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Effect of Phyto-Extract Fermented Mixture (MP119) on the Sexual Functions and on the Toxicities of Cadmium (식물추출복합발효물(MP119)이 성기능에 미치는 영향 및 카드뮴 독성에 대한 효과)

  • Jang, Young-Sun;Jeong, Jong-Moon
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.38 no.12
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    • pp.1724-1731
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    • 2009
  • This study was aimed to investigate the effect of phyto-extract fermented mixture (MP119) on the male sexual functions. The MP119 was evaluated for anti-impotency and anti-hypertensive effects via ACE (angiotensin converting enzyme) or PDE (phosphodiesterase) inhibition assay. $IC_{50}$ values of MP119 against ACE and PDE were 241.3${\pm}$35.5 ppm and 372.2${\pm}$33.8 ppm, respectively. To investigate the effect of testosterone expression by MP119, we performed cell media test using mouse Leydig-derived TM3 cells. Production of testosterone in TM3 cell was increased by MP119. Also, NO (nitric oxide) production of HUVEC (human umbilical vein endothelial cell) was increased when MP119 was added to the cultures. Forty male ICR mice were divided into 4 groups. MP119 was orally intubated for 7 days to group 1 and 3, and same volume of vehicle to group 2 and 4 as controls. After that, group 3 and 4 were intraperitoneally injected cadmium chloride at a single dose of 2 mg/kg. On the 8th experimental day, weights of testis, epididymis and seminal vesicle, number of sperm, concentrations of serum testosterone and cGMP were determined. The number of sperm, the concentrations of testosterone and cGMP were significantly increased in two experimental groups (group 1, 3). These results suggest that MP119 enhanced the sexual function of male mice, and could protect the sexual organs from the cadmium chloride as one of the endocrine disrupters.

Analysis on Survival and Prognostic Factors for Cancer Patients with Malignancy-associated Hypercalcemia

  • Zhang, Su-Jie;Hu, Yi;Cao, Jing;Qian, Hai-Li;Jiao, Shun-Chang;Liu, Zhe-Feng;Tao, Hai-Tao;Han, Lu
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.11
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    • pp.6715-6719
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    • 2013
  • Objective: To explore the incidence, clinical characteristics, diagnosis and treatment strategies, prognosis of patients with malignancy-associated hypercalcemia (MAH). Methods: The data of 115 patients with MAH who were treated at the Medical Oncology Department of Chinese PLA General Hospital from Jan., 2001 to Dec., 2010 was retrospectively reviewed. Survival analysis was performed using the Kaplan-Meier method and the Cox proportional hazard model with statistic software SPSS 18.0. Results: The patients had blood calcium levels ranging from 2.77 to 4.87 mmol/L. Except for 9 cases who died or were discharged within 5 days after admission, all other patients recovered to normal blood calcium level after treatment with bisphosphonates or intravenous hydration and diuretics; their survival after occurrence of MAH was from 1 day to 4,051 days, and the median survival time was only 50 days. In the log-rank test, the male, renal metastasis, central nervous system symptoms and hypercalcemia occurring over 140 days after cancer diagnosis were predictors of poor survival (P=0.002, P=0.046, P=0.000, P=0.009). In the COX analysis, being male, central nervous system symptoms and hypercalcemia lasting over 140 days after cancer diagnosis were independent prognostic factors for survival time (RR=2.131, P=0.027; RR=3.054, P=0.002; RR=2.403, P=0.001). According to these factors, a score system was established to predict the patient prognosis and adjust the treatment. Conclusion: Cancer patients with MAH have an extremely poor median survival. Some independent factors indicate poor prognosis, including male gender, central nervous system symptoms and hypercalcemia lasting over 140 days after cancer diagnosis. The prognostic score can serve as a reference for MAH prognosis and treatment, worthy of further investigation.

