• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3767-3771
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• 2015

Background: Lynch syndrome (LS) is an inherited predisposition to colorectal, endometrial (uterine) and other cancers. Although most cancers are not inherited, about 5 percent (%) of people who have colorectal or endometrial cancer have the Lynch syndrome. It involves the alteration of mismatch repair (MMR) genes; MLH1, MSH2, MSH6 or PMS2. In this study, we analyzed the expression of MMR proteins in colorectal cancer in a Malay cohort by immunohistochemistry. Materials and Methods: A total of 17 patients were selected fulfilling one of the Bethesda criteria: colorectal cancer diagnosed in a patient aged less than 50 years old, having synchronous and metachronous colorectal cancer or with a strong family history. Immunohistochemical staining was performed on paraffin embedded tumour tissue samples using four antibodies: MLH1, MSH2, MSH6 and PMS2. Results: Twelve out of 17 patients (70.6%) were noted to have a family history. A total of 41% (n=7) of the patients had abnormal immunohistochemical staining with one or more of the four antibodies. Loss of expression were noted in 13 tumour tissues with a negative staining score <4. Of 13 tumour tissues, four showed loss expression of MLH1. For PMS2, loss of expression were noted in five cases. Both MSH2 and MSH6 showed loss of expression in two tumour tissues respectively. Conclusions: Revised Bethesda criteria and immunohistochemical analysis constituted a convenient approach and is recommended to be a first-line screening for Lynch syndrome in Malay cohorts.

• Steel and Composite Structures
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• v.23 no.1
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• pp.95-105
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• 2017

The use of superelastic shape memory alloys (SMAs) as reinforcements in concrete structures is gradually gaining interest among researchers. Because of different mechanical properties of SMAs compared to the regular steel bars, the use of SMAs as reinforcement in the concrete may change the response of structures under seismic loads. In this study, the effect of SMAs as reinforcement in concrete structures is analytically investigated for 3-, 6- and 8-story reinforced concrete (RC) buildings. For each concrete building, three different reinforcement details are considered: (1) steel reinforcement (Steel) only, (2) SMA bar used in the plastic hinge region of the beams and steel bar in other regions (Steel-SMA), and (3), beams fully reinforced with SMA bar (SMA) and steel bar in other regions. For each case, columns are reinforced with steel bar. Incremental Dynamic Analyses (IDA) are performed using ten different ground motion records to determine the seismic performance of Steel, Steel-SMA and SMA RC buildings. Then fragility curves for each type of RC building by using IDA results for IO, LS and CP performance levels are calculated. Results obtained from the analyses indicate that 3-story frames have approximately the same spectral acceleration corresponding with failure of frames, but in the cases of 6 and 8-story frames, the spectral acceleration is higher in frames equipped with steel reinforcements. Furthermore, the probability of fragility in all frames increases by the building height for all performance levels. Finally, economic evaluation of the three systems are compared.

• Advances in aircraft and spacecraft science
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• v.1 no.2
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• pp.233-251
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• 2014

Each aircraft have to be certified for a specified level of impact energy, for assuring the capability of a safe flight and landing after the impact against a bird at cruise speed. The aim of this research work was to define a scientific and methodological approach to the study of the birdstrike phenomenon against several windshield geometries. A series of numerical simulations have been performed using the explicit finite element solver code LS-Dyna, in order to estimate the windshield-surround structure capability to absorb the bird impact energy, safely and efficiently, according to EASA Certification Specifications 25.631 (2011). The research considers the results obtained about a parametric numerical analysis of a simplified, but realistic, square flat windshield model, as reported in the last work (Grimaldi et al. 2013), where this model was subjected to the impact of a 1.8 kg bird model at 155 m/s to estimate the sensitivity of the target geometry, the impact angle, and the plate curvature on the impact response of the windshield structure. Then on the basis of these results in this paper the topic is focused about the development of a numerical simulation on a complete aircraft windshield-surround model with an innovative configuration. Both simulations have used a FE-SPH coupled approach for the fluid-structure interaction. The main achievement of this research has been the collection of analysis and results obtained on both simplified realistic and complete model analysis, addressed to approach with gained confidence the birdstrike problem. Guidelines for setting up a certification test, together with a design proposal for a test article are an important result of such simulations.

• Journal of the Korean Solar Energy Society
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• v.29 no.1
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• pp.32-37
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• 2009

Photovoltaic(PV) permits the on-site production of electricity without concern for fuel supply or environmental adverse effects. The electrical power is produced without noise and little depletion of resources. So BIPV(Building-Integrated Photovoltaic) system have been increased around the world. Hereby the relative installation costs of the system will be relatively low compared to traditional installations of PV in high-rise buildings. This paper examined possibility of building integrated balcony PV system and analyzed both performance and problems of this system. The system is influenced by conditions such as irradiation, module temperature, shade and architectural component etc. If this BIPV system of 1.1kW is possible the natural ventilation in the summer case, the temperature of PV module decrease and then the efficiency of PV system increase generally. By the results, the annual averaged PR of BIPV system of cold facade type is about 74.7%.

