acted synergistically in inducing clonogenic cell death and apoptosis in RKO cells when ${\beta}$-Lap treatment was applied after but not before the radiation exposure of the cells. Interestingly, a 4 h treatment with 5 ${\mu}$M of ${\beta}$-Lap starting 5 h after irradiation was as effective as that starting immediately after irradiation. The mechanisms of ${\beta}$-Lap-induced cell killing is controversial but a recent hypothesis is that ${\beta}$-Lap is activated by NAD(P)H: quinone-onidoreductase (NQO1) in the cells followed by an elevation of cytosolic Ca$\^$2+/ level and activation of proteases leading to apoptosis. It has been reported that NQO1 level in cells is markedly up-regulated for longer than 10 h after irradiation. Indeed, using immunological staining of NQO1, we observed a significant elevation of NQO1 expression in RKO cells 5h after 2-4 Gy irradiation. Such a prolonged elevation of NQO1 level after irradiation may be the reasons why the ${\beta}$-Lap treatment applied S h after irradiation was as effective as that applied immediately after irradiation in killing the cells. In view of the fact that the repair of radiation-induced damage is usually completed within 1-2 h after irradiation, it is highly likely that the ${\beta}$-Lap treahment applied 5 h after irradiation could not inhibit the repair of radiation-induced damage. For in vivo study, RKO cells were injected S.C. into the hind-leg of Nu/Nu mice, and allowed to grow to 130 mm3 tumor. The mice were i.p. injected with ${\beta}$-lapachone or saline 2 h after irradiation of tumors with 10 Gy of X-rays. The radiation induced growth delay was increased by 2.4 $\mu\textrm{g}$/g of ${\beta}$-lapachone. Taken together, we may conclude that the synergistic interaction of radiation and ${\beta}$-Lap in killing cancer cells is not due to radiosensitization by ${\beta}$-Lap but to an enhancement of ${\beta}$-Lap cytotoxicity by radiation through an upregulation of NQO1. The fact that NQO1 is elevated in tumors and that radiation causes prolonged increase of the NQO1 expression may be exploited to preferentially kill tumor cells using ${\beta}$-Lap in combination with radiotherapy.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2004년도 춘계학술발표대회 논문집
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• pp.266-269
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• 2004

In this study, bond strengths for the self-healing agents were evaluated through the modified lap shear test in order to suggest the optimal healing conditions for the repair of polymeric composites. The healing agents of DCPD, ENB, and their mixtures were activated with Grubbs' catalysts. According to the results, the mixture of DCPD and ENB gave better opportunity than DCPD only due to the rapid acivation with catalyst in view of the economic and practical use.

• 한국언론정보학보
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• 제16권
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• pp.168-206
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• 2001

This study attempts to examine the relationships between the major market-based media and the government after closing military regime era, 1961-1987. After the military regime was collapsed, while the mass media in Korea obtained independence and autonomy from government, they have been confronted with the terrible competition not so much comparatively as before. The watchdog role in the traditional liberalism, which is regarded as normative relationship between the media and the government would be transformed in accordance with the market condition and the maturity of democracy. Thus, the watchdog metaphor has been variously deviated in rower-centered society; lap dog, guard dog, attack dog. liberalists argue that the primary democratic role of the media is to art as a public watchdog overseeing the state. Social democrats, however, criticize them as simplistic conception which could be only applied to the government. They argue that the media should be seen as a source of redress against the abuse of all forms of power over others; the home, the economy, and the civil society. The lap dog view is that the media is overwhelmingly dependent on the established power structure contrary to the watchdog. While the guard dog perspective is a means to preserve the power structure alarming with playing 'conflict role', the attack do8 aims to the private interest of the media in intruding into the politics. The attack dog perspective by T. Patterson could be composed of the interpretive style of report, the game schema report over the policy schema in the election, and the negativism against politics and government. The market-dominant press has been likely to transform from lap-guard dog into attack-guard dog. In Roh Tae Woo government(1988-1992), while the press was a lessened lap-guard dog before three parties merger in 1990, after merger the press had been transformed as the reinforced lap-guard dog because this merger entailed joint, party-to-party negotiations, and the formation of the new party preceded by dissolution of the ruling blot. In the early stage of Kim Young Sam government(1993-1997), the press has kept in pace with the reform movement drive-forced by the government. However, the press withdrew the support of Kim's reform in reaching the level of threat to ruling bloc. The press coalesced only circumstantially with government and was interested in preserving some margin of independence. The failure of Kim's reform proved the political muscle of the press in post-autho-ritarianism. In the middle stage of Kim Dae Jung government (1998-) that resulted in the shift of power structure as once-opposition party leader, the stress has been a manifested attack-guard dog owing to the anti-cold war policy, the realignment policy of power, and the minority-base of Kim's government. The press has endeavored to hold political communication within limits relatively less threatening to the established order.

