• Journal of Radiation Industry
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• v.7 no.2_3
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• pp.127-134
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• 2013

Bombesin receptors are overexpressed in many kinds of human tumors. In particular, the gastrin releasing peptide receptor (GRPR) which is also called bombesin receptor subtype 2, has been identified in prostate cancer. In the present study, we developed a bombesin antagonist-based $^{177}Lu$-labeled peptide, $^{177}Lu$-DOTA-$Ala(SO_3H)$-Aminooctanoyl-Gln-Trp-Ala-Val-N methyl Gly-His-Statine-Leu-$NH_2$ (DOTA-sBBNA). DOTA-sBBNA was prepared using a solid phase synthesis method. It was labeled with $^{177}Lu$ by a high radiolabeling yield (>98%), and its Log P value was -2.05. The radiolabeled peptide was highly stable in serum incubation at $37^{\circ}C$ for 48 hr. A competitive displacement of $^{125}I-[Tyr^4]$-Bombesin on the PC-3 human prostate carcinoma cells revealed that the $IC_{50}$ value of the peptide was 6.76 nM indicating a highly nanomolar binding affinity for GRPR. These results suggest that $^{177}Lu$-DOTA-sBBNA can be a potential candidate for targeting prostate cancer, and further studies to evaluate its biological characteristics are needed.

• Earthquakes and Structures
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• v.7 no.5
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• pp.627-645
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• 2014

Using OpenSees as a framework, constitutive models of reinforced, prestressed and prestressed steel fiber concrete found by the panel tests have been implemented into a finite element program called Simulation of Concrete Structures (SCS) to predict the seismic behavior of shear-critical reinforced and prestressed concrete structures. The developed finite element program was validated by tests on prestressed steel fiber concrete beams under monotonic loading, post tensioned precast concrete column under reversed cyclic loading, framed shear walls under reversed cyclic loading or shaking table excitations, and a seven-story wall building under shake table excitations. The comparison of analytical results with test outcomes indicates good agreement.

• Proceedings of the Korean Magnestics Society Conference
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• 2005.12a
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• pp.7-7
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• 2005

• Genomics & Informatics
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• v.19 no.3
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• pp.20.1-20.2
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• 2021

• Korean Journal of Acupuncture
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• v.33 no.2
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• pp.47-57
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• 2016

Objectives : Six command points are individual points that have strong and broad effects on their related part of the body, but there is a controversy about which acupoints are should be included in the six command points. This research was reviewed which acupoints are suitable for the construction of the six command points. Methods : We searched acupoints mentioned six command points in literatures, then investigated the effects of the acupoints to identify that they can be included in the six command points. And we deliberated which acupoints are suitable for the six command points. Results : Acupoints mentioned the six command points are LU7, LI4, ST36, BL40, PC6, TE6, GV26, ouch point, GB34 and SP6. Among the acupoints, LU7, LI4, ST36, BL40 and PC6 was included in the six command points in all of searched literatures. And GV26, ouch point, GB34 and SP6 were excluded because GV26 and ouch point were not fit the definition of the six command points, ST36 can be an alternative to SP6 based on their effects, and GB34 has a similar but little effect compared to TE6. Conclusions : Based on the definition of six command points and the effect of the acupoints, we suggest that the six command points should be composed of LU7, LI4, ST36, BL40, PC6 and TE6.