• Journal of Sensor Science and Technology
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• v.6 no.4
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• pp.258-264
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• 1997

$YBa_{2}Cu_{3}O_{7}$ single layer dc SQUID magnetometers, prepared on $1\;cm^{2}\;SrTiO_{3}$ substrates, have been fabricated and characterized. Based on the analytical description, a SQUID magnetometer design having a 8.5 mm pickup coil with 2.6 mm linewidth, and a SQUID inductance Ls = 50 pH with $3\;{\mu}m$ Josephson junctions is presented. The devices showed a maximum modulation voltage depth of $65\;{\mu}V$ and a magnetic field noise of 0.6 pT /$\sqrt{Hz}$ at 1 Hz. Clear traces of human magnetocardiogram could be obtained with the SQUID magnetometer operating at 77 K.

• International Journal of High-Rise Buildings
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• v.10 no.4
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• pp.265-283
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• 2021

To ensure that fire induced collapse of a building is prevented it is important to understand the sequence of events that can lead to this event. In this paper, the initiation of collapse mechanisms of generic a multi-storey steel frame subjected to vertical and horizontal travelling fires are analysed computationally by tracking the formation of plastic hinges in the frame and generation of fire induced loads. Both uniform and travelling fires are considered. In total 58 different cases are analysed using finite element software LS-DYNA. For the frame examined with a simple and generic structural arrangement and higher applied fire protection to the columns, the results indicate that collapse mechanisms for singe floor and multiple floor fires can be each split into two main groups. For single floor fires (taking place in the upper floors of the frame (Group S1)), collapse is initiated by the pull-in of external columns when heated beams in end bays go into catenary action. For single floor fires occurring on the lower floors(Group S2), failure is initiated (i.e. ultimate strain of the material is exceeded) after the local beam collapse. Failure in both groups for single floor fires is governed by the generation of high loads due to restrained thermal expansion and the loss of material strength. For multiple floor fires with a low number of fire floors (1 to 3) - Group M1, failure is dominated by the loss of material strength and collapse is mainly initiated by the pull-in of external columns. For the cases with a larger number of fire floors (5 to 10) - Group M2, failure is dominated by thermal expansion and collapse is mainly initiated by swaying of the frame to the side of fire origin. The results show that for the investigated frame initiation of collapse mechanisms are affected by the fire type, the number of fire floors, and the location of the fire floor. The findings of this study could be of use to designers of buildings when developing fire protection strategies for steel framed buildings where the potential for a multifloor fire exists.

• Journal of Nutrition and Health
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• v.35 no.4
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• pp.464-472
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• 2002

This study was conducted to investigate dietary and other factors affecting bone mineral density in young Korean collage women. Thirty subjects were recruited; the mean age was 22.1 years and the mean age at menarche was 12.6 years. Bone mineral density (BMD) was measured in the spine (LS), femoral neck (FN), ward's triangle (WT), and femoral trochanter (FT) by Dual Energy X-ray Absorptiometry (DEXA), and physical activity was assessed by a questionnaire. Dietary intake data were obtained 8 times by using a 24 hour recall method to evaluate the subjects' usual diet. Bone mineral densities of lumbar spine, femoral neck, ward's triangle and femoral trochanter were 1.149 g/$\textrm{cm}^2$, 0.980 g/$\textrm{cm}^2$, 0.936 g/$\textrm{cm}^2$ and 0.759 g/$\textrm{cm}^2$ respectively. The met energy intake of subjects was 1,790 kcal, and calcium and iron intakes were found to be inadequate compared to the Korean RDA. The BMD of the lumbar spine was significantly and positively related to the BMI and intake of vitamin C, carbohydrate, potatoes, fruits and plant food. The BMD of the femur (FN, WT, FT) was positively related to the BMI, to carbohydrate and fruit intake, and to the percentage of plant food in total food intake. Multiple recession analysis showed that fruit intake was significantly related to the BMD of the LS. The subjects'ages and fruit intakes were significantly related to the BMD of the femur (FN, WT, FT). These results indicate that higher fruit intakes may have a beneficial effect on bone mineral density.