Long Term Average Spectrum Characteristics of Head and Chest Register Sounds of Western Operatic Singers : Extended Study (성악다들의 목소리에 대한 Long Term Average Spectrum 분석 -$2^{nd}$ Singer's Formant의 존재 가능성에 대하여-)

  • Ban, Jae-Ho;Kwon, Young-Kyung;Jin, Sung-Min
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.15 no.1
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    • pp.31-36
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    • 2004
  • Background and Objectives : It has been shown that the epilaryngeal tube in the human airway is responsible for vocal ring, or the singer's formant. In previous study, authors showed that in trained tenors, besides the conventional singer's formant in the region of ,5500Hz, another energy peak was observed in the region of 8,000Hz. This peak was interpreted as the second resonance of the epilarynx tube. Singers in other voice categories who produce vocal ring are assumed to have the same peak, but no measurements have as yet been made. Materials and Methods : Fifteen tenors, fourteen baritones, seven sopranos and five mezzo sopranos attending the music college, department of vocal music who could reliably produce the head and chest registers were chosen for this study. Each subject was asked to produce an/ah/sound for at least three seconds for the head register sound(tenors ; G4, barions ; E4 sopranos ; F5 and mezzosopranos ; C5) and for the chest register sound (tenors ; C3, baritones ; D3, sopranos ; D4 and Mezzosoprano ; A3). The sound data was analyzed using the Fast Fourier Transform (FFT)-based power spectrum, Long term average(LTA) power spectrum using the FFT algorithm of the Computerized Speech Lab (CSL, Kay elemetrics, Model 4300B, USA). Statistical analysis was performed using the Mann-Whitney test of the Statistical Package for Social sciences(SPSS). Results : For head register sounds, a significant increase was seen in the 2,200-3,400Hz region(p<0.05) and the Similar to the head register sounds, there was a significant increase in energy in the four trained singer group compared with the untrained group in the 2,200-3,100Hz region(p<0.05), the 7,800-8,400Hz region(p<0.05) for the chest register sounds. Conclusions : When good vocal production was made for the head and chest registers, an energy peak was observed near 2,500Hz, a frequency already known as the "singer's formant', in all subjects in the study group. Another region of increased energy was observed around 8,000Hz that had not been noticed previously. The authors believe this region to be the second singer's formant.

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Characteristic Evaluation of Bending Strength Distributions on Revised Korean Visual Grading Rule (개정된 육안등급 구분에 따른 휨강도 특성 평가)

  • Pang, Sung-Jun;Oh, Jung-Kwon;Park, Chun-Young;Park, Joo-Saeng;Park, Mun-Jae;Lee, Jun-Jae
    • Journal of the Korean Wood Science and Technology
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    • v.39 no.1
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    • pp.1-7
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    • 2011
  • Recently, the visual grading rule of Korea Forest Research Institute (KFRI) was revised and it is necessary to investigate the distribution characteristics of visual graded lumber in accordance with the revised rule. Therefore, in this study, the distribution characteristics of bending strength was investigated with revised visual grading rule and changed prior rule, respectively. The size of specimens was $38{\times}140{\times}3,000$ (mm) and the species were $Larix$ $kaempferi$ and $Pinus$ $koraiensis$. The moisture content was under 18% and the specimens were tested in accordance with ASTM D-198. The number of No. 1 and 2 grades, suitable for structural lumber, was increased when the revised visual grading rule was applied. Moreover, the revised rule was more effective to distinguish sharply between No. 1 and 2 grades and below No. 3 grade. Meanwhile, the lower 5% exclusion limit and allowable stresses were generally decreased when revised visual grading rule had been applied. However, the announcement of Korea Forest Service, tested with small clear specimen, was much lower than the allowable stresses of this test, tested with structural lumber. Therefore, the revision of allowable design values should be considered for more exact use and effective structural design.

A study on vision system based on Generalized Hough Transform 2-D object recognition (Generalized Hough Transform을 이용한 이차원 물체인식 비젼 시스템 구현에 대한 연구)

  • Koo, Bon-Cheol;Park, Jin-Soo;Chien Sung-Il
    • Journal of the Korean Institute of Telematics and Electronics B
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    • v.33B no.1
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    • pp.67-78
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    • 1996
  • The purpose of this paper is object recognition even in the presence of occlusion by using generalized Hough transform(GHT). The GHT can be considered as a kind of model based object recognition algorithm and is executed in the following two stages. The first stage is to store the information of the model in the form of R-table (Reference table). The next stage is to identify the existence of the objects in the image by using the R-table. The improved GHT method is proposed for the practical vision system. First, in constructing the R-table, we extracted the partial arc from the portion of the whole object boundary, and this partial arc can be used for constructing the R-table. Also, clustering algorithm is employed for compensating an error arised by digitizing an object image. Second, an efficient method is introduced to avoid Ballard's use of 4-D array which is necessary for estimating position, orientation and scale change of an object. Only 2-D array is enough for recognizing an object. Especially, scale token method is introduced for calculating the scale change which is easily affected by camera zoom. The results of our test show that the improved hierarchical GHT method operates stably in the realistic vision situation, even in the case of object occlusion.

