• Microbiology and Biotechnology Letters
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• v.51 no.2
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• pp.135-146
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• 2023

Viral oncology is focused on understanding the relationship between cancer and viruses, which are known to play a role in the development of certain types of cancer. Approximately 15-20% of human cancers are believed to be caused by oncogenic viruses, and as a result, there is significant interest in understanding how these viruses contribute to cancer development. There are several viruses that have been linked to cancer, including human papillomavirus, hepatitis B and C virus, Epstein-Barr virus, human T-cell lymphotropic virus type 1, Kaposi's sarcoma-associated herpesvirus, and Merkel cell polyomavirus. Each of these viruses is associated with different types of cancer, and the mechanisms by which they contribute to cancer development are diverse. This article discusses these mechanisms as well as current and future strategies for preventing and treating virus-associated cancers with the goal of presenting a thorough review of the current state of knowledge in viral oncology and to highlight the importance of continued research in this field.

• Advances in concrete construction
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• v.16 no.5
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• pp.243-254
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• 2023

Microtubules in the cell are influenced by internal and external stimulation and play an important part in conveying protein substances and in carrying out medications to the intended targets. Waves are produced during these functions and in order to control the biological cell functions, it is important to know the wave velocities of microtubules. Owing to cylindrical shell shaped and mechanically elastic and orthotropic, cylindrical shell model based on gradient elasticity theory has been used. Wave velocities of the protein microtubule are carried out by considering Love's thin shell theory and Navier solution. Also the effect of size parameter and other variables on the results are investigated.

• International Journal of Computer Science & Network Security
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• v.24 no.2
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• pp.67-78
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• 2024

Software-Defined Networking (SDN) is a new emerging networking paradigm that has adopted a logically centralized architecture to increase overall network performance agility and programmability. Combining network virtualization with SDN will guarantees for combined advantages of improved flexibility and network performance. Combining SDN with hypervisors divides the network physical resources into several logical transparent and isolated virtual SDN network (vSDN), where each has its virtual controller. However, SDN hypervisors bring several advantages as well as several challenges to its network operators as for the virtual appliances, their efficient placement, assurance of network performance is mandatory, and their dynamic instantiation with their migration. In this article, we provide a brief and concise review of network virtualization along with its implementation in the SDN network. SDN hypervisors types are discussed, and taxonomy is provided to demonstrate the importance of hypervisors in SDN. A comparison of SDN hypervisors is performed to elaborate on the vital hypervisor software along with their features, and different challenges are discussed faced by the SDN network. A framework is proposed to add combined functionalities of hypervisors to create a more effective and efficient virtual system. The purpose of the framework is to increase network performance through proper configuration of resources, software, control plane isolation functions with defined rules and policies.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.12
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• pp.627-633
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• 2020

The study attempts to analyze the impact of firm's risk on capital structure in the context of seasonal and non-seasonal businesses. We use two independent variables namely credit risk and systematic risk and one dependent variable to explore this connection. Sugar sector is taken as seasonal while the textile sector as non-seasonal businesses. The panel data of twenty-five firms from each sector are taken ranging for the period of 2012 to 2019 which has been retrieved from their annual reports for empirical analysis of the study. The results reveal the negative impact of credit risk on capital structure in both types of businesses. Increasing (decreasing) one point of credit risk causes a decrease (increase) leverage ratio by 0.27 points for seasonal while increasing (decreasing) one point of credit risk causes to decrease (increase) leverage by 0.15 points for non-seasonal businesses. Furthermore, the study shows positive impact of systematic risk on leverage ratio in non-seasonal business and no impact in seasonal business. Any increase (decrease) in the systematic risk causes an incline (decline) leverage ratio by 2.68 units for non-seasonal businesses. The study provides a guideline to managers for risk management in businesses. The research focusses on theoretical as well as managerial and policy implications on risk management in businesses.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.693-698
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• 2012

