• The Korean Journal of Pain
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• v.6 no.2
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• pp.224-230
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• 1993

Most patients who have suffered from pain and muscle weakness on femoral nerve distributing area show no definite pathologic finding on X-ray or laboratory examinations. Therefore proper diagnosis is difficult to determine for the proper treatment of the symptoms. Based on my clinical experiences and anatomical studies, I have found most of these symptoms are a result of femoral nerve compression on trigger point of psoas major muscle. Accordingly, releasing the compression of femoral nerve by Laser stimulation and local anesthetic injection to the identified trigger point of psoas major muscle was found to be an effective treatment for femoral neuralgic pain.

• ETRI Journal
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• v.36 no.3
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• pp.333-342
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• 2014

Most hyper-ellipsoidal clustering (HEC) approaches use the Mahalanobis distance as a distance metric. It has been proven that HEC, under this condition, cannot be realized since the cost function of partitional clustering is a constant. We demonstrate that HEC with a modified Gaussian kernel metric can be interpreted as a problem of finding condensed ellipsoidal clusters (with respect to the volumes and densities of the clusters) and propose a practical HEC algorithm that is able to efficiently handle clusters that are ellipsoidal in shape and that are of different size and density. We then try to refine the HEC algorithm by utilizing ellipsoids defined on the kernel feature space to deal with more complex-shaped clusters. The proposed methods lead to a significant improvement in the clustering results over K-means algorithm, fuzzy C-means algorithm, GMM-EM algorithm, and HEC algorithm based on minimum-volume ellipsoids using Mahalanobis distance.

• Korean Journal of Veterinary Research
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• v.53 no.4
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• pp.225-230
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• 2013

To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.

• Biomedical Science Letters
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• v.10 no.4
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• pp.507-514
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• 2004

The Pseudomonas aeruginosa isolated from the clinical specimens has a mutation on the QRDR (quinolone resistance determining region). There were obvious mutations in both gyrA and parC gene which are major targets of quinolone. Simultaneous mutations were found two sites or more on these genes in all of ten strains. GyrB or parE gene had only silent mutation without converted amino acids. We confirmed that P. aeruginosa from clinical specimens exhibited decreased sensitivity to fluroquiolone due to changed Thr-83→lle and Asp-87→Asn types on gyrA and altered Ser-87→Leu type on parC. This is the first finding that a new Met-93→Thr type on parC as well as mutations on gyrB or parE genes differed from existing patterns. This study showed more mutations of gyrA rather than parC, suggesting that change of Type Ⅳ topoisomerase is more serious than that of type Ⅱ (DNA gyrase).

• Bioinformatics and Biosystems
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• v.2 no.1
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• pp.12-16
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• 2007

DNA repair means a collection of processes that a cell identifies and corrects damage to genome sequence. The DNA repair processes are important because a genome would not be able to maintain its essential cellular functions without the processes. In this research, we make some gene regulatory networks of DNA repair in S. cerevisiae to know how each gene interacts with others. Two approaches are adapted to make the networks; Bayesian Network and ARACNE. After construction of gene regulatory networks based on the two approaches, the two networks are compared to each other to predict which genes have important roles in the DNA repair processes by finding conserved interactions and looking for hubs. In addition, each interaction between genes in the networks is validated with interaction information in S. cerevisiae genome database to support the meaning of predicted interactions in the networks.

• International Journal of Naval Architecture and Ocean Engineering
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• v.2 no.2
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• pp.57-67
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• 2010

Experimental investigations were carried out on an Axi-symmetric Body Model fitted with Pump-jet Propulsor (PJP) in the Cavitation Tunnel at Naval Science and Technological Laboratory (NSTL). The tests were intended for evaluating the propulsion characteristics of the body and propulsor. The self propulsion point of the model for two configurations was determined after finding the corrections for tunnel blockage effects and differences in model length at zero trim. The results were found to match closely with the towing tank results. The rotor and stator torques also matched closely over full range of experiment. Further experiments were carried out on the body at $4.5^{\circ}$ angle of trim to investigate the propulsive performance and assess the operational difficulties in the sea. The results indicated an increase in resistance and decrease in rotor thrust; but the balance of torques between the rotor and stator was undisturbed, causing no concern to vehicle roll.

• Journal of Technologic Dentistry
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• v.12 no.1
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• pp.67-72
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• 1990

The purpose of this study was to find job maturity of dental technology students in Taegu area. In order to accomplish the objectives stated above, the following research methods were utilized : 1. The related literatures including previous studies and journal were reviewed to develop the questionnaire for this purpose. 2. Field survey and questionnaire survey were conducted to collect data from 360 students sampled and analyzed by frequency percentage $X^2$-score. In consquence of analysis of the responses, the finding were as follows : 1. The job maturity of students was shown high. The grade point of 98.6 percent students as a whole was above three point. 2. As compared by academic year of sophomore students was higher than that of freshmen's, and male students were shown greater score than female students.

• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1487-1493
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• 2013

Based on the finding that the 2-aminobenzamido group of MS-275 plays a crucial role in inhibiting HDACs through chelation of zinc existing at the active site of HDAC enzymes, novel N-(2-hydroxyphenyl)arylsulfonamide derivatives were synthesized for their potential ability to inhibit HDACs and evaluated for anticancer activity against human breast cancer cell line (MCF-7). Although the synthesized arylsulfonamides have failed to significantly inhibit total HDACs activity, phenyl carbamate-linked arylsulfonamide 10 and benzyl thiocarbamate-linked arylsulfonamide 15 exhibited good anticancer activities, which were only 4.3- and 3.6-fold lower anticancer activities, respectively, than MS-275 that is undergoing phase II clinical trials. These results suggest that these compounds may act as a selective HDAC inhibitor and probably N-(2-hydroxyphenyl) sulfamoyl group may play an important role in interacting with HDAC enzymes through chelation of zinc ion.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.10a
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• pp.354-360
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• 1998

In general, it is very difficult to find optimal fuzzy rules by experience when a system is dynamical and/or complex. Futhermore proper fuzzy partitioning is not deterministic and there is no unique solution. Therefore we propose a new design method of an optimal fuzzy logic controller, that is a co-evolutionary genetic algorithm finding optimal fuzzy rule and proper membership functions at the same time. We formalize the relation between fuzzy rules and membership functions in terms of fitness. We review the typical approaching methods to co-evolutionary genetic algorithms , and then classify them by fitness relation matrix. Applications of the proposed method to a path planning problem of autonomous mobile robots when moving objects exist are presented to demonstrate the performance and effectiveness of the method.

• Journal of Power Electronics
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• v.18 no.6
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• pp.1634-1641
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• 2018

This study focuses on a high-performance direct active and reactive power controller design that is successfully applicable to three-phase pulse width modulation (PWM) AC/DC converters used in renewable distributed energy generation systems. The proposed controller can overcome the sluggish transient dynamic response of conventional controllers to rapid power command changes. Desired active and reactive powers can be thoroughly obtained at the end of each PWM period through a deadbeat solution. The proposed controller achieves an exact nonlinear cross-coupling decoupling of system power without using a predefined switching table or bang/bang hysteresis control. A graphical and analytical analysis that naturally leads to a control voltage vector selection is provided to confirm the finding. The proposed control strategy is evaluated on a 3 kW PWM AC/DC converter in the simulation and experiment.