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Drone-Based Micro-SAR Imaging System and Performance Analysis through Error Corrections (드론을 활용한 초소형 SAR 영상 구현 및 품질 보상 분석)

  • Lee, Kee-Woong;Kim, Bum-Seung;Moon, Min-Jung;Song, Jung-Hwan;Lee, Woo-Kyung;Song, Yong-Kyu
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.27 no.9
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    • pp.854-864
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    • 2016
  • The use of small drone platform has become a popular topic in these days but its application for SAR operation has been little known due to the burden of the payload implementation. Drone platforms are distinguished from the conventional UAV system by the increased vulnerability to the turbulences, control-errors and poor motion stability. Consequently, sophisticated motion compensation may be required to guarantee the successful acquisition of high quality SAR imagery. Extremely limited power and mass budgets may prevent the use of additional hardwares for motion compensation and the difficulty of SAR focusing is further aggravated. In this paper, we have carried out a feasibility study of mico-SAR drone operation. We present the image acquisition results from the preliminary flight tests and a quality assessment is followed on the experimental SAR images. The in-flight motion errors derived from the unique drone movements are investigated and attempts have been made to compensate for the geometrical and phase errors caused by motions against the nominal trajectory. Finally, the successful operation of drone SAR system is validated through the focussed SAR images taken over test sites.

Narrative Characteristics in High School Students' Geological Field Trip Reports: the Relationship Between the Narrative Mode of Thought and the Academic Achievement (지질 답사 보고서에 나타난 고등학생들의 내러티브 특성: 내러티브적 사고와 학업 성취도의 관계)

  • Chung, Sue-Im;Shin, Dong-Hee
    • Journal of The Korean Association For Science Education
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    • v.35 no.4
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    • pp.735-750
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    • 2015
  • The purpose of this study is to draw an educational implication by analyzing the context of narrative texts, students' narrative thinking, and their academic achievement. We investigated text types in students' geological field trip reports, the reason why students favors narrative texts, the relationship between narrative texts and their scientific knowledge recall, and the relationship between narrative thought and academic achievement. All students used expository texts, 82% of them expressed argumentative texts, and 36% of them used narrative texts. It is likely that students use more narrative texts because students were in the context of outdoor activity and so, their emotional feelings were more activated than when they are doing lab activities. The academic characteristics of earth science seemed to contribute more narrative texts in students' reports. The post-test revealed that students with narrative texts recalled better than the others. On the other hand, there were no statistically meaningful differences in academic achievement between the two groups. However, we have noted that female students whose reports contain narrative texts achieved significantly higher scores than female students whose reports are without narrative texts. From in-depth interviews, we found that students who properly used both paradigmatic and narrative mode of thought were in a more advantageous position than those who used narrative thought only. It was also found that some narratively thinking students tended to feel uncomfortable with the way of learning or evaluating questions about science. In the future, a complementary approach of narrative and paradigmatic mode of thoughts would be encouraged by understanding students' tendency of thinking.

A Study on Corrosion Inhibitors for applying to Iron objects (철제유물의 부식억제를 위한 부식억제제에 관한 연구)

  • Kim, Hye Sun;Hur, Yoon Hyun;Kim, Soo Ki
    • Journal of Conservation Science
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    • v.30 no.1
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    • pp.1-11
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    • 2014
  • Stabilization of iron artifacts is focused on desalination than corrosion inhibitors. However artifacts are not condition of desalination treatment must be applied to corrosion inhibitors. But iron artifacts is not representative of inhibitors which drug is most effective qualities have not been identified. Therefore in this study validates the effectiveness of existing inhibitors and its purpose is to suggest corrosion inhibitors for iron artifacts. In this study, Comparative experiment of corrosion inhibitors is selected BTA, DAN and MEA, TEA. This study was studied using Corrosion resistance test, Contact angle, XPS. As a result, all the samples treated with corrosion inhibitors was formed hydrophobic coating and was rising corrosion resistance. Also, the concentration of corrosion inhibitors was 3% better than 0.3%. BTA in the XPS experiment, the corrosive material to block the CH bond of the peak concentration was highly. This is considered corrosion potential is very high to see out the effect in the polarization experiment. Ethanolamine was superior to the MEA rather than in the TEA. MEA is likely to be appropriate in an outdoor iron artifacts seem to be suitable as corrosion inhibitors.