Breast cancer is the most frequent cancer of women worldwide, with considerable geographic and racial/ethnic variation. Data are generally derived from population based cancer registries in the developed countries but hospital data are the most reliable source in the developing countries. Ten years data from 1st Jan 2000 to 31st Dec 2009 of a cancer hospital in Pakistan were here analyzed by descriptive statistics to evaluate the clinicopathologic profile of local breast cancer patients. Among 28,740 cancer patients, 6,718 were registered as breast cancer. The female to male ratio was 100:2. Breast cancer accounted for 23% of all and 41% of female cancers. Some 46% were residents of Lahore, with a mean age of $47{\pm}12$ years. Less than 1% were at Stage 0 and 10%, 32%, 35% and 23% were at Stage I, II, III and IV respectively. Histopathology was unknown in 4% while 91%, 2% and 1% had invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC) and mucinous carcinoma respectively. Rare carcinomas accounted for the rest. Tumor grade 1, 2 and 3 was 11%, 55% and 34% among the known. Profile of breast cancer patients in Pakistan follows a pattern similar to that of other developing countries with earlier peak age and advanced disease stage at presentation. The male breast cancer accounts for higher proportion in the local population. Local women have higher frequency of IDC and lower frequency of ILC and DCIS, owing probably to a different risk profile. Use of hospital information systems and establishment of population based cancer registry is required to have accurate and detailed local data. Promotion of breast health awareness and better health care system is required to decrease the burden of advanced disease.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4369-4371
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• 2012

Aim: Metastatic tumor of bone is the most common malignancy involving bone and is an important predictor of prognosis in advanced cancers. The prognosis depends upon the primary site of origin and the extent of disease. In current study, we present the pattern and distribution of metastatic bone disease seen in the leading cancer care center of Pakistan, Shaukat Khanum Cancer Hospital & Research Center (SKMCH & RC), Lahore. Materials & Methods: All cases of bony metastatic disease were included that presented in the Pathology Department, from Jan 2005 to July 2011. Patients of all ages and both sexes were included. Primary bone tumors, lymphomas, sarcomas and other malignancies were excluded. The data were recorded and analyzed with SPSS 16.0. Results: A total of 146 cases of metastatic bone disease were included in the study. Out of the total cases, 79 were male and 67 were female. Age range 25-82 years (median 52). Hip bone was the most frequent bone involved, with femur and vertebrae as second and third in the list. The commonest bone involved in males was vertebrae with 23 cases and in females was hip bone with 22 cases. Regarding primary site, cancers of breast, prostate and gastrointestinal tract were at the top of the list with prostate and breast being the most frequent primary sites of metastasis in males and females respectively. Conclusion: Bone metastasis is an important entity to consider in the differential diagnosis whenever a bony tumor especially carcinoma present in older age. Our data are comparable with international findings and the literature available regarding the site and distribution of skeletal metastatic lesions. A slight deviation noted was more common bony metastatic lesions with ovarian primaries in females and gastrointestinal tract cancers in males in our study.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4877-4883
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• 2014

Cervical cancer is one of the leading causes of morbidity and mortality amongst the gynecological cancers worldwide, especially in developing countries. There are few to no initial symptoms and signs. This study was conducted to assess the awareness level of young Pakistani women about cervical cancer and to educate them about this deadly disease. A detailed questionnaire regarding demographic data and information about cervical cancer was distributed in different cities of Punjab. A total of 873 women took part in this survey and 70.1 percent were totally unaware of this cancer. Only 8.5% of the whole surveyed population knew accurately about cancer of cervix, 7% of the surveyed respondents correctly specified the human papilloma virus as the causative agent. Only 5.2% respondents were able to identify the Pap smear test as a diagnostic measure. Out of all the surveyed population only 4.3% of individuals were found to be vaccinated against this disease and the majority was found from the medical profession. Medical professionals, students, working women, housewives and uneducated individuals took active part in this survey. This study demonstrates a low level of awareness among Pakistani women and a need for an active campaign by media and government to increase understanding as well as introducing measures for improved prevention and treatment of cervical cancer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.4
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• pp.2002-2019
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• 2017

