• 한국전산유체공학회:학술대회논문집
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• 2004.03a
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• pp.23-26
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• 2004

Drag prediction is sought for the aifoil having laminar and turbulent flow characteristics with CFD code being unable to predict transition to turbulent flow. Laminar flow simulation presents some insight to the transition position. Separate simulations with laminar and turbulent flow and their combination estimate the drag of the airfoil containing laminar and turbulent flow characteristics.

• Molecules and Cells
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• v.41 no.11
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• pp.964-970
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• 2018

Atherosclerosis preferentially involves in prone area of low and disturbed blood flow while steady and high levels of laminar blood flow are relatively protected from atherosclerosis. Disturbed flow induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). ER stress is caused under stress that disturbs the processing and folding of proteins resulting in the accumulation of misfolded proteins in the ER and activation of the UPR. Prolonged or severe UPR leads to activate apoptotic signaling. Recent studies have indicated that disturbed flow significantly up-regulated $p-ATF6{\alpha}$, $p-IRE1{\alpha}$, and its target spliced XBP-1. However, the role of laminar flow in ER stress-mediated endothelial apoptosis has not been reported yet. The present study thus investigated the role of laminar flow in ER stress-dependent endothelial cell death. The results demonstrated that laminar flow protects ER stress-induced cleavage forms of PARP-1 and caspase-3. Also, laminar flow inhibits ER stress-induced $p-eIF2{\alpha}$, ATF4, CHOP, spliced XBP-1, ATF6 and JNK pathway; these effects are abrogated by pharmacological inhibition of PI3K with wortmannin. Finally, nitric oxide affects thapsigargin-induced cell death in response to laminar flow but not UPR. Taken together, these findings indicate that laminar flow inhibits UPR and ER stress-induced endothelial cell death via PI3K/Akt pathway.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.233-238
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• 2010

A two-dimensional laminar flow past a vertical plate in a microchannel is investigated. At far upstream and downstream from the plate in the microchannel, the plane Poiseuille flow exists. The Stokes flow for this microchannel is investigated analytically and then the laminar flow by numerical method. For the Stokes flow analysis, the method of eigenfunction expansion is used. From the results, the streamline pattern and the pressure distribution are plotted, and the additional pressure drop induced by the plate and the force exerted on the plate are calculated as functions of the length of the plate. For the laminar flow, finite difference method (FDM) is used to obtain the vorticity and the stream function. When the Reynolds number exceeds a critical value, a pair of viscous eddies appears behind the plate.

• Journal of Biomedical Engineering Research
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• v.17 no.4
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• pp.515-524
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• 1996

The flow characteristics of developing unsteady laminar flow in a square-sectional $180^{\circ}$ curved duct are experimentally investigated by using laser doppler velocimerty (LDV) system with data acquisition and processing system of rotating machinery resolver(RMR) and PHASE software. The major flow characteristics of developing laminar pulsating flows are presented by mean velocity profilel velocity distribution of secondary flow, wall shear stress distributions, entrance lengths according to dimensionless angular frequency($\omega^+$), velocity amplitude ratio($A^1$), and time-averaged Dean number($De_ta$). The velocity profiles and wall shear stress distribution of laminar pulsating flow with dimensionlessangular frequency show the flow characteristics of the quasi-steady laminar flow in a curved duct. The developing region of laminar pulsatile flows in a square-sectional $180^{\circ}$ curved duct is extended to the curved duct angle of approximately $120^{\circ}$ under the present experimental condition.

• Journal of computational fluids engineering
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• v.7 no.3
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• pp.53-59
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• 2002

A two-dimensional laminar flow through a channel with a pair of symmetric vertical fins is investigated. At far up- and down-stream from the fins, the plane Poiseuille flow exists in the channel. The Stokes flow for this channel is first investigated analytically and then the other laminar flows by numerical method. For analytic method, the method of eigen function expansion and collocation method are employed. In numerical solution for laminar flows, finite difference method(FDM) is used to obtain vorticity and stream function. From the results, the streamline patterns are shown and the additional pressure drop due to the attached fins and the force exerted on the fin are calculated. It is clear that the force depends on the length of fins and Reynolds number. When the Reynolds number exceeds a critical value, the flow becomes asymmetric. This critical Reynolds number Re/sub c/ depends on the length of the fins.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.5
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• pp.165-172
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• 1993

On the basis of Nikuradse laboratory experiments conducted in circular pipe with uniform roughness, five flow regimes are defined with respect to the characteristics of boundary layer such as laminar, transition laminar, smooth turbulent, transition turbulent and rough turbulent flows. Two cases are found for the transition laminar flow: one for the transition between laminar flow and smooth turbulent flow and the other for the one between laminar flow and rough turbulent flow. They all can be clearly determined by the relative roughness or the ratio of pipe diameter to the roughness. Explicit functions are developed for the estimation of pipe friction factor for the various flow conditions including turbulent flow regimes, which have excellent agreement with the Nikuradse laboratory data.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.33 no.10
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• pp.783-788
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• 2009

In this paper, we have performed a parametric study on the characteristics of multiphase laminar flow with density difference in various microchannels. The interface between multiphase fluids is rotated by the gravitational forces induced by density difference. The numerical simulations were carried out via commercial CFD package to study the characteristics of multiphase laminar flow. The results of the numerical simulations in this study were verified by comparing with the previously reported experimental results in the literature. We have also proposed a new dimensionless relationship between dimensionless rotation angle of interface and dimensionless parameters are proposed for square microchannels with various aspect ratios. The dimensionless relationship could be widely applied to the reliable design of various microfluidic devices dealing with multiphase laminar flow.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.545-550
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• 2001

A two-dimensional laminar flow through a channel, on which a couple of symmetric vertical fins are attached, is investigated. The stokes flow for this channel flow is investigated analytically and laminar flow numerically. For analytic solution, the method of eigen function expansion and collocation method are employed. For numerical solution, finite difference method(FDM) is used to obtain vorticity and stream function. From the results, streamline patterns are shown and the pressure drop due to the attached fins is calculated, which depends on the length of fins and Reynolds number. While $Re, streamline pattern is symmetric, a pair of additional asymmetric solutions appear for $Re>Re_c$, where the critical Reynolds number $Re_c$ depends on the length of the fin.

• Proceedings of the KSME Conference
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• 2002.08a
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• pp.521-524
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• 2002

In the present study, kinetic energy of laminar steady flow in the exit region connected to the square-sectional $180^{\circ}$curved duct was investigated experimentally. The experimental study for air flows was conducted to measure kinetic energy distributions by using the Particle Image Velocimetry(PIV) system with the data acquisition and processing system of Cactus 2000 software. The results obtained from experimental studies are summarized as follows : (1) The critical Reynolds number for a change from laminar steady flow to transitional steadt flow was about 1910, in the 50 region of dimensionless axial position (x/Dh) whirh was considered as a fully developed flow region. (2) Maximum kinetic energy of laminar steady flow was gradually increased as the Reynolds number increased.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.7
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• pp.667-673
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• 2000

In order to understand the laminar flow heat transfer enhancement by the swirl flow, the effects of heat transfer in a circular pipe with a twisted tape insert were investigated experimentally. In the present study, the uniform heat flux condition was considered. The laminar heat transfer correlations were developed using the least-square-fit from the surface temperature distribution of an electrically-heated pipe and flow property data. Average Nusselt number correlations with the twisted tape insert were expressed as a function of swirl parameter, Reynolds number and Prandtl number. In the case of the twisted ratio y = 6.05, the mean Nusselt number increased approximately 500% and the friction factor increased approximately 300%, compared to the case of the empty pipe, respectively.