• 한국기계가공학회지
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• 제7권2호
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• pp.3-7
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• 2008

A polishing machine adopting a new unique structural mechanism has been developed, named as a swing-arm type polishing machine. The mechanism is such that the tool path tracks on a spherical surface, of which the diameter is adjusted by setting up the machine mechanism properly. It has a strong benefit especially for polishing axis-symmetric concave mirror surfaces. The swing-arm type polishing machine with 5-axes has been designed in order to polish a concave mirror surface lip to diameter of 2 meters. The drawings are made using 3D CAD and strain-stress analysis has been done by finite element method. AC servo-motor has been used to move the swing arm and a operating software has been developed using a LapVIEW tool. Result of the test run was satisfactory which convinces the usefulness of the swing-arm type polishing machine.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2007년도 동계학술발표대회 논문집
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• pp.46-51
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• 2007

The near-optimal control algorithm for central cooling system has been developed for minimizing energy consumption while maintaining the comfort of indoor thermal environment in terms of the environmental variables such as time varying indoor cooling load and outdoor temperatures. The optimal set-points of control parameters with near-optimal control are supply air temperature and chilled water temperature. This study has been done by using LapVIEW program with PID control in order to analyze the central cooling system energy saving.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 춘계학술대회 논문집
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• pp.1781-1788
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• 2008

본 연구는 철도 터널에서의 화재유동 실험을 위하여 제작된 모형 터널에서의 환기 유동 효과를 생성시키기 위하여 모형 터널 내에 제연 팬 및 주파수 방식의 인버터(invert control)를 설치하여 터널내의 유속을 변형시키면서 환기유동의 형태가 어떻게 생성되는지에 대한 기초연구를 수행한 결과이다. 본 실험에 사용된 덕트는 길이10m, 높이0.5m, 폭0.25m로서 아크릴로 제작하였고, 제연 및 환기유동을 위하여 최대 10m/sec의 유속을 발생시키는 모터를 장착한 제연시스템을 제작하였다. 덕트의 입구에는 터널에 존재하는 난류유동을 생성시키기 위하여 하니컴을 설치하였다. 환기유동을 모사 하고자 제연시스템을 이용하여 모형터널 내에서 4m/s, 6m/s, 8m/s로 유속를 발생시켜 각각의 유동의 형태를 조사하였다. 덕트내에서 1m간격으로 Hot wire(TSI) 및 Pressure sensor(ENDEVCO)를 설치하여 유속 및 압력을 계측하였다. 유속 및 압력은 Lap view 프로그램 및 PC를 이용하여 자동적으로 계측하여 저장하였으며, 하니컴으로 인한 난류 발생의 정도 및 모형 터널내에서의 유속의 특징을 자세히 조사하였고, 덕트 내에서의 압력 분포의 특징 및 압력 강하 등을 조사하였다.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2006년 제4회 한국유체공학학술대회 논문집
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• pp.175-176
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• 2006

Electrowetting is prevailing for its various applicability on lap-on-a-chip, and MEMS devices, such as a pump, lens, micro-actuator in the micro-TAS technology. In the usual electrowetting, an AC power is preferred to DC practically. The AC electric field delays the contact angle-saturation, decreases the hysterisis, and is more stable in the view point of dielectric strength. But researches for AC electric field on electrowetting have not been reported very much yet. The different effect of AC on the electrowetting system, especially the effect of a frequency needs to be understood more concretely. In this work, the usual system for electrowetting, water droplet on the dielectric coated electrode (EWOD) is analyzed. Experimental study on the response of contact angles on input frequencies is performed. The simple circuit-model for EWOD system is considered to explain the experimental results. For more concrete understanding, the system is analyzed numerically, where simple AC-conduction model is used. Wetting tensions are analyzed under various input frequency to excavate the experimental results for the responses of the system on input frequencies.

• 정보저장시스템학회논문집
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• 제3권4호
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• pp.196-201
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• 2007

As the demand for the lap-top computer has been increased, most users ask quiet environment to work comfortably. Therefore, noise problems of an ODD are of great interest. For the high speed ODD, the flow induced noise is caused by the turbulent flow[1], which is known to be a major source of overall noise of a slim type ODD. In this study, we introduce a new attempt to reduce the noise level using the concept of Helmholtz resonator[2].The experimental analysis is carried out for several cases at different resonance frequencies and different hole patterns. The results show reductions in the noise level from the acoustic noise absorption point of view.