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http://dx.doi.org/10.7314/APJCP.2013.14.5.3011

B7-H4 Expression is Associated with Cancer Progression and Predicts Patient Survival in Human Thyroid Cancer  

Zhu, Jian (Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University school of Medicine)
Chu, Bing-Feng (Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University school of Medicine)
Yang, Yi-Peng (Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University school of Medicine)
Zhang, Sheng-Lai (Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University school of Medicine)
Zhuang, Ming (Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University school of Medicine)
Lu, Wen-Jie (Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University school of Medicine)
Liu, Ying-Bin (Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University school of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.5, 2013 , pp. 3011-3015 More about this Journal
Abstract
Objective: This study aimed to investigate the expression of B7-H4 in human thyroid cancer and determine any association with patient clinicopathological parameters and survival. Methods: B7-H4 expression in 64 clinical thyroid cancer specimens was assessed with immunohistochemistry. Moreover, B7-H4 mRNA expression in 10 fresh resected specimens were evaluated by the reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining of CD3 was performed to assess the number of tumor infiltrating T lymphocytes (TILs) in thyroid cancers. Results: Positive B7-H4 immunohistochemical staining was observed in 61 out of 64 (95.3%) specimens of thyroid cancer tissues. Significantly more B7-H4 mRNA copies were found in thyroid cancer tissue than that adjacent normal tissue. Moreover, B7-H4 expression in human thyroid cancer tissues was significantly correlated with patient TNM stages and extrathyroidal extension (P<0.05), being inversely correlated with the number of TILs (P<0.05). The overall survival rate of the patients with higher B7-H4 expression was significantly worse than that of the patients with lower B7-H4 expression. Conclusions: This present study suggests that high B7-H4 expression is associated with cancer progression, reduced tumor immunosurveillance and worse patient outcomes in human thyroid cancer.
Keywords
Thyroid cancer; B7-H4; progression; prognosis; tumor infiltrating lymphocytes;
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