• Korean Journal of Acupuncture
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• v.23 no.4
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• pp.27-47
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• 2006

Objectives : The aim of this study was to analyze how to treat various symptoms through the combination of Yoelgyoel $(LU_7)$ and Johae $(KI_6)$, according to reviewing the contents and data since Ling Shu (靈樞經) to recent literatures including thirty-five medical books. Methods : It was arranged and considered that the location, needling, and symptoms of each acupoint were described in various literatures before the publication of Chim Kyung Ji Nam (鍼經指南). Through various literature since the Publication of Chim Kyung Ji Nam, it was examined how to be recognized and be referred about Yoelgyoel $(LU_7)$ and Johae $(KI_6)$. Results and Conclusions : The location of Yoelgyoel is the superior 1.5cun at wrist joint striation, medial of extensor carpi radialis longus; the location of Johae is the depression part under foot medial condyle. Yoelgyoel is often used for respiratory organ disease, urinary organ disease, neuopsychiatory disease, musculoskeletal system disease; Johae is often used for urinary organ disease, circulatory organ disease. At Chim Kyung Ji Nam, Yoelgyoel is often used for thoraco-abdominal Pain, gynecological disease, digestive organ disease; Johae is often used for abdominal pain, gynecological disease, digestive organ disease. Therefore, these points are used together for general internal disease. As well, these are not directly continuous with Previous literatures from Chim Kyung Ji Nam. The combination of Yoelgyoel and Johae have been developed to the three categories as follows; it is quoted from as it is; it is reconstructed in the form of song; it has new symptoms enlarged. Consequently, the combination of Yoelgyoel and Johae was not bind to the rule of Up-Bottom harmony (上下配合), but asserted for the rule of Ju-Eng harmony (主應配合), which add specific acupoints to e combination of Yolgyol and Chohae as the complication of the symptoms.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.12 no.6
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• pp.672-680
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• 2019

This paper proposes "A Smart Farm Environment Optimization and Yield Prediction Platform based on IoT and Deep Learning" which gathers bio-sensor data from farms, diagnoses the diseases of growing crops, and predicts the year's harvest. The platform collects all the information currently available such as weather and soil microbes, optimizes the farm environment so that the crops can grow well, diagnoses the crop's diseases by using the leaves of the crops being grown on the farm, and predicts this year's harvest by using all the information on the farm. The result shows that the average accuracy of the AEOM is about 15% higher than that of the RF and about 8% higher than the GBD. Although data increases, the accuracy is reduced less than that of the RF or GBD. The linear regression shows that the slope of accuracy is -3.641E-4 for the ReLU, -4.0710E-4 for the Sigmoid, and -7.4534E-4 for the step function. Therefore, as the amount of test data increases, the ReLU is more accurate than the other two activation functions. This paper is a platform for managing the entire farm and, if introduced to actual farms, will greatly contribute to the development of smart farms in Korea.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.7
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• pp.3371-3396
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• 2016

Authentication protocols for multi-server architectures have gained momentum in recent times due to advancements in computing technologies and associated constraints. Lu et al. recently proposed a biometrics and smartcards-based authentication scheme for multi-server environment. The careful analysis of this paper demonstrates Lu et al.'s protocol is susceptible to user impersonation attacks and comprises insufficient data. In addition, this paper proposes an improved authentication with key-agreement protocol for multi-server architecture based on biometrics and smartcards. The formal security of the proposed protocol is verified using the widely accepted AVISPA (Automated Validation of Internet Security Protocols and Applications) tool to ensure that our protocol can withstand active and passive attacks. The formal and informal security analysis, and performance analysis sections determines that our protocol is robust and efficient compared to Lu et al.'s protocol and existing similar protocols.

• The Korean Journal of Nuclear Medicine Technology
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• v.26 no.2
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• pp.20-31
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• 2022