Phosphate Adsorption Characteristics of a Filter Medium, Adphos, and Its Efficiency by the Filtration Experiment Combined with the Vegetation Mat (Adphos 여재의 인 흡착특성과 식생 매트와 결합한 여과실험에 의한 효율)

  • Kim, Ji Ah;Joo, Gwang Jin;Choi, I Song;Chang, Kwang Hyeon;Oh, Jong Min
    • Ecology and Resilient Infrastructure
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    • v.3 no.4
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    • pp.231-237
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    • 2016
  • The purpose of this study is to analyze phosphate adsorption characteristic of the filter media applied in water purification technology. And it is also to observe the removal efficiency of the technology that was developed by combining the purification abilities of filter media and the vegetation mat. The filter media, Adphos, is the subject of this study. The result of adsorption test shows that $PO_4{^{3-}-P}$ adsorption characteristics of Adphos is determined by the Langmuir isotherm model fitting and the $q_m$ (maximum adsorption amount) value is calculated as 1.162 mg/g. To verify the removal efficiency of the purification technology, a lab-scale reactor, including a 400 mm depth of filter bed filled by Adphos, was manufactured. Yellow flag Iris (Iris pseudacours L.) was planted on the vegetation bed and the coir-roll was used to fix the root of vegetation. The reactor ran 8 hours per day over 71 days, and the results of filtration experiment show that average removal efficiency of SS, T-N and T-P were calculated as 94%, 41% and 64% respectively. With these results, it was proved that the purification technology is highly effective. And for the long-time use, a maintenance guide is also required.

Prognosis for Blunt Abdominal Trauma Patients with Contrast Extravasation on the Abdominopelvic CT Scan (조영제 혈관 외 유출이 관찰된 복부 둔상 환자의 유출부위에 따른 예후)

  • Shin, Hyung Jin;Lee, Kang Hyun;Kwak, Young Soo;Kim, Sun Hyu;Kim, Hyun;Hwang, Sung Oh
    • Journal of Trauma and Injury
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    • v.22 no.1
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    • pp.57-64
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    • 2009
  • Purpose: Computed tomography (CT) is an accurate test for evaluating hemodynamically stable patients with blunt abdominal trauma. Until now, there have been few studies concentrating on the diagnostic and prognostic significance of the intravenous contrast extravasation (CE) site. We investigated the site of CE on abdominopelvic CT (APCT) and its effect on treating trauma patients and predicting the clinical outcome. Methods: The 50 patients admitted to our emergency department with blunt abdominal trauma showing CE on APCT from January 2004 to September 2006 were included in this study. Patients were prospectively collected, and medical records were reviewed and analyzed. The patients'clinical and lab findings, Focused Assessment with Sonography for Trauma (FAST) findings, CT findings were analyzed. CE sites were classified as intraperitoneal, retroperitoneal, and pelvic cavity and were correlated with post-treatment complications, mortality, and morbidity. Results: Of the 50 patients (mean age : $45{\pm}18years$, 29 males, 21 females) included in our study, 33 patients died (66%). There was no correlation between CE site and ICU or total hospitalization duration (p=0.553, p=0.523). During the first 24 hours of resuscitation, the pelvic cavity group required a mean of 20 units more of packed red blood cell (pRBC) transfusion compared to other groups (p=0.003). In the intraperitoneal group, more patients received operative invasive intervention - either laparotomy or embolization (p=0.025). The intraperitoneal group had the highest mortality, with 13 deaths (11/33, 39%), and the highest early mortality rate (10/13, 76%) in the first 24 hours (p=0.001). Conclusion: Intraperitoneal CE on the CT scan in cases of blunt abdominal trauma is regarded as an indication of a need for invasive intervention (either angiography or laparotomy) and of a higher mortality rate in the first 24 hours. A pelvic cavity CE rquires more aggressive transfusion with pRBC. However, the CT findings themselves showed no significant correlation with overall mortality, morbidity, or hospitalization.