RPL routing protocol for low-power and lossy networks is an Internet Engineering Task Force (IETF) recommended IPv6 based protocol for routing over Low power Lossy Networks (LLNs). RPL is proposed for networks with characteristics like small packet size, low bandwidth, low data rate, lossy wireless links and low power. RPL is a proactive routing protocol that creates a Directed Acyclic Graph (DAG) of the network topology. RPL is increasingly used for Internet of Things (IoT) which comprises of heterogeneous networks and applications. RPL proposes a single path routing strategy. The forwarding technique of RPL does not support multiple paths between source and destination. Multipath routing is an important strategy used in both sensor and ad-hoc network for performance enhancement. Multipath routing is also used to achieve multi-fold objectives including higher reliability, increase in throughput, fault tolerance, congestion mitigation and hole avoidance. In this paper, M-RPL (Multi-path extension of RPL) is proposed, which aims to provide temporary multiple paths during congestion over a single routing path. Congestion is primarily detected using buffer size and packet delivery ratio at forwarding nodes. Congestion is mitigated by creating partially disjoint multiple paths and by avoiding forwarding of packets through the congested node. Detailed simulation analysis of M-RPL against RPL in both grid and random topologies shows that M-RPL successfully mitigates congestion and it enhances overall network throughput.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.10
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• pp.4724-4737
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• 2018

Facebook has quickly infused across cultures worldwide to become a common household term for diverse spectra of netizens, especially youngsters. Inherently, interactive in nature, Facebook provides a common cyber enabled platform for online interactions with social friends, living across the world. However, despite its merits, users also experience certain disadvantages, which include but are not limited to rise in feelings of social comparison, decline in self-esteem, contentment and general subjective well-being. This work aims to determine the role of Facebook in spreading envy and identify factors that trigger such emotions. Due to abductive nature of the study, we used pilot interviews and consulted relevant literature to formulate hypotheses. Further, we used deductive approach and conducted a survey. The results showed that frequent use of Facebook, particularly passive following is main predictor of envy, and social interaction is the biggest cause for development of envious feelings in Facebook users. However, insignificant variation was found while investigating relationship between envy and factors, such as pretentiousness, time spent, accomplishment, everything in life, likes on posts, popularity across genders, marital status and genre.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.9
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• pp.1361-1366
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• 2007

In this project, ovarian size and activity during the peak (November-April) and the low (May-October) breeding seasons in young and adult camels were studied. Ovaries of 92 camels (Camelus dromedarius), with clinically normal reproductive tracts, aged 3-15 years and slaughtered at Faisalabad or Lahore abattoirs over a period of 24 months, were collected. Jugular blood was collected from each animal before slaughter; the serum was separated and analyzed for oestradiol concentration. The size (length, width and thickness) and weight of each ovary were measured. Grossly observable Graafian follicles were counted and their diameter was measured using Vernier Calipers. The camels having ovaries presenting follicles more than 5 mm in diameter were taken as having active ovaries. The results showed that ovarian length, width and weight were significantly higher (p<0.05) during the peak than the low breeding season. The percentage of active ovaries was also significantly higher (p<0.01) during the peak than the low breeding season. However, the effect of season on ovarian thickness was non-significant. Similarly, the ovarian length, width, thickness, weight and activity did not vary significantly between young (3-7 years old) and adult (8-15 years old) animals. Serum oestradiol concentrations were significantly higher (p<0.05) during the peak ($67.70{\pm}1.36$ pg/ml) than the low breeding season ($15.25{\pm}1.54$ pg/ml). It was concluded that in Pakistani camels ovarian size and activity were higher during the peak than the low breeding season. However, age of the camel (from 3 to 15 years) had no effect on these parameters.