Purpose Broad Quantification Calibration(B.Q.C) is the procedure for Quantitative Analysis to measure Standard Uptake Value(SUV) in SPECT/CT scanner. B.Q.C was performed with Tc-99m, I-123, I-131, Lu-177 respectively and then we acquired the phantom images whether the SUVs were measured accurately. Because there is no standard for SUV test in SPECT, we used ACR Esser PET phantom alternatively. The purpose of this study was to lay the groundwork for Quantitative Analysis with various isotopes in SPECT/CT scanner. Materials and Methods Siemens SPECT/CT Symbia Intevo 16 and Intevo Bold were used for this study. The procedure of B.Q.C has two steps; first is point source Sensitivity Cal. and second is Volume Sensitivity Cal. to calculate Volume Sensitivity Factor(VSF) using cylinder phantom. To verify SUV, we acquired the images with ACR Esser PET phantom and then we measured SUV_mean on background and SUV_max on hot vials(25, 16, 12, 8 mm). SPSS was used to analyze the difference in the SUV between Intevo 16 and Intevo Bold by Mann-Whitney test. Results The results of Sensitivity(CPS/MBq) and VSF were in Detector 1, 2 of four isotopes (Intevo 16 D1 sensitivity/D2 sensitivity/VSF and Intevo Bold) 87.7/88.6/1.08, 91.9/91.2/1.07 on Tc-99m, 79.9/81.9/0.98, 89.4/89.4/0.98 on I-123, 124.8/128.9/0.69, 130.9, 126.8/0.71, on I-131, 8.7/8.9/1.02, 9.1/8.9/1.00 on Lu-177 respectively. The results of SUV test with ACR Esser PET phantom were (Intevo 16 BKG SUV_mean/25mm SUV_max/16mm/12mm/8mm and Intevo Bold) 1.03/2.95/2.41/1.96/1.84, 1.03/2.91/2.38/1.87/1.82 on Tc-99m, 0.97/2.91/2.33/1.68/1.45, 1.00/2.80/2.23/1.57/1.32 on I-123, 0.96/1.61/1.13/1.02/0.69, 0.94/1.54/1.08/0.98/ 0.66 on I-131, 1.00/6.34/4.67/2.96/2.28, 1.01/6.21/4.49/2.86/2.21 on Lu-177. And there was no statistically significant difference of SUV between Intevo 16 and Intevo Bold(p>0.05). Conclusion Only Qualitative Analysis was possible with gamma camera in the past. On the other hand, it's possible to acquire not only anatomic localization, 3D tomography but also Quantitative Analysis with SUV measurements in SPECT/CT scanner. We could lay the groundwork for Quantitative Analysis with various isotopes; Tc-99m, I-123, I-131, Lu-177 by carrying out B.Q.C and could verify the SUV measurement with ACR phantom. It needs periodic calibration to maintain for precision of Quantitative evaluation. As a result, we can provide Quantitative Analysis on follow up scan with the SPECT/CT exams and evaluate the therapeutic response in theranosis.

• Journal of Haehwa Medicine
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• v.9 no.1
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• pp.423-442
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• 2000

Objectives : The objectives of this study is to find out the classification methods of the cause of disease and the Acupuncture points on the cough(咳嗽, hae-soo) from the oriental medical literature. The results obtained as follows. Methods : We surveyed the oriental medical books from Hung-Ti-Nei-Ching $\ll$黃帝內經$\gg$ to recent books concerning the Acupuncture therapy for the cough(咳嗽, hae-soo). Results : 1. There are the classification methods of the cause of the cough(咳嗽, hae-soo) by affection by exopathogen and internal injury, by five zang-organs and six fu-organs, by time-belt, and by cold and heat. 2. The acupuncture points at P'yesu(肺兪, BL13), T'aeyon(太淵, LU9), Ch'okt'aek(尺澤, LU5), P'ungmun(風門, BL12), Yolgyol(列缺, LU7), Ch'ondol(天突, CV22), Taech'u(大椎, GV14), Hapkok(合谷, LI4), Kohwang(BL43), T'aegye(太谿, KI3), Chok-samni(足三里, ST36) are most frequently used on the acupuncture therapy for the cough(咳嗽, hae-soo). Conclusions : Among the classification methods of the cause of the cough(咳嗽, hae-soo), the classification methods by affection by exopathogen and internal injury may be most effective and the acupuncture points at Lung meridian(手太陰肺經, LU), Bladder mendian(足太陽膀胱經, BL) are most frequently used on the acupuncture therapy for the cough(咳嗽, hae-soo).