• Horticultural Science & Technology
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• v.33 no.2
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• pp.219-226
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• 2015

The objective of this research was to investigate the influence of various root media on the growth of mother and daughter plants during propagation and early yield after transplanting of 'Seolhyang' strawberry. To achieve this, daughter plants were fixed to connected small pots that contained expanded rice-hull (ERH), a strawberry-specialized commercial medium (SSCM), soil mother materials (SMM), or loamy sand (LS). Then, growth of daughter plants in above- and below-ground tissue as well as early yield after transplanting to plastic house soil were investigated. The growth of daughter plants in terms of plant height, leaf area and fresh weight were the highest in the SSCM treatment. Root growth in terms of the amount of primary roots and root dry weight were the highest in the treatments of ERH and SMM and the lowest in that of SSCM, among treatments tested. The ERH treatment also showed the highest values among treatments in root length, surface area and volume when roots with 0 to 0.4 mm in diameter were investigated. The flower bud differentiation of daughter plants began on Sept. 3 in the ERH treatments, earlier than the SMM (Sept. 5) and in SSCM (Sept. 7) treatments. The tissue N contents of daughter plants were in the range of 1.41 to 1.55% in all treatments, and no significant differences were observed among treatments. This indicates that the low moisture retention capacity of ERH and water stress, rather than tissue N contents, promote the flower differentiation of daughter plants. In the evaluation of early yield after transplant, the ERH treatment of showed the highest yield in the period from November to December, reaching 667 g fruit weight per 10 plants. The yields per 10 plants in the other treatments were 581 g in SMM, 475 g in SSCM and 295 g in LS. Above results imply that the various root media have different effects on the growth of daughter plants as well as flower bud differentiation. Therefore, improvement in early yield after transplant can be achieved through selection of proper root medium for daughter plant propagation.

• The korean journal of orthodontics
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• v.30 no.3 s.80
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• pp.343-355
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• 2000

The purpose of this study was to evaluate the amount and interrelationship of hard and soft tissue changes after mandibular setback osteotomy and reduction genioplasty in mandibular prognathism with long anterior facial height. The control group (Group A) consisted of 20 patients who had severe horizontal discrepancy. They experienced Presurgical orthodontic treatment and orthognathic surgery via mandibular setback. The experimental group (Group B) consisted of 20 patients who had severe horizontal and vertical discrepancy. They experienced presurgical orthodontic treatment and orthognathic surgery via mandibular setback and reduction genioplasty. The presurgical and postsurgical lateral cephalograms were evaluated. The computerized statistical analysis was tarried on with EXCEL 97 program. The results were as follows : 1. The correlation of hard and soft tissue horizontal changes in lower 2/3 of lower anterior facial height were high for both groups. The correlation coefficients of hard tissue changes and Ls, Stm, Li changes in Group B were moderately higher than Group A. 2. The correlation of hard and soft tissue vortical changes in Group B were lower than Group A. (except for pointB-Ils, Me-Me') 3. The ratio for soft tissue to Pog in Group B was lower than Group A. The ratios of hard and soft tissue vertical changes were 32% at Ils, 54% at Pog', and 60% at Me'. 4. The ratio of lower anterior facial height to total anterior facial height was reduced for both groups. But ratio of upper 1/3 of lower anterior facial height to total anterior facial height did not changed significantly in Group B. 5. Reduction genioplasty combined with mandibular setback procedure showed no change in upper one third(Sn-Stm) and significant decrease(Stm-Me') in the lower two thirds of the soft-tissue anterior lower facial height

• Journal of the korean academy of Pediatric Dentistry
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• v.28 no.3
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• pp.403-411
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• 2001

The aim of this study was to evaluate the resistance to degradation of four commercial composite resins in an alkaline solution. The brands studied were Unifil(GC, Japan), Palfique(Tokuyama Japan). Definite$Degussa-H\ddot{u}ls$ AG, Germany). Revolution(Kerr, U.S.A.). Preweighed discs of each brand were exposed 0.1N NaOH solution at $60^{\circ}C$. After 14 days they were removed, neutralized with HCl, washed with water and dried. Resistance to degradation was evaluated on the basis of following parameters: (a) mass loss(%) - determined from pre-and post-exposed specimen weights; (b) Si loss(ppm) - obtained from ICP-AE analysis of solution exposed to specimens; and (c) degradation depth$({\mu}m)$ - measured microscopically (SEM) from polished circular sections of exposed specimens. The results were follows: 1. The mass loss of Unifil was 3.21%, it was the highest of materials. But, there was no significant difference among the materials. 2. The degree of degradation layer depth was $107.69\sim47.40{\mu}m$, the sequence of the degree pf degradation layer depth was in descending order by Unifil, Palfique, Revolution, Definite. There was significant difference among the materials except Palfique and Definite. 3. The Si loss of Paltique was 8940.0ppm, it was the highest. There was significant difference among the materials, except Revolution and Definite(p<0.05). 4. The correlation coefficient between mass loss and degradation depth was relatively high(r = 0.06, p<0.05). 5. There was no significant coefficient correlation between Si loss and mass loss, and/or the degree of degradation layer depth and Si loss. 6. When observed with SEM, destruction of bonding is observed between resin matrix and filler. Above results suggested that the hydrolytic degradation is considered as evaluation factor of composite resins.