• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3681-3685
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• 2012

Background: In breast cancer, estrogen receptors have been demonstrated to interact with transcription factors to regulate target gene expression. However, high-throughput identification of the transcription regulation relationship between transcription factors and their target genes in response to estradiol is still in its infancy. Purpose: Thus, the objective of our study was to interpret the transcription regulation network of MCF7 breast cancer cells exposed to estradiol. Methods: In this work, GSE11352 microarray data were used to identify differentially expressed genes (DEGs). Results: Our results showed that the MYB (v-myb myeloblastosis viral oncogene homolog [avian]), PGR (progesterone receptor), and MYC (v-myc myelocytomatosis viral oncogene homolog [avian]) were hub nodes in our transcriptome network, which may interact with ER and, in turn, regulate target gene expression. MYB can up-regulate MCM3 (minichromosome maintenance 3) and MCM7 expression; PGR can suppress BCL2 (B-cell lymphoma 2) expression; MYC can inhibit TGFB2 (transforming growth factor, beta 2) expression. These genes are associated with breast cancer progression via cell cycling and the $TGF{\beta}$ signaling pathway. Conclusion: Analysis of transcriptional regulation may provide a better understanding of molecular mechanisms and clues to potential therapeutic targets in the treatment of breast cancer.

• Current Optics and Photonics
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• 제7권6호
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• pp.714-720
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• 2023

Laser cleaning has the advantages of environmental protection, precision, and high efficiency, and has good prospects for application in removing oxide films on the surface of aluminum alloy. This paper discusses the cleaning threshold and cleaning mechanism of aluminum alloy surface oxide film. A nanosecond pulsed laser was used to remove a 5-㎛-thick oxide film from the surface of 7A04 aluminum alloy, and the target surface temperature and cleaning depth were simulated. The effects of different laser energy densities on the surface morphology of the aluminum alloy were analyzed, and the plasma motion process was recorded using a high-speed camera. The temperature measurement results of the experiment are close to the simulation results. The results show that the laser cleaning of aluminum alloy oxide film is mainly based on the vaporization mechanism and the shock wave generated by the explosion.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3011-3015
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• 2013

Objective: This study aimed to investigate the expression of B7-H4 in human thyroid cancer and determine any association with patient clinicopathological parameters and survival. Methods: B7-H4 expression in 64 clinical thyroid cancer specimens was assessed with immunohistochemistry. Moreover, B7-H4 mRNA expression in 10 fresh resected specimens were evaluated by the reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining of CD3 was performed to assess the number of tumor infiltrating T lymphocytes (TILs) in thyroid cancers. Results: Positive B7-H4 immunohistochemical staining was observed in 61 out of 64 (95.3%) specimens of thyroid cancer tissues. Significantly more B7-H4 mRNA copies were found in thyroid cancer tissue than that adjacent normal tissue. Moreover, B7-H4 expression in human thyroid cancer tissues was significantly correlated with patient TNM stages and extrathyroidal extension (P<0.05), being inversely correlated with the number of TILs (P<0.05). The overall survival rate of the patients with higher B7-H4 expression was significantly worse than that of the patients with lower B7-H4 expression. Conclusions: This present study suggests that high B7-H4 expression is associated with cancer progression, reduced tumor immunosurveillance and worse patient outcomes in human thyroid cancer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권1호
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• pp.56-67
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• 2013

Because H.264/SVC can meet the needs of different networks and user terminals, it has become more and more popular. In this paper, we focus on the spatial resolution scalability of H.264/SVC and propose a blind video watermarking algorithm for the copyright protection of H.264/SVC coded video. The watermark embedding occurs before the H.264/SVC encoding, and only the original enhancement layer sequence is watermarked. However, because the watermark is embedded into the average matrix of each macro block, it can be detected in both the enhancement layer and base layer after downsampling, video encoding, and video decoding. The proposed algorithm is examined using JSVM, and experiment results show that is robust to H.264/SVC coding and has little influence on video quality.

• 한국진공학회지
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• 제7권s1호
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• pp.156-158
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• 1998

This paper describes the preparation of boron-doped polycrystalline diamond thin film whose electrical resitivity is lower than $10^{-1}\Omega$cm. The 1$\times$1$\textrm{mm}^2$ microelectrodes, its conducting line with 0.2mm wide and 0.5$\times$0.5$\textrm{mm}^2$ pads was patterned by reactive ion beam etching. A glucose microsensor based on diamond film microelectrode and pyramidal containment produced on silicon by anisotropic etching was developed. Its advantages are high sensitivity and high stability.

• 한국음향학회:학술대회논문집
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• 한국음향학회 2004년도 추계학술발표대회논문집 제23권 2호
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• pp.487-490
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• 2004

OFDM(Orthogonal Frequency Division Multiplexing) 방식의 수중음향 데이터 통신시스템에서 도플러 편이(Doppler Shift)와 도플러 확산(Doppler Spread)의 영향을 완화하여 주파수 효율을 향상시킬 수 있는 수신신호처리 방안을 설계하고 해상에서 송수신 된 시험 데이터의 BER 로써 성능을 평가한다. 도플러 편이를 OFDM 심볼에 부가된 Cyclic Prefix 와 상관계수법을 통해 추정하였으며 도플러 확산에 의해 시간에 따라 변화하는 채널을 Time-Frequency 축상에서 $2\times1D$ MMSE 방식으로 추정한다. 해상실험 결과, $8kHz\~11kHz$ 의 전송대역을 사용 할 때 복호 전 전송률 3098bps, 송수신 소자간 거리 7km, SNR 15dB에서 약 $1\~3\%$의 BER이 추정된다.

• Industrial Engineering and Management Systems
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• 제7권3호
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• pp.266-287
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• 2008

To manage collaborative negotiation in software system design, we have built a socio-technical argument-based negotiation management approach by integrating a Socio-technical Co-construction Process (STCP) with an Argument-based Negotiation Process (ABNP). This paper reviews relevant research work and presents each step of this approach. The STCP provides rich contextual information of technical decisions and social interactions in a system design process. The ABNP provides STCP with a negotiation management and conflict resolution strategy by guiding software engineers to generate, exchange and evaluate their argument claims in negotiation activities. In addition, this paper describes a prototype system which implements this new approach using the advanced Web-based software technologies with the goal of demonstrating how to systematically enhance the negotiation management capabilities in a dynamic socio-technical framework.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권7호
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• pp.2703-2718
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• 2015

Nowadays, public cloud storage is gaining popularity and a growing number of users are beginning to use the public cloud storage for online data storing and sharing. However, how the encrypted data stored in public clouds can be effectively shared becomes a new challenge. Proxy re-encryption is a public-key primitive that can delegate the decryption right from one user to another. In a proxy re-encryption system, a semi-trusted proxy authorized by a data owner is allowed to transform an encrypted data under the data owner's public key into a re-encrypted data under an authorized recipient's public key without seeing the underlying plaintext. Hence, the paradigm of proxy re-encryption provides a promising solution to effectively share encrypted data. In this paper, we propose a new certificate-based proxy re-encryption scheme for encrypted data sharing in public clouds. In the random oracle model, we formally prove that the proposed scheme achieves chosen-ciphertext security. The simulation results show that it is more efficient than the previous certificate-based proxy re-encryption schemes.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.370.4-371
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• 2002

The roots of Juglans mandshurica Maximowicz (Juglandaceae) have been used as a folk medicine for treatment of cancer in Korea. Several naphthoquinones and naphthalenyl glucosides from Juglans species have been reported (1-7). In the course of isolating cytotoxic compounds from the roots of this plant. we have isolated six naphthalene glycosides. four tetralone, one naphthalene carboxylic acid glucoside and nine diarylheptanoids (8-13). (omitted)

• Journal of Information Display
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• 제7권4호
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• pp.5-8
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• 2006

The optical structures and rigorous electromagnetic modeling of OLEDs will be discussed of first and then their applications in analyses and designs of various advanced OLED structures, e.g. microcavity OLEDs, tandem OLEDs and top-emitting OLEDs etc